PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30939964-5 2019 By screening a library of nuclear-receptor-agonists for modifiers of the SQSTM1 aggregates, we identified 4-hydroxy(phenyl)retinamide (4HPR) as a potent modifier exerting detrimental effects on mutant-TBK1 motoneurons fitness exacerbating the autophagy overload. Fenretinide 106-133 sequestosome 1 Homo sapiens 73-79 30939964-5 2019 By screening a library of nuclear-receptor-agonists for modifiers of the SQSTM1 aggregates, we identified 4-hydroxy(phenyl)retinamide (4HPR) as a potent modifier exerting detrimental effects on mutant-TBK1 motoneurons fitness exacerbating the autophagy overload. Fenretinide 135-139 sequestosome 1 Homo sapiens 73-79 30939964-7 2019 4HPR-increased toxicity was associated with the upregulation of SQSTM1 in a context of strongly reduced ATG10, while rescue of ATG10 levels abolished 4HPR toxicity. Fenretinide 0-4 sequestosome 1 Homo sapiens 64-70