PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9657065-3 1997 TNF and IL-1 both inhibit cAMP-stimulated testosterone production as well as mRNA and protein levels of cholesterol side chain cleavage enzyme (P450scc) and 17 alpha-hydroxylase/C17,20 lyase (P450c17) in mouse Leydig cells. Testosterone 42-54 interleukin 1 complex Mus musculus 8-12 9464752-11 1998 In contrast, testosterone-treated female mice that had experienced hemorrhage showed significant depression in splenic and peritoneal macrophage IL-1 and IL-6 production, comparable with the values seen in macrophages from male mice that had experienced hemorrhage. Testosterone 13-25 interleukin 1 complex Mus musculus 145-149 9657065-5 1997 In the present study, we tested the effects of TNF and IL-1 on basal testosterone production and 8-Br-cAMP-stimulated 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase (3 beta HSD) expression in Leydig cells. Testosterone 69-81 interleukin 1 complex Mus musculus 55-59 9657065-10 1997 These results demonstrate that TNF and IL-1 have different effects on basal steroidogenesis in Leydig cells and suggest that TNF-mediated inhibition of basal testosterone production may be owing to the inhibition of basal 3 beta-HSD expression in Leydig cells. Testosterone 158-170 interleukin 1 complex Mus musculus 39-43 8318028-7 1993 Testosterone antagonized the effects of IL-1 on both proteoglycan loss and proteoglycan synthesis. Testosterone 0-12 interleukin 1 complex Mus musculus 40-44 1425417-3 1992 Addition of IL-1 to macrophage-depleted primary cultures of mouse Leydig cells caused a dose-dependent decrease in cAMP-dependent testosterone production and 17 alpha-hydroxylase/C17-20 lyase (P450c17) mRNA levels. Testosterone 130-142 interleukin 1 complex Mus musculus 12-16 22217835-12 1992 In parallel, in vitro treatment of Leydig cells with recombinant IL-1 resulted in a dose-dependent inhibition of P450c17 mRNA expression and testosterone production. Testosterone 141-153 interleukin 1 complex Mus musculus 65-69 1425417-5 1992 Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone. Testosterone 60-72 interleukin 1 complex Mus musculus 45-49 1425417-5 1992 Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone. Testosterone 168-180 interleukin 1 complex Mus musculus 45-49 1425417-5 1992 Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone. Testosterone 168-180 interleukin 1 complex Mus musculus 153-157 1425417-6 1992 Chronic treatment with IL-1 plus 8-Br-cAMP caused a shift in steroid production from testosterone to progesterone, but total steroid production (the sum of testosterone plus progesterone) was unaffected by IL-1 treatment. Testosterone 85-97 interleukin 1 complex Mus musculus 23-27 1425417-6 1992 Chronic treatment with IL-1 plus 8-Br-cAMP caused a shift in steroid production from testosterone to progesterone, but total steroid production (the sum of testosterone plus progesterone) was unaffected by IL-1 treatment. Testosterone 156-168 interleukin 1 complex Mus musculus 23-27 2157407-1 1990 Previously we have reported that human chorionic gonadotropin(hCG)-stimulated testosterone biosynthesis was markedly inhibited by purified natural human interleukin-1 (IL-1). Testosterone 78-90 interleukin 1 complex Mus musculus 168-172 29566712-6 2018 IL1ss and IL6 had a subtle but significant negative effect on cell viability and testosterone concentrations, with a marked significant decrease in progesterone concentration at all concentrations investigated. Testosterone 81-93 interleukin 1 complex Mus musculus 0-3 33562323-8 2021 The addition of IL-1 did not affect developed cells in MCS compared to control, but in combination with testosterone, it significantly increased the percentages of VASA-positive cells and BOULE-positive cells compared to IL-1 or testosterone. Testosterone 104-116 interleukin 1 complex Mus musculus 221-225