PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12023534-5	2002	Additionally and surprisingly, this reaction was also inhibited by quinidine and quinine, with respective IC(50) values of 1.38 +/- 0.10 and 3.31 +/- 0.14 microM, compared with those for CYP2D6 debrisoquine 4-hydroxylase of 0.018 +/- 0.05 and 3.75 +/- 2.07 microM, respectively.	Quinine	81-88	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	187-193	
12023534-5	2002	Additionally and surprisingly, this reaction was also inhibited by quinidine and quinine, with respective IC(50) values of 1.38 +/- 0.10 and 3.31 +/- 0.14 microM, compared with those for CYP2D6 debrisoquine 4-hydroxylase of 0.018 +/- 0.05 and 3.75 +/- 2.07 microM, respectively.	Quinine	81-88	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	194-220	
10806376-9	2000	The reaction was sensitive to inhibition by the CYP2D6-selective inhibitors quinidine, quinine, lobeline and norfluoxetine, whereas chemical inhibitors selective for other CYP isoforms failed to affect the reaction.	Quinine	87-94	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	48-54	
10421620-7	1999	The enzyme activity was significantly (p <.01) and stereoselectively inhibited by CYP2D1 inhibitors quinine and quinidine (not by CYP2C or CYP3A inhibitors), and by anti-CYP2D6 peptide antiserum (not by anti-CYP2C, -CYP2B, or -CYP3A antibodies).	Quinine	103-110	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	173-179	
9256169-6	1997	The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine).	Quinine	110-117	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-38	
9256169-6	1997	The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine).	Quinine	110-117	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-37	
27618912-5	2016	RESULTS: Both CQ and QN significantly inhibited the activity of CYP2D6.	Quinine	21-23	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	64-70	
9264312-8	1997	This reaction was negligible in CYP2D6-deficient liver microsomes, was inhibited stereoselectively by the quinidine/quinine enantiomer pair, and was cosegregated with dextromethorphan O-demethylation (r = 0.975).	Quinine	116-123	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-38	
7835228-7	1994	MP metabolism studies were also conducted with CYP2D6 microsomes in the presence of quinidine and quinine.	Quinine	98-105	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	47-53	
2775304-0	1989	The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.	Quinine	86-93	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	33-59	
2775304-1	1989	The kinetics of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in rat and human liver microsomes have been compared.	Quinine	83-90	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	30-56	
2775304-7	1989	Inhibition of debrisoquine 4-hydroxylase activity by both quinine and quinidine in human and rat liver is competitive.	Quinine	58-65	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	14-40	
2775304-10	1989	Although both quinidine and quinine are competitive inhibitors of debrisoquine 4-hydroxylase activity in rat and man, their potency is reversed.	Quinine	28-35	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	66-92	
27618912-2	2016	However, both CQ and QN are considered effective, although perhaps moderate inhibitors of CYP2D6, an enzyme now regarded as necessary for primaquine (PQ) pharmacologic activity.	Quinine	21-23	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	90-96	
27618912-7	2016	CYP2D6-mediated hydroxylation was largely suppressed by both CQ and QN.	Quinine	68-70	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6