PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29032204-10 2017 Furthermore, preincubation of tissues for 15 min with forskolin, a cAMP activator, markedly blocked the Isc evoked by AngII, while intracellular Ca2+ pump inhibitor thapsigargin, L-type Ca2+ channel blocker nicadipine or the epithelial Na+ channel blocker amiloride didn"t show such function. Amiloride 256-265 angiotensinogen Rattus norvegicus 118-123 27122543-7 2017 Chronic intramedullary infusion of an ENaC inhibitor amiloride in rats significantly attenuated ANG II-induced hypertension. Amiloride 53-62 angiotensinogen Rattus norvegicus 96-102 22169010-2 2012 Application of 50 nM ANG II increased ENaC activity, defined by NP(o) (a product of channel numbers and open probability), and the amiloride-sensitive whole cell Na currents by twofold. Amiloride 131-140 angiotensinogen Rattus norvegicus 21-27 15654262-7 2005 HOE-140, a selective antagonist of the bradykinin B2 receptor, and amiloride, a Na+/H+ exchanger inhibitor, abolished angiotensin II-induced relaxation. Amiloride 67-76 angiotensinogen Rattus norvegicus 118-132 9388483-0 1997 Angiotensin II mediates cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride- and furosemide-sensitive mechanism. Amiloride 122-131 angiotensinogen Rattus norvegicus 0-14 9388483-3 1997 In both SD- and TGR-VSMC, AII increased both cell size, by a furosemide- and amiloride-sensitive mechanism, and Na+/K+/2Cl- cotransport activity, by an amiloride-sensitive mechanism. Amiloride 77-86 angiotensinogen Rattus norvegicus 26-29 9388483-3 1997 In both SD- and TGR-VSMC, AII increased both cell size, by a furosemide- and amiloride-sensitive mechanism, and Na+/K+/2Cl- cotransport activity, by an amiloride-sensitive mechanism. Amiloride 152-161 angiotensinogen Rattus norvegicus 26-29 8951724-9 1996 Amiloride at 10(-4) M significantly attenuated the action of AII at 10(-11) M (P < 0.0001) and inhibited the transient response to AII at 10(-5) M (P < 0.01). Amiloride 0-9 angiotensinogen Rattus norvegicus 61-64 8951724-9 1996 Amiloride at 10(-4) M significantly attenuated the action of AII at 10(-11) M (P < 0.0001) and inhibited the transient response to AII at 10(-5) M (P < 0.01). Amiloride 0-9 angiotensinogen Rattus norvegicus 134-137 8760255-9 1996 The effects of ANG II on fluid and ion transport were abolished by the luminal application of amiloride (10(-3) M) and of the angiotensin-receptor blocker [Sar1,Ile8]ANG II (10(-6) M). Amiloride 94-103 angiotensinogen Rattus norvegicus 15-21 1548835-8 1992 In contrast, the alkalization induced by AII was abolished by both amiloride and Na(+)-free medium. Amiloride 67-76 angiotensinogen Rattus norvegicus 41-44 1548835-11 1992 These results indicate that AII stimulates cytoplasmic alkalization via an amiloride-sensitive Na+/H+ exchange system in cultured rat VSMCs, and that this AII-stimulated Na+/H+ exchange is mediated by Ca(2+)-dependent and protein kinase C-dependent mechanisms. Amiloride 75-84 angiotensinogen Rattus norvegicus 28-31 1548835-11 1992 These results indicate that AII stimulates cytoplasmic alkalization via an amiloride-sensitive Na+/H+ exchange system in cultured rat VSMCs, and that this AII-stimulated Na+/H+ exchange is mediated by Ca(2+)-dependent and protein kinase C-dependent mechanisms. Amiloride 75-84 angiotensinogen Rattus norvegicus 155-158 2542311-4 1989 In addition, amiloride also attenuated the inhibitory effects of atrial natriuretic factor (ANF 99-126) and angiotensin II on cAMP levels and adenylate cyclase activity. Amiloride 13-22 angiotensinogen Rattus norvegicus 92-122 2537850-7 1989 In comparison to WKY cells early passage SHR VSMC exhibited 2.5-fold greater alkalinization and amiloride-sensitive 22Na+ influx in response to 100 nM angiotensin II. Amiloride 96-105 angiotensinogen Rattus norvegicus 151-165 2837093-4 1988 Although amiloride inhibited the angiotensin II- and adrenocorticotropic hormone (ACTH)-induced aldosterone response, HMA, a more specific inhibitor of Na+-H+ exchange, failed to do that. Amiloride 9-18 angiotensinogen Rattus norvegicus 33-47 2837094-4 1988 ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+. Amiloride 18-27 angiotensinogen Rattus norvegicus 0-6 2837094-4 1988 ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+. Amiloride 18-27 angiotensinogen Rattus norvegicus 201-207 2837094-4 1988 ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+. Amiloride 18-27 angiotensinogen Rattus norvegicus 201-207 2837094-4 1988 ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+. Amiloride 156-165 angiotensinogen Rattus norvegicus 0-6 2837094-4 1988 ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+. Amiloride 156-165 angiotensinogen Rattus norvegicus 201-207 2837094-4 1988 ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+. Amiloride 156-165 angiotensinogen Rattus norvegicus 201-207 2837094-5 1988 However, at pHi 6.8, ANG II increased the Vmax of amiloride-sensitive Na+ influx from 25 to 33 nmol.mg protein-1.min-1 and markedly decreased the Km for Na+o from 23.6 +/- 7.4 to 3.7 (SD, n = 4; P less than 0.005) mM. Amiloride 50-59 angiotensinogen Rattus norvegicus 21-27 2452306-7 1988 Amiloride (10(-3) M) and verapamil (10(-5) M) abolished the AII induced increase in kei. Amiloride 0-9 angiotensinogen Rattus norvegicus 60-63 2452306-8 1988 These findings are consistent with angiotensin II stimulation of an amiloride-sensitive Na+ transport, which is likely to represent the Na+/H+ antiport. Amiloride 68-77 angiotensinogen Rattus norvegicus 35-49 3031037-3 1987 The fact that the Na+/H+ exchange inhibitor, amiloride, blocks angiotensin II-stimulated Na+ influx and is itself a vasodilator suggests that Na+/H+ exchange may play a role in the angiotensin II-mediated effects on VSMC. Amiloride 45-54 angiotensinogen Rattus norvegicus 63-77 3031037-3 1987 The fact that the Na+/H+ exchange inhibitor, amiloride, blocks angiotensin II-stimulated Na+ influx and is itself a vasodilator suggests that Na+/H+ exchange may play a role in the angiotensin II-mediated effects on VSMC. Amiloride 45-54 angiotensinogen Rattus norvegicus 181-195