PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29142407-0	2017	Molecular Docking Analysis of Phytic Acid and 4-hydroxyisoleucine as Cyclooxygenase-2, Microsomal Prostaglandin E Synthase-2, Tyrosinase, Human Neutrophil Elastase, Matrix Metalloproteinase-2 and -9, Xanthine Oxidase, Squalene Synthase, Nitric Oxide Synthase, Human Aldose Reductase, and Lipoxygenase Inhibitors.	Phytic Acid	30-41	matrix metallopeptidase 2	Homo sapiens	165-198	
30066850-9	2018	IP6-treated cells also showed decreased expression of N-cadherin, increased levels of E-cadherin and decreased expression of MMP-2 and MMP-9.	Phytic Acid	0-3	matrix metallopeptidase 2	Homo sapiens	125-130	
23285695-10	2012	A significant decrease in MMP-2, MMP-3, MMP-10, MMP-13, and TIMP-1 expression in response to IP6 was observed.	Phytic Acid	93-96	matrix metallopeptidase 2	Homo sapiens	26-31	
23285695-11	2012	IP6 down-regulated MMP-9 transcription induced by PMA and decreased the level of both MMP-2 and MMP-3 mRNAs in PMA-stimulated cells.	Phytic Acid	0-3	matrix metallopeptidase 2	Homo sapiens	86-91	
23285695-14	2012	IP6 exerts an influence of basal mRNA expression of some MMPs and their tissue inhibitors and down-regulates MMP-1, MMP-2, MMP-3 and MMP-9 in cells treated with PMA.	Phytic Acid	0-3	matrix metallopeptidase 2	Homo sapiens	116-121	
21229878-2	2010	One postulated mechanism by which inositol hexaphosphate (phytic acid, IP6), an ubiquitous plant component, prevents the activation of MMPs may be due to its ability to chelate minerals.	Phytic Acid	34-56	matrix metallopeptidase 2	Homo sapiens	135-139	
21229878-2	2010	One postulated mechanism by which inositol hexaphosphate (phytic acid, IP6), an ubiquitous plant component, prevents the activation of MMPs may be due to its ability to chelate minerals.	Phytic Acid	58-69	matrix metallopeptidase 2	Homo sapiens	135-139	
21229878-2	2010	One postulated mechanism by which inositol hexaphosphate (phytic acid, IP6), an ubiquitous plant component, prevents the activation of MMPs may be due to its ability to chelate minerals.	Phytic Acid	71-74	matrix metallopeptidase 2	Homo sapiens	135-139	
21229878-3	2010	The aim of the study was to evaluate the expression profile of MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 at the mRNA level in human colorectal cancer cell line Caco-2 treated with IP6.	Phytic Acid	197-200	matrix metallopeptidase 2	Homo sapiens	63-68	
21229878-6	2010	IP6 at the concentration of 1 mM evoked increase in MMP-2 transcript level, however, its higher doses (2.5; 5 mM) caused a decrease in this gene expression at 1 h incubation.	Phytic Acid	0-3	matrix metallopeptidase 2	Homo sapiens	52-57	
21229878-7	2010	In 24 h lasting culture along with increasing IP6 concentration, the cells expressed lower and lower MMP-2 mRNA level.	Phytic Acid	46-49	matrix metallopeptidase 2	Homo sapiens	101-106	
21229878-10	2010	The results of this study show that IP6 modulates MMP-2, TIMP-1 and TIMP-2 genes expression in colon cancer cells at the transcriptional level in a way dependent on its concentration and time of interaction.	Phytic Acid	36-39	matrix metallopeptidase 2	Homo sapiens	50-55	
22415590-7	2012	A significant decrease in MMP-13, MMP-3, MMP-2, and TIMP-1 basal expression was achieved by IP6.	Phytic Acid	92-95	matrix metallopeptidase 2	Homo sapiens	41-46	
22415590-9	2012	After 12 h, IL-1beta-induced MMP-2 mRNA expression was significantly reduced by IP6.	Phytic Acid	80-83	matrix metallopeptidase 2	Homo sapiens	29-34