PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18941459-5 2008 In this study, we report that although NF-kappaB subunits p50/p65 translocate to the nucleus of PC3 cells in response to IP6, inhibition of NF-kappaB-mediated transcription using non-degradable inhibitor of kappaB (IkappaB)-alpha does not modulate IP6 sensitivity. Phytic Acid 121-124 nuclear factor kappa B subunit 1 Homo sapiens 58-61 23285696-0 2012 The effect of phytic acid on the expression of NF-kappaB, IL-6 and IL-8 in IL-1beta-stimulated human colonic epithelial cells. Phytic Acid 14-25 nuclear factor kappa B subunit 1 Homo sapiens 47-56 23285696-9 2012 IP6 at all used concentrations had no influence on transcription of p65 gene and modulated expression of p50 and IkappaBalpha genes in Caco-2 cells. Phytic Acid 0-3 nuclear factor kappa B subunit 1 Homo sapiens 105-108 23285696-11 2012 The results of these studies suggest that IP6 may exert immunoregulatory effects on intestinal epithelium by influencing transcriptional activity of genes encoding p50 subunit of NF-kappaB, its inhibitor IkappaBalpha and proinflammatory cytokines IL-6 and IL-8. Phytic Acid 42-45 nuclear factor kappa B subunit 1 Homo sapiens 164-167 23285696-11 2012 The results of these studies suggest that IP6 may exert immunoregulatory effects on intestinal epithelium by influencing transcriptional activity of genes encoding p50 subunit of NF-kappaB, its inhibitor IkappaBalpha and proinflammatory cytokines IL-6 and IL-8. Phytic Acid 42-45 nuclear factor kappa B subunit 1 Homo sapiens 179-188 18941459-5 2008 In this study, we report that although NF-kappaB subunits p50/p65 translocate to the nucleus of PC3 cells in response to IP6, inhibition of NF-kappaB-mediated transcription using non-degradable inhibitor of kappaB (IkappaB)-alpha does not modulate IP6 sensitivity. Phytic Acid 248-251 nuclear factor kappa B subunit 1 Homo sapiens 58-61 19172851-0 2008 Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells. Phytic Acid 76-87 nuclear factor kappa B subunit 1 Homo sapiens 55-64 19172851-2 2008 The aim of this study was to evaluate the influence of phytic acid on the expression of genes encoding p65 and p50 subunits of NF-kappaB and of its inhibitor IkappaBalpha in human colorectal cancer cell line Caco-2. Phytic Acid 55-66 nuclear factor kappa B subunit 1 Homo sapiens 111-114 19172851-2 2008 The aim of this study was to evaluate the influence of phytic acid on the expression of genes encoding p65 and p50 subunits of NF-kappaB and of its inhibitor IkappaBalpha in human colorectal cancer cell line Caco-2. Phytic Acid 55-66 nuclear factor kappa B subunit 1 Homo sapiens 127-136 14666688-0 2003 Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells. Phytic Acid 0-22 nuclear factor kappa B subunit 1 Homo sapiens 59-70 14666688-3 2003 Since transcription factor NF-kappa B is constitutively active in advanced and androgen-independent human PCA DU145 cells, here we assessed whether IP6 inhibits this constitutively active NF-kappa B and associated upstream effectors and whether such an affect of IP6 has biological relevance in causing inhibition of proliferation and induction of apoptosis in DU145 cells. Phytic Acid 148-151 nuclear factor kappa B subunit 1 Homo sapiens 188-198 14666688-7 2003 RESULTS: Treatment of cells with 1 and 2 mM doses of IP6 resulted in a strong inhibition of NF-kappa B activation, which was consistent with a decrease in nuclear levels of NF-kappa B sub-unit proteins p65 and p50. Phytic Acid 53-56 nuclear factor kappa B subunit 1 Homo sapiens 92-102 14666688-7 2003 RESULTS: Treatment of cells with 1 and 2 mM doses of IP6 resulted in a strong inhibition of NF-kappa B activation, which was consistent with a decrease in nuclear levels of NF-kappa B sub-unit proteins p65 and p50. Phytic Acid 53-56 nuclear factor kappa B subunit 1 Homo sapiens 173-183 14666688-7 2003 RESULTS: Treatment of cells with 1 and 2 mM doses of IP6 resulted in a strong inhibition of NF-kappa B activation, which was consistent with a decrease in nuclear levels of NF-kappa B sub-unit proteins p65 and p50. Phytic Acid 53-56 nuclear factor kappa B subunit 1 Homo sapiens 210-213 14666688-11 2003 CONCLUSION: Our results suggest that IP6 could be a potent dietary agent in controlling the growth of advanced PCA cells and inducing their apoptotic death, in part, by its inhibitory effect on constitutively active NF-kappa B signaling pathway. Phytic Acid 37-40 nuclear factor kappa B subunit 1 Homo sapiens 216-226 11604545-2 2001 At pH 7.0 and 15 degrees C, the oxygen pressure at half saturation (p50) was measured to be 12.4 +/- 0.2 and 139 +/- 4 torr for hemoglobin gels prepared in the absence and presence of the strong allosteric effectors inositol hexaphosphate and bezafibrate, respectively. Phytic Acid 216-238 nuclear factor kappa B subunit 1 Homo sapiens 68-71 12507926-0 2002 Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway. Phytic Acid 0-25 nuclear factor kappa B subunit 1 Homo sapiens 118-126 3252931-0 1988 Cardiac effects of phytic acid induced high P50 with free and limited coronary blood flow. Phytic Acid 19-30 nuclear factor kappa B subunit 1 Homo sapiens 44-47 3252931-1 1988 A blood preparation with a large increase in P50, obtained by a new technique to encapsulate inositol hexaphosphate (IHP) in erythrocytes was evaluated on an isolated heart model. Phytic Acid 93-115 nuclear factor kappa B subunit 1 Homo sapiens 45-48 3252931-2 1988 Each heart was alternatively perfused with control stored human blood (P50 = 2.12.+/- 0.9 mmHg) and IHP-treated human blood (P50 = 42.5 +/- 9.33 mmHg). Phytic Acid 100-103 nuclear factor kappa B subunit 1 Homo sapiens 125-128 3482484-6 1987 Inositolhexaphosphate (IHP) is added to SFHS containing bicarbonate to obtain a normal p50 (around 3.55 kPa). Phytic Acid 0-21 nuclear factor kappa B subunit 1 Homo sapiens 87-90 3482484-6 1987 Inositolhexaphosphate (IHP) is added to SFHS containing bicarbonate to obtain a normal p50 (around 3.55 kPa). Phytic Acid 23-26 nuclear factor kappa B subunit 1 Homo sapiens 87-90 6534139-0 1984 Enhancement of P50 by inositol hexa phosphate entrapped in resealed erythrocytes in piglets. Phytic Acid 22-45 nuclear factor kappa B subunit 1 Homo sapiens 15-18