PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31139627-3 2019 While PA produced by PLD1 is critical for mTOR activation upon mitogenic stimulation at the lysosome, it is unclear where PA is produced upon mechanical stimulation in skeletal muscle. Phosphatidic Acids 6-8 phospholipase D1 Homo sapiens 21-25 28229303-4 2017 Phospholipase D1 (PLD1) is a critical enzyme responsible for the making lipid second messenger phosphatidic acid. Phosphatidic Acids 95-112 phospholipase D1 Homo sapiens 0-16 29136407-1 2018 BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. Phosphatidic Acids 103-120 phospholipase D1 Homo sapiens 12-36 29136407-1 2018 BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. Phosphatidic Acids 103-120 phospholipase D1 Homo sapiens 38-44 28318354-7 2017 When HS1BP3 is depleted, the total cellular PA content is upregulated stemming from increased activity of the PA-producing enzyme PLD (phospholipase D) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 44-46 phospholipase D1 Homo sapiens 182-186 28323521-5 2017 HS1BP3 is proposed to act by inhibiting PLD1 (phospholipase D1) activity and localization to ATG16L1 and TFRC (transferrin receptor)-positive vesicles thereby modulating the phosphatidic acid (PA) levels and lipid composition of autophagosome precursor membranes. Phosphatidic Acids 174-191 phospholipase D1 Homo sapiens 40-44 28323521-5 2017 HS1BP3 is proposed to act by inhibiting PLD1 (phospholipase D1) activity and localization to ATG16L1 and TFRC (transferrin receptor)-positive vesicles thereby modulating the phosphatidic acid (PA) levels and lipid composition of autophagosome precursor membranes. Phosphatidic Acids 193-195 phospholipase D1 Homo sapiens 40-44 28209987-2 2017 The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface receptors, including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and integrins. Phosphatidic Acids 100-117 phospholipase D1 Homo sapiens 37-41 28229303-4 2017 Phospholipase D1 (PLD1) is a critical enzyme responsible for the making lipid second messenger phosphatidic acid. Phosphatidic Acids 95-112 phospholipase D1 Homo sapiens 18-22 24811005-3 2014 Phospholipase D1 (PLD1), an enzyme that generates phosphatidic acid through hydrolysis of phosphatidylcholine and additionally yields choline as a product, has been described as regulator of the cell mobility. Phosphatidic Acids 50-67 phospholipase D1 Homo sapiens 0-16 28004827-5 2016 Furthermore, we find the total PA content of cells to be significantly upregulated in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 31-33 phospholipase D1 Homo sapiens 222-226 25678627-7 2015 These results suggest that interactions of NEU3 with PA produced by PLD1 are important for regulation of transmembrane signaling, this aberrant acceleration probably promoting malignancy in cancers. Phosphatidic Acids 53-55 phospholipase D1 Homo sapiens 68-72 27696687-3 2016 However, the mechanism by which phosphatidic acid (PA), the product of PLD1 action, might regulate decidualization is not known. Phosphatidic Acids 32-49 phospholipase D1 Homo sapiens 71-75 27696687-3 2016 However, the mechanism by which phosphatidic acid (PA), the product of PLD1 action, might regulate decidualization is not known. Phosphatidic Acids 51-53 phospholipase D1 Homo sapiens 71-75 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidic Acids 96-113 phospholipase D1 Homo sapiens 0-16 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidic Acids 96-113 phospholipase D1 Homo sapiens 18-22 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidic Acids 115-117 phospholipase D1 Homo sapiens 0-16 26883475-4 2016 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline, has been implicated in the regulation of neurite outgrowth. Phosphatidic Acids 115-117 phospholipase D1 Homo sapiens 18-22 26883475-7 2016 We later demonstrated that PA was the key mediator for astrocyte PLD1 to regulate dendritic branching. Phosphatidic Acids 27-29 phospholipase D1 Homo sapiens 65-69 26883475-10 2016 Taken together, our results demonstrate that astrocyte PLD1 and its lipid product PA are essential regulators of dendritic branching in neurons. Phosphatidic Acids 82-84 phospholipase D1 Homo sapiens 55-59 24811005-3 2014 Phospholipase D1 (PLD1), an enzyme that generates phosphatidic acid through hydrolysis of phosphatidylcholine and additionally yields choline as a product, has been described as regulator of the cell mobility. Phosphatidic Acids 50-67 phospholipase D1 Homo sapiens 18-22 24802400-3 2014 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy. Phosphatidic Acids 107-109 phospholipase D1 Homo sapiens 18-22 24802400-3 2014 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy. Phosphatidic Acids 88-105 phospholipase D1 Homo sapiens 0-16 24802400-3 2014 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy. Phosphatidic Acids 88-105 phospholipase D1 Homo sapiens 18-22 24802400-3 2014 Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) and choline, was recently shown to modulate autophagy. Phosphatidic Acids 107-109 phospholipase D1 Homo sapiens 0-16 22797597-4 2012 The subsequent recruitment of phospholipase D1 allows polarized accumulation of phosphatidic acid, which provides a local cue for successive signalling by the guanine nucleotide exchange factor PDZGEF, the small G protein Rap2A, its effector TNIK, the kinase MST4 and, ultimately, the actin-binding protein Ezrin. Phosphatidic Acids 80-97 phospholipase D1 Homo sapiens 30-46 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidic Acids 120-137 phospholipase D1 Homo sapiens 48-64 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidic Acids 120-137 phospholipase D1 Homo sapiens 66-70 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidic Acids 139-141 phospholipase D1 Homo sapiens 48-64 24556997-4 2014 Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Phosphatidic Acids 139-141 phospholipase D1 Homo sapiens 66-70 24068326-8 2013 The product of PLD, phosphatidic acid, activates the enhancer in a rapamycin-sensitive but mTOR kinase-independent manner. Phosphatidic Acids 20-37 phospholipase D1 Homo sapiens 15-18 19763255-4 2009 We also demonstrate that the PLD1-mu2 interaction requires the binding of PLD1 with phosphatidic acid, its own product. Phosphatidic Acids 84-101 phospholipase D1 Homo sapiens 29-33 22343288-8 2012 Furthermore, depletion of phosphatidic acid by inhibition of phospholipase D1 prevents cAMP-induced translocation of Epac1 as well as the subsequent activation of Rap at the plasma membrane. Phosphatidic Acids 26-43 phospholipase D1 Homo sapiens 61-77 20473892-5 2011 Phosphatidic acid, the product of PLD activity, leads to an increase in the Ras-ERK/PI3K-NFkappaB signaling cascade and enhances binding of NFkappaB to the PLD1 promoter, consequently inducing selective PLD1 expression in SK-BR3 breast cancer cells. Phosphatidic Acids 0-17 phospholipase D1 Homo sapiens 156-160 20473892-5 2011 Phosphatidic acid, the product of PLD activity, leads to an increase in the Ras-ERK/PI3K-NFkappaB signaling cascade and enhances binding of NFkappaB to the PLD1 promoter, consequently inducing selective PLD1 expression in SK-BR3 breast cancer cells. Phosphatidic Acids 0-17 phospholipase D1 Homo sapiens 203-207 20074053-4 2010 An RNAi (RNA interference) strategy coupled with the detection of PA in living cells has pointed to plasma membrane-associated PLD1 (phospholipase D(1)) as the main producer of PA in response to secretagogue stimulation. Phosphatidic Acids 66-68 phospholipase D1 Homo sapiens 127-131 20074053-4 2010 An RNAi (RNA interference) strategy coupled with the detection of PA in living cells has pointed to plasma membrane-associated PLD1 (phospholipase D(1)) as the main producer of PA in response to secretagogue stimulation. Phosphatidic Acids 177-179 phospholipase D1 Homo sapiens 127-131 22504301-2 2012 Overexpression of PLD1 or PLD2 increased Bcl-2 expression and phosphatidic acid (PA), the product of PLDs, also upregulated Bcl-2 expression. Phosphatidic Acids 62-79 phospholipase D1 Homo sapiens 18-22 22504301-2 2012 Overexpression of PLD1 or PLD2 increased Bcl-2 expression and phosphatidic acid (PA), the product of PLDs, also upregulated Bcl-2 expression. Phosphatidic Acids 81-83 phospholipase D1 Homo sapiens 18-22 21678474-5 2011 We demonstrate that PLD1 activators, RhoA, and PKCalpha are critical for stress fiber formation and ERK activation, and enhance the production of phosphatidic acid (PA) upon phenylephrine addition. Phosphatidic Acids 146-163 phospholipase D1 Homo sapiens 20-24 21678474-5 2011 We demonstrate that PLD1 activators, RhoA, and PKCalpha are critical for stress fiber formation and ERK activation, and enhance the production of phosphatidic acid (PA) upon phenylephrine addition. Phosphatidic Acids 165-167 phospholipase D1 Homo sapiens 20-24 21620893-8 2011 Blocking PA production with 1-butanol and siRNA against PLD1 significantly inhibited the IL-15-stimulated expression of RANKL and PLD1. Phosphatidic Acids 9-11 phospholipase D1 Homo sapiens 56-60 21620893-8 2011 Blocking PA production with 1-butanol and siRNA against PLD1 significantly inhibited the IL-15-stimulated expression of RANKL and PLD1. Phosphatidic Acids 9-11 phospholipase D1 Homo sapiens 130-134 21737445-6 2011 Phospholipase D 1, a PA-generating enzyme that is an established upstream regulator of mTORC1, is found to negatively affect mTOR-FKBP38 interaction, confirming the role of endogenous PA in this regulation. Phosphatidic Acids 21-23 phospholipase D1 Homo sapiens 0-17 21737445-6 2011 Phospholipase D 1, a PA-generating enzyme that is an established upstream regulator of mTORC1, is found to negatively affect mTOR-FKBP38 interaction, confirming the role of endogenous PA in this regulation. Phosphatidic Acids 184-186 phospholipase D1 Homo sapiens 0-17 20442281-6 2010 Conversely, tactics to elevate intracellular levels of phosphatidic acid, the product of PLD1 enzyme activity, enhanced beta-catenin/TCF-4 complex formation as well as beta-catenin-dependent TCF transcriptional activity. Phosphatidic Acids 55-72 phospholipase D1 Homo sapiens 89-93 20231899-12 2010 In addition, extracellular signal-regulated kinase (ERK) is stimulated by AMPK-induced PLD1 activation through the formation of phosphatidic acid (PA), which is a product of PLD. Phosphatidic Acids 128-145 phospholipase D1 Homo sapiens 87-91 20231899-12 2010 In addition, extracellular signal-regulated kinase (ERK) is stimulated by AMPK-induced PLD1 activation through the formation of phosphatidic acid (PA), which is a product of PLD. Phosphatidic Acids 147-149 phospholipase D1 Homo sapiens 87-91 20074053-4 2010 An RNAi (RNA interference) strategy coupled with the detection of PA in living cells has pointed to plasma membrane-associated PLD1 (phospholipase D(1)) as the main producer of PA in response to secretagogue stimulation. Phosphatidic Acids 177-179 phospholipase D1 Homo sapiens 133-151 19763255-4 2009 We also demonstrate that the PLD1-mu2 interaction requires the binding of PLD1 with phosphatidic acid, its own product. Phosphatidic Acids 84-101 phospholipase D1 Homo sapiens 74-78 18765678-7 2009 In addition, Rheb-GTP stimulates phospholipase D1 to generate phosphatidic acid, a positive effector of mTORC1 activation, and binds to the mTOR inhibitor FKBP38, to displace it from mTOR. Phosphatidic Acids 62-79 phospholipase D1 Homo sapiens 33-49 19289180-3 2009 Over the last decade, chromaffin cells have served as an important cellular model to demonstrate a key role for phospholipase D1 (PLD1) generated phosphatidic acid in regulated exocytosis. Phosphatidic Acids 146-163 phospholipase D1 Homo sapiens 112-128 19289180-3 2009 Over the last decade, chromaffin cells have served as an important cellular model to demonstrate a key role for phospholipase D1 (PLD1) generated phosphatidic acid in regulated exocytosis. Phosphatidic Acids 146-163 phospholipase D1 Homo sapiens 130-134 19422932-4 2009 In this article it is proposed that PLD2 plays the role of "master regulator" and in an ill-defined manner regulates Rho function, PLD1 activity is downstream of this activation, however the generated phosphatidic acid controls changes in cytoskeletal organisation through its regulation of phosphatidylinositol-4-phosphate-5-kinase activity. Phosphatidic Acids 201-218 phospholipase D1 Homo sapiens 131-135 15210717-5 2004 Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. Phosphatidic Acids 228-230 phospholipase D1 Homo sapiens 168-172 18945966-4 2009 PLD1 is translocated to the plasma membrane upon stimulation of endothelial secretion, and this process correlates with the generation of phosphatidic acid (PA) in the plasma membrane. Phosphatidic Acids 138-155 phospholipase D1 Homo sapiens 0-4 18945966-4 2009 PLD1 is translocated to the plasma membrane upon stimulation of endothelial secretion, and this process correlates with the generation of phosphatidic acid (PA) in the plasma membrane. Phosphatidic Acids 157-159 phospholipase D1 Homo sapiens 0-4 15772157-7 2005 The fusion block caused by RNA interference-mediated PLD1 deficiency is rescued by exogenous provision of a lipid that promotes fusion pore formation and expansion, suggesting that the step regulated by PA is late in the process of vesicle fusion. Phosphatidic Acids 203-205 phospholipase D1 Homo sapiens 53-57 15475361-6 2004 Consistent with the model structure that suggests the presence of a second lipid-binding pocket, vesicle binding studies indicated that the PLD1 PX domain could also bind with moderate affinity to PA, phosphatidylserine, and other anionic lipids, which were mediated by a cluster of cationic residues in the secondary binding site. Phosphatidic Acids 197-199 phospholipase D1 Homo sapiens 140-144 15475361-9 2004 Collectively, our results suggest that the interaction of the PLD1 PX domain with PtdIns(3,4,5)P(3) and/or PA (or phosphatidylserine) may be an important factor in the spatiotemporal regulation and activation of PLD1. Phosphatidic Acids 107-109 phospholipase D1 Homo sapiens 62-66 15475361-9 2004 Collectively, our results suggest that the interaction of the PLD1 PX domain with PtdIns(3,4,5)P(3) and/or PA (or phosphatidylserine) may be an important factor in the spatiotemporal regulation and activation of PLD1. Phosphatidic Acids 107-109 phospholipase D1 Homo sapiens 212-216 16878700-2 2006 The functional significance of PLD derives from its generation of phosphatidic acid, which has both direct signaling properties via activation of numerous kinases, phosphatases, phopspholipases, and other enzymes, as well as via its conversion to diglycerides, the endogenous activators of protein kinase C. The two mammalian PLD isoforms, PLD1 and PLD2, are peripheral membrane proteins that exhibit important physical and functional interactions with the actin cytoskeleton. Phosphatidic Acids 66-83 phospholipase D1 Homo sapiens 340-344 15210717-5 2004 Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. Phosphatidic Acids 256-258 phospholipase D1 Homo sapiens 168-172 14653992-9 2003 However, when exogenous PA was used as a stimulus, the PLD1-inactive Cdc42 mutant behaved similarly to the wild-type protein. Phosphatidic Acids 24-26 phospholipase D1 Homo sapiens 55-59 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidic Acids 130-147 phospholipase D1 Homo sapiens 53-69 12546662-0 2003 Phospholipase D1 and potential targets of its hydrolysis product, phosphatidic acid. Phosphatidic Acids 66-83 phospholipase D1 Homo sapiens 0-16 12055293-3 2002 PLD1 catalyses the formation of phosphatidic acid (PA), which has been shown to activate PI4P5Ks in mammalian and Saccharomyces cerevisiae cells. Phosphatidic Acids 32-49 phospholipase D1 Homo sapiens 0-4 12055293-3 2002 PLD1 catalyses the formation of phosphatidic acid (PA), which has been shown to activate PI4P5Ks in mammalian and Saccharomyces cerevisiae cells. Phosphatidic Acids 51-53 phospholipase D1 Homo sapiens 0-4 10566654-9 1999 These receptors are also coupled to the phospholipase D-1 pathway, leading to accumulation of phosphatidic acid. Phosphatidic Acids 94-111 phospholipase D1 Homo sapiens 40-57 10364223-4 1999 Phosphatidic acid, which potently stimulates type I phosphatidylinositol 4-phosphate 5-kinase activity, is generated on the bilayer by a phospholipase D1-like enzyme located on the lysosomal surface. Phosphatidic Acids 0-17 phospholipase D1 Homo sapiens 137-153 10364223-6 1999 Generating phosphatidic acid directly on lysosomes with exogenous bacterial phospholipase D in the absence of ATP still drives adaptor recruitment and limited coat assembly, indicating that PtdIns(4,5)P2 functions, at least in part, to activate the PtdIns(4,5)P2-dependent phospholipase D1. Phosphatidic Acids 11-28 phospholipase D1 Homo sapiens 273-289 34876384-0 2022 Phospholipase D1-generated phosphatidic acid modulates secretory granule trafficking from biogenesis to compensatory endocytosis in neuroendocrine cells. Phosphatidic Acids 27-44 phospholipase D1 Homo sapiens 0-16 34876384-6 2022 The enzyme phospholipase D1 (PLD1), producing PA from phosphatidylcholine, seems to be the major responsible of these effects in this model. Phosphatidic Acids 46-48 phospholipase D1 Homo sapiens 11-27 34876384-6 2022 The enzyme phospholipase D1 (PLD1), producing PA from phosphatidylcholine, seems to be the major responsible of these effects in this model. Phosphatidic Acids 46-48 phospholipase D1 Homo sapiens 29-33 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidic Acids 130-147 phospholipase D1 Homo sapiens 71-75 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidic Acids 149-151 phospholipase D1 Homo sapiens 53-69 34320341-5 2021 Mechanistically, RalA performs this function through phospholipase D1 (PLD1), an enzyme that converts phosphatidylcholine (PC) to phosphatidic acid (PA) and that is recruited to lysosomes during nutrient stress in a RalA-dependent fashion. Phosphatidic Acids 149-151 phospholipase D1 Homo sapiens 71-75 34320341-7 2021 Our data support a model in which RalA recruits PLD1 to lysosomes during nutrient deprivation to promote the localized production of PA and the recruitment of perilipin 3 to expanding LDs. Phosphatidic Acids 133-135 phospholipase D1 Homo sapiens 48-52 35007762-2 2022 Among them, PLD1/2/6 catalyze phosphatidic acid (PA) production, while PLD3/4/5 have no catalytic activities. Phosphatidic Acids 30-47 phospholipase D1 Homo sapiens 12-18 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidic Acids 121-138 phospholipase D1 Homo sapiens 42-46 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidic Acids 140-142 phospholipase D1 Homo sapiens 42-46 35007762-2 2022 Among them, PLD1/2/6 catalyze phosphatidic acid (PA) production, while PLD3/4/5 have no catalytic activities. Phosphatidic Acids 49-51 phospholipase D1 Homo sapiens 12-18 32826291-4 2020 Phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] becomes enriched at WPB-plasma membrane contact sites at the time of fusion, most likely downstream of phospholipase D1-mediated production of phosphatidic acid (PA) that activates phosphatidylinositol 4-phosphate (PI4P) 5-kinase gamma. Phosphatidic Acids 195-212 phospholipase D1 Homo sapiens 155-171 33945837-1 2021 Invasion of bladder cancer (BC) cells from the mucosa into the muscle layer is canonical for BC progression while phospholipase D isoform 1 (PLD1) is known to mediate development of cancer through phosphatidic acid (PA) production. Phosphatidic Acids 197-214 phospholipase D1 Homo sapiens 114-139 33945837-1 2021 Invasion of bladder cancer (BC) cells from the mucosa into the muscle layer is canonical for BC progression while phospholipase D isoform 1 (PLD1) is known to mediate development of cancer through phosphatidic acid (PA) production. Phosphatidic Acids 197-214 phospholipase D1 Homo sapiens 141-145 33945837-1 2021 Invasion of bladder cancer (BC) cells from the mucosa into the muscle layer is canonical for BC progression while phospholipase D isoform 1 (PLD1) is known to mediate development of cancer through phosphatidic acid (PA) production. Phosphatidic Acids 216-218 phospholipase D1 Homo sapiens 114-139 33945837-1 2021 Invasion of bladder cancer (BC) cells from the mucosa into the muscle layer is canonical for BC progression while phospholipase D isoform 1 (PLD1) is known to mediate development of cancer through phosphatidic acid (PA) production. Phosphatidic Acids 216-218 phospholipase D1 Homo sapiens 141-145 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidic Acids 94-111 phospholipase D1 Homo sapiens 31-37 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidic Acids 113-115 phospholipase D1 Homo sapiens 31-37 32826291-4 2020 Phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] becomes enriched at WPB-plasma membrane contact sites at the time of fusion, most likely downstream of phospholipase D1-mediated production of phosphatidic acid (PA) that activates phosphatidylinositol 4-phosphate (PI4P) 5-kinase gamma. Phosphatidic Acids 214-216 phospholipase D1 Homo sapiens 155-171 32571842-6 2020 These two AKAP proteins form signaling complexes containing protein kinases A and C, which phosphorylate and activate PLD1 to produce phosphatidic acid (PA). Phosphatidic Acids 134-151 phospholipase D1 Homo sapiens 118-122 32571842-6 2020 These two AKAP proteins form signaling complexes containing protein kinases A and C, which phosphorylate and activate PLD1 to produce phosphatidic acid (PA). Phosphatidic Acids 153-155 phospholipase D1 Homo sapiens 118-122 32571842-8 2020 These results suggest that BCALM promotes negative feedback that downmodulates BCR-mediated Ca+ signaling by promoting phosphorylation of PLD1 by AKAP-associated kinases, enhancing production of PA. Phosphatidic Acids 195-197 phospholipase D1 Homo sapiens 138-142 31673104-1 2019 BACKGROUND: Phospholipases D1 and D2 (PLD1/2) are implicated in tumorigenesis through their generation of the signalling lipid phosphatidic acid and its downstream effects. Phosphatidic Acids 127-144 phospholipase D1 Homo sapiens 12-36 31673104-1 2019 BACKGROUND: Phospholipases D1 and D2 (PLD1/2) are implicated in tumorigenesis through their generation of the signalling lipid phosphatidic acid and its downstream effects. Phosphatidic Acids 127-144 phospholipase D1 Homo sapiens 38-44 32198492-1 2020 The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer. Phosphatidic Acids 125-142 phospholipase D1 Homo sapiens 31-47 32198492-1 2020 The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer. Phosphatidic Acids 125-142 phospholipase D1 Homo sapiens 49-53 31541323-2 2020 PLD1 and PLD2, which are activated as a consequence of extracellular signaling events and generate the second messenger signaling lipid phosphatidic acid (PA), have been reported to play roles in settings ranging from platelet activation to the response to cardiac ischemia, viral infection, neurodegenerative disease, and cancer. Phosphatidic Acids 136-153 phospholipase D1 Homo sapiens 0-4 31541323-2 2020 PLD1 and PLD2, which are activated as a consequence of extracellular signaling events and generate the second messenger signaling lipid phosphatidic acid (PA), have been reported to play roles in settings ranging from platelet activation to the response to cardiac ischemia, viral infection, neurodegenerative disease, and cancer. Phosphatidic Acids 155-157 phospholipase D1 Homo sapiens 0-4