PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17521968-6 2007 Collectively, the data show a prolonged antihypertensive effect of AT1 receptor antisense oligonucleotides during the developmental phase of hypertension in TGR when applied as a single treatment in prehypertensive animals which, however, does not persist up to the maintenance phase of hypertension in adulthood. Oligonucleotides 90-106 angiotensin II receptor, type 1a Rattus norvegicus 67-70 12215476-6 2002 Whereas the re-expression of AT1R at both transcriptional and functional expression levels after baroreceptor activation was discernibly blunted by prior bilateral application into the NTS of an antisense c-fos oligonucleotide (50 pmol), the suppression in SHR was again significantly more intense. Oligonucleotides 211-226 angiotensin II receptor, type 1a Rattus norvegicus 29-33 15371269-5 2004 The response to bradykinin was determined every 50 min after intracerebroventricular administration (lateral ventricle) or microinjection (into paraventricular nucleus) of antisense or scrambled oligonucleotides to AT(1)R mRNA. Oligonucleotides 195-211 angiotensin II receptor, type 1a Rattus norvegicus 215-221 12010195-5 2002 The use of antisense oligonucleotides to AT1 receptors indicates both pre- and post-synaptic AngII receptors are likely to be involved in these actions. Oligonucleotides 21-37 angiotensin II receptor, type 1a Rattus norvegicus 41-44 10823348-0 2000 In vivo effects of partial phosphorothioated AT1 receptor antisense oligonucleotides in spontaneously hypertensive and normotensive rats. Oligonucleotides 68-84 angiotensin II receptor, type 1a Rattus norvegicus 45-48 10807582-1 2000 Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT(1)) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch. Oligonucleotides 10-25 angiotensin II receptor, type 1a Rattus norvegicus 60-89 10807582-7 2000 Blockade of either angiotensinogen or AT(1) mRNA translation by antisense oligonucleotide inhibition prior to cell stretch was found to significantly decrease osteopontin mRNA levels 2.4-fold (P<0.004) and 1.6-fold (P<0.001), respectively, compared with values observed in control unstretched cells. Oligonucleotides 74-89 angiotensin II receptor, type 1a Rattus norvegicus 38-43 11566954-3 2001 The AT(1A) receptor antisense oligonucleotide labeled with fluorescein shows that the antisense oligonucleotide at 24 hours was taken up into aorta, mesenteric artery, liver, kidney glomeruli, and medulla, remaining up to 6 days. Oligonucleotides 30-45 angiotensin II receptor, type 1a Rattus norvegicus 4-9 11566954-3 2001 The AT(1A) receptor antisense oligonucleotide labeled with fluorescein shows that the antisense oligonucleotide at 24 hours was taken up into aorta, mesenteric artery, liver, kidney glomeruli, and medulla, remaining up to 6 days. Oligonucleotides 96-111 angiotensin II receptor, type 1a Rattus norvegicus 4-9 11566954-4 2001 The AT(1A) receptor number in fmol/g tissue was significantly decreased after AT(1A) receptor antisense oligonucleotide treatment in the dorsal aorta, mesenteric artery, renal cortex, and renal medulla (P<0.05) compared with that of the AT(1A) receptor-scrambled antisense oligonucleotide control-treated group. Oligonucleotides 104-119 angiotensin II receptor, type 1a Rattus norvegicus 4-9 11566954-4 2001 The AT(1A) receptor number in fmol/g tissue was significantly decreased after AT(1A) receptor antisense oligonucleotide treatment in the dorsal aorta, mesenteric artery, renal cortex, and renal medulla (P<0.05) compared with that of the AT(1A) receptor-scrambled antisense oligonucleotide control-treated group. Oligonucleotides 104-119 angiotensin II receptor, type 1a Rattus norvegicus 78-83 11566954-4 2001 The AT(1A) receptor number in fmol/g tissue was significantly decreased after AT(1A) receptor antisense oligonucleotide treatment in the dorsal aorta, mesenteric artery, renal cortex, and renal medulla (P<0.05) compared with that of the AT(1A) receptor-scrambled antisense oligonucleotide control-treated group. Oligonucleotides 104-119 angiotensin II receptor, type 1a Rattus norvegicus 78-83 11566954-4 2001 The AT(1A) receptor number in fmol/g tissue was significantly decreased after AT(1A) receptor antisense oligonucleotide treatment in the dorsal aorta, mesenteric artery, renal cortex, and renal medulla (P<0.05) compared with that of the AT(1A) receptor-scrambled antisense oligonucleotide control-treated group. Oligonucleotides 276-291 angiotensin II receptor, type 1a Rattus norvegicus 4-9 11566954-4 2001 The AT(1A) receptor number in fmol/g tissue was significantly decreased after AT(1A) receptor antisense oligonucleotide treatment in the dorsal aorta, mesenteric artery, renal cortex, and renal medulla (P<0.05) compared with that of the AT(1A) receptor-scrambled antisense oligonucleotide control-treated group. Oligonucleotides 276-291 angiotensin II receptor, type 1a Rattus norvegicus 78-83 11566954-4 2001 The AT(1A) receptor number in fmol/g tissue was significantly decreased after AT(1A) receptor antisense oligonucleotide treatment in the dorsal aorta, mesenteric artery, renal cortex, and renal medulla (P<0.05) compared with that of the AT(1A) receptor-scrambled antisense oligonucleotide control-treated group. Oligonucleotides 276-291 angiotensin II receptor, type 1a Rattus norvegicus 78-83 11566954-5 2001 The data clearly demonstrate a prolonged antihypertensive effect of AT(1A) receptor antisense oligonucleotide in the 2K1C renovascular model of hypertension when it is administered intravenously in a single low dose (0.33 mg/kg(-1)). Oligonucleotides 94-109 angiotensin II receptor, type 1a Rattus norvegicus 68-73 11566954-6 2001 It also shows that the AT(1A) receptor antisense oligonucleotide is actively taken up by AT(1A) target tissues and that there is a significant decrease in receptor density. Oligonucleotides 49-64 angiotensin II receptor, type 1a Rattus norvegicus 23-28 11566954-6 2001 It also shows that the AT(1A) receptor antisense oligonucleotide is actively taken up by AT(1A) target tissues and that there is a significant decrease in receptor density. Oligonucleotides 49-64 angiotensin II receptor, type 1a Rattus norvegicus 89-94 11358943-4 2001 We used antisense oligonucleotides to the angiotensin type 1 (AT(1)) receptor, which should reduce receptors on neurons within the injection site but not those on fiber terminals projecting to the nTS. Oligonucleotides 18-34 angiotensin II receptor, type 1a Rattus norvegicus 62-67 8754788-7 1996 The stimulation of TH mRNA was mediated by the AT1 receptor subtype, resulted from an increase in its transcription, and involved activation of phospholipase C and protein kinase C. Antisense oligonucleotide for c-fos attenuated Ang II stimulation of TH mRNA in a time- and dose-dependent fashion, indicating an involvement of c-fos as a putative third messenger in Ang II stimulation of TH. Oligonucleotides 192-207 angiotensin II receptor, type 1a Rattus norvegicus 47-50 9092554-1 1997 The subunit composition of angiotensin AT1 receptor-activated G protein was identified by using antisense oligonucleotide injection into the nucleus of rat portal vein myocytes. Oligonucleotides 106-121 angiotensin II receptor, type 1a Rattus norvegicus 39-42 9092554-3 1997 The angiotensin AT1 receptor-activated increases in [Ca2+]i were selectively inhibited by injection of antisense oligonucleotides directed against the mRNAs coding for the alpha13, beta1, and gamma3 subunits. Oligonucleotides 113-129 angiotensin II receptor, type 1a Rattus norvegicus 16-19 8158154-1 1994 Antisense oligonucleotides were developed to study the expression and function of angiotensin type 1 (AT1) receptors in cultured cells and brain. Oligonucleotides 10-26 angiotensin II receptor, type 1a Rattus norvegicus 102-105 8584752-0 1995 A decrease in angiotensin receptor binding in rat brain nuclei by antisense oligonucleotides to the angiotensin AT1 receptor. Oligonucleotides 76-92 angiotensin II receptor, type 1a Rattus norvegicus 112-115 8584752-2 1995 injections of antisense oligonucleotides against mRNA of the angiotensin type 1 (AT1) receptor have been shown to reduce blood pressure in spontaneously hypertensive (SHR) rats and angiotensin II-induced drinking in both SHR and Sprague-Dawley (SD) rats. Oligonucleotides 24-40 angiotensin II receptor, type 1a Rattus norvegicus 81-84 8584752-4 1995 injections of antisense oligonucleotides to the AT1 receptor mRNA on brain angiotensin receptors using membrane binding and autoradiographic analysis. Oligonucleotides 24-40 angiotensin II receptor, type 1a Rattus norvegicus 48-51 8584752-6 1995 Three daily injections of antisense oligonucleotides into the third ventricle of SD rats decreased the AT1 receptor number significantly by 25% in a hypothalamic tissue block. Oligonucleotides 36-52 angiotensin II receptor, type 1a Rattus norvegicus 103-106 8584752-9 1995 AT2 receptors were not reduced indicating the AT1 antisense oligonucleotides were specific. Oligonucleotides 60-76 angiotensin II receptor, type 1a Rattus norvegicus 46-49 8584752-15 1995 injections of antisense oligonucleotides to AT1 receptor mRNA. Oligonucleotides 24-40 angiotensin II receptor, type 1a Rattus norvegicus 44-47 8584753-0 1995 Intracerebroventricular administration of angiotensin type 1 (AT1) receptor antisense oligonucleotides attenuate thirst in the rat. Oligonucleotides 86-102 angiotensin II receptor, type 1a Rattus norvegicus 62-65 8584753-4 1995 More recently, antisense oligonucleotides specific for the AT1 receptor have been developed and after intracerebroventricular (i.c.v.) Oligonucleotides 25-41 angiotensin II receptor, type 1a Rattus norvegicus 59-62 7716285-0 1994 Antisense oligonucleotide to AT1 receptor mRNA inhibits central angiotensin induced thirst and vasopressin. Oligonucleotides 10-25 angiotensin II receptor, type 1a Rattus norvegicus 29-32 8432862-5 1993 The intrarenal distribution of AT1 mRNA was assessed by in situ hybridization to a 35S-labeled 24 residues oligonucleotide complementary to rat AT1 mRNA. Oligonucleotides 107-122 angiotensin II receptor, type 1a Rattus norvegicus 31-34