PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11010810-3	2000	Fenretinide induced high levels of caspase-dependent apoptosis accompanied by an increase in free radicals and the release of cytochrome c in the absence of mitochondrial permeability transition.	Fenretinide	0-11	cytochrome c, somatic	Homo sapiens	126-138	
15326375-6	2004	4HPR-induced apoptosis in these cells was associated with stimulation of reactive oxygen species generation, decreased levels of Bcl-2 protein, release of cytochrome c into the cytosol, increased caspase-3 activity, and poly(ADP-ribose) polymerase cleavage.	Fenretinide	0-4	cytochrome c, somatic	Homo sapiens	155-167	
12815470-0	2003	Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation.	Fenretinide	0-11	cytochrome c, somatic	Homo sapiens	20-32	
15650234-2	2004	Fenretinide-induced cell death of neuroblastoma cells is caspase dependent and results in the release of cytochrome c from mitochondria independently of changes in permeability transition.	Fenretinide	0-11	cytochrome c, somatic	Homo sapiens	105-117	
11010810-7	2000	These results suggest that the effector pathway of fenretinide-induced apoptosis of neuroblastoma is caspase dependent, involving mitochondrial release of cytochrome c independently of permeability changes, and mediated by specific RARs.	Fenretinide	51-62	cytochrome c, somatic	Homo sapiens	155-167	
17216584-1	2007	Fenretinide-induced apoptosis of neuroectodermal tumour cells is mediated through generation of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, mitochondrial cytochrome c release and caspase activation.	Fenretinide	0-11	cytochrome c, somatic	Homo sapiens	176-188	
18549809-4	2008	4-HPR-induced mitochondrial translocation of Bax, release of mitochondrial cytochrome c, and activation of caspase-3 were markedly attenuated in U373MG cells that stably expressed COX6A1.	Fenretinide	0-5	cytochrome c, somatic	Homo sapiens	75-87	
17700534-5	2008	Furthermore, inhibition of p38(MAPK) activity and knockdown of EWS-Fli1 reduced fenretinide-induced mitochondrial permeabilization, cytochrome c release, caspase and PARP cleavage, consistent with the hypothesis that p38(MAPK) is critical for activation of the death cascade by fenretinide in ESFT cells.	Fenretinide	80-91	cytochrome c, somatic	Homo sapiens	132-144	
10597238-0	1999	Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells.	Fenretinide	91-120	cytochrome c, somatic	Homo sapiens	61-73	
16407847-5	2006	SP600125, a JNK inhibitor, suppressed 4HPR-induced c-Jun phosphorylation, cytochrome c release from mitochondria and apoptosis.	Fenretinide	38-42	cytochrome c, somatic	Homo sapiens	74-86