PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14645220-4 2004 We found that endogenous Nedd4-2, but not Nedd4, negatively regulates ENaC in two epithelial cell lines (Fischer rat thyroid and H441); small interfering RNA (siRNA) against Nedd4-2 increased amiloride-sensitive Na+ current (compared with control siRNA), but Nedd4 siRNA did not. Amiloride 192-201 NEDD4 like E3 ubiquitin protein ligase Rattus norvegicus 25-32 12876068-9 2003 Coexpression, in Fischer rat thyroid epithelia, of ENaC and Nedd4-2 cDNAs leads to a significant reduction in amiloride-sensitive currents, confirming a role in Na+ transport regulation. Amiloride 110-119 NEDD4 like E3 ubiquitin protein ligase Rattus norvegicus 60-67 14645220-4 2004 We found that endogenous Nedd4-2, but not Nedd4, negatively regulates ENaC in two epithelial cell lines (Fischer rat thyroid and H441); small interfering RNA (siRNA) against Nedd4-2 increased amiloride-sensitive Na+ current (compared with control siRNA), but Nedd4 siRNA did not. Amiloride 192-201 NEDD4 like E3 ubiquitin protein ligase Rattus norvegicus 174-181