PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18620421-9 2008 First, wild-type CBL is activated by Mg (2+) (a 12-75-fold increase in activity is observed depending on assay conditions) and its kinetic mechanism (ping-pong) supports the structure-derived prediction that PP i dissociation must precede the switch from conformation 1 to conformation 2 and therefore CoA binding. mg (2+) 37-44 Cbl proto-oncogene Homo sapiens 17-20