PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2556151-0 1989 Potentiation of the effects of atrial natriuretic factor on the cardiovascular system by amiloride. Amiloride 89-98 natriuretic peptide A Rattus norvegicus 31-56 2145725-8 1990 Although, by luminal administration of ANF in vivo, we were able to confirm an amiloride-like action of the hormone at this site, we could not thereby mimic the effects of systemic ANF on MCD Na reabsorption. Amiloride 79-88 natriuretic peptide A Rattus norvegicus 39-42 8941347-5 1996 in a concentration dependent manner and provide evidence that rANP affects the amiloride sensitive Na+/H- channel. Amiloride 79-88 natriuretic peptide A Rattus norvegicus 62-66 1652938-6 1991 The inhibitory effect of ANF on adenylate cyclase was also dependent on the presence of guanine nucleotides and was attenuated by amiloride and pertussis toxin. Amiloride 130-139 natriuretic peptide A Rattus norvegicus 25-28 2553866-0 1989 Atrial natriuretic peptide modulates amiloride-sensitive Na+ transport across the blood-brain barrier. Amiloride 37-46 natriuretic peptide A Rattus norvegicus 0-26 2553866-1 1989 We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex. Amiloride 26-35 natriuretic peptide A Rattus norvegicus 84-110 2553866-1 1989 We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex. Amiloride 26-35 natriuretic peptide A Rattus norvegicus 119-145 2553866-1 1989 We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex. Amiloride 26-35 natriuretic peptide A Rattus norvegicus 147-150 2553866-1 1989 We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex. Amiloride 26-35 natriuretic peptide A Rattus norvegicus 162-166 2553866-3 1989 When the effect of rANP was investigated on in vitro 22Na+ uptake into isolated cerebral capillaries, 10(-7) M rANP significantly inhibited the uptake in the presence of 1.0 mM ouabain, 1.0 mM furosemide, and 2.0 mM LiCl in the uptake buffer, a finding suggesting a specific inhibitory effect of rANP on amiloride-sensitive Na+ transport. Amiloride 304-313 natriuretic peptide A Rattus norvegicus 111-115 2553866-3 1989 When the effect of rANP was investigated on in vitro 22Na+ uptake into isolated cerebral capillaries, 10(-7) M rANP significantly inhibited the uptake in the presence of 1.0 mM ouabain, 1.0 mM furosemide, and 2.0 mM LiCl in the uptake buffer, a finding suggesting a specific inhibitory effect of rANP on amiloride-sensitive Na+ transport. Amiloride 304-313 natriuretic peptide A Rattus norvegicus 111-115 2556151-1 1989 Amiloride has previously been shown to facilitate receptor binding of atrial natriuretic factor (ANF) to membranes of adrenal cortex and to enhance ANF induced inhibition of steroid secretion in vitro. Amiloride 0-9 natriuretic peptide A Rattus norvegicus 70-95 2556151-1 1989 Amiloride has previously been shown to facilitate receptor binding of atrial natriuretic factor (ANF) to membranes of adrenal cortex and to enhance ANF induced inhibition of steroid secretion in vitro. Amiloride 0-9 natriuretic peptide A Rattus norvegicus 97-100 2556151-1 1989 Amiloride has previously been shown to facilitate receptor binding of atrial natriuretic factor (ANF) to membranes of adrenal cortex and to enhance ANF induced inhibition of steroid secretion in vitro. Amiloride 0-9 natriuretic peptide A Rattus norvegicus 148-151 2556151-2 1989 This interaction of amiloride and ANF also holds true for the cardiovascular system. Amiloride 20-29 natriuretic peptide A Rattus norvegicus 34-37 2556151-5 1989 In spontaneously hypertensive rats ANF-induced decreases in blood pressure were potentiated by amiloride. Amiloride 95-104 natriuretic peptide A Rattus norvegicus 35-38 2556151-9 1989 Binding of labeled ANF to aortic tissue was concentration-dependently increased by amiloride. Amiloride 83-92 natriuretic peptide A Rattus norvegicus 19-22 2556151-11 1989 Therefore it can be suggested that amiloride and ATP interfere with a mechanism regulating the sensitivity of the vascular ANF-receptor for its ligand regarding binding and signal transforming presumably by a kinase mediated phosphorylation/dephosphorylation process. Amiloride 35-44 natriuretic peptide A Rattus norvegicus 123-126 2567705-4 1989 ANF stimulation of cGMP accumulation was specific, in that high concentrations (10(-6)M) of atriopeptin I [rat ANF-(103-123)], angiotensin II, arginine vasopressin, and amiloride (10(-4)M) did not increase basal cGMP. Amiloride 169-178 natriuretic peptide A Rattus norvegicus 0-3 2542311-4 1989 In addition, amiloride also attenuated the inhibitory effects of atrial natriuretic factor (ANF 99-126) and angiotensin II on cAMP levels and adenylate cyclase activity. Amiloride 13-22 natriuretic peptide A Rattus norvegicus 65-90 2542756-4 1989 The binding of ANF to this subtype is potentiated by amiloride and by divalent cations. Amiloride 53-62 natriuretic peptide A Rattus norvegicus 15-18 2571140-4 1989 These data suggest that under physiological conditions amiloride augments ANF-stimulated intracellular cGMP accumulation. Amiloride 55-64 natriuretic peptide A Rattus norvegicus 74-77 2571140-2 1989 Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. Amiloride 0-9 natriuretic peptide A Rattus norvegicus 20-23 2571140-3 1989 In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees C in whole glomeruli or at 37 degrees C in membrane preparations. Amiloride 13-22 natriuretic peptide A Rattus norvegicus 32-35 2571140-5 1989 The discrepancies between amiloride augmentation of ANF binding and failure to increase ANF-stimulated cGMP accumulation may result from ANF receptor heterogeneity. Amiloride 26-35 natriuretic peptide A Rattus norvegicus 52-55 2571140-6 1989 This is the first report of an amiloride augmentation of ANF-stimulated cGMP accumulation in renal tissue. Amiloride 31-40 natriuretic peptide A Rattus norvegicus 57-60 2542756-10 1989 This subtype recognizes the active forms of ANF as well as its metabolites, and the binding is insensitive to amiloride and is decreased by divalent cations. Amiloride 110-119 natriuretic peptide A Rattus norvegicus 44-47 2570337-0 1989 Effect of ATP and amiloride on ANF binding and stimulation of cyclic GMP accumulation in rat glomerular membranes. Amiloride 18-27 natriuretic peptide A Rattus norvegicus 31-34 2570337-2 1989 Amiloride enhanced high affinity binding of ANF without affecting its stimulation of cGMP. Amiloride 0-9 natriuretic peptide A Rattus norvegicus 44-47 2524641-4 1989 The effect of ANP on kallikrein excretion was abolished when amiloride (2.5 mg i.v.) Amiloride 61-70 natriuretic peptide A Rattus norvegicus 14-17 2853740-1 1988 We have demonstrated an interaction between the effects of amiloride and atrial natriuretic factor (ANF) on the vascular system. Amiloride 59-68 natriuretic peptide A Rattus norvegicus 100-103 2853740-4 1988 In spontaneously hypertensive rats (SHR) ANF-induced decreases in blood pressure were potentiated by amiloride. Amiloride 101-110 natriuretic peptide A Rattus norvegicus 41-44 2853740-5 1988 Binding experiments revealed an interaction between amiloride and ANF at the receptor level; binding of labelled ANF to aortic tissue was increased by amiloride but decreased by ATP. Amiloride 52-61 natriuretic peptide A Rattus norvegicus 113-116 2853740-5 1988 Binding experiments revealed an interaction between amiloride and ANF at the receptor level; binding of labelled ANF to aortic tissue was increased by amiloride but decreased by ATP. Amiloride 151-160 natriuretic peptide A Rattus norvegicus 66-69 2853740-5 1988 Binding experiments revealed an interaction between amiloride and ANF at the receptor level; binding of labelled ANF to aortic tissue was increased by amiloride but decreased by ATP. Amiloride 151-160 natriuretic peptide A Rattus norvegicus 113-116 2853740-6 1988 These data show that amiloride and ATP influence a mechanism that determines the sensitivity of vessels to ANF and this interaction occurs both at receptor level and at the level of transduction. Amiloride 21-30 natriuretic peptide A Rattus norvegicus 107-110 6851418-9 1983 Distal tubular blockade with a combination of frusemide and amiloride was employed to differentiate between proximal and distal tubular sites of action of ANF. Amiloride 60-69 natriuretic peptide A Rattus norvegicus 155-158 2853740-0 1988 Amiloride potentiates the vascular effects of atrial natriuretic factor. Amiloride 0-9 natriuretic peptide A Rattus norvegicus 46-71 2970886-0 1988 Interaction of amiloride and hydrochlorothiazide with atrial natriuretic factor in the medullary collecting duct. Amiloride 15-24 natriuretic peptide A Rattus norvegicus 54-79 2970886-5 1988 Atrial natriuretic factor reduced collecting duct sodium reabsorption when added to amiloride or hydrochlorothiazide to 23% and to 41%, respectively, but had no additional effect when given with amiloride and hydrochlorothiazide. Amiloride 84-93 natriuretic peptide A Rattus norvegicus 0-25 2989338-13 1985 In rats infused with ANF, the rate of amiloride-sensitive Na+-H+ exchange across the brush border membrane (BBM) was significantly (P less than 0.05) decreased (-40%), whereas the diffusional 22Na+ uptake (0.5 min) and the equilibrium (120 min) uptake of 22Na+ were not changed. Amiloride 38-47 natriuretic peptide A Rattus norvegicus 21-24