PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17353921-7	2007	In contrast to the apoptosis-inducing chemotherapeutic drugs vincristine and temozolomide, fenretinide induced the phosphorylation of eIF2alpha, expression of ATF4 and splicing of XBP-1 mRNA, events that define ER stress.	Fenretinide	91-102	eukaryotic translation initiation factor 2A	Homo sapiens	134-143	
20022965-3	2010	The aim of this study was to test the hypothesis that the early events of ER stress signaling and response pathways induced by fenretinide and bortezomib are mediated by the eukaryotic initiation factor 2alpha (eIF2alpha)-ATF4 signaling pathway.	Fenretinide	127-138	eukaryotic translation initiation factor 2A	Homo sapiens	211-220	
20022965-4	2010	Treatment of neuroblastoma and melanoma cell lines with fenretinide, bortezomib, or thapsigargin resulted in induction of eIF2alpha signaling, characterized by increased expression of phosphorylated eIF2alpha, ATF4, ATF3, and GADD34.	Fenretinide	56-67	eukaryotic translation initiation factor 2A	Homo sapiens	122-131	
20022965-4	2010	Treatment of neuroblastoma and melanoma cell lines with fenretinide, bortezomib, or thapsigargin resulted in induction of eIF2alpha signaling, characterized by increased expression of phosphorylated eIF2alpha, ATF4, ATF3, and GADD34.	Fenretinide	56-67	eukaryotic translation initiation factor 2A	Homo sapiens	199-208	
20022965-7	2010	Although PERK-dependent phosphorylation of eIF2alpha enhanced ATF4 protein levels during ER stress, cell death in response to fenretinide, bortezomib, or thapsigargin was not abrogated by inhibition of eIF2alpha phosphorylation through PERK knockdown or overexpression of wild-type eIF2alpha.	Fenretinide	126-137	eukaryotic translation initiation factor 2A	Homo sapiens	43-52	
18342855-0	2008	The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells.	Fenretinide	84-113	eukaryotic translation initiation factor 2A	Homo sapiens	9-19	
18342855-0	2008	The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells.	Fenretinide	115-119	eukaryotic translation initiation factor 2A	Homo sapiens	9-19