PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12455379-9 2002 Under simultaneous stimulation of fluorescein and EGF endocytosis in the presence of the amiloride derivative, such a residual fluorescence shifted with time to the juxtranuclear region, which is characteristic of the late steps of RME. Amiloride 89-98 epidermal growth factor Homo sapiens 50-53 34354180-8 2021 This was corroborated by a markedly reduced ENaC activity, while amiloride-insensitive pathways as well as barrier function were raised by EGF. Amiloride 65-74 epidermal growth factor Homo sapiens 139-142 7689888-2 1993 This novel effect of EGF was markedly decreased by various tyrosine kinase inhibitors, such as alpha-cyano-3-ethoxy-4-hydroxy-5-phenyl-thiomethyl cinnamamide, amiloride and biochanin A. Amiloride 159-168 epidermal growth factor Homo sapiens 21-24 6195155-1 1983 Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport. Amiloride 100-109 epidermal growth factor Homo sapiens 0-23 2537620-5 1989 At concentrations of the amiloride analogues which block Na+/H+ exchange in both cell types by 76-98%, the EGF-dependent alterations in [3H]thymidine incorporation or induction in c-myc or c-fos gene transcription were unaltered. Amiloride 25-34 epidermal growth factor Homo sapiens 107-110 3030848-8 1987 It has been possible to discriminate between the proliferative and dedifferentiating actions of EGF using amiloride, a non-specific inhibitor of the Na+/H+ antiporter. Amiloride 106-115 epidermal growth factor Homo sapiens 96-99 3030848-9 1987 An optimum concentration of amiloride (0.1 mM) was able to block EGF-stimulated incorporation of [3H]thymidine into DNA without preventing the blockade of iodide uptake, which implies that dedifferentiation is not a consequence of proliferation. Amiloride 28-37 epidermal growth factor Homo sapiens 65-68 6195155-1 1983 Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport. Amiloride 100-109 epidermal growth factor Homo sapiens 25-28 6195155-4 1983 257, 4883-4889) that EGF rapidly activates amiloride-sensitive net Na+ influx in the A431 human epidermoid carcinoma cell line. Amiloride 43-52 epidermal growth factor Homo sapiens 21-24 6195155-10 1983 The pHi increase is half-maximal at 5-10 ng/ml of EGF, is dependent on external Na+, independent of external Ca2+, and inhibited by millimolar amiloride. Amiloride 143-152 epidermal growth factor Homo sapiens 50-53 6300103-0 1983 Epidermal growth factor stimulates amiloride-sensitive 22Na+ uptake in A431 cells. Amiloride 35-44 epidermal growth factor Homo sapiens 0-23 6300103-2 1983 Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport. Amiloride 100-109 epidermal growth factor Homo sapiens 0-23 6300103-2 1983 Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport. Amiloride 100-109 epidermal growth factor Homo sapiens 25-28 6300103-6 1983 Amiloride inhibits the EGF-dependent Na+ uptake (65% inhibition at 3 mM, ID50 approximately 0.3 mM) and inhibits much less the EGF-independent uptake. Amiloride 0-9 epidermal growth factor Homo sapiens 23-26 6300103-6 1983 Amiloride inhibits the EGF-dependent Na+ uptake (65% inhibition at 3 mM, ID50 approximately 0.3 mM) and inhibits much less the EGF-independent uptake. Amiloride 0-9 epidermal growth factor Homo sapiens 127-130 6300103-9 1983 1) EGF effectively stimulates an amiloride-sensitive 22Na+ uptake in the absence of external Ca2+. Amiloride 33-42 epidermal growth factor Homo sapiens 3-6 6984193-2 1982 Initial results show that (i) there is no significant difference in membrane potential between growing and quiescent cells, (ii) addition of epidermal growth factor or serum to quiescent BSC-1 cells induces a brief and transient depolarization, (iii) the mitogenic response of BSC-1 cells to epidermal growth factor and the transient depolarization show similar concentration dependences, and (iv) serum addition to quiescent BSC-1 cells induces a sustained increase in Na+ influx that is electroneutral and amiloride sensitive. Amiloride 508-517 epidermal growth factor Homo sapiens 141-164 6979542-2 1982 The diuretic amiloride, an inhibitor of Na+/H+ exchange, completely blocks EGF-induced Na+ influx, Na+,K+-pump activity, and DNA synthesis without affecting the cellular binding, visible clustering, and internalization of 125I-labeled and fluorescent EGF. Amiloride 13-22 epidermal growth factor Homo sapiens 75-78 6979542-2 1982 The diuretic amiloride, an inhibitor of Na+/H+ exchange, completely blocks EGF-induced Na+ influx, Na+,K+-pump activity, and DNA synthesis without affecting the cellular binding, visible clustering, and internalization of 125I-labeled and fluorescent EGF. Amiloride 13-22 epidermal growth factor Homo sapiens 251-254 6979542-3 1982 In the absence of EGF, the induction of amiloride-sensitive Na+ influx and Na+,K+-pump activity can be mimicked by exposing the cells to weak acids. Amiloride 40-49 epidermal growth factor Homo sapiens 18-21