PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10859487-10 2000 The release of both ACTH and corticosterone was significantly attenuated in the intact (n = 9) and testosterone-replaced (n = 5) animals compared to the castrated animals without replacement (n = 7). Testosterone 99-111 proopiomelanocortin Homo sapiens 20-24 10859487-11 2000 Peak ACTH levels were 340 +/- 58 and 133 +/- 41 pg/ml in the intact and testosterone-replaced animals versus 678 +/- 170 pg/ml in the castrated animals (p < 0.02). Testosterone 72-84 proopiomelanocortin Homo sapiens 5-9 10593368-10 1999 The administration of metformin was associated with a significant reduction in the response of 17alpha-hydroxyprogesterone, testosterone, free testosterone, and androstenedione to ACTH. Testosterone 124-136 proopiomelanocortin Homo sapiens 180-184 10593368-10 1999 The administration of metformin was associated with a significant reduction in the response of 17alpha-hydroxyprogesterone, testosterone, free testosterone, and androstenedione to ACTH. Testosterone 143-155 proopiomelanocortin Homo sapiens 180-184 9824829-3 1998 Thus, the mean circadian level of melatonin, by determining the manner and rapidity of proopiomelanocortin (POMC) cleavage, would also determine the mean proopiomelanocortin (POMC) level, maintained in dynamic equilibrium as a result of the simultaneous influence of testosterone, estradiol and cortisol on the intensity of POMC mRNA synthesis. Testosterone 267-279 proopiomelanocortin Homo sapiens 154-173 9824829-3 1998 Thus, the mean circadian level of melatonin, by determining the manner and rapidity of proopiomelanocortin (POMC) cleavage, would also determine the mean proopiomelanocortin (POMC) level, maintained in dynamic equilibrium as a result of the simultaneous influence of testosterone, estradiol and cortisol on the intensity of POMC mRNA synthesis. Testosterone 267-279 proopiomelanocortin Homo sapiens 175-179 9824829-3 1998 Thus, the mean circadian level of melatonin, by determining the manner and rapidity of proopiomelanocortin (POMC) cleavage, would also determine the mean proopiomelanocortin (POMC) level, maintained in dynamic equilibrium as a result of the simultaneous influence of testosterone, estradiol and cortisol on the intensity of POMC mRNA synthesis. Testosterone 267-279 proopiomelanocortin Homo sapiens 175-179 9798131-11 1998 The incremental response in terms of serum progesterone, DHEAS, and testosterone levels to the ACTH stimulation test for each 30 min interval was not different in women with PCOS than in healthy controls. Testosterone 68-80 proopiomelanocortin Homo sapiens 95-99 2154903-4 1990 The pretreatment testosterone concentrations correlated significantly (r = 0.47; p = 0.019) with the midnight ACTH concentration. Testosterone 17-29 proopiomelanocortin Homo sapiens 110-114 8860745-3 1996 We report a rare case of excessive testosterone production by bilateral testicular tumors in a patient with Nelson syndrome (ACTH-secreting pituitary adenoma after bilateral adrenalectomy in patients with Cushing"s disease). Testosterone 35-47 proopiomelanocortin Homo sapiens 125-129 1654748-1 1991 The examination of the function of the ACTH-adrenal cortex system in females of reproductive age following ovariectomy revealed certain hormonal relationships in terms of the clinical course of the disease: in persistent autonomic vascular and psychoemotional disorders there was a reduction or an increase in blood levels of ACTH (depending on the presence or absence of hypertension), cortisol and a decrease in blood testosterone levels, whereas in regression of the disorders there was a decrease in ACTH and cortisol and an elevation of testosterone levels. Testosterone 420-432 proopiomelanocortin Homo sapiens 39-43 1654748-1 1991 The examination of the function of the ACTH-adrenal cortex system in females of reproductive age following ovariectomy revealed certain hormonal relationships in terms of the clinical course of the disease: in persistent autonomic vascular and psychoemotional disorders there was a reduction or an increase in blood levels of ACTH (depending on the presence or absence of hypertension), cortisol and a decrease in blood testosterone levels, whereas in regression of the disorders there was a decrease in ACTH and cortisol and an elevation of testosterone levels. Testosterone 542-554 proopiomelanocortin Homo sapiens 39-43 2004607-0 1991 Testosterone regulates pro-opiomelanocortin gene expression in the primate brain. Testosterone 0-12 proopiomelanocortin Homo sapiens 23-43 2004607-3 1991 Sex steroids, such as testosterone, are thought to inhibit GnRH secretion by enhancing the inhibitory activity of beta-endorphin; however, the cellular mechanisms by which steroid hormones regulate the activity of POMC neurons in the primate brain are unknown. Testosterone 22-34 proopiomelanocortin Homo sapiens 114-128 2004607-3 1991 Sex steroids, such as testosterone, are thought to inhibit GnRH secretion by enhancing the inhibitory activity of beta-endorphin; however, the cellular mechanisms by which steroid hormones regulate the activity of POMC neurons in the primate brain are unknown. Testosterone 22-34 proopiomelanocortin Homo sapiens 214-218 2004607-4 1991 In this study, we tested the hypothesis that testosterone stimulates POMC gene expression within the primate brain and that this regulation occurs within a specific subset of POMC neurons residing in the arcuate nucleus of the hypothalamus. Testosterone 45-57 proopiomelanocortin Homo sapiens 69-73 2004607-7 1991 Moreover, we found that this testosterone-dependent modulation of POMC gene expression is restricted to a small fraction of the numerous POMC neurons located within the most anterior region of the arcuate nucleus in the brain of this primate species. Testosterone 29-41 proopiomelanocortin Homo sapiens 66-70 2004607-7 1991 Moreover, we found that this testosterone-dependent modulation of POMC gene expression is restricted to a small fraction of the numerous POMC neurons located within the most anterior region of the arcuate nucleus in the brain of this primate species. Testosterone 29-41 proopiomelanocortin Homo sapiens 137-141 1964216-3 1990 A significant rise of the level of testosterone and 17-oxyprogesterone was revealed in response to ACTH administration in 30% of the examinees indicating the adrenal genesis of hyperandrogenism. Testosterone 35-47 proopiomelanocortin Homo sapiens 99-103 2154903-5 1990 The likely determinant of the raised serum testosterone would appear to be the intensity of the ACTH drive, although an individual"s inherent sensitivity to ACTH may also be a factor. Testosterone 43-55 proopiomelanocortin Homo sapiens 96-100 1688992-6 1990 Finally, circulating steroids regulate the hypothalamic POMC system with testosterone stimulating POMC gene expression whilst oestradiol and glucocorticoids induce an inhibitory control. Testosterone 73-85 proopiomelanocortin Homo sapiens 56-60 2153199-3 1990 Their spontaneous and adrenocorticotropic hormone-stimulated blood concentrations of 17 alpha-hydroxyprogesterone, androstenedione, and testosterone were measured initially and were normal. Testosterone 136-148 proopiomelanocortin Homo sapiens 22-49 1688992-6 1990 Finally, circulating steroids regulate the hypothalamic POMC system with testosterone stimulating POMC gene expression whilst oestradiol and glucocorticoids induce an inhibitory control. Testosterone 73-85 proopiomelanocortin Homo sapiens 98-102 2830098-2 1988 Consequently, this study was designed to determine the effects of ACTH and other POMC-derived peptides on testosterone secretion by the in vitro perfused testis. Testosterone 106-118 proopiomelanocortin Homo sapiens 66-70 2166066-11 1990 The remaining 36 patients showed increased values of androstenedione and testosterone after ACTH stimulation and a decrease of these two parameters after both dexamethasone inhibition and cyproterone acetate treatment. Testosterone 73-85 proopiomelanocortin Homo sapiens 92-96 2830098-3 1988 Infusion of synthetic human ACTH-(1-24) at a concentration of 500 ng/ml increased (P less than 0.01) testosterone secretion over that in nontreated controls by in vitro perfused rabbit and guinea pig testes, but not by rat, hamster, or dog testes. Testosterone 101-113 proopiomelanocortin Homo sapiens 28-32 2830098-4 1988 This increase in testosterone secretion after ACTH treatment, however, was less (P less than 0.01) than that after the infusion of a maximally stimulating concentration of ovine LH (100 ng/ml). Testosterone 17-29 proopiomelanocortin Homo sapiens 46-50 2830098-5 1988 Using rabbit testes, the testosterone response to ACTH was demonstrated to be dose dependent and specific, since similar responses were observed after the infusion of synthetic human ACTH-(1-39) and purified porcine ACTH-(1-39) and since no response was observed after the infusion of a variety of ACTH fragments. Testosterone 25-37 proopiomelanocortin Homo sapiens 50-54 2830098-5 1988 Using rabbit testes, the testosterone response to ACTH was demonstrated to be dose dependent and specific, since similar responses were observed after the infusion of synthetic human ACTH-(1-39) and purified porcine ACTH-(1-39) and since no response was observed after the infusion of a variety of ACTH fragments. Testosterone 25-37 proopiomelanocortin Homo sapiens 183-187 2830098-5 1988 Using rabbit testes, the testosterone response to ACTH was demonstrated to be dose dependent and specific, since similar responses were observed after the infusion of synthetic human ACTH-(1-39) and purified porcine ACTH-(1-39) and since no response was observed after the infusion of a variety of ACTH fragments. Testosterone 25-37 proopiomelanocortin Homo sapiens 183-187 2830098-5 1988 Using rabbit testes, the testosterone response to ACTH was demonstrated to be dose dependent and specific, since similar responses were observed after the infusion of synthetic human ACTH-(1-39) and purified porcine ACTH-(1-39) and since no response was observed after the infusion of a variety of ACTH fragments. Testosterone 25-37 proopiomelanocortin Homo sapiens 183-187 2830098-7 1988 These data show that rabbit and guinea pig, but not rat, hamster, and dog, testes secrete testosterone in response to ACTH. Testosterone 90-102 proopiomelanocortin Homo sapiens 118-122 3038815-2 1987 Acute administration of synthetic ACTH (10 micrograms/kg BW) elevated (P less than 0.01) serum cortisol and transiently suppressed (P less than 0.05) serum testosterone and LH. Testosterone 156-168 proopiomelanocortin Homo sapiens 34-38 3614548-3 1987 The addition of testosterone restored the rhythm of the intact males and increased alpha-MSH content in MBH and POA. Testosterone 16-28 proopiomelanocortin Homo sapiens 83-92 2977468-4 1988 Unidirectional shifts were detected in hormonal systems of neurotic patients, with respect to the time of the disease onset and the duration of last exacerbation: ACTH secretion increased with reduced response of adrenal cortisol production, compensatory increase in thyroid functions, redistribution of gonadotropic fractions increasing the FSH/LH ratio, decrease in testosterone production. Testosterone 368-380 proopiomelanocortin Homo sapiens 163-167 2834927-5 1987 Selective adrenal venous samplings revealed that testosterone and dehydroepiandrosterone (DHA) were produced in response to stimulation by 0.25 mg exogenous adrenocorticotropic hormone (ACTH). Testosterone 49-61 proopiomelanocortin Homo sapiens 157-184 2834927-5 1987 Selective adrenal venous samplings revealed that testosterone and dehydroepiandrosterone (DHA) were produced in response to stimulation by 0.25 mg exogenous adrenocorticotropic hormone (ACTH). Testosterone 49-61 proopiomelanocortin Homo sapiens 186-190 2834927-7 1987 This is the first report of a patient with a virilizing adrenocortical carcinoma, which produced testosterone and DHA in response to exogenous ACTH stimulation. Testosterone 97-109 proopiomelanocortin Homo sapiens 143-147 2939305-9 1986 Furthermore, following intratesticular administration of opiate antagonists, testosterone production was reduced, suggesting that Leydig cell function may be also modulated by beta-endorphin and/or other related peptides. Testosterone 77-89 proopiomelanocortin Homo sapiens 176-190 2939405-2 1986 Short-term treatment with ACTH or glucocorticoids results, in males, in a fall in plasma testosterone levels. Testosterone 89-101 proopiomelanocortin Homo sapiens 26-30 6279191-3 1982 dose of adrenocorticotropic hormone (ACTH; 80 IU) resulted in a corticosteroid peak which lasted approximately 6 h. During this 6 h period, no episodic increases in secretion of LH or testosterone were initiated and basal concentrations of testosterone were suppressed (P less than 0.05) below control values. Testosterone 184-196 proopiomelanocortin Homo sapiens 8-35 2990678-4 1985 Both monolayer cells maintained for 6 weeks and organ culture explants maintained for over 3 days responded to ACTH (10(-7) M) with increased production of androgens (testosterone, androstenedione, dehydroepiandrosterone) but decreased production of cortisol as measured by radioimmunoassay of steroids in the culture media. Testosterone 167-179 proopiomelanocortin Homo sapiens 111-115 6320915-0 1984 Ability of cortisol and progesterone to mediate the stimulatory effect of adrenocorticotropic hormone upon testosterone production by the porcine testis. Testosterone 107-119 proopiomelanocortin Homo sapiens 74-101 6100019-9 1984 Immunostainable beta-endorphin and other POMC-derived peptides are present in testicular Leydig cells during fetal life and following puberty at times when testosterone secretion is maximal. Testosterone 156-168 proopiomelanocortin Homo sapiens 16-30 6100019-9 1984 Immunostainable beta-endorphin and other POMC-derived peptides are present in testicular Leydig cells during fetal life and following puberty at times when testosterone secretion is maximal. Testosterone 156-168 proopiomelanocortin Homo sapiens 41-45 6100019-16 1984 These observations suggest that Leydig cell-derived beta-endorphin may facilitate testosterone secretion either directly or indirectly. Testosterone 82-94 proopiomelanocortin Homo sapiens 52-66 6315094-1 1983 Variation in ability of boars to produce testosterone and luteinizing hormone (LH) in response to both gonadotropin releasing hormone (GnRH) and adrenocorticotropic hormone (ACTH) stimulation, as well as quantitative relationships between pretreatment and posttreatment responses, were assessed in a population of 38 boars of similar age and breeding. Testosterone 41-53 proopiomelanocortin Homo sapiens 145-172 6315094-1 1983 Variation in ability of boars to produce testosterone and luteinizing hormone (LH) in response to both gonadotropin releasing hormone (GnRH) and adrenocorticotropic hormone (ACTH) stimulation, as well as quantitative relationships between pretreatment and posttreatment responses, were assessed in a population of 38 boars of similar age and breeding. Testosterone 41-53 proopiomelanocortin Homo sapiens 174-178 6315094-2 1983 Peripheral testosterone concentrations following either GnRH or ACTH increased (P less than 0.01) to peak circulating levels of 7.16 +/- 0.62 and 8.42 +/- 0.81 ng/ml by 120 and 45 min, respectively. Testosterone 11-23 proopiomelanocortin Homo sapiens 64-68 6315094-3 1983 Post-GnRH testosterone area varied from 7.44 to 50.84 ng/ml X h (CV = 47.44%) and post-ACTH testosterone area ranged from 3.05 to 28.78 ng/ml X h (CV = 46.09%). Testosterone 92-104 proopiomelanocortin Homo sapiens 87-91 6315094-6 1983 Significant (P less than 0.01) correlations were obtained between pre-GnRH and post-GnRH testosterone areas (r = 0.58) and between pre-ACTH and post-ACTH testosterone areas (r = 0.67). Testosterone 154-166 proopiomelanocortin Homo sapiens 149-153 6315094-8 1983 The testosterone producing ability of boars was highly variable and their innate ability to produce testosterone influenced their response to GnRH and ACTH. Testosterone 100-112 proopiomelanocortin Homo sapiens 151-155 6315094-9 1983 Additionally, the mechanisms by which GnRH and ACTH influence testosterone production in boars appear to differ. Testosterone 62-74 proopiomelanocortin Homo sapiens 47-51 6348068-1 1983 The effect of acute activation of the ACTH-adrenal axis on circulating testosterone (T) levels was investigated. Testosterone 71-83 proopiomelanocortin Homo sapiens 38-42 6277699-5 1982 In patients whose elevated testosterone levels were suppressed by dexamethasone, adrenocorticotropic hormone (ACTH) induced a prompt return of the testosterone levels to baseline, suggesting an ACTH-dependent hyperandrogenism. Testosterone 27-39 proopiomelanocortin Homo sapiens 81-108 6277699-5 1982 In patients whose elevated testosterone levels were suppressed by dexamethasone, adrenocorticotropic hormone (ACTH) induced a prompt return of the testosterone levels to baseline, suggesting an ACTH-dependent hyperandrogenism. Testosterone 27-39 proopiomelanocortin Homo sapiens 110-114 6277699-5 1982 In patients whose elevated testosterone levels were suppressed by dexamethasone, adrenocorticotropic hormone (ACTH) induced a prompt return of the testosterone levels to baseline, suggesting an ACTH-dependent hyperandrogenism. Testosterone 27-39 proopiomelanocortin Homo sapiens 194-198 6277699-5 1982 In patients whose elevated testosterone levels were suppressed by dexamethasone, adrenocorticotropic hormone (ACTH) induced a prompt return of the testosterone levels to baseline, suggesting an ACTH-dependent hyperandrogenism. Testosterone 147-159 proopiomelanocortin Homo sapiens 81-108 6277699-5 1982 In patients whose elevated testosterone levels were suppressed by dexamethasone, adrenocorticotropic hormone (ACTH) induced a prompt return of the testosterone levels to baseline, suggesting an ACTH-dependent hyperandrogenism. Testosterone 147-159 proopiomelanocortin Homo sapiens 110-114 6277699-5 1982 In patients whose elevated testosterone levels were suppressed by dexamethasone, adrenocorticotropic hormone (ACTH) induced a prompt return of the testosterone levels to baseline, suggesting an ACTH-dependent hyperandrogenism. Testosterone 147-159 proopiomelanocortin Homo sapiens 194-198 7027244-3 1981 The data obtained suggest that the adrenocorticotropic hormone, immunoreactive insulin, protein-bound iodine and follicle-stimulating hormone retain the immunologic activity not more than one year, while the hormone, stimulating interstitial cells, thyrotrophic hormone, somatotrophic hormone, 17-HOCS, testosterone and aldosterone up to 1-1.5 years. Testosterone 303-315 proopiomelanocortin Homo sapiens 35-62 6279191-3 1982 dose of adrenocorticotropic hormone (ACTH; 80 IU) resulted in a corticosteroid peak which lasted approximately 6 h. During this 6 h period, no episodic increases in secretion of LH or testosterone were initiated and basal concentrations of testosterone were suppressed (P less than 0.05) below control values. Testosterone 240-252 proopiomelanocortin Homo sapiens 8-35 6279191-3 1982 dose of adrenocorticotropic hormone (ACTH; 80 IU) resulted in a corticosteroid peak which lasted approximately 6 h. During this 6 h period, no episodic increases in secretion of LH or testosterone were initiated and basal concentrations of testosterone were suppressed (P less than 0.05) below control values. Testosterone 240-252 proopiomelanocortin Homo sapiens 37-41 6279191-4 1982 Episodic secretion of LH and testosterone resumed 6--7 h after ACTH when concentrations of serum corticosteroids had returned to basal levels. Testosterone 29-41 proopiomelanocortin Homo sapiens 63-67 6279191-5 1982 These results suggest that ACTH-induced increases in serum corticosteroids suppress the episodic secretion of LH, resulting in a suppression of testosterone secretion by the bull testis. Testosterone 144-156 proopiomelanocortin Homo sapiens 27-31 488333-2 1979 Meanwhile bucarban enhances the synthesis of autoantibodies to endogenous insulin and ACTH to hydrocortisone and testosterone. Testosterone 113-125 proopiomelanocortin Homo sapiens 86-90 6263558-13 1981 The injection of ACTH at 0700 was followed by a clear and statistically significant rise of plasma testosterone. Testosterone 99-111 proopiomelanocortin Homo sapiens 17-21 6263558-27 1981 Peaks of plasma testosterone, plasma aldosterone as well as plasma cortisol (reported in a previous paper) resulting from ACTH stimulation coincided in time with the acrophase of the physiological circadian rhythm in plasma levels of these hormones... Testosterone 16-28 proopiomelanocortin Homo sapiens 122-126 166091-1 1975 ACTH dependency of plasma androstenedione (A) and testosterone (T) was determined in normal and hirsute women by measuring the magnitude of change of A and T between the time of the cortisol (F) peak and F nadir in a diurnal study. Testosterone 50-62 proopiomelanocortin Homo sapiens 0-4 219005-6 1979 ACTH and dexamethasone were additive in their effects on cAMP and testosterone in the tumor tissue. Testosterone 66-78 proopiomelanocortin Homo sapiens 0-4 233672-11 1978 Thus, under the influence of endogenous ACTH which is moderately increased, 17-OHP concentrations far exceed normal values, whereas plasma testosterone seems to be unaffected. Testosterone 139-151 proopiomelanocortin Homo sapiens 40-44 956348-5 1976 It was concluded that administration of cortisol leading to plasma levels as seen under treatment with ACTH suppresses testosterone by abolishing or flattening the nocturnal rise. Testosterone 119-131 proopiomelanocortin Homo sapiens 103-107 956348-7 1976 Our data suggest that the ACTH-induced suppression of testosterone is due to an action of cortisol. Testosterone 54-66 proopiomelanocortin Homo sapiens 26-30 174367-0 1976 The effect of ACTH on plasma testosterone and androstenedione concentrations in patients with prostatic carcinoma. Testosterone 29-41 proopiomelanocortin Homo sapiens 14-18 174367-6 1976 The work provides further evidence that in the patient being treated with oestrogen for carcinoma of the prostate a rise in plasma testosterone concentration will result from an increased secretion of ACTH. Testosterone 131-143 proopiomelanocortin Homo sapiens 201-205 171102-2 1975 These patients were selected on the basis that each showed an exaggerated response of urinary testosterone excretion to ACTH stimulation. Testosterone 94-106 proopiomelanocortin Homo sapiens 120-124 233683-10 1978 These observations are consistent with the hypothesis that ACTH may directly affect LH and testosterone secretion. Testosterone 91-103 proopiomelanocortin Homo sapiens 59-63 195973-4 1977 Evidence for a major adrenal origin of the elevated testosterone values in the women with Cushing"s disease was derived from the parallel suppression of cortisol and testosterone during dexamethasone administration, the testosterone responsiveness to ACTH and its dramatic fall after adrenalectomy. Testosterone 52-64 proopiomelanocortin Homo sapiens 251-255 191557-4 1977 The increase in ACTH release induced by hypothalamic extract of vasopressin was reduced by corticossterone, cortisol or progesterone but not by testosterone or oestradiol, but the increase in pituitary ACTH content was not affected by any of these steroids. Testosterone 144-156 proopiomelanocortin Homo sapiens 16-20 170770-0 1975 Adrenal mediation of the effect of excess ACTH on testosterone levels in male: a study of a patient with probable ACTH secreting medullary thyroid carcinoma. Testosterone 50-62 proopiomelanocortin Homo sapiens 42-46 170770-3 1975 The clinical course and study of the patient showed that, 1) chronic excess of ACTH may lower plasma testosterone levels in man, and 2) that this may be mediated through its effect on the adrenals. Testosterone 101-113 proopiomelanocortin Homo sapiens 79-83 4377768-0 1974 Surgical stress: decrease in plasma testosterone levels due to hypersecretion of ACTH? Testosterone 36-48 proopiomelanocortin Homo sapiens 81-85 164096-0 1975 Plasma testosterone in Klinefelter"s syndrome: diurnal variation and response to ACTH and dexamethasone. Testosterone 7-19 proopiomelanocortin Homo sapiens 81-85 4324509-0 1969 [Effect of testosterone, estradiol, progesterone, and their derivatives on the release of ACTH]. Testosterone 11-23 proopiomelanocortin Homo sapiens 90-94 4362397-0 1974 Diurnal plasma testosterone rhythm and the effects of short-term ACTH administration on plasma testosterone in man. Testosterone 95-107 proopiomelanocortin Homo sapiens 65-69 4315832-0 1969 [Loss of the capacity of ACTH to induce sexual excitation caused by lesions of the areas of the brain accumulating testosterone]. Testosterone 115-127 proopiomelanocortin Homo sapiens 25-29 4292353-0 1966 Excretion of testosterone and 17-ketosteroids following administration of HCG and ACTH to normal adult males. Testosterone 13-25 proopiomelanocortin Homo sapiens 82-86 4381106-0 1966 The effects of ACTH and HCG on the urinary excretion of testosterone in male patients with various endocrine disorders. Testosterone 56-68 proopiomelanocortin Homo sapiens 15-19 13800053-0 1960 Study of the adrenal response to ACTH after prolonged treatment with prednisone alone or in combination with ACTH or testosterone. Testosterone 117-129 proopiomelanocortin Homo sapiens 33-37 170352-1 1975 Injection of a "rapid-acting" preparation of porcine adrenocorticotrophic hormone (ACTH) into three boars resulted in a rapid rise in plasma testosterone levels which accompanied the expected rise in plasma corticosteroids. Testosterone 141-153 proopiomelanocortin Homo sapiens 83-87 170352-4 1975 This action of ACTH is thought to be mediated through the adrenal cortex since injection of cortisol elecited a rise in testosterone similar to that observed after injection of ACTH. Testosterone 120-132 proopiomelanocortin Homo sapiens 15-19 170352-6 1975 When a "long-acting" preparation of ACTH was administered to two boars twice daily for 5 days, testosterone levels were depressed. Testosterone 95-107 proopiomelanocortin Homo sapiens 36-40 170352-7 1975 It was concluded that ACTH may bring about an increase or a decrease in plasma testosterone levels in the boar depending upon the length of time increased levels of ACTH are present in the circulation. Testosterone 79-91 proopiomelanocortin Homo sapiens 22-26 170352-7 1975 It was concluded that ACTH may bring about an increase or a decrease in plasma testosterone levels in the boar depending upon the length of time increased levels of ACTH are present in the circulation. Testosterone 79-91 proopiomelanocortin Homo sapiens 165-169 13619212-0 1958 [Adrenal response to ACTH during prolonged therapy with cortisone (cortancyl) alone or with testosterone]. Testosterone 92-104 proopiomelanocortin Homo sapiens 21-25 30328339-10 2018 In future, we are planning to place him onandrogen replacement as well.Learning points:Ambiguous genitalia with subsequent development of sexual precocity in a phenotypic male points towards someunusual varieties of CAH.High level of serum testosterone, adrenal androgen, plasma ACTH and low basal cortisol are proof of CAH,whereas elevated level of 17-OH pregnenolone is biochemical marker of 3beta-HSD enzyme deficiency.Final diagnosis can be obtained with sequencing of HSD3B2 gene showing various mutations.Presence of bilateral cryptorchidism in such a patient may be due to underlying hypogonadism.Karyotyping in such patient may rarely show mosaic KS (47,XXY/46,XX) and there might be unmasking ofhypergonadotropic hypogonadism resulting from adrenal androgen suppression from glucocorticoid treatment. Testosterone 240-252 proopiomelanocortin Homo sapiens 279-283 32091276-8 2020 Serum testosterone & ACTH returned to normal levels after surgery with subsequent regression of the virilizing symptoms. Testosterone 6-18 proopiomelanocortin Homo sapiens 25-29 30897530-8 2019 The ACTH/Cortisol-ratio indicated that testosterone attenuated sensitivity for ACTH at the adrenal level in transmen. Testosterone 39-51 proopiomelanocortin Homo sapiens 4-8 30897530-8 2019 The ACTH/Cortisol-ratio indicated that testosterone attenuated sensitivity for ACTH at the adrenal level in transmen. Testosterone 39-51 proopiomelanocortin Homo sapiens 79-83 28186359-7 2017 We believe that the assessment of circulating adrenocorticotropic hormone concentrations together with glucocorticoid levels, reflecting the hypothalamic-pituitary-adrenal axis feedback loop operativeness during testosterone supplementation, represents a well-balanced bone-related therapeutic update. Testosterone 212-224 proopiomelanocortin Homo sapiens 46-73 29808249-12 2018 In women with biochemical hyperandrogenemia, beta endorphin levels in FF correlated with testosterone levels. Testosterone 89-101 proopiomelanocortin Homo sapiens 45-59 24573184-2 2014 We postulated that testosterone (T) in men and estradiol (E2) in women govern unstressed cortisol-mediated negative feedback on ACTH secretion. Testosterone 19-31 proopiomelanocortin Homo sapiens 128-132 21418339-4 2011 Examination of the effect of prenatal testosterone exposure on the number of AgRP and POMC neurones in adult ewes showed that prenatal testosterone excess significantly increased the number of AgRP but not POMC neurones compared to controls; this increase was restricted to the middle division of the ARC, was mimicked by prenatal treatment with dihydrotestosterone, a non-aromatisable androgen, and was blocked by co-treatment of prenatal testosterone with the anti-androgen, flutamide. Testosterone 38-50 proopiomelanocortin Homo sapiens 86-90 21418339-4 2011 Examination of the effect of prenatal testosterone exposure on the number of AgRP and POMC neurones in adult ewes showed that prenatal testosterone excess significantly increased the number of AgRP but not POMC neurones compared to controls; this increase was restricted to the middle division of the ARC, was mimicked by prenatal treatment with dihydrotestosterone, a non-aromatisable androgen, and was blocked by co-treatment of prenatal testosterone with the anti-androgen, flutamide. Testosterone 135-147 proopiomelanocortin Homo sapiens 86-90 21418339-4 2011 Examination of the effect of prenatal testosterone exposure on the number of AgRP and POMC neurones in adult ewes showed that prenatal testosterone excess significantly increased the number of AgRP but not POMC neurones compared to controls; this increase was restricted to the middle division of the ARC, was mimicked by prenatal treatment with dihydrotestosterone, a non-aromatisable androgen, and was blocked by co-treatment of prenatal testosterone with the anti-androgen, flutamide. Testosterone 135-147 proopiomelanocortin Homo sapiens 86-90 15841103-4 2005 Paradoxically, CRH-stimulated corticotropin (ACTH) was increased significantly during testosterone replacement (p<0.05). Testosterone 86-98 proopiomelanocortin Homo sapiens 45-49 19336506-4 2009 DESIGN AND METHODS: Adrenal vein sampling was used to confirm ACTH stimulation of adrenal testosterone production. Testosterone 90-102 proopiomelanocortin Homo sapiens 62-66 19336506-7 2009 RESULTS: Acute ACTH administration significantly increased adrenal vein testosterone levels. Testosterone 72-84 proopiomelanocortin Homo sapiens 15-19 16860499-13 2007 Ovarian androstenedione and testosterone contributed to the basal circulating levels and, in the case of androstenedione, was stimulated by ACTH. Testosterone 28-40 proopiomelanocortin Homo sapiens 140-144 16870362-7 2007 ACTH treatment caused a significant increase in plasma levels of cortisol, progesterone, androstenedione and testosterone in all mares (P<0.05). Testosterone 109-121 proopiomelanocortin Homo sapiens 0-4 21158935-7 2011 Moreover, alpha-MSH increased MC-1R immunoreactivity and lipid synthesis in SZ95 sebocytes in the presence of testosterone. Testosterone 110-122 proopiomelanocortin Homo sapiens 10-19 20884032-7 2010 The serum adrenocorticotropic hormone level after androgen deprivation therapy was correlated with the serum levels of testosterone (p = 0.002), dehydroepiandrosterone sulfate (p = 0.002), androstenedione (p = 0.006) and prostate specific antigen (p <0.001). Testosterone 119-131 proopiomelanocortin Homo sapiens 10-37 16585961-8 2006 ACTH also stimulated the adrenal gland to secrete androstenedione and testosterone. Testosterone 70-82 proopiomelanocortin Homo sapiens 0-4 15841103-5 2005 The cortisol : ACTH ratio, a measure of adrenal sensitivity, was lower during testosterone replacement (p<0.1). Testosterone 78-90 proopiomelanocortin Homo sapiens 15-19 12676591-7 2003 In previous studies of more highly POC-exposed groups of adult men, the correlation between POC exposure, including CB-153, and free testosterone levels was not statistically significant. Testosterone 133-145 proopiomelanocortin Homo sapiens 92-95 16136011-9 2005 CONCLUSIONS: Our results might indicate that the rise of ACTH and cortisol inhibit the conversion of adrostendion into testosterone in Leydig-cells resulting in the rise of androstendion, drop of testosterone production and lower average values of semen volume, sperm cells concentration and A sperm cell mobility and higher value of D sperm cells mobility. Testosterone 119-131 proopiomelanocortin Homo sapiens 57-61 16136011-9 2005 CONCLUSIONS: Our results might indicate that the rise of ACTH and cortisol inhibit the conversion of adrostendion into testosterone in Leydig-cells resulting in the rise of androstendion, drop of testosterone production and lower average values of semen volume, sperm cells concentration and A sperm cell mobility and higher value of D sperm cells mobility. Testosterone 196-208 proopiomelanocortin Homo sapiens 57-61 12047726-9 2002 Basal adrenocorticotropic hormone (ACTH) release is regulated by testosterone-dependent effects on arginine vasopressin synthesis, and corticosterone-dependent effects on corticotropin-releasing hormone (CRH) synthesis in the paraventricular nucleus (PVN) of the hypothalamus. Testosterone 65-77 proopiomelanocortin Homo sapiens 6-33 12047726-10 2002 In contrast, testosterone and corticosterone interact on stress-induced ACTH release and drive to the PVN motor neurones. Testosterone 13-25 proopiomelanocortin Homo sapiens 72-76 12571170-8 2003 Stepwise regression analysis, after exclusion of testosterone, revealed significant correlations between the groups (lean controls, obese controls, infertility) and ACTH-stimulated 11-deoxycortisol/cortisol ratio (P < 0.05), but not with fasting glucose, insulin, cortisol, 11-deoxycortisol and baseline 11-deoxycortisol/cortisol ratios. Testosterone 49-61 proopiomelanocortin Homo sapiens 165-169 12047726-9 2002 Basal adrenocorticotropic hormone (ACTH) release is regulated by testosterone-dependent effects on arginine vasopressin synthesis, and corticosterone-dependent effects on corticotropin-releasing hormone (CRH) synthesis in the paraventricular nucleus (PVN) of the hypothalamus. Testosterone 65-77 proopiomelanocortin Homo sapiens 35-39 12018035-3 2002 In general, estradiol and testosterone exert a stimulatory, progesterone an inhibitory effect on neuronal activities which are mediated by excitatory (e.g. glutamate, aspartate), and inhibitory amino acids (e.g. GABA) and neuropeptides (e.g. beta-endorphin), respectively. Testosterone 26-38 proopiomelanocortin Homo sapiens 242-256 11912073-4 2002 ACTH and prolactin correlated positively with cortisol, DHEAS and testosterone in women, which suggests that prolactin and ACTH could contribute to stimulated adrenal androgen production. Testosterone 66-78 proopiomelanocortin Homo sapiens 0-4 11912073-4 2002 ACTH and prolactin correlated positively with cortisol, DHEAS and testosterone in women, which suggests that prolactin and ACTH could contribute to stimulated adrenal androgen production. Testosterone 66-78 proopiomelanocortin Homo sapiens 123-127 11341305-10 2001 However, a linear regression analysis revealed that the increase of ACTH in relation to cortisol depends on serum free testosterone in men (p=0.042) and on serum free 17 beta-estradiol (p<0.001) together with serum IL-6 in women (p=0.021). Testosterone 119-131 proopiomelanocortin Homo sapiens 68-72