PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11700850-17 2001 Follicle-stimulating hormone (FSH) stimulated (P < .05) and testosterone tended to stimulate (P < .07) mRNA expression of EGFR. Testosterone 63-75 epidermal growth factor receptor Rattus norvegicus 128-132 8804359-1 1996 Our recent studies have implicated the TGF-alpha/epidermal growth factor receptor pathway in the genesis of testosterone (T) and estradiol-17 beta (E2)-induced dysplasia in the dorsolateral prostate (DLP) of Noble rats. Testosterone 108-120 epidermal growth factor receptor Rattus norvegicus 49-81 9492074-13 1998 EGFR mRNA levels were stimulated by EGF and keratinocyte growth factor treatment and inhibited by testosterone treatment in epithelial cells. Testosterone 98-110 epidermal growth factor receptor Rattus norvegicus 0-4 9492074-18 1998 Results indicate that testosterone does not directly regulate TGF-alpha mRNA levels but does inhibit EGFR mRNA levels. Testosterone 22-34 epidermal growth factor receptor Rattus norvegicus 101-105 9492074-21 1998 TGF-alpha mRNA levels were influenced by EGF in stromal cells only, and EGFR mRNA levels were influenced by testosterone, EGF, and keratinocyte growth factor in epithelial cells. Testosterone 108-120 epidermal growth factor receptor Rattus norvegicus 72-76 25013941-7 2014 The results showed that treatment of cultured VSMC with testosterone downregulated mitogenic signaling pathways initiated by the ligand-dependent activation of the EGFR. Testosterone 56-68 epidermal growth factor receptor Rattus norvegicus 164-168 33875082-0 2021 Nano-TiO2 Reduces Testosterone Production in Primary Cultured Leydig Cells from Rat Testis Through the Cyclic Adenosine Phosphate/Cyclic Guanosine Phosphate/Epidermal Growth Factor Receptor/Matrix Metalloproteinase Signaling Pathway. Testosterone 18-30 epidermal growth factor receptor Rattus norvegicus 157-189 33875082-7 2021 Collectively, our results indicated that the inhibition of testosterone production by nano-TiO2 is related to the dysfunction of the cAMP/CGMP/EGFR/MMP signaling pathway. Testosterone 59-71 epidermal growth factor receptor Rattus norvegicus 143-147 17252557-4 2007 RESULTS: Both castration alone and testosterone treatment in castrated animals increased the mRNA and protein levels of EGFR and phospho-EGFR in the ventral prostate. Testosterone 35-47 epidermal growth factor receptor Rattus norvegicus 120-124 19820831-4 2009 Since decreases in body weight could lead to a reduction in circulating testosterone concentration, we believe that the reduction in EGF-R expression in parotid glands of infected rats is due to alterations in testosterone levels and atrophy of parotid glands is caused by changes in EGF-R expression. Testosterone 72-84 epidermal growth factor receptor Rattus norvegicus 133-138 19820831-4 2009 Since decreases in body weight could lead to a reduction in circulating testosterone concentration, we believe that the reduction in EGF-R expression in parotid glands of infected rats is due to alterations in testosterone levels and atrophy of parotid glands is caused by changes in EGF-R expression. Testosterone 210-222 epidermal growth factor receptor Rattus norvegicus 133-138 18180313-10 2008 Testosterone may thus induce HIF-1alpha and its downstream angiogenesis promoting genes by at least two mechanisms, hypoxia and EGFR signaling. Testosterone 0-12 epidermal growth factor receptor Rattus norvegicus 128-132 17252557-0 2007 Inhibition of the epidermal growth factor receptor enhances castration-induced prostate involution and reduces testosterone-stimulated prostate growth in adult rats. Testosterone 111-123 epidermal growth factor receptor Rattus norvegicus 18-50 17252557-4 2007 RESULTS: Both castration alone and testosterone treatment in castrated animals increased the mRNA and protein levels of EGFR and phospho-EGFR in the ventral prostate. Testosterone 35-47 epidermal growth factor receptor Rattus norvegicus 137-141 17252557-5 2007 Inhibition of EGFR during castration and during testosterone-stimulated prostate growth resulted in a decrease in total epithelial weight, epithelial cell proliferation, endothelial cell proliferation, and increased epithelial cell apoptosis. Testosterone 48-60 epidermal growth factor receptor Rattus norvegicus 14-18 17252557-6 2007 CONCLUSIONS: This study suggests that increased EGFR signaling during castration mediates stimulatory effects balancing castration-induced prostate regression, and that EGFR signaling is a necessary component in testosterone-stimulated prostate growth. Testosterone 212-224 epidermal growth factor receptor Rattus norvegicus 48-52 17252557-6 2007 CONCLUSIONS: This study suggests that increased EGFR signaling during castration mediates stimulatory effects balancing castration-induced prostate regression, and that EGFR signaling is a necessary component in testosterone-stimulated prostate growth. Testosterone 212-224 epidermal growth factor receptor Rattus norvegicus 169-173