PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29980579-8 2018 Electrophoretic mobility shift assay (EMSA) showed that oligonucleotides with the AA genotype displayed higher LCL nuclear extract binding after 3MC treatment than did those with the GG genotype, and mass spectrometric analysis of EMSA protein-DNA complex bands identified three candidate proteins, two of which were co-immunoprecipitated with AHR. Oligonucleotides 56-72 aryl hydrocarbon receptor Homo sapiens 344-347 21861773-6 2011 Furthermore, ablation of ETK expression by a specific antisense oligonucleotide or AG879, a specific inhibitor of ETK kinase suppressed activation of AHR induced by omeprazole, a strong ligand-independent activator of AHR. Oligonucleotides 64-79 aryl hydrocarbon receptor Homo sapiens 150-153 22034498-5 2012 The effects of TCDD and MCDF on miR-335 and SOX4 expression and interactions of miR-335 with the 3"-UTR target sequence in the SOX4 gene were all inhibited in cells transfected with an oligonucleotide (iAHR) that knocks down the AHR, thus confirming AHR-miR-335 interactions. Oligonucleotides 185-200 aryl hydrocarbon receptor Homo sapiens 203-206 22034498-5 2012 The effects of TCDD and MCDF on miR-335 and SOX4 expression and interactions of miR-335 with the 3"-UTR target sequence in the SOX4 gene were all inhibited in cells transfected with an oligonucleotide (iAHR) that knocks down the AHR, thus confirming AHR-miR-335 interactions. Oligonucleotides 185-200 aryl hydrocarbon receptor Homo sapiens 229-232 18001219-6 2007 The TCDD-induced binding of the AhR to COX-2 and CYP1A1 oligonucleotides was repressed by cotreatment with CLA (t10,c12-CLA > c9,t11-CLA), and the AhR antagonists, 3-methoxy-4-naphthoflavone, and resveratrol. Oligonucleotides 56-72 aryl hydrocarbon receptor Homo sapiens 32-35 18001219-4 2007 We found that TCDD stimulated the binding of the AhR to COX-2 and cytochrome P4501A1 (CYP1A1) oligonucleotides containing consensus XREs. Oligonucleotides 94-110 aryl hydrocarbon receptor Homo sapiens 49-52 19022240-6 2008 Rg1 and Rb1 were able to activate the ability of the aryl hydrocarbon receptor to bind to an oligonucleotide containing the xenobiotic-responsive element (XRE) of the cyp1a1 promoter. Oligonucleotides 93-108 aryl hydrocarbon receptor Homo sapiens 53-78 18001219-6 2007 The TCDD-induced binding of the AhR to COX-2 and CYP1A1 oligonucleotides was repressed by cotreatment with CLA (t10,c12-CLA > c9,t11-CLA), and the AhR antagonists, 3-methoxy-4-naphthoflavone, and resveratrol. Oligonucleotides 56-72 aryl hydrocarbon receptor Homo sapiens 150-153 8524236-7 1995 Electrophoretic mobility shift assays showed that the nuclear or transformed cytosolic Ah receptor complex blocked formation of the ER-Sp1 complex with the wild-type but not the ER/Sp1 mutant oligonucleotide. Oligonucleotides 192-207 aryl hydrocarbon receptor Homo sapiens 87-98 15342792-4 2004 AhR-mediated change in expression of AhR target genes was measured by oligonucleotide microarrays and by reverse transcription-polymerase chain reaction in human and rat hepatocytes. Oligonucleotides 70-85 aryl hydrocarbon receptor Homo sapiens 0-3 15342792-4 2004 AhR-mediated change in expression of AhR target genes was measured by oligonucleotide microarrays and by reverse transcription-polymerase chain reaction in human and rat hepatocytes. Oligonucleotides 70-85 aryl hydrocarbon receptor Homo sapiens 37-40 15342792-6 2004 Rules were established on the local oligonucleotide context in the flanks of the AhR binding sites, on the occurrence of clusters of AhR recognition elements, and on the presence in the promoters of specific combinations of multiple binding sites for the transcription factors cooperating in the AhR regulatory network. Oligonucleotides 36-51 aryl hydrocarbon receptor Homo sapiens 81-84 9637800-3 1998 Oligonucleotides containing single-base changes at polymorphic sites were immobilized on a solid support and hybridized with C57BL/6 or DBA/2 AHR cDNA radiolabeled probes. Oligonucleotides 0-16 aryl hydrocarbon receptor Homo sapiens 142-145 9637800-10 1998 Screening human AHR cDNAs by oligonucleotide-hybridization and yeast two-hybrid methodologies will be invaluable for the rapid and unequivocal determination of changes in DNA sequence and receptor-ligand affinities associated with human AHR polymorphisms. Oligonucleotides 29-44 aryl hydrocarbon receptor Homo sapiens 16-19 11216487-5 2000 The transformed AhR was detected by an electrophoretic mobility shift assay with a DNA oligonucleotide consensus to dioxin response element. Oligonucleotides 87-102 aryl hydrocarbon receptor Homo sapiens 16-19 10359656-7 1999 Gel retardation studies demonstrated that quercetin activated the ability of the AhR to bind to an oligonucleotide containing the xenobiotic-responsive element (XRE) of the CYP1A1 promoter. Oligonucleotides 99-114 aryl hydrocarbon receptor Homo sapiens 81-84 9710958-7 1998 The specificity of the 690-bp band was established by Southern blotting and hybridization with a degenerate AhR oligonucleotide. Oligonucleotides 112-127 aryl hydrocarbon receptor Homo sapiens 108-111 9056263-4 1997 The purified AhR retained in vitro DRE binding activity in the presence of carrier protein and dithiothreitol, and its affinity for the DRE oligonucleotide was equivalent to that of the other receptor preparations (crude and partially purified cytosolic and crude nuclear). Oligonucleotides 140-155 aryl hydrocarbon receptor Homo sapiens 13-16 9056263-5 1997 When the ligand.receptor complex was bound to a DRE oligonucleotide containing BrdU and then UV-irradiated, two proteins in each of the receptor preparations were found to crosslink to BrdU-DRE, and we concluded that they are the AhR monomer and ARNT protein. Oligonucleotides 52-67 aryl hydrocarbon receptor Homo sapiens 230-233 9067605-9 1997 Using data obtained by the QuESSD method, we designed oligonucleotides specific for XF1 or for the AH receptor, and prepared CAT reporter gene constructs carrying these oligonucleotides, or wild-type XRE1, upstream of a minimal promoter. Oligonucleotides 54-70 aryl hydrocarbon receptor Homo sapiens 99-110 8524236-8 1995 Moreover, incubation of the wild-type bromodeoxyuridine-substituted ER/Sp1 oligonucleotide with the nuclear Ah receptor complex gave a specifically bound cross-linked 200-kDa band. Oligonucleotides 75-90 aryl hydrocarbon receptor Homo sapiens 108-119 1331752-4 1992 Using a gel retardation assay we examined the interaction of transformed human cytosolic TCDD-AhR complexes with a synthetic DNA oligonucleotide containing a single DRE site. Oligonucleotides 129-144 aryl hydrocarbon receptor Homo sapiens 94-97 7786196-9 1995 Moreover, using a series of synthetic oligonucleotides which include the wild-type ER/Sp1 and various mutants, it was shown by gel electromobility shift and transient transfection assays that the nuclear Ah receptor complex binds to an imperfect DRE located between the ER and Sp1 binding sequences. Oligonucleotides 38-54 aryl hydrocarbon receptor Homo sapiens 204-215 8391813-3 1993 To test the ability of the coding region DRE (+102) to bind the activated AhR, two complementary oligonucleotides corresponding to the DRE-containing region of the human ER gene were synthesized, termed hERO, and used in a gel shift assay. Oligonucleotides 97-113 aryl hydrocarbon receptor Homo sapiens 74-77 35626744-4 2022 Despite these concerns, several approaches to target the AhR have been explored such as small molecules, microbials, PROTACs, and oligonucleotide-based approaches. Oligonucleotides 130-145 aryl hydrocarbon receptor Homo sapiens 57-60