PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17627018-0	2007	2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	0-46	N-acetyltransferase 2	Homo sapiens	209-230	
10537291-2	1999	Cytochrome P4501A2 (CYP1A2)-mediated N-hydroxylation followed by phase II O-esterification by N-acetyltransferase (NAT2) are generally regarded as activation processes in which MeIQx and other HAAs are converted to genotoxic species.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	177-182	N-acetyltransferase 2	Homo sapiens	115-119	
7586210-1	1995	Heterocyclic aromatics amines (HAAs), such as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), are metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2).	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	46-91	N-acetyltransferase 2	Homo sapiens	185-189	
7586210-2	1995	We examined the relationship between CYP1A2 and NAT2 activity and the excretion of total unconjugated MeIQx in 66 healthy subjects.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	102-107	N-acetyltransferase 2	Homo sapiens	48-52	
17627018-9	2007	Only cells transfected with both CYP1A1 and NAT2*4 showed concentration-dependent cytotoxicity and hypoxanthine phosphoribosyl transferase mutagenesis following MeIQx treatment.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	161-166	N-acetyltransferase 2	Homo sapiens	44-48	
17627018-11	2007	MeIQx DNA adduct levels were significantly higher (P < 0.001) in CYP1A1/NAT2*4 than CYP1A1/NAT2*5B cells at all concentrations of MeIQx tested.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	0-5	N-acetyltransferase 2	Homo sapiens	75-79	
17627018-11	2007	MeIQx DNA adduct levels were significantly higher (P < 0.001) in CYP1A1/NAT2*4 than CYP1A1/NAT2*5B cells at all concentrations of MeIQx tested.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	0-5	N-acetyltransferase 2	Homo sapiens	94-98	
17627018-11	2007	MeIQx DNA adduct levels were significantly higher (P < 0.001) in CYP1A1/NAT2*4 than CYP1A1/NAT2*5B cells at all concentrations of MeIQx tested.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	133-138	N-acetyltransferase 2	Homo sapiens	75-79	
17627018-13	2007	These results strongly support extrahepatic activation of MeIQx by CYP1A1 and a robust effect of human NAT2 genetic polymorphism on MeIQx-induced DNA adducts and mutagenesis.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	132-137	N-acetyltransferase 2	Homo sapiens	103-107	
20004212-4	2010	MeIQx and IQ both induced decreases in cell survival and significantly (p<0.001) greater number of endogenous hypoxanthine phosphoribosyl transferase (hprt) mutants in the CYP1A2/NAT2*4 than the CYP1A2/NAT2*5B cell line.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	0-5	N-acetyltransferase 2	Homo sapiens	182-186	
20004212-4	2010	MeIQx and IQ both induced decreases in cell survival and significantly (p<0.001) greater number of endogenous hypoxanthine phosphoribosyl transferase (hprt) mutants in the CYP1A2/NAT2*4 than the CYP1A2/NAT2*5B cell line.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	0-5	N-acetyltransferase 2	Homo sapiens	205-209	
20004212-9	2010	These results suggest substantially increased risk for IQ- and MeIQx-induced DNA damage and mutagenesis in rapid NAT2 acetylators.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	63-68	N-acetyltransferase 2	Homo sapiens	113-117