PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31509959-7 2019 Calcium release from HEK293T cells stably expressing the T2R4 human bitter taste receptor was significantly (p < 0.05) attenuated by BPAH-AGEs (up to 96%) and BPCH-AGEs (up to 92%) when compared to the BPAH (62%) and BPCH (3%) or quinine (0%). Quinine 230-237 taste 2 receptor member 4 Homo sapiens 57-61 21303656-11 2011 The functional assays showed an increase in intracellular calcium levels after the application of exogenous ligands for T2R4, denatonium benzoate and quinine to these cultured cells, suggesting that endogenous T2R4 expressed in these cells is functional. Quinine 150-157 taste 2 receptor member 4 Homo sapiens 210-214 32413538-3 2020 For examples, amino acid derivatives such as gamma-aminobutyric acid (GABA) and Nalpha,Nalpha-bis(carboxymethyl)-L-Lysine (BCML) blocked responses to quinine mediated by human TAS2R4. Quinine 150-157 taste 2 receptor member 4 Homo sapiens 176-182 27288892-9 2016 Interestingly, cholesterol sensitivity of T2R4 was observed at quinine concentrations in the lower mM range. Quinine 63-70 taste 2 receptor member 4 Homo sapiens 42-46 25036266-7 2014 Chloroquine, denatonium, dextromethorphan, noscapine and quinine, agonists for TAS2R3, TAS2R4, TAS2R10 and TAS2R14, induced strong endothelium-independent relaxations (responses between 82-96% of maximal relaxations) in phenylephrine pre-contracted guinea-pig aorta that persisted in the presence of L-type Ca2+ and KCa1.1-channel blockers. Quinine 57-64 taste 2 receptor member 4 Homo sapiens 87-93 22794107-5 2012 Although the feeding preference varied considerably among different strains and individuals, statistical analysis using large numbers of transformants indicated that transformants expressing T2R4 showed a small but significant increase in the preference for denatonium and quinine, the T2R4 ligands, as compared to the control flies, whereas transformants expressing T2R38 did not. Quinine 273-280 taste 2 receptor member 4 Homo sapiens 191-195