PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25870196-0	2015	6beta-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice.	Testosterone	13-25	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	29-48	
31948482-0	2020	6beta-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.	Testosterone	13-25	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	69-75	
31948482-1	2020	BACKGROUND: Previously, we showed that 6beta-hydroxytestosterone (6beta-OHT), a cytochrome P450 1B1 (CYP1B1)-derived metabolite of testosterone, contributes to angiotensin II (Ang II)-induced hypertension in male mice.	Testosterone	52-64	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	80-99	
31948482-1	2020	BACKGROUND: Previously, we showed that 6beta-hydroxytestosterone (6beta-OHT), a cytochrome P450 1B1 (CYP1B1)-derived metabolite of testosterone, contributes to angiotensin II (Ang II)-induced hypertension in male mice.	Testosterone	52-64	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	101-107	
34420370-1	2021	This study was conducted to test the hypothesis that the CYP1B1 (cytochrome P450 1B1)-testosterone metabolite 6beta-hydroxytestosterone contributes to angiotensin II-induced hypertension by promoting activation of group IV cPLA2alpha (cytosolic phospholipase A2alpha) and generation of prohypertensive eicosanoids in male mice.	Testosterone	86-98	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	57-63	
34420370-1	2021	This study was conducted to test the hypothesis that the CYP1B1 (cytochrome P450 1B1)-testosterone metabolite 6beta-hydroxytestosterone contributes to angiotensin II-induced hypertension by promoting activation of group IV cPLA2alpha (cytosolic phospholipase A2alpha) and generation of prohypertensive eicosanoids in male mice.	Testosterone	86-98	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	65-84	
33719500-3	2021	We also found that a cytochrome P450 1B1-generated metabolite of testosterone, 6beta-hydroxytestosterone (6beta-OHT), contributes to Ang II-induced hypertension and associated cardiovascular and renal pathogenesis in male mice.	Testosterone	65-77	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	21-40	
33719500-10	2021	Conclusions Our results indicate that the testosterone-cytochrome P450 1B1-generated metabolite 6beta-OHT contributes to Ang II-induced AAA development in Apoe-/- male mice.	Testosterone	42-54	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	55-74	
32755412-0	2020	Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6beta-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation.	Testosterone	6-18	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	19-25	
32755412-0	2020	Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6beta-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation.	Testosterone	6-18	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	27-46	
32755412-1	2020	Previously, we showed that peripheral administration of 6beta-hydroxytestosterone, a CYP1B1 (cytochrome P450 1B1)-generated metabolite of testosterone, promotes angiotensin II-induced hypertension in male mice.	Testosterone	69-81	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	85-91	
32755412-1	2020	Previously, we showed that peripheral administration of 6beta-hydroxytestosterone, a CYP1B1 (cytochrome P450 1B1)-generated metabolite of testosterone, promotes angiotensin II-induced hypertension in male mice.	Testosterone	69-81	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	93-112	
32755412-4	2020	This study was conducted to determine whether testosterone-CYP1B1 generated metabolite 6beta-hydroxytestosterone locally in the brain promotes the effect of systemic angiotensin II to produce hypertension in male mice.	Testosterone	46-58	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	59-65	
32755412-8	2020	These data suggest that testosterone-CYP1B1-generated metabolite 6beta-hydroxytestosterone, most likely in the paraventricular nucleus via AR and GPRC6A, contributes to angiotensin II-induced hypertension and neuroinflammation in male mice.	Testosterone	24-36	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	37-43	
26928804-0	2016	6beta-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.	Testosterone	49-61	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	29-48	
26928804-1	2016	6beta-Hydroxytestosterone, a cytochrome P450 1B1-derived metabolite of testosterone, contributes to the development of angiotensin II-induced hypertension and associated cardiovascular pathophysiology.	Testosterone	13-25	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	29-48	
25870196-2	2015	This study was conducted to test the hypothesis that cytochrome P450 1B1-generated metabolites of testosterone, 6beta-hydroxytestosterone and 16alpha-hydroxytestosterone, contribute to angiotensin II-induced hypertension and its pathogenesis.	Testosterone	98-110	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	53-72	
25870196-8	2015	Moreover, cytochrome P450 1B1 could serve as a novel target for developing agents for treating renin-angiotensin and testosterone-dependent hypertension and associated pathogenesis in males.	Testosterone	117-129	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	10-29	
17365149-2	2007	The aims of this study was to determine if 7,12-dimethylbenz[a]anthracene (DMBA) functions as testosterone or doxycycline in its ability to induce or reduce expression of hCYP1B1 or endogenous mouse CYP1B1 (mCYP1B1).	Testosterone	94-106	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	172-178	
17365149-2	2007	The aims of this study was to determine if 7,12-dimethylbenz[a]anthracene (DMBA) functions as testosterone or doxycycline in its ability to induce or reduce expression of hCYP1B1 or endogenous mouse CYP1B1 (mCYP1B1).	Testosterone	94-106	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	207-214