PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17159502-6 2007 Western blot analysis further showed down-regulation of procaspase-3, X-linked inhibitor of apoptosis protein and poly(ADP-ribose) polymerase cleavage in Bel-7402 cells treated with 15 mumol/l fenretinide for 48 h. Overexpression of p53 was observed in a time-dependent manner, along with a decrease in the Bcl-2/Bax ratio. Fenretinide 193-204 BCL2 apoptosis regulator Homo sapiens 307-312 14645667-2 2003 The stress-inducible transcription factor known as growth and DNA damage (GADD)-inducible transcription factor 153 is induced in response to fenretinide and in other cell types modulates apoptosis via pro- and antiapoptotic members of the BCL2 family. Fenretinide 141-152 BCL2 apoptosis regulator Homo sapiens 239-243 15326375-6 2004 4HPR-induced apoptosis in these cells was associated with stimulation of reactive oxygen species generation, decreased levels of Bcl-2 protein, release of cytochrome c into the cytosol, increased caspase-3 activity, and poly(ADP-ribose) polymerase cleavage. Fenretinide 0-4 BCL2 apoptosis regulator Homo sapiens 129-134 14645667-3 2003 Because BCL2-family proteins are important in apoptosis induced by chemotherapeutic drugs, GADD153 may be a key mediator of synergy between fenretinide and chemotherapeutic drugs. Fenretinide 140-151 BCL2 apoptosis regulator Homo sapiens 8-12 31484706-10 2019 Thus, fenretinide + venetoclax is a synergistic combination that warrants clinical testing in high BCL-2-expressing neuroblastoma. Fenretinide 6-17 BCL2 apoptosis regulator Homo sapiens 99-104 31484706-0 2019 Fenretinide via NOXA Induction, Enhanced Activity of the BCL-2 Inhibitor Venetoclax in High BCL-2-Expressing Neuroblastoma Preclinical Models. Fenretinide 0-11 BCL2 apoptosis regulator Homo sapiens 57-62 13679861-0 2003 The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family. Fenretinide 26-55 BCL2 apoptosis regulator Homo sapiens 137-142 31839811-0 2019 Fenretinide-induced Apoptosis of Acute Myeloid Leukemia Cells via NR4A1 Translocation into Mitochondria and Bcl-2 Transformation. Fenretinide 0-11 BCL2 apoptosis regulator Homo sapiens 108-113 31839811-14 2019 At the same time, fenretinide promoted NR4A1 translocation from nuclei into mitochondria, and enhanced the interaction between NR4A1 and Bcl-2, thereby exposing the BH3 domain of Bcl-2 to exert the anti-apoptotic effect. Fenretinide 18-29 BCL2 apoptosis regulator Homo sapiens 137-142 31839811-14 2019 At the same time, fenretinide promoted NR4A1 translocation from nuclei into mitochondria, and enhanced the interaction between NR4A1 and Bcl-2, thereby exposing the BH3 domain of Bcl-2 to exert the anti-apoptotic effect. Fenretinide 18-29 BCL2 apoptosis regulator Homo sapiens 179-184 31484706-2 2019 Fenretinide (4-HPR) is a cytotoxic retinoid with clinical activity in recurrent neuroblastoma and venetoclax (ABT-199) is a selective inhibitor of the antiapoptotic protein B-cell lymphoma-2 (BCL-2). Fenretinide 0-11 BCL2 apoptosis regulator Homo sapiens 173-190 31484706-2 2019 Fenretinide (4-HPR) is a cytotoxic retinoid with clinical activity in recurrent neuroblastoma and venetoclax (ABT-199) is a selective inhibitor of the antiapoptotic protein B-cell lymphoma-2 (BCL-2). Fenretinide 0-11 BCL2 apoptosis regulator Homo sapiens 192-197