PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20687958-0 2010 Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1. Fenretinide 36-47 secreted protein acidic and cysteine rich Homo sapiens 70-75 20687958-7 2010 Interestingly, fenretinide [N-4(hydroxyphenyl) retinamide, 4-HPR], a synthetic retinoid with anti-cancer properties, was found to up-regulate the transcription, expression and secretion of SPARC via induction of the Brg-1 in a dose-dependent manner. Fenretinide 15-26 secreted protein acidic and cysteine rich Homo sapiens 189-194 20687958-7 2010 Interestingly, fenretinide [N-4(hydroxyphenyl) retinamide, 4-HPR], a synthetic retinoid with anti-cancer properties, was found to up-regulate the transcription, expression and secretion of SPARC via induction of the Brg-1 in a dose-dependent manner. Fenretinide 28-57 secreted protein acidic and cysteine rich Homo sapiens 189-194 20687958-8 2010 Finally, our results demonstrated that fenretinide-induced expression of SPARC contributes significantly to a decreased invasion of mammary carcinoma cells. Fenretinide 39-50 secreted protein acidic and cysteine rich Homo sapiens 73-78 20687958-9 2010 CONCLUSIONS: Overall, our results reveal a novel cooperative role of Brg-1 and Sp1 in mediating the constitutive and fenretinide-induced expression of SPARC, and provide new insights for the understanding of the anti-cancer effects of fenretinide. Fenretinide 117-128 secreted protein acidic and cysteine rich Homo sapiens 151-156 20687958-9 2010 CONCLUSIONS: Overall, our results reveal a novel cooperative role of Brg-1 and Sp1 in mediating the constitutive and fenretinide-induced expression of SPARC, and provide new insights for the understanding of the anti-cancer effects of fenretinide. Fenretinide 235-246 secreted protein acidic and cysteine rich Homo sapiens 151-156