PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17909264-6 2007 Investigation of the involved signaling pathways revealed that MK-4 enhanced the phosphorylation of protein kinase A (PKA), and the MK-4-dependent induction of both GDF15 and STC2 genes was reduced by the treatment with a PKA inhibitor H89 or siRNA against PKA. menatetrenone 63-67 growth differentiation factor 15 Homo sapiens 165-170 17909264-5 2007 The induction of GDF15 and STC2 is likely specific to MK-4, as it was not exerted by another vitamin K(2) isoform MK-7, vitamin K(1), or the MK-4 side chain structure geranylgeraniol. menatetrenone 54-58 growth differentiation factor 15 Homo sapiens 17-22 17909264-6 2007 Investigation of the involved signaling pathways revealed that MK-4 enhanced the phosphorylation of protein kinase A (PKA), and the MK-4-dependent induction of both GDF15 and STC2 genes was reduced by the treatment with a PKA inhibitor H89 or siRNA against PKA. menatetrenone 132-136 growth differentiation factor 15 Homo sapiens 165-170