PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18284918-4 2008 HBV-transfected hepatoma cell line, HepG2.2.15, pretreated with antisense oligonucleotide against preS2 gene, showed a lower sensitivity towards TRAIL-induced apoptosis. Oligonucleotides 74-89 TNF superfamily member 10 Homo sapiens 145-150 19157446-9 2009 RESULTS: Although no direct correlation between TRAIL sensitivity and the relative expression levels of Bcl-2 and clusterin was found in the bladder transitional cell carcinoma cell lines examined, antisense oligonucleotide mediated the down-regulation of Bcl-2 and clusterin, increasing the sensitivity of the partially resistant cells to TRAIL. Oligonucleotides 208-223 TNF superfamily member 10 Homo sapiens 340-345 15378029-6 2004 The effects observed by stable RNAi with respect to TRAIL sensitization were also achieved following downregulation of XIAP in Panc-1 cells treated with a second-generation, mixed-backbone antisense oligonucleotide, AEG 35156/GEM640. Oligonucleotides 199-214 TNF superfamily member 10 Homo sapiens 52-57 17332931-13 2007 In addition, XIAP antisense oligonucleotide sensitized RCC to Fas/TRAIL-induced apoptosis. Oligonucleotides 28-43 TNF superfamily member 10 Homo sapiens 66-71 17192900-7 2007 Treatment of B-CLL cells with specific PED antisense oligonucleotides, a protein synthesis inhibitor or HDAC inhibitors, induced a significant downregulation of PED and sensitized these cells to TRAIL-induced cell death. Oligonucleotides 53-69 TNF superfamily member 10 Homo sapiens 195-200 16983347-1 2006 In order to define genetic determinants of primary and metastatic melanoma cell susceptibility to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), we have applied oligonucleotide microarrays to TRAIL-sensitive primary T1 cells and TRAIL-resistant metastatic G1 cells treated or not with TRAIL. Oligonucleotides 179-194 TNF superfamily member 10 Homo sapiens 155-160 16863850-11 2006 Conversely, inhibiting survivin expression in NB3 by antisense oligonucleotides enhanced TRAIL sensitivity. Oligonucleotides 63-79 TNF superfamily member 10 Homo sapiens 89-94 16092761-6 2005 In addition, phosphorothioated antisense oligonucleotide against the translation initial region of HBx gene (PS-asODNs/HBx) was used to block the expression of HBx in HepG2.2.15 cells and to further confirm the effects of HBx on TRAIL-induced apoptosis. Oligonucleotides 41-56 TNF superfamily member 10 Homo sapiens 229-234 15511228-11 2004 In further experiments using an antisense oligonucleotide, a specific repression of IRF-1 expression abolished enhancer activity of IFN-gamma for TRAIL-induced apoptosis. Oligonucleotides 42-57 TNF superfamily member 10 Homo sapiens 146-151 17637740-3 2008 Increase in caspase-8 messenger RNA and protein expression disabled tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced proliferation and restored sensitivity toward TRAIL-induced apoptosis which was inhibited by transfection of p53 decoy oligonucleotides, p53 shRNA and caspase-8 shRNA. Oligonucleotides 259-275 TNF superfamily member 10 Homo sapiens 68-123 17637740-3 2008 Increase in caspase-8 messenger RNA and protein expression disabled tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced proliferation and restored sensitivity toward TRAIL-induced apoptosis which was inhibited by transfection of p53 decoy oligonucleotides, p53 shRNA and caspase-8 shRNA. Oligonucleotides 259-275 TNF superfamily member 10 Homo sapiens 125-130 17637740-3 2008 Increase in caspase-8 messenger RNA and protein expression disabled tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced proliferation and restored sensitivity toward TRAIL-induced apoptosis which was inhibited by transfection of p53 decoy oligonucleotides, p53 shRNA and caspase-8 shRNA. Oligonucleotides 259-275 TNF superfamily member 10 Homo sapiens 186-191 15966315-4 2003 A gene fragment encoding for the active domain of TRAIL was modified with oligo-nucleotide directed mutagenesis according to the characters of Pichia pastoris expressing vector. Oligonucleotides 74-90 TNF superfamily member 10 Homo sapiens 50-55 14729643-7 2004 Also, down-regulation of survivin using survivin antisense oligonucleotides sensitized cells for TRAIL-induced apoptosis. Oligonucleotides 59-75 TNF superfamily member 10 Homo sapiens 97-102 12895357-18 2003 Survivin may play a role in resistance to TRAIL-induced apoptosis in HCC, and antisence oligonucleotide could partly reverse the resistance to TRAIL-inducing apoptosis. Oligonucleotides 88-103 TNF superfamily member 10 Homo sapiens 143-148 11114725-6 2000 Inhibition of Bcl-XL function by overexpression of Bax or administration of antisense oligonucleotides against Bcl-XL mRNA resulted in sensitization of Panc-1 cells to TRAIL and PancTuI cells to anti-CD95 antibody-induced cell death. Oligonucleotides 86-102 TNF superfamily member 10 Homo sapiens 168-173 12520089-0 2002 Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis. Oligonucleotides 92-108 TNF superfamily member 10 Homo sapiens 152-157 12163389-4 2002 We found that the emergence of resistance to Apo2L/TRAIL, after prolonged incubation with this cytokine, was associated with increased levels of FLICE inhibitory protein (FLIP), and was overcome by cycloheximide and bisindolylmaleimide, that specifically down-regulated FLIP expression, as well as by transfection of a FLIP anti-sense oligonucleotide. Oligonucleotides 335-350 TNF superfamily member 10 Homo sapiens 45-50 12163389-4 2002 We found that the emergence of resistance to Apo2L/TRAIL, after prolonged incubation with this cytokine, was associated with increased levels of FLICE inhibitory protein (FLIP), and was overcome by cycloheximide and bisindolylmaleimide, that specifically down-regulated FLIP expression, as well as by transfection of a FLIP anti-sense oligonucleotide. Oligonucleotides 335-350 TNF superfamily member 10 Homo sapiens 51-56 11877293-6 2002 Forced expression of procaspase-8 or FLIP antisense oligonucleotides also sensitized TRAIL-resistant cells to TRAIL. Oligonucleotides 52-68 TNF superfamily member 10 Homo sapiens 85-90 11877293-6 2002 Forced expression of procaspase-8 or FLIP antisense oligonucleotides also sensitized TRAIL-resistant cells to TRAIL. Oligonucleotides 52-68 TNF superfamily member 10 Homo sapiens 110-115 34546729-2 2021 Here we report the RuAAC-catalyzed synthesis of a novel 1,5-disubstituted triazole (TL2) dinucleoside phosphoramidite as well as its incorporation into oligonucleotides and compare its DNA polymerase replication competency with other TL analogues. Oligonucleotides 152-168 TNF superfamily member 10 Homo sapiens 84-87 21107885-6 2012 Targeting cFLIP(L) directly with siRNA oligonucleotides also sensitizes human breast tumour cells to TRAIL-induced apoptosis. Oligonucleotides 39-55 TNF superfamily member 10 Homo sapiens 101-106 28410209-7 2017 Silencing of miR-106b with antisense oligonucleotide (anti-miR-106b) is proved to enhance the TRAIL-induced apoptosis and reduce the acquired drug resistance to TRAIL in HCC. Oligonucleotides 37-52 TNF superfamily member 10 Homo sapiens 94-99 28410209-7 2017 Silencing of miR-106b with antisense oligonucleotide (anti-miR-106b) is proved to enhance the TRAIL-induced apoptosis and reduce the acquired drug resistance to TRAIL in HCC. Oligonucleotides 37-52 TNF superfamily member 10 Homo sapiens 161-166 27840896-5 2016 Furthermore, we found that knockdown of miR-25 by its antisense oligonucleotide (anti-miR-25) significantly increased the sensitivity of LCSCs to TRAIL-induced apoptosis. Oligonucleotides 64-79 TNF superfamily member 10 Homo sapiens 146-151 21877251-8 2011 Using oligonucleotide microarray, we demonstrated a dramatic increase in proinflammatory cytokine and chemokine transcripts (CXCL10, CXCL11, TNFSF10, CCL5, CCL4, CCL2, IFNB1, CCL20, IL-8, and CCL11). Oligonucleotides 6-21 TNF superfamily member 10 Homo sapiens 141-148