PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31926189-0 2020 Interplay of ERalpha binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of cystatin A in breast cancer cells. Estrogens 95-103 estrogen receptor 1 Homo sapiens 13-20 31643093-3 2020 There are two main types of estrogen receptors: ER-alpha and ER-beta. Estrogens 28-36 estrogen receptor 1 Homo sapiens 48-56 31643093-5 2020 Estrogen receptors have recently been identified in subglottic tissue samples, with elevated levels of ER-alpha and progesterone receptors, and no expression of ER-beta, in stenotic specimens reported in one study. Estrogens 0-8 estrogen receptor 1 Homo sapiens 103-111 32001259-4 2020 At the cellular level, the mechanisms by which estrogens regulate diverse cellular functions including reproduction and behavior is by binding to estrogen receptors alpha, beta (ERalpha and ERbeta) and G-protein coupled ER (GPER1). Estrogens 47-56 estrogen receptor 1 Homo sapiens 155-196 32001259-4 2020 At the cellular level, the mechanisms by which estrogens regulate diverse cellular functions including reproduction and behavior is by binding to estrogen receptors alpha, beta (ERalpha and ERbeta) and G-protein coupled ER (GPER1). Estrogens 47-55 estrogen receptor 1 Homo sapiens 155-196 32046982-1 2020 Estrogen signaling through estrogen receptor alpha (ER) plays a major role in endometrial cancer risk and progression, however, the molecular mechanisms underlying ER"s regulatory role in endometrial cancer are poorly understood. Estrogens 0-8 estrogen receptor 1 Homo sapiens 27-50 31952790-0 2020 Estrogen downregulates gp130 expression in HUVECs by regulating ADAM10 and ADAM17 via the estrogen receptor. Estrogens 0-8 estrogen receptor 1 Homo sapiens 90-107 31930332-8 2020 In ER+ breast tumors, the effect of estrogen may be masking the association of rs17000526 with A3B expression, which was apparent in ER- tumors. Estrogens 36-44 estrogen receptor 1 Homo sapiens 3-5 32035111-2 2020 We have previously characterized the global basal and estrogen-regulated transcriptomes estrogen receptor alpha (ERalpha)-positive MCF-7 breast cancer cells. Estrogens 54-62 estrogen receptor 1 Homo sapiens 88-111 32035111-2 2020 We have previously characterized the global basal and estrogen-regulated transcriptomes estrogen receptor alpha (ERalpha)-positive MCF-7 breast cancer cells. Estrogens 54-62 estrogen receptor 1 Homo sapiens 113-120 32066877-8 2020 Our study uncovers a novel mechanism whereby phosphorylation independent eIF4E translational reprogramming in governing the protein synthesis of ERalpha and FOXM1 contributes to anti-estrogen insensitivity in ER+ breast cancer. Estrogens 183-191 estrogen receptor 1 Homo sapiens 145-152 32022540-3 2020 Estrone, one of the mammalian estrogens, has affinity for estrogen receptors (ERalpha) which are over-expressed in hormone-responsive breast cancers. Estrogens 30-39 estrogen receptor 1 Homo sapiens 78-85 32022540-3 2020 Estrone, one of the mammalian estrogens, has affinity for estrogen receptors (ERalpha) which are over-expressed in hormone-responsive breast cancers. Estrogens 30-38 estrogen receptor 1 Homo sapiens 78-85 31932415-1 2020 BACKGROUND: Tamoxifen and its metabolites compete with estrogen to occupy the estrogen receptor. Estrogens 55-63 estrogen receptor 1 Homo sapiens 78-95 31926189-11 2020 5-aza significantly demethylated intron-2 CpGs, and enhanced estrogen-induced ERalpha occupancy at the intron-2 ERE, leading to restoration of estrogen-regulation. Estrogens 61-69 estrogen receptor 1 Homo sapiens 78-85 31926189-11 2020 5-aza significantly demethylated intron-2 CpGs, and enhanced estrogen-induced ERalpha occupancy at the intron-2 ERE, leading to restoration of estrogen-regulation. Estrogens 143-151 estrogen receptor 1 Homo sapiens 78-85 31926189-14 2020 Furthermore, our results indicate the convergence of ERalpha-mediated estrogen regulation and DNA methylation in the intron-2, thereby offering a novel context to understand the role of estrogen-ERalpha signaling axis in breast tumor invasion and metastasis. Estrogens 70-78 estrogen receptor 1 Homo sapiens 53-60 31926189-14 2020 Furthermore, our results indicate the convergence of ERalpha-mediated estrogen regulation and DNA methylation in the intron-2, thereby offering a novel context to understand the role of estrogen-ERalpha signaling axis in breast tumor invasion and metastasis. Estrogens 70-78 estrogen receptor 1 Homo sapiens 195-202 31926189-14 2020 Furthermore, our results indicate the convergence of ERalpha-mediated estrogen regulation and DNA methylation in the intron-2, thereby offering a novel context to understand the role of estrogen-ERalpha signaling axis in breast tumor invasion and metastasis. Estrogens 186-194 estrogen receptor 1 Homo sapiens 53-60 31926189-14 2020 Furthermore, our results indicate the convergence of ERalpha-mediated estrogen regulation and DNA methylation in the intron-2, thereby offering a novel context to understand the role of estrogen-ERalpha signaling axis in breast tumor invasion and metastasis. Estrogens 186-194 estrogen receptor 1 Homo sapiens 195-202 32075246-1 2020 The peptide ERalpha17p, which corresponds to the 295-311 fragment of the hinge/AF2 domains of the human estrogen receptor alpha (ERalpha), exerts apoptosis in breast cancer cells through a mechanism involving the G protein-coupled estrogen-dependent receptor GPER. Estrogens 104-112 estrogen receptor 1 Homo sapiens 12-19 31767456-5 2020 Moreover, 4-n-NP was found to induce estrogen response element (ERE)-mediated activity via ERalpha in MVLN cells. Estrogens 37-45 estrogen receptor 1 Homo sapiens 91-98 31760044-1 2020 Environmental disrupting compounds (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through their interaction with nuclear receptors like the estrogen receptors alpha and beta (ERalpha and ERbeta), the androgen receptor (AR), the pregnan X receptor (PXR), the peroxysome proliferator activated receptor alpha and gamma (PPARalpha, PPARgamma) and the thyroid receptors alpha and beta (TRalpha and beta). Estrogens 210-218 estrogen receptor 1 Homo sapiens 245-252 32047236-5 2020 Eleanors are clusters of ncRNAs that accumulate around the estrogen receptor-alpha (ESR1) gene locus in long-term estrogen deprivation (LTED) breast cancer cells, and markedly enhance the transcription of the ESR1 gene. Estrogens 59-67 estrogen receptor 1 Homo sapiens 209-213 31780379-7 2020 Use of selective estrogen down-regulators over aromatase inhibitors is best once the patient has an acquired ESR1 mutation. Estrogens 17-25 estrogen receptor 1 Homo sapiens 109-113 31821857-5 2020 Mechanistically, these examples call attention to the importance of evolutionary changes in (1) androgen- and estrogen-mediated gene expression, (2) androgen and estrogen receptor expression, and (3) the distribution of androgen and estrogen response elements in target genes throughout the genome. Estrogens 110-118 estrogen receptor 1 Homo sapiens 162-179 32047236-5 2020 Eleanors are clusters of ncRNAs that accumulate around the estrogen receptor-alpha (ESR1) gene locus in long-term estrogen deprivation (LTED) breast cancer cells, and markedly enhance the transcription of the ESR1 gene. Estrogens 59-67 estrogen receptor 1 Homo sapiens 84-88 31605532-7 2020 SNP rs4442975 was associated with a greater reduction of risk of ER-positive breast cancer [odds ratio (OR)int = 0.85 (0.78-0.93), Pint = 2.8 x 10-4] and overall breast cancer [ORint = 0.85 (0.78-0.92), Pint = 7.4 x 10-5) in current users of estrogen-progesterone therapy compared with non-users. Estrogens 242-263 estrogen receptor 1 Homo sapiens 65-67 31662448-10 2020 Estradiol (E2) induced UBE2C expression via estrogen receptor (ER)alpha, which binds directly to the UBE2C promoter element. Estrogens 44-52 estrogen receptor 1 Homo sapiens 63-71 31689473-5 2020 MCF-7 human breast cancer cells normally exhibit growth through estradiol-triggered ERalpha signaling; however, the MCF-7 cells cultured in estrogen-deprived conditions for a long time (~ 6 months) eventually result in LTED cells that can be used to utilize to study the proliferation of ERalpha-positive breast cancer cells obtained from post-menopausal women. Estrogens 140-148 estrogen receptor 1 Homo sapiens 84-91 31689473-5 2020 MCF-7 human breast cancer cells normally exhibit growth through estradiol-triggered ERalpha signaling; however, the MCF-7 cells cultured in estrogen-deprived conditions for a long time (~ 6 months) eventually result in LTED cells that can be used to utilize to study the proliferation of ERalpha-positive breast cancer cells obtained from post-menopausal women. Estrogens 140-148 estrogen receptor 1 Homo sapiens 288-295 31877464-0 2020 Clinical Implications of Monitoring ESR1 Mutations by Circulating Tumor DNA in Estrogen Receptor Positive Metastatic Breast Cancer: A Pilot Study. Estrogens 79-87 estrogen receptor 1 Homo sapiens 36-40 32019136-2 2020 AFP has been shown to inhibit estrogen receptor (ER)-positive tumor growth, which can be attributed to its estrogen-binding ability. Estrogens 30-38 estrogen receptor 1 Homo sapiens 49-51 31629931-2 2020 Our previous studies have identified a three-dimensional SERM, oxabicycloheptene sulfonate (OBHS), as an estrogen receptor alpha (ERalpha) ligand, which is effective for the prevention and treatment of estrogen-dependent endometriosis in vivo. Estrogens 105-113 estrogen receptor 1 Homo sapiens 130-137 32064044-8 2020 Chromatin immunoprecipitation analysis confirmed that REDD1 is an estrogen receptor (ER) target gene with multiple estrogen response elements in its promoter. Estrogens 66-74 estrogen receptor 1 Homo sapiens 85-87 32021303-7 2020 All ESR1 point mutations occurred in the estrogen receptor ligand-binding domain. Estrogens 41-49 estrogen receptor 1 Homo sapiens 4-8 31778358-2 2020 Oestrogen action is mediated by receptors encoded by ESR1 (ERalpha) and ESR2 (ERbeta): ERalpha plays a key role in regulating endometrial cell proliferation. Estrogens 0-9 estrogen receptor 1 Homo sapiens 53-57 31778358-2 2020 Oestrogen action is mediated by receptors encoded by ESR1 (ERalpha) and ESR2 (ERbeta): ERalpha plays a key role in regulating endometrial cell proliferation. Estrogens 0-9 estrogen receptor 1 Homo sapiens 59-66 31778358-2 2020 Oestrogen action is mediated by receptors encoded by ESR1 (ERalpha) and ESR2 (ERbeta): ERalpha plays a key role in regulating endometrial cell proliferation. Estrogens 0-9 estrogen receptor 1 Homo sapiens 87-94 31551256-4 2019 Here, we describe the role of BRDs in estrogen (E2)-dependent gene expression in ERalpha-positive breast cancer cells. Estrogens 38-46 estrogen receptor 1 Homo sapiens 81-88 32047550-2 2020 Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC patients. Estrogens 40-48 estrogen receptor 1 Homo sapiens 60-62 31936631-3 2020 In estrogen receptor alpha-positive breast cancer cells treated with D and its metabolites, single or in mixture, ERalpha activation and Neuroglobin (NGB) levels, an anti-apoptotic estrogen/ERalpha-inducible protein, were evaluated. Estrogens 3-11 estrogen receptor 1 Homo sapiens 190-197 31820173-6 2020 Both estrogen and androgen exert their effects via the estrogen receptor (ER) or the androgen receptor (AR), which belongs to the nuclear receptor superfamily. Estrogens 5-13 estrogen receptor 1 Homo sapiens 55-72 31820173-6 2020 Both estrogen and androgen exert their effects via the estrogen receptor (ER) or the androgen receptor (AR), which belongs to the nuclear receptor superfamily. Estrogens 5-13 estrogen receptor 1 Homo sapiens 74-76 31788039-2 2019 Estrogen exhibits various functions through binding to its specific receptors, estrogen receptor alpha, estrogen receptor beta and G protein-coupled estrogen receptor 1. Estrogens 0-8 estrogen receptor 1 Homo sapiens 79-102 31975979-4 2019 Furthermore, the authors evaluated the expression of the genes encoding the oestrogen receptors (ERalpha and ERbeta) at the mRNA level and protein level in the studied population. Estrogens 76-85 estrogen receptor 1 Homo sapiens 97-104 31975979-4 2019 Furthermore, the authors evaluated the expression of the genes encoding the oestrogen receptors (ERalpha and ERbeta) at the mRNA level and protein level in the studied population. Estrogens 76-85 estrogen receptor 1 Homo sapiens 109-115 31975979-10 2019 Conclusions: Personality traits may be linked with the expression of genes encoding oestrogen receptors (ERalpha and ERbeta) among patients with depressive disorders. Estrogens 84-93 estrogen receptor 1 Homo sapiens 105-112 31975979-10 2019 Conclusions: Personality traits may be linked with the expression of genes encoding oestrogen receptors (ERalpha and ERbeta) among patients with depressive disorders. Estrogens 84-93 estrogen receptor 1 Homo sapiens 117-123 31617730-3 2020 Estrogen, a major female sex steroid mediates its role through estrogen receptors (ER), ERalpha and ERbeta which are shown to be expressed in human ASM and their expression is upregulated in inflammation/asthma. Estrogens 0-8 estrogen receptor 1 Homo sapiens 88-95 31669227-0 2020 Detection of ESR1 Mutations in Single Circulating Tumor Cells upon Estrogen Deprivation Therapy but not in Primary Tumors from Metastatic Luminal Breast Cancer Patients. Estrogens 67-75 estrogen receptor 1 Homo sapiens 13-17 31669227-1 2020 Mutations in the ligand-binding domain (LBD) of the ESR1 gene result in resistance to estrogen deprivation therapy (EDT) in breast cancer. Estrogens 86-94 estrogen receptor 1 Homo sapiens 52-56 31867004-1 2019 ERalpha, one of the classical receptors of estrogen, has been found to be abnormally up-regulated in patients with primary biliary cholangitis (PBC), which is an important factor leading to ductopenia. Estrogens 43-51 estrogen receptor 1 Homo sapiens 0-7 31657150-5 2019 By contrast, silencing SALL2 induced downregulation of ERalpha and PTEN and activated the Akt/mTOR signaling, resulting in estrogen-independent growth and tamoxifen resistance in ERalpha-positive breast cancer. Estrogens 123-131 estrogen receptor 1 Homo sapiens 179-186 31689915-1 2019 Although a large fraction of high-grade serous epithelial ovarian cancers (OCs) expresses Estrogen Receptor alpha (ERalpha), anti-estrogen-based therapies are still not widely used against these tumors due to a lack of sufficient evidence. Estrogens 130-138 estrogen receptor 1 Homo sapiens 90-113 31689915-1 2019 Although a large fraction of high-grade serous epithelial ovarian cancers (OCs) expresses Estrogen Receptor alpha (ERalpha), anti-estrogen-based therapies are still not widely used against these tumors due to a lack of sufficient evidence. Estrogens 130-138 estrogen receptor 1 Homo sapiens 115-122 31938154-1 2018 In this study, we analyzed soluble factors secreted by two Estrogen Receptor Positive (ER-alpha) human breast cancer cell lines, ZR 75.30 (luminal B) and MCF7 (luminal A), and evaluated their effect on endothelial activation. Estrogens 59-67 estrogen receptor 1 Homo sapiens 87-95 31749762-8 2019 Last two decades has witnessed the discovery of alternate forms of ER-alpha, as well as other receptors for estrogen such as ERRgamma, GPER-1 as well as ER-beta, which are activated not only by estrogen, but also by the therapeutic agents such as tamoxifen that are routinely used in treatment of breast cancer. Estrogens 194-202 estrogen receptor 1 Homo sapiens 67-75 31578396-1 2019 Estrogen receptor-positive breast cancers are treated with tamoxifen, a drug that competitively inhibits the binding of estrogen to its receptor. Estrogens 120-128 estrogen receptor 1 Homo sapiens 0-17 31546660-1 2019 Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogens 0-8 estrogen receptor 1 Homo sapiens 32-40 31652854-2 2019 The aryl hydrocarbon receptor (AHR) is often overexpressed in TNBC, and its activation results in the epigenetic silencing of BRCA1, which is a necessary factor for the transcriptional activation of estrogen receptor (ER)alpha. Estrogens 199-207 estrogen receptor 1 Homo sapiens 218-226 31696058-1 2019 Expression patterns of estrogen receptors [ERalpha, ERbeta, and G-protein associated ER (GPER)] in melanoma and skin may suggest their differential roles in carcinogenesis. Estrogens 23-31 estrogen receptor 1 Homo sapiens 43-50 31749762-7 2019 Most of the therapeutics which are used currently are targeting the major receptor of estrogen namely ER-alpha. Estrogens 86-94 estrogen receptor 1 Homo sapiens 102-110 31547326-1 2019 Estrogens are major regulators of the mammary gland development, notably during puberty, via estrogen receptor (ER) activation, leading to the proliferation and differentiation of mammary cells. Estrogens 0-9 estrogen receptor 1 Homo sapiens 93-110 31547326-1 2019 Estrogens are major regulators of the mammary gland development, notably during puberty, via estrogen receptor (ER) activation, leading to the proliferation and differentiation of mammary cells. Estrogens 0-9 estrogen receptor 1 Homo sapiens 112-114 31552220-1 2019 The most frequently diagnosed cancers in women are the estrogen receptor (ER)-positive breast cancer subtypes, which are characterized by estrogen dependency for their growth. Estrogens 55-63 estrogen receptor 1 Homo sapiens 74-76 31552220-2 2019 The mainstay of clinical treatment for this tumor relies on the modulation of ERalpha action or on the suppression of estrogen biosynthesis via the administration of Selective ERalpha Modulators/Down-regulators (SERMs/SERDs) or aromatase inhibitors, respectively. Estrogens 118-126 estrogen receptor 1 Homo sapiens 176-183 31966711-7 2017 In conclusion, these results suggest that estrogen may play an important role in androgen-independent prostate cancer cell proliferation through ERbeta-mediated suppression of TGF-beta1/IGF-1. Estrogens 42-50 estrogen receptor 1 Homo sapiens 145-151 31569840-5 2009 The mRNA varieties that potentially encoding for the synthesis of different subtypes of estrogen receptors (ER) - ER-alpha and ERbeta, which are also coded by various genes located in different chromosomes. Estrogens 88-96 estrogen receptor 1 Homo sapiens 114-122