PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24105369-6 2014 We could observe an association of rare EHF haplotypes among homozygotes for c.1521_1523delCTT in CFTR, which exhibit a CF-untypical manifestation of the CF basic defect such as CFTR-mediated residual chloride secretion and low response to amiloride. Amiloride 240-249 CF transmembrane conductance regulator Homo sapiens 98-102 32712714-0 2020 Transport properties in CFTR-/- knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption. Amiloride 102-111 CF transmembrane conductance regulator Homo sapiens 24-28 30272672-4 2018 The test allows the measurement of the stable baseline voltage and the successive net voltage changes after perfusion of 100 microM amiloride, an inhibitor of Na+ reabsorption in Ringer"s solution; a chloride-free solution containing amiloride to drive chloride secretion and 10 microM isoproterenol in a chloride-free solution with amiloride to stimulate the cyclic adenosine monophosphate (cAMP)-dependent chloride conductance related to CFTR. Amiloride 132-141 CF transmembrane conductance regulator Homo sapiens 440-444 32712714-14 2020 In contrast, enhanced amiloride-sensitive Na+ absorption may contribute to lung pathology in CFTR-/- piglets, along with a compromised CFTR- and TMEM16A-dependent Cl- transport. Amiloride 22-31 CF transmembrane conductance regulator Homo sapiens 93-97 27941075-7 2017 In oocytes coexpressing deltabetagamma-ENaC and CFTR the ENaC-mediated amiloride-sensitive whole cell current (DeltaIami) was reduced by ~50% compared with that measured in oocytes expressing deltabetagamma-ENaC alone. Amiloride 71-80 CF transmembrane conductance regulator Homo sapiens 48-52 24105369-6 2014 We could observe an association of rare EHF haplotypes among homozygotes for c.1521_1523delCTT in CFTR, which exhibit a CF-untypical manifestation of the CF basic defect such as CFTR-mediated residual chloride secretion and low response to amiloride. Amiloride 240-249 CF transmembrane conductance regulator Homo sapiens 178-182 21145458-8 2010 Like human CF, CFTR-(/)- pigs showed increased amiloride-sensitive voltage and current, but lack of apical Cl- conductance caused the change, not increased Na(+) transport. Amiloride 47-56 CF transmembrane conductance regulator Homo sapiens 15-19 23732645-8 2013 We find that while the loss of CFTR permeability hyperpolarises Vt and also increases amiloride-sensitive Vt, these effects are too small to account for the magnitude of change observed in CF epithelia. Amiloride 86-95 CF transmembrane conductance regulator Homo sapiens 31-35 22302997-10 2012 In non-capacitated sperm, amiloride, an ENaC inhibitor, and genistein, a CFTR activator, caused a decrease in [Na+](i), suggesting that also in these cells [Na+](i) is dependent on the crosstalk between ENaC and CFTR. Amiloride 26-35 CF transmembrane conductance regulator Homo sapiens 212-216 19633071-6 2009 Impaired efferocytosis appears to be mediated through an amiloride-sensitive ion channel, because amiloride restores phagocytic competency in CFTR-deficient cells. Amiloride 57-66 CF transmembrane conductance regulator Homo sapiens 142-146 18309088-3 2008 In this study, we report that in human airway epithelial CF15 cells treated with the CFTR corrector miglustat (n-butyldeoxynojyrimicin), whole-cell patch-clamp experiments showed reduced amiloride-sensitive ENaC current in parallel with a rescue of defective CFTR Cl- channel activity activated by forskolin and genistein. Amiloride 187-196 CF transmembrane conductance regulator Homo sapiens 85-89 10788432-5 2000 The forskolin/3-isobutyl-1-methylxanthine-stimulated whole-cell conductance in hCFTR-mENaC co-injected oocytes was amiloride-insensitive, indicating an inhibition of mENaC following hCFTR activation, and it was blocked by DPC (diphenylamine-2-carboxylic acid) and was DIDS (4, 4"-diisothiocyanatostilbene-2,2"-disulfonic acid)-insensitive. Amiloride 115-124 CF transmembrane conductance regulator Homo sapiens 79-84 18288363-2 2008 The freshly isolated airway epithelial tissue displayed a transepithelial basal current of (94.9+-8.2) muA/cm(2), 16.6% and 62.7% of which was inhibited by amiloride (epithelial Na(+) channel blocker, 100 mumol/L) and NPPB (cystic fibrosis transmembrane conductance regulator Cl(-) channel blocker, 100 mumol/L). Amiloride 156-165 CF transmembrane conductance regulator Homo sapiens 224-275 16463140-1 2005 We previously showed that activation of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl- conductance (gCFTR) supports parallel activation of amiloride-sensitive epithelial Na+ channel (ENaC) in the native human sweat duct. Amiloride 164-173 CF transmembrane conductance regulator Homo sapiens 44-100 16463140-1 2005 We previously showed that activation of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl- conductance (gCFTR) supports parallel activation of amiloride-sensitive epithelial Na+ channel (ENaC) in the native human sweat duct. Amiloride 164-173 CF transmembrane conductance regulator Homo sapiens 102-106 16714334-6 2006 The decrease in resistance was accompanied by an increase in mannitol flux across the epithelium and occurred in cystic fibrosis transmembrane conductance receptor (CFTR) epithelium pretreated with amiloride to block Na and Cl conductances, confirming that the decrease in resistance represented an increase in paracellular conductance. Amiloride 198-207 CF transmembrane conductance regulator Homo sapiens 113-163 16714334-6 2006 The decrease in resistance was accompanied by an increase in mannitol flux across the epithelium and occurred in cystic fibrosis transmembrane conductance receptor (CFTR) epithelium pretreated with amiloride to block Na and Cl conductances, confirming that the decrease in resistance represented an increase in paracellular conductance. Amiloride 198-207 CF transmembrane conductance regulator Homo sapiens 165-169 16226002-14 2006 In the present study, we have demonstrated an enhanced amiloride-sensitive Isc and fluid absorption in NHMEE cells, where the role of CFTR is limited. Amiloride 55-64 CF transmembrane conductance regulator Homo sapiens 134-138 16027156-4 2005 Coexpression of rat ENaC with human CFTR or the human Cl- channel CLC-0 caused inhibition of amiloride-sensitive Na+ currents after cAMP-dependent stimulation and in the presence of a 100 mM bath Cl- concentration. Amiloride 93-102 CF transmembrane conductance regulator Homo sapiens 36-40 12177237-8 2002 CFTR functionality was assessed by analyzing the Cl(-) secretion after amiloride and forskolin perfusion. Amiloride 71-80 CF transmembrane conductance regulator Homo sapiens 0-4 9649552-0 1998 The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways. Amiloride 4-13 CF transmembrane conductance regulator Homo sapiens 60-111 7491973-3 1995 2) Amiloride-insensitive baseline short-circuit current (Isc) and mediator-induced increases in Isc were inhibited by diphenylamine-2-carboxylic acid (DPAC) but not by 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS), a pharmacology consistent with passage of apical membrane Cl current through CFTR; Ca-activated Cl channels are inhibited by DIDS but not by DPAC. Amiloride 3-12 CF transmembrane conductance regulator Homo sapiens 302-306 9476862-10 1998 Subjects in the 4PBA group demonstrated small, but statistically significant improvements of the NPD response to perfusion of an isoproterenol/amiloride/chloride-free solution; this measure reflects epithelial CFTR function and is highly discriminatory between patients with and without CF. Amiloride 143-152 CF transmembrane conductance regulator Homo sapiens 210-214 9311495-6 1997 Patients with apical CFTR protein showed higher residual chloride secretion than those without (amiloride to isoprenaline value of 4.59 and 0.56 mV, respectively, p = 0.01). Amiloride 96-105 CF transmembrane conductance regulator Homo sapiens 21-25 8759925-7 1996 In addition to serving as a Cl channel, there is compelling evidence that CFTR inhibits the amiloride-sensitive, epithelial sodium channel (ENaC). Amiloride 92-101 CF transmembrane conductance regulator Homo sapiens 74-78 8967432-6 1996 Such findings suggest that CFTR may also regulate amiloride-insensitive Na+ channels. Amiloride 50-59 CF transmembrane conductance regulator Homo sapiens 27-31