PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22767612-2 2012 Amiloride was the first organic blocker to selectively block the native T-type calcium channel, but the potency and mechanism of block of this drug on the three recombinant T-type calcium channels (Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3) have not been systematically determined. Amiloride 0-9 immunoglobulin lambda variable 7-43 Homo sapiens 208-216 22767612-4 2012 By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3. Amiloride 139-148 immunoglobulin lambda variable 7-43 Homo sapiens 232-240 22767612-8 2012 The preferential block of Ca(V)3.2 channels labels amiloride as the only organic blocker to be selective for any T-type channel. Amiloride 51-60 immunoglobulin lambda variable 7-43 Homo sapiens 26-34