PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33846320-3	2021	We demonstrate mTOR pathway activation and metabolic adaptation specifically in medulloblastoma of the molecular subgroup G4 characterised by a BMI1High;CHD7Low signature and show this can be counteracted by IP6 treatment.	Phytic Acid	208-211	mechanistic target of rapamycin kinase	Homo sapiens	15-19	
33767863-2	2021	The IP6Ks convert IP6 to IP7, which inhibits activation of the tumor-promoting PI3K/Akt/mTOR signaling pathway.	Phytic Acid	4-7	mechanistic target of rapamycin kinase	Homo sapiens	88-92	
30393482-4	2018	In the present study the effect of IP6 on autophagy-mediated death by modulating the mTOR pathway in HT-29 colon cancer cells was studied.	Phytic Acid	35-38	mechanistic target of rapamycin kinase	Homo sapiens	85-89	
30393482-10	2018	mTOR pathway regulates autophagy and incubation with IP6 to HT-29 cells showed decreased expression of p-70S6Kinase, 4-EBP-1 in a time-dependent manner.	Phytic Acid	53-56	mechanistic target of rapamycin kinase	Homo sapiens	0-4	
30393482-14	2018	Conclusions: Our results clearly indicate that IP6 induces autophagy by inhibiting the Akt/mTOR pathway.	Phytic Acid	47-50	mechanistic target of rapamycin kinase	Homo sapiens	91-95	
33158864-6	2020	Two previously uncharacterized small-molecule binding sites are visualized, an inositol hexakisphosphate (InsP6) pocket in mTOR and an mTORC2-specific nucleotide binding site in Rictor, which also forms a zinc finger.	Phytic Acid	79-104	mechanistic target of rapamycin kinase	Homo sapiens	123-127	
28972559-0	2017	Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway.	Phytic Acid	0-22	mechanistic target of rapamycin kinase	Homo sapiens	113-117