PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26740400-6	2016	Results indicated that loss of mitochondrial membrane potential, cytochrome c releasing, upregulation of Bcl-2-associated X protein (Bax), downregulation of B-cell CLL/lymphoma 2 (Bcl-2) and caspases activation were reversed by IP6.	Phytic Acid	228-231	BCL2 apoptosis regulator	Homo sapiens	157-178	
25372635-10	2014	Higher expression of IGFBP-3 and lower expression of Bcl-2 in LNCaP cells treated with IP6 were found at both mRNA and protein levels.	Phytic Acid	87-90	BCL2 apoptosis regulator	Homo sapiens	53-58	
25372635-14	2014	CONCLUSION: IP6 can inhibit the proliferation of LNCaP cells, which may be associated with the changes of IGFBP-3 level through Bcl-2 expression.	Phytic Acid	12-15	BCL2 apoptosis regulator	Homo sapiens	128-133	
18646526-9	2008	The bcl-2 protein expressions treated with IP6 were reduced, and the bax protein expressions treated with IP6 were more than those of control groups in dose and time dependent manners.	Phytic Acid	43-46	BCL2 apoptosis regulator	Homo sapiens	4-9	
24870784-0	2014	Rice bran phytic acid induced apoptosis through regulation of Bcl-2/Bax and p53 genes in HepG2 human hepatocellular carcinoma cells.	Phytic Acid	10-21	BCL2 apoptosis regulator	Homo sapiens	62-67	
24870784-9	2014	PA treated HepG2 cells showed up-regulation of p53, Bax, Caspase-3 and -9, and down- regulation of Bcl-2 gene (p <= 0.01).	Phytic Acid	0-2	BCL2 apoptosis regulator	Homo sapiens	99-104	
18941459-4	2008	We have previously shown that treatment of PC3 cells with IP6 induces the transcription of a subset of nuclear factor-kappaB (NF-kappaB)-responsive and pro-apoptotic BCL-2 family genes.	Phytic Acid	58-61	BCL2 apoptosis regulator	Homo sapiens	166-171	
18941459-6	2008	Treatment with IP6 also leads to increased protein levels of PUMA, BIK/NBK and NOXA between 4 and 8 h of treatment and decreased levels of MCL-1 and BCL-2 after 24 h. Although blocking transcription using actinomycin D does not modulate PC3 cell sensitivity to IP6, inhibition of protein translation using cycloheximide has a significant protective effect.	Phytic Acid	15-18	BCL2 apoptosis regulator	Homo sapiens	149-154	
18941459-9	2008	The enhanced effect of combined MG132/IP6 treatment is almost completely inhibited by cycloheximide and correlates with changes in BCL-2 family protein levels.	Phytic Acid	38-41	BCL2 apoptosis regulator	Homo sapiens	131-136	
18941459-10	2008	Altogether these results suggest a role for BCL-2 family proteins in mediating the combined effect of IP6 and proteasome inhibitors and warrant further pre-clinical studies for the treatment of AIPCa.	Phytic Acid	102-105	BCL2 apoptosis regulator	Homo sapiens	44-49	
18646526-10	2008	CONCLUSION: The proliferation of gastric carcinoma SGC-7901 cells inhibitited by IP6 could be associated with apoptosis of gene bax and bcl-2.	Phytic Acid	81-84	BCL2 apoptosis regulator	Homo sapiens	136-141	
15548374-9	2004	In other studies, IP6 caused a dose- and a time-dependent apoptotic death of LNCaP cells, and a decrease in Bcl2 levels, causing a strong increase in Bax versus Bcl2 ratio, as well as an inhibition of constitutively active AKT phosphorylation.	Phytic Acid	18-21	BCL2 apoptosis regulator	Homo sapiens	108-112	
15548374-9	2004	In other studies, IP6 caused a dose- and a time-dependent apoptotic death of LNCaP cells, and a decrease in Bcl2 levels, causing a strong increase in Bax versus Bcl2 ratio, as well as an inhibition of constitutively active AKT phosphorylation.	Phytic Acid	18-21	BCL2 apoptosis regulator	Homo sapiens	161-165