PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9657065-3	1997	TNF and IL-1 both inhibit cAMP-stimulated testosterone production as well as mRNA and protein levels of cholesterol side chain cleavage enzyme (P450scc) and 17 alpha-hydroxylase/C17,20 lyase (P450c17) in mouse Leydig cells.	Testosterone	42-54	interleukin 1 complex	Mus musculus	8-12	
9464752-11	1998	In contrast, testosterone-treated female mice that had experienced hemorrhage showed significant depression in splenic and peritoneal macrophage IL-1 and IL-6 production, comparable with the values seen in macrophages from male mice that had experienced hemorrhage.	Testosterone	13-25	interleukin 1 complex	Mus musculus	145-149	
9657065-5	1997	In the present study, we tested the effects of TNF and IL-1 on basal testosterone production and 8-Br-cAMP-stimulated 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase (3 beta HSD) expression in Leydig cells.	Testosterone	69-81	interleukin 1 complex	Mus musculus	55-59	
9657065-10	1997	These results demonstrate that TNF and IL-1 have different effects on basal steroidogenesis in Leydig cells and suggest that TNF-mediated inhibition of basal testosterone production may be owing to the inhibition of basal 3 beta-HSD expression in Leydig cells.	Testosterone	158-170	interleukin 1 complex	Mus musculus	39-43	
22217835-12	1992	In parallel, in vitro treatment of Leydig cells with recombinant IL-1 resulted in a dose-dependent inhibition of P450c17 mRNA expression and testosterone production.	Testosterone	141-153	interleukin 1 complex	Mus musculus	65-69	
8318028-7	1993	Testosterone antagonized the effects of IL-1 on both proteoglycan loss and proteoglycan synthesis.	Testosterone	0-12	interleukin 1 complex	Mus musculus	40-44	
1425417-3	1992	Addition of IL-1 to macrophage-depleted primary cultures of mouse Leydig cells caused a dose-dependent decrease in cAMP-dependent testosterone production and 17 alpha-hydroxylase/C17-20 lyase (P450c17) mRNA levels.	Testosterone	130-142	interleukin 1 complex	Mus musculus	12-16	
1425417-5	1992	Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone.	Testosterone	60-72	interleukin 1 complex	Mus musculus	45-49	
1425417-5	1992	Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone.	Testosterone	168-180	interleukin 1 complex	Mus musculus	45-49	
1425417-5	1992	Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone.	Testosterone	168-180	interleukin 1 complex	Mus musculus	153-157	
1425417-6	1992	Chronic treatment with IL-1 plus 8-Br-cAMP caused a shift in steroid production from testosterone to progesterone, but total steroid production (the sum of testosterone plus progesterone) was unaffected by IL-1 treatment.	Testosterone	85-97	interleukin 1 complex	Mus musculus	23-27	
1425417-6	1992	Chronic treatment with IL-1 plus 8-Br-cAMP caused a shift in steroid production from testosterone to progesterone, but total steroid production (the sum of testosterone plus progesterone) was unaffected by IL-1 treatment.	Testosterone	156-168	interleukin 1 complex	Mus musculus	23-27	
2157407-1	1990	Previously we have reported that human chorionic gonadotropin(hCG)-stimulated testosterone biosynthesis was markedly inhibited by purified natural human interleukin-1 (IL-1).	Testosterone	78-90	interleukin 1 complex	Mus musculus	168-172	
29566712-6	2018	IL1ss and IL6 had a subtle but significant negative effect on cell viability and testosterone concentrations, with a marked significant decrease in progesterone concentration at all concentrations investigated.	Testosterone	81-93	interleukin 1 complex	Mus musculus	0-3	
33562323-8	2021	The addition of IL-1 did not affect developed cells in MCS compared to control, but in combination with testosterone, it significantly increased the percentages of VASA-positive cells and BOULE-positive cells compared to IL-1 or testosterone.	Testosterone	104-116	interleukin 1 complex	Mus musculus	221-225