PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25620703-1	2015	Aromatase-expressing neuroendocrine neurons in the vertebrate male brain synthesize estradiol from circulating testosterone.	Testosterone	111-123	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	0-9	
22876297-4	2012	Aromatase metabolizes testosterone to 17beta- estradiol (E2) and thereby significantly contributes to local estrogen synthesis.	Testosterone	22-34	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	0-9	
22028441-2	2011	Estrogen synthesis depends on androgen availability, with aromatase regulating conversion of testosterone to estradiol.	Testosterone	93-105	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	58-67	
23483029-10	2011	The recovery of wheel running in mice with androgen supplementation and the further persistence of wheel running in mice with compromised aromatase function suggests that the androgens-testosterone in particular-may directly affect wheel running patterns in male mice.	Testosterone	185-197	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	138-147	
21646391-3	2011	In this study, we show that the increase in steroidal response is associated with enhanced expression of Cyp17a1, Hsd17b, and Cyp19a1, which encode the enzymes catalyzing the synthesis of 17-OHP(4), testosterone, and E(2) respectively.	Testosterone	199-211	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	126-133	
20861231-6	2010	Compared with placebo, testosterone reduced lesion area both in Orx wild-type (WT) mice (by 50%, P < 0.001) and ARKO mice (by 24%, P < 0.05).	Testosterone	23-35	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	115-119	
20861231-7	2010	However, lesion area was larger in testosterone-supplemented ARKO compared with testosterone-supplemented WT mice (+57%, P < 0.05).	Testosterone	35-47	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	61-65	
20861231-10	2010	Testosterone treatment reduced atherosclerosis in both WT and ARKO mice.	Testosterone	0-12	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	62-66	
18063054-1	2008	The final step in the physiological synthesis of 17beta estradiol (E(2)) is aromatization of precursor testosterone by a CYP19 gene product, cytochrome P450 estrogen aromatase in the C19 steroid metabolic pathway.	Testosterone	103-115	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	121-126	
16336225-7	2006	Concomitantly, the testosterone metabolizing CYP isoforms CYP3A11 and CYP19 (aromatase) have been found to be induced 2.4- and 4.2-fold, respectively.	Testosterone	19-31	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	70-75	
16336225-12	2006	The increased metabolism of testosterone leading to augmented androgen metabolite formation most likely led to enhanced expression of CYP19 and AR in hippocampus.	Testosterone	28-40	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	134-139	
14561933-2	2003	Aromatase-knockout (ArKO) mice are unable to produce estrogen because they lack a functional Cyp 19 gene that encodes for aromatase, the enzyme that converts testosterone into estrogen.	Testosterone	158-170	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	0-18	
14561933-2	2003	Aromatase-knockout (ArKO) mice are unable to produce estrogen because they lack a functional Cyp 19 gene that encodes for aromatase, the enzyme that converts testosterone into estrogen.	Testosterone	158-170	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	20-24	
14561933-2	2003	Aromatase-knockout (ArKO) mice are unable to produce estrogen because they lack a functional Cyp 19 gene that encodes for aromatase, the enzyme that converts testosterone into estrogen.	Testosterone	158-170	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	93-99	
12388618-3	2002	When treated with testosterone, ArKO females spent significantly less time sniffing odors (both volatile and nonvolatile) from either male or female stimuli compared with WT and HET females.	Testosterone	18-30	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	32-36	
11427738-5	2001	Expression of the aromatase (Cyp19) gene, which encodes the enzyme that converts testosterone to estradiol, was increased significantly in the Leydig cells isolated from mutant mice, whereas the expression of other proteins (e.g., StAR and Cyp11a) was not altered.	Testosterone	81-93	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	18-27	
11427738-5	2001	Expression of the aromatase (Cyp19) gene, which encodes the enzyme that converts testosterone to estradiol, was increased significantly in the Leydig cells isolated from mutant mice, whereas the expression of other proteins (e.g., StAR and Cyp11a) was not altered.	Testosterone	81-93	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	29-34	
9137943-0	1997	The effect of aromatase inhibitor on basal and testosterone-supplemented estradiol secretion by Leydig cells in vitro.	Testosterone	47-59	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	14-23	
7606769-1	1995	The transformation of testosterone into estradiol in the brain plays a key role in several behavioral and physiological processes, but it has been so far impossible to localize precisely the cells of the mammalian brain containing the relevant enzyme, viz., aromatase.	Testosterone	22-34	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	258-267	
8363622-6	1993	The content of aromatase mRNA in castrated males was elevated by 2-fold by injection of testosterone and restored to the level observed in intact males.	Testosterone	88-100	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	15-24	
8363622-7	1993	Injection of testosterone also affected the level of aromatase mRNA in normal mice of both sexes, though to lesser extent.	Testosterone	13-25	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	53-62	
8363622-9	1993	These results show that transcriptional control of the aromatase gene is involved in the mechanism of testosterone to affect sexual behavior.	Testosterone	102-114	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	55-64	
34865136-5	2022	Although plasma levels of testosterone were not affected by cannabis exposure in any ages or generations of males, dysregulated steroidogenic enzymes, Cyp11a1 and Cyp19a1, were observed in F0 testis.	Testosterone	26-38	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	163-170	
33711761-12	2021	Using a larger number of biological replicates and RT-qPCR we showed that genes implicated in testosterone synthesis (Akr1b3, Cyp11a1, Cyp17a1, Srd5a1) were dramatically upregulated in PIN samples; Cyp19a1, converting testosterone to estradiol was elevated as well.	Testosterone	94-106	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	198-205	
33711761-12	2021	Using a larger number of biological replicates and RT-qPCR we showed that genes implicated in testosterone synthesis (Akr1b3, Cyp11a1, Cyp17a1, Srd5a1) were dramatically upregulated in PIN samples; Cyp19a1, converting testosterone to estradiol was elevated as well.	Testosterone	218-230	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	198-205	
32910181-2	2020	A single gene, Cyp19a1, encodes aromatase, the enzyme that catalyzes the conversion of testosterone to estradiol in the testis and brain of male mice.	Testosterone	87-99	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	15-22	
32471845-9	2020	We determined that in mice, medial amygdala neurons expressing aromatase - an enzyme that converts testosterone to estradiol and plays an important role in establishing neuroanatomical sex differences - receive sensory information from a restricted population of pheromone-sensitive neurons in the vomeronasal pathway.	Testosterone	99-111	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	63-72	
29665500-3	2018	Reduction of testosterone by aromatase generates proconvulsant 17-beta estradiol.	Testosterone	13-25	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	29-38	
29289721-1	2018	Aromatase is a key enzyme responsible for the biosynthesis of estrogen from testosterone.	Testosterone	76-88	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	0-9	
28341248-9	2017	These results strongly suggest that Cyp19 gene disruption, which induces a sexually dimorphic response and high plasma testosterone levels in male mice, also induces hepatic steatosis.	Testosterone	119-131	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	36-41	
26231585-1	2015	Aromatase, which converts testosterone in estradiol, is involved in the generation of brain sex dimorphisms.	Testosterone	26-38	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	0-9	
26169831-6	2015	Cyp19a1 encodes aromatase, which transforms testosterone into estradiol.	Testosterone	44-56	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	0-7	
26169831-9	2015	We conclude that CELF1 downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.	Testosterone	113-125	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	37-44