PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33123895-7 2020 CD34+ AML stem/progenitor cells separated from 32 AML samples were treated with 4-HPR. Fenretinide 80-85 CD34 molecule Homo sapiens 0-4 24021153-1 2014 AIMS: We have recently shown that fenretinide preferentially targets CD34(+) cells of acute myeloid leukemia (AML), and here, we test whether this agent exerts the effect on CD34(+) cells of chronic myeloid leukemia (CML), which are refractory to imatinib. Fenretinide 34-45 CD34 molecule Homo sapiens 69-73 24021153-2 2014 RESULTS: As tested by colony-forming cell assays using clinical specimens, both number and size of total colonies derived from CD34(+) CML cells were significantly reduced by fenretinide, and by combining fenretinide with imatinib. Fenretinide 175-186 CD34 molecule Homo sapiens 127-131 24021153-2 2014 RESULTS: As tested by colony-forming cell assays using clinical specimens, both number and size of total colonies derived from CD34(+) CML cells were significantly reduced by fenretinide, and by combining fenretinide with imatinib. Fenretinide 205-216 CD34 molecule Homo sapiens 127-131 24021153-4 2014 Accordantly, fenretinide appeared to induce apoptosis in CD34(+) CML cells, particularly with regard to the cells in the subpopulation of CD34(+)CD38(-). Fenretinide 13-24 CD34 molecule Homo sapiens 57-61 24021153-4 2014 Accordantly, fenretinide appeared to induce apoptosis in CD34(+) CML cells, particularly with regard to the cells in the subpopulation of CD34(+)CD38(-). Fenretinide 13-24 CD34 molecule Homo sapiens 138-142 24021153-5 2014 Through cell quiescent assays, including Ki-67 negativity test, we added evidence that nonproliferative CD34(+) CML cells were largely eliminated by fenretinide. Fenretinide 149-160 CD34 molecule Homo sapiens 104-108 24021153-7 2014 INNOVATION AND CONCLUSION: As compared with CD34(+) AML cells, the apoptotic effects of fenretinide on CD34(+) CML cells were more prominent whereas less varied among the samples of different patients, and also various stress-responsive events appeared to be more robust in fenretinide-treated CD34(+) CML cells. Fenretinide 88-99 CD34 molecule Homo sapiens 103-107 24021153-7 2014 INNOVATION AND CONCLUSION: As compared with CD34(+) AML cells, the apoptotic effects of fenretinide on CD34(+) CML cells were more prominent whereas less varied among the samples of different patients, and also various stress-responsive events appeared to be more robust in fenretinide-treated CD34(+) CML cells. Fenretinide 88-99 CD34 molecule Homo sapiens 103-107 23513221-4 2013 Fenretinide exerted a selective cytotoxic effect on primary AML CD34(+) cells, especially the LSC-enriched CD34(+)CD38(-) subpopulation, whereas no significant effect was observed on normal counterparts. Fenretinide 0-11 CD34 molecule Homo sapiens 64-68 23513221-4 2013 Fenretinide exerted a selective cytotoxic effect on primary AML CD34(+) cells, especially the LSC-enriched CD34(+)CD38(-) subpopulation, whereas no significant effect was observed on normal counterparts. Fenretinide 0-11 CD34 molecule Homo sapiens 107-111 23513221-5 2013 Methylcellulose colony formation assays further showed that fenretinide significantly suppressed the formation of colonies derived from AML CD34(+) cells but not those from normal CD34(+) cells. Fenretinide 60-71 CD34 molecule Homo sapiens 140-144