PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27009163-5 2016 In contrast, TNF-alpha dramatically and reversibly decreased Na(+) flux in polarized taste buds via amiloride-sensitive and amiloride-insensitive Na(+) transport systems. Amiloride 100-109 tumor necrosis factor Homo sapiens 13-22 27094771-4 2016 Inhibition of urokinase by amiloride abated the effects of TNF-alpha on BBB integrity and MMP-2 activity without affecting that of total PKC. Amiloride 27-36 tumor necrosis factor Homo sapiens 59-68 27009163-5 2016 In contrast, TNF-alpha dramatically and reversibly decreased Na(+) flux in polarized taste buds via amiloride-sensitive and amiloride-insensitive Na(+) transport systems. Amiloride 124-133 tumor necrosis factor Homo sapiens 13-22 27009163-6 2016 The speed and partial amiloride sensitivity of these changes in Na(+) flux indicate that IL-1beta and TNF-alpha modulate epithelial Na(+) channel (ENaC) function. Amiloride 22-31 tumor necrosis factor Homo sapiens 102-111 27009163-7 2016 A portion of the TNF-mediated decrease in Na(+) flux is also blocked by the TRPV1 antagonist capsazepine, although TNF-alpha further reduced Na(+) transport independently of both amiloride and capsazepine. Amiloride 179-188 tumor necrosis factor Homo sapiens 17-20 22697478-1 2012 The lectin-like domain of Tumor Necrosis Factor (TNF), mimicked by the TIP peptide, activates amiloride-sensitive sodium uptake in type II alveolar epithelial cells and as such increases alveolar liquid clearance in dysfunctional lungs. Amiloride 94-103 tumor necrosis factor Homo sapiens 26-47 22697478-1 2012 The lectin-like domain of Tumor Necrosis Factor (TNF), mimicked by the TIP peptide, activates amiloride-sensitive sodium uptake in type II alveolar epithelial cells and as such increases alveolar liquid clearance in dysfunctional lungs. Amiloride 94-103 tumor necrosis factor Homo sapiens 49-52 20979368-0 2010 Essential structural features of TNF-alpha lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells. Amiloride 97-106 tumor necrosis factor Homo sapiens 33-42 20979368-2 2010 The lectin-like domain of TNF-alpha has been shown to activate amiloride-sensitive sodium uptake in type II alveolar epithelial cells. Amiloride 63-72 tumor necrosis factor Homo sapiens 26-35 14973065-10 2004 Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process. Amiloride 0-9 tumor necrosis factor Homo sapiens 98-107 14514522-6 2004 A strong correlation was found at different TNF-alpha concentrations between the decrease of amiloride-sensitive current and alpha-ENaC mRNA expression. Amiloride 93-102 tumor necrosis factor Homo sapiens 44-53 14973065-10 2004 Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process. Amiloride 0-9 tumor necrosis factor Homo sapiens 152-161 7591712-4 1995 The amiloride analog 5-(N-ethyl-N-isopropyl)amiloride (EIPA), an inhibitor of the Na+/H+ antiporter, inhibited TNF-alpha production with an EC50 of 3.3 microM. Amiloride 4-13 tumor necrosis factor Homo sapiens 111-120 11751211-5 2002 Exposure of alveolar epithelial cells to amiloride or its analog, 5-(N,N-hexamethylene)-amiloride (HMA), reduced, in a dose-dependent manner, lipopolysaccharide (LPS)-induced secretion of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. Amiloride 41-50 tumor necrosis factor Homo sapiens 215-248 11350806-7 2001 The TNF-alpha-elicited Na(+) current was inhibited by amiloride, and there was no change when A549 cells were perfused with the triple-mutant TNF-alpha or after preincubation with blocking antibodies to the two TNF-alpha receptors before perfusion with TNF-alpha. Amiloride 54-63 tumor necrosis factor Homo sapiens 4-13 11350806-8 2001 In conclusion, although TNF- alpha can initiate acute inflammation and edema formation in the lung, TNF-alpha can also increase AFC by an amiloride-sensitive, cAMP-independent mechanism that enhances the resolution of alveolar edema in pathological conditions by either binding to its receptors or activating Na(+) channels by means of its lectinlike domain. Amiloride 138-147 tumor necrosis factor Homo sapiens 100-109 8494532-6 1993 Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid]. Amiloride 175-184 tumor necrosis factor Homo sapiens 24-27 1591007-4 1992 In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta. Amiloride 38-47 tumor necrosis factor Homo sapiens 101-122 1591007-5 1992 Amiloride in concentrations of 10(-4) to 10(-6) M, concentrations capable of being achieved in the distal airways via nebulization, were shown to inhibit lipopolysaccharide-stimulated, AM-derived IL-8 and TNF in both a time- and dose-dependent fashion. Amiloride 0-9 tumor necrosis factor Homo sapiens 205-208 1591007-7 1992 Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered. Amiloride 39-48 tumor necrosis factor Homo sapiens 95-98 35601958-3 2022 TIP peptide, AP301) is a 17-mer cyclic peptide that mimics the LLD of human TNF which activates the amiloride-sensitive epithelial sodium channel (ENaC) and, as such, recapitulates the capacity of TNF to enhance alveolar fluid clearance, as demonstrated in numerous preclinical studies. Amiloride 100-109 tumor necrosis factor Homo sapiens 76-79 3165095-10 1988 A sensitizing effect was noted with amiloride or cytochalasin B, characterized by greater relative increases of [3H]TdR incorporation and TdR kinase activity in response to TNF. Amiloride 36-45 tumor necrosis factor Homo sapiens 173-176