PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2915439-5 1989 In contrast, testosterone decreased HDL-cholesterol concentration by only 9% and the decrease was in the HDL3 subfraction. Testosterone 13-25 HDL3 Homo sapiens 105-109 8678922-10 1996 The results of this study indicate that testosterone replacement therapy in hypogonadal and elderly men may have a beneficial effect on lipid metabolism through decreasing total cholesterol and atherogenic fraction of LDL-cholesterol without significant alterations in HDL-cholesterol levels or its subfractions HDL2-C and HDL3-C. Testosterone 40-52 HDL3 Homo sapiens 323-327 12736156-1 2003 Testosterone administration to men is known to decrease high-density lipoprotein cholesterol (HDL-C) and the subclasses HDL(2) and HDL(3). Testosterone 0-12 HDL3 Homo sapiens 131-137 12736156-7 2003 Testosterone is therefore a potent stimulator of hepatic lipase activity, decreasing HDL-C, HDL(2), and HDL(3) as well as increasing LDL particle density changes, all associated with increased cardiovascular risk. Testosterone 0-12 HDL3 Homo sapiens 104-110 8487666-6 1993 In contrast, both testosterone regimens decreased HDL3-C levels by 13% (P < .05 for both). Testosterone 18-30 HDL3 Homo sapiens 50-54