PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18794388-3 2008 METHODS AND RESULTS: Antisense oligonucleotides were used to inhibit SCD1 in a mouse model of hyperlipidemia and atherosclerosis (LDLr(-/-)Apob(100/100)). Oligonucleotides 31-47 stearoyl-Coenzyme A desaturase 1 Mus musculus 69-73 18832746-7 2008 In mice exposed to CIH and treated with SCD-1 antisense oligonucleotides, dyslipidemia and atherosclerosis in the ascending aorta were abolished, whereas lesions in the descending aorta showed 56% reduction. Oligonucleotides 56-72 stearoyl-Coenzyme A desaturase 1 Mus musculus 40-45 16741573-4 2006 This commentary focuses on 2 recent studies published in the JCI that address this question using antisense oligonucleotide inhibition of SCD1. Oligonucleotides 108-123 stearoyl-Coenzyme A desaturase 1 Mus musculus 138-142 15761499-0 2005 Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. Oligonucleotides 43-58 stearoyl-Coenzyme A desaturase 1 Mus musculus 73-98 15761499-4 2005 SCD1-specific antisense oligonucleotide inhibitors (ASOs) reduced SCD1 expression, reduced fatty acid synthesis and secretion, and increased fatty acid oxidization in primary mouse hepatocytes. Oligonucleotides 24-39 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 15761499-4 2005 SCD1-specific antisense oligonucleotide inhibitors (ASOs) reduced SCD1 expression, reduced fatty acid synthesis and secretion, and increased fatty acid oxidization in primary mouse hepatocytes. Oligonucleotides 24-39 stearoyl-Coenzyme A desaturase 1 Mus musculus 66-70