PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20858461-13 2011 Characterization of these putative PA-binding proteins constitutes another step forward for a better understanding of the role of PLD-derived PA in neutrophil physiology. Phosphatidic Acids 35-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 20858461-13 2011 Characterization of these putative PA-binding proteins constitutes another step forward for a better understanding of the role of PLD-derived PA in neutrophil physiology. Phosphatidic Acids 142-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 21228924-4 2010 Moreover, phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as one of the upstream activators of mTOR signaling. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 19800928-4 2010 Among those lipids, phosphatidic acid (PA) synthesized through the activity of phospholipase D (PLD) has been recently shown to be necessary to hormonal release in various cell types as well as in neurotransmitter release. Phosphatidic Acids 20-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 79-94 19800928-4 2010 Among those lipids, phosphatidic acid (PA) synthesized through the activity of phospholipase D (PLD) has been recently shown to be necessary to hormonal release in various cell types as well as in neurotransmitter release. Phosphatidic Acids 20-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 96-99 19800928-4 2010 Among those lipids, phosphatidic acid (PA) synthesized through the activity of phospholipase D (PLD) has been recently shown to be necessary to hormonal release in various cell types as well as in neurotransmitter release. Phosphatidic Acids 39-41 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 79-94 19800928-4 2010 Among those lipids, phosphatidic acid (PA) synthesized through the activity of phospholipase D (PLD) has been recently shown to be necessary to hormonal release in various cell types as well as in neurotransmitter release. Phosphatidic Acids 39-41 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 96-99 21228924-4 2010 Moreover, phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as one of the upstream activators of mTOR signaling. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 21228924-4 2010 Moreover, phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as one of the upstream activators of mTOR signaling. Phosphatidic Acids 68-70 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 21228924-4 2010 Moreover, phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as one of the upstream activators of mTOR signaling. Phosphatidic Acids 68-70 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 20693286-1 2010 Phospholipase D (PLD), a major source of lipid second messengers (phosphatidic acid, diglycerides) in many cell types, is tightly regulated by protein kinases, but only a few of them have been identified. Phosphatidic Acids 66-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20693286-1 2010 Phospholipase D (PLD), a major source of lipid second messengers (phosphatidic acid, diglycerides) in many cell types, is tightly regulated by protein kinases, but only a few of them have been identified. Phosphatidic Acids 66-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20438709-5 2010 mTOR exists in at least two distinct complexes-mTORC1 and mTORC2-that are both dependent on PLD-generated PA. Phosphatidic Acids 106-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-95 20735042-1 2010 Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20735042-1 2010 Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20554760-3 2010 Our previous observation that PKA inhibitors induce EGFR internalization prompted us to test phosphatidic acid (PA) generated by phospholipase D (PLD) as an endogenous down-regulator of PKA activity, which activates rolipram-sensitive type 4 phosphodiesterases (PDE4) that degrade cAMP. Phosphatidic Acids 93-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 129-144 20554760-3 2010 Our previous observation that PKA inhibitors induce EGFR internalization prompted us to test phosphatidic acid (PA) generated by phospholipase D (PLD) as an endogenous down-regulator of PKA activity, which activates rolipram-sensitive type 4 phosphodiesterases (PDE4) that degrade cAMP. Phosphatidic Acids 93-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 146-149 20554760-3 2010 Our previous observation that PKA inhibitors induce EGFR internalization prompted us to test phosphatidic acid (PA) generated by phospholipase D (PLD) as an endogenous down-regulator of PKA activity, which activates rolipram-sensitive type 4 phosphodiesterases (PDE4) that degrade cAMP. Phosphatidic Acids 112-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 129-144 20554760-3 2010 Our previous observation that PKA inhibitors induce EGFR internalization prompted us to test phosphatidic acid (PA) generated by phospholipase D (PLD) as an endogenous down-regulator of PKA activity, which activates rolipram-sensitive type 4 phosphodiesterases (PDE4) that degrade cAMP. Phosphatidic Acids 112-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 146-149 20417698-4 2010 Exogenous phosphatidic acid mimicked the effects of PLD activation, and diphenyliodonium (NADPH oxidase inhibitor) reversed the decline in cell viability induced by H(2)O(2) exposure. Phosphatidic Acids 10-27 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-55 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-74 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-74 20573978-6 2010 Unexpectedly, PLD inhibition caused an increase in cellular PA, suggesting that PLD activity negatively regulates PA synthesis by other more productive pathways. Phosphatidic Acids 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 20573978-6 2010 Unexpectedly, PLD inhibition caused an increase in cellular PA, suggesting that PLD activity negatively regulates PA synthesis by other more productive pathways. Phosphatidic Acids 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-83 20573978-6 2010 Unexpectedly, PLD inhibition caused an increase in cellular PA, suggesting that PLD activity negatively regulates PA synthesis by other more productive pathways. Phosphatidic Acids 114-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 20573978-6 2010 Unexpectedly, PLD inhibition caused an increase in cellular PA, suggesting that PLD activity negatively regulates PA synthesis by other more productive pathways. Phosphatidic Acids 114-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-83 20711340-7 2010 Suppressing PLD using gene silencing or selective inhibitor blocked the ability of beta-catenin to transcriptionally activate PLD and other Wnt target genes by preventing formation of the beta-catenin/TCF-4 complex, whereas tactics to elevate intracellular levels of phosphatidic acid, the product of PLD activity, enhanced these effects. Phosphatidic Acids 267-284 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 12-15 20417698-6 2010 We speculate that PLD activation at the initiation of H(2)O(2) exposure predominantly results in NAPDH oxidase activation, which mediates A549 cell injury, but turns to mediating cell survival as the H(2)O(2) attack continues, which might be mainly due to the accumulation of intracellular phosphatidic acid. Phosphatidic Acids 290-307 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-21 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 109-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 109-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 128-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 128-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20623096-14 2010 A clear connection between PLD with the mTOR/S6K pathway has been established, in that PA binds to mTOR and also binds to S6K independently of mTOR. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 19931432-3 2010 PLD incubation of EY mainly converts phosphatidylcholine into phosphatidic acid (PA). Phosphatidic Acids 62-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 20372065-4 2010 mTOR has a requirement for the lipid second messenger phosphatidic acid (PA), which is generated by phospholipase D (PLD). Phosphatidic Acids 54-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-115 20372065-4 2010 mTOR has a requirement for the lipid second messenger phosphatidic acid (PA), which is generated by phospholipase D (PLD). Phosphatidic Acids 54-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 117-120 20372065-4 2010 mTOR has a requirement for the lipid second messenger phosphatidic acid (PA), which is generated by phospholipase D (PLD). Phosphatidic Acids 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-115 20372065-4 2010 mTOR has a requirement for the lipid second messenger phosphatidic acid (PA), which is generated by phospholipase D (PLD). Phosphatidic Acids 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 117-120 20372065-6 2010 Significantly, PLD utilizes ethanol preferentially over water in the hydrolysis reaction that ordinarily generates PA. Phosphatidic Acids 115-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-18 20231899-12 2010 In addition, extracellular signal-regulated kinase (ERK) is stimulated by AMPK-induced PLD1 activation through the formation of phosphatidic acid (PA), which is a product of PLD. Phosphatidic Acids 128-145 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 87-90 20231899-12 2010 In addition, extracellular signal-regulated kinase (ERK) is stimulated by AMPK-induced PLD1 activation through the formation of phosphatidic acid (PA), which is a product of PLD. Phosphatidic Acids 147-149 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 87-90 19931432-3 2010 PLD incubation of EY mainly converts phosphatidylcholine into phosphatidic acid (PA). Phosphatidic Acids 81-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19931432-6 2010 The improved emulsifying activity of EY after PLD incubation could be attributed both to a higher interface activity of the PA itself and to modified interactions of protein and phospholipids in EY. Phosphatidic Acids 124-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 20950571-5 2010 In the first one, phospholipids are hydrolysed by phospholipase D (PLD) to release PA. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-65 21326806-7 2010 Phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as an activator of mTOR signaling, including the direct phosphorylative activation of p70S6K atthreonine 389. Phosphatidic Acids 39-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21326806-7 2010 Phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as an activator of mTOR signaling, including the direct phosphorylative activation of p70S6K atthreonine 389. Phosphatidic Acids 39-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 21326806-7 2010 Phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as an activator of mTOR signaling, including the direct phosphorylative activation of p70S6K atthreonine 389. Phosphatidic Acids 58-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21326806-7 2010 Phospholipase D (PLD) and its product, phosphatidic acid (PA) have been implicated as an activator of mTOR signaling, including the direct phosphorylative activation of p70S6K atthreonine 389. Phosphatidic Acids 58-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20950571-5 2010 In the first one, phospholipids are hydrolysed by phospholipase D (PLD) to release PA. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 19845506-9 2009 Primary alcohols, used previously as a means to reduce PLD-derived phosphatidic acid, were potent inhibitors of membrane blebbing, but a more selective inhibitor of PLD, FIPI (5-fluoro-2-indolyl des-chlorohalopemide), was without effect. Phosphatidic Acids 67-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-58 19497293-0 2009 Spectrophotometric determination of phosphatidic acid via iron(III) complexation for assaying phospholipase D activity. Phosphatidic Acids 36-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-109 19264150-2 2009 PLD catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA). Phosphatidic Acids 91-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19738202-1 2009 Phosphatidic acid (PA), which can be produced by phospholipase D (PLD), is involved in various signaling events, such as cell proliferation, survival, and migration. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-64 19738202-1 2009 Phosphatidic acid (PA), which can be produced by phospholipase D (PLD), is involved in various signaling events, such as cell proliferation, survival, and migration. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 66-69 19738202-1 2009 Phosphatidic acid (PA), which can be produced by phospholipase D (PLD), is involved in various signaling events, such as cell proliferation, survival, and migration. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-64 19738202-1 2009 Phosphatidic acid (PA), which can be produced by phospholipase D (PLD), is involved in various signaling events, such as cell proliferation, survival, and migration. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 66-69 19394438-2 2009 Besides phospholipase D (PLD) activity, PA can also be generated by diacylglycerol kinase (DGK). Phosphatidic Acids 40-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 8-23 19394438-4 2009 Based on this, and more recently on reverse-genetic approaches, DGK has taken center stage, next to PLD, as a generator of PA in biotic and abiotic stress responses. Phosphatidic Acids 123-125 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-103 19394438-9 2009 Whether the PA molecules engaged in these interactions come from PLD or DGK remains to be elucidated. Phosphatidic Acids 12-14 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-68 19410013-4 2009 PLD regulates downstream molecules by generating phosphatidic acid (PA), but it also dynamically interacts with a variety of intracellular molecules and these interactions spatiotemporally regulate EGFR function and serve as a hub that orchestrates signaling flow. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19410013-4 2009 PLD regulates downstream molecules by generating phosphatidic acid (PA), but it also dynamically interacts with a variety of intracellular molecules and these interactions spatiotemporally regulate EGFR function and serve as a hub that orchestrates signaling flow. Phosphatidic Acids 68-70 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-104 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-109 19345277-1 2009 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19345277-1 2009 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19540356-3 2009 In this chapter, we review a newly identified, non-canonical member of the PLD superfamily, MitoPLD, which localizes to the mitochondrial surface and plays a role in mitochondrial fusion via the hydrolysis of cardiolipin (CL) to generate PA. Phosphatidic Acids 238-240 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 75-78 19540356-4 2009 The role of PA in facilitating the mitochondrial fusion event carried out by proteins known as Mitofusins is intriguing in light of the role classic PLD-generated PA plays in facilitating SNARE-mediated fusion of secretory membrane vesicles into the plasma membrane. Phosphatidic Acids 12-14 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 149-152 19540356-4 2009 The role of PA in facilitating the mitochondrial fusion event carried out by proteins known as Mitofusins is intriguing in light of the role classic PLD-generated PA plays in facilitating SNARE-mediated fusion of secretory membrane vesicles into the plasma membrane. Phosphatidic Acids 163-165 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 149-152 19540357-2 2009 PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. Phosphatidic Acids 47-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19540357-2 2009 PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. Phosphatidic Acids 66-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19540930-2 2009 Recent studies indicate that the signaling PA generated from phospholipase D (PLD) and diacylglycerol kinase (DGK) plays critical roles in regulating the activity of some members of Ras superfamily of small guanosine triphosphatases (GTPases), such as Ras, Rac and Arf. Phosphatidic Acids 43-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-76 19540930-2 2009 Recent studies indicate that the signaling PA generated from phospholipase D (PLD) and diacylglycerol kinase (DGK) plays critical roles in regulating the activity of some members of Ras superfamily of small guanosine triphosphatases (GTPases), such as Ras, Rac and Arf. Phosphatidic Acids 43-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 78-81 19264150-2 2009 PLD catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA). Phosphatidic Acids 110-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19264150-7 2009 PA interacts with mTOR in a manner that is competitive with rapamycin, and as a consequence, elevated PLD activity confers rapamycin resistance - a point that has been largely overlooked in clinical trials involving rapamycin-based strategies. Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-105 19114562-3 2009 Phospholipase D (PLD) and its metabolite phosphatidic acid (PA) have been implicated in the regulation of mTOR; however, their role has been controversial. Phosphatidic Acids 41-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19366706-1 2009 Phosphatidic acid generated by the activation of phospholipase D (PLD) functions as a second messenger and plays a vital role in cell signaling. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-64 19366706-1 2009 Phosphatidic acid generated by the activation of phospholipase D (PLD) functions as a second messenger and plays a vital role in cell signaling. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 66-69 19366706-2 2009 Here we demonstrate that PLD-dependent generation of phosphatidic acid is critical for Rac1/IQGAP1 signal transduction, translocation of p47(phox) to cell periphery, and ROS production. Phosphatidic Acids 53-70 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-28 19064628-1 2009 The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. Phosphatidic Acids 88-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-36 19064628-1 2009 The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. Phosphatidic Acids 88-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 19064628-1 2009 The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. Phosphatidic Acids 107-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-36 19064628-1 2009 The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. Phosphatidic Acids 107-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 19064628-2 2009 PLD production of PA is inhibited by the primary alcohol 1-butanol, which has thus been widely employed to identify PLD/PA-driven processes. Phosphatidic Acids 18-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19064628-2 2009 PLD production of PA is inhibited by the primary alcohol 1-butanol, which has thus been widely employed to identify PLD/PA-driven processes. Phosphatidic Acids 18-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 116-119 19064628-2 2009 PLD production of PA is inhibited by the primary alcohol 1-butanol, which has thus been widely employed to identify PLD/PA-driven processes. Phosphatidic Acids 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19064628-2 2009 PLD production of PA is inhibited by the primary alcohol 1-butanol, which has thus been widely employed to identify PLD/PA-driven processes. Phosphatidic Acids 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 116-119 19470781-7 2009 These observations led us to investigate an alternative pathway for the activation of mTOR signalling involving the synthesis of phosphatidic acid (PA) by phospholipase D (PLD). Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 155-170 19470781-7 2009 These observations led us to investigate an alternative pathway for the activation of mTOR signalling involving the synthesis of phosphatidic acid (PA) by phospholipase D (PLD). Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 172-175 19470781-7 2009 These observations led us to investigate an alternative pathway for the activation of mTOR signalling involving the synthesis of phosphatidic acid (PA) by phospholipase D (PLD). Phosphatidic Acids 148-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 155-170 19470781-7 2009 These observations led us to investigate an alternative pathway for the activation of mTOR signalling involving the synthesis of phosphatidic acid (PA) by phospholipase D (PLD). Phosphatidic Acids 148-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 172-175 19470781-8 2009 Our results demonstrate that ECs induce a sustained elevation in [PA] and inhibiting the synthesis of PA by PLD prevented the activation of mTOR. Phosphatidic Acids 102-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 19371764-2 2009 Phospholipase D (PLD) activation resulting in the generation of phosphatidic acid (PA) is increasingly recognized as a key event in the initiation of various cell responses. Phosphatidic Acids 64-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19371764-2 2009 Phospholipase D (PLD) activation resulting in the generation of phosphatidic acid (PA) is increasingly recognized as a key event in the initiation of various cell responses. Phosphatidic Acids 64-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19371764-2 2009 Phospholipase D (PLD) activation resulting in the generation of phosphatidic acid (PA) is increasingly recognized as a key event in the initiation of various cell responses. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19371764-2 2009 Phospholipase D (PLD) activation resulting in the generation of phosphatidic acid (PA) is increasingly recognized as a key event in the initiation of various cell responses. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19287190-1 2009 Phosphatidic acid (PA), the product of a PLD-mediated reaction, is a lipid second messenger that participates in various intracellular signaling events and is known to regulate a growing list of signaling proteins. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-44 19287190-1 2009 Phosphatidic acid (PA), the product of a PLD-mediated reaction, is a lipid second messenger that participates in various intracellular signaling events and is known to regulate a growing list of signaling proteins. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-44 19146388-4 2009 Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline. Phosphatidic Acids 133-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-80 19146388-4 2009 Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline. Phosphatidic Acids 133-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 82-85 19114562-3 2009 Phospholipase D (PLD) and its metabolite phosphatidic acid (PA) have been implicated in the regulation of mTOR; however, their role has been controversial. Phosphatidic Acids 41-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19114562-3 2009 Phospholipase D (PLD) and its metabolite phosphatidic acid (PA) have been implicated in the regulation of mTOR; however, their role has been controversial. Phosphatidic Acids 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19114562-3 2009 Phospholipase D (PLD) and its metabolite phosphatidic acid (PA) have been implicated in the regulation of mTOR; however, their role has been controversial. Phosphatidic Acids 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19136975-1 2009 Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic Acids 106-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19126647-5 2009 The upregulation of MMP-2 induced by phosphatidic acid (PA), the product of PLD, was mediated by protein kinase C (PKC), protein kinase A (PKA), nuclear factor-kappaB (NF-kappaB) and Sp1 and it enhanced glioma cell invasion. Phosphatidic Acids 37-54 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-79 19126647-5 2009 The upregulation of MMP-2 induced by phosphatidic acid (PA), the product of PLD, was mediated by protein kinase C (PKC), protein kinase A (PKA), nuclear factor-kappaB (NF-kappaB) and Sp1 and it enhanced glioma cell invasion. Phosphatidic Acids 56-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-79 19136975-1 2009 Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic Acids 106-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19160674-1 2009 Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine. Phosphatidic Acids 45-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19160674-1 2009 Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine. Phosphatidic Acids 45-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 56-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 56-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 56-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 142-145 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 75-77 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 75-77 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 75-77 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 142-145 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 98-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 98-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidic Acids 98-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 142-145 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidic Acids 132-149 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18573349-2 2008 The product of PLD activity, phosphatidic acid (PA) has mitogenic potential and elevated PLD expression has been detected in many tumor cell lines. Phosphatidic Acids 29-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-18 18573349-2 2008 The product of PLD activity, phosphatidic acid (PA) has mitogenic potential and elevated PLD expression has been detected in many tumor cell lines. Phosphatidic Acids 48-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-18 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidic Acids 132-149 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidic Acids 151-153 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidic Acids 151-153 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 18550814-3 2008 Phospholipase D (PLD) and its product phosphatidic acid are also upstream regulators of the mitogenic mTOR signaling. Phosphatidic Acids 38-55 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18480413-6 2008 We show that PLD product phosphatidic acid (PA) acts as a membrane anchor of Rac1. Phosphatidic Acids 25-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 13-16 18480413-6 2008 We show that PLD product phosphatidic acid (PA) acts as a membrane anchor of Rac1. Phosphatidic Acids 44-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 13-16 18550814-3 2008 Phospholipase D (PLD) and its product phosphatidic acid are also upstream regulators of the mitogenic mTOR signaling. Phosphatidic Acids 38-55 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 18550821-3 2008 Phospholipase D (PLD) has recently emerged as a promoter of membrane fusion in various exocytotic events potentially by providing fusogenic cone-shaped phosphatidic acid. Phosphatidic Acids 152-169 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18550821-3 2008 Phospholipase D (PLD) has recently emerged as a promoter of membrane fusion in various exocytotic events potentially by providing fusogenic cone-shaped phosphatidic acid. Phosphatidic Acids 152-169 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidic Acids 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidic Acids 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 18423386-6 2008 This response was inhibited by 1-butanol, a well known distracter of PLD activity, or upon overexpression of a dominant negative PLD2, and it was concomitant with a boost of PA/DAG production. Phosphatidic Acids 174-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 18358832-5 2008 Phosphatidic acid (PA), which is a signaling messenger produced by PLD, reverses ETOH inhibition of NSC proliferation. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 18358832-5 2008 Phosphatidic acid (PA), which is a signaling messenger produced by PLD, reverses ETOH inhibition of NSC proliferation. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 101-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 101-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17986621-5 2008 PLD activity was induced by stimulation with these two activators, and phosphatidic acid (PA), a product generated from the PLD enzymatic activity, was detected in stimulated HGECs. Phosphatidic Acids 71-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 124-127 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidic Acids 63-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidic Acids 63-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17936375-4 2008 Here, we show that the inhibition of phospholipase D (PLD)-mediated phosphatidic acid (PA) formation by 1-butanol inhibited the maturation and export of CFTR from the ER. Phosphatidic Acids 68-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 17936375-4 2008 Here, we show that the inhibition of phospholipase D (PLD)-mediated phosphatidic acid (PA) formation by 1-butanol inhibited the maturation and export of CFTR from the ER. Phosphatidic Acids 68-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 17936375-4 2008 Here, we show that the inhibition of phospholipase D (PLD)-mediated phosphatidic acid (PA) formation by 1-butanol inhibited the maturation and export of CFTR from the ER. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 17936375-4 2008 Here, we show that the inhibition of phospholipase D (PLD)-mediated phosphatidic acid (PA) formation by 1-butanol inhibited the maturation and export of CFTR from the ER. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidic Acids 82-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidic Acids 82-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17986621-5 2008 PLD activity was induced by stimulation with these two activators, and phosphatidic acid (PA), a product generated from the PLD enzymatic activity, was detected in stimulated HGECs. Phosphatidic Acids 90-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 124-127 17724165-8 2007 The addition of phosphatidic acid, a reaction product of PLD, partially restored fMLP-mediated transepithelial migration in the presence of 1-butanol but not the migration of Mac-1-deficient neutrophil-differentiated HL-60 cells. Phosphatidic Acids 16-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 17151288-6 2007 In this study, we show that platelet activation by PAR1-activating peptide (PAR1-AP) requires a phospholipase D (PLD)-mediated phosphatidic acid (PA) signaling pathway. Phosphatidic Acids 127-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 96-111 19704674-8 2007 The most important PA formation routes in plant signalling are: phospholipase C (PLC)/diacylglycerol kinase (DGK) and phospholipase D (PLD).3 We investigated which one of the pathways was affected by aluminum treatment and found that aluminum affects mainly the PLC/DGK route of PA formation. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 118-133 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 143-160 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 17054901-3 2007 Many receptors also stimulate phospholipase D (PLD), leading to the generation of the versatile lipid, phosphatidic acid. Phosphatidic Acids 103-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 17054901-3 2007 Many receptors also stimulate phospholipase D (PLD), leading to the generation of the versatile lipid, phosphatidic acid. Phosphatidic Acids 103-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 17242159-1 2007 The product of phospholipase D (PLD) enzymatic action in cell membranes, phosphatidic acid (PA), regulates kinases implicated in NADPH oxidase activation, as well as the mammalian target of rapamycin (mTOR) kinase. Phosphatidic Acids 73-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-30 17242159-1 2007 The product of phospholipase D (PLD) enzymatic action in cell membranes, phosphatidic acid (PA), regulates kinases implicated in NADPH oxidase activation, as well as the mammalian target of rapamycin (mTOR) kinase. Phosphatidic Acids 73-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-35 17242159-1 2007 The product of phospholipase D (PLD) enzymatic action in cell membranes, phosphatidic acid (PA), regulates kinases implicated in NADPH oxidase activation, as well as the mammalian target of rapamycin (mTOR) kinase. Phosphatidic Acids 92-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-30 17242159-1 2007 The product of phospholipase D (PLD) enzymatic action in cell membranes, phosphatidic acid (PA), regulates kinases implicated in NADPH oxidase activation, as well as the mammalian target of rapamycin (mTOR) kinase. Phosphatidic Acids 92-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-35 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 87-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 87-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 106-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 106-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17914593-2 2007 PA acts as a second messenger in cell proliferation; therefore PLD is believed to play an important role in carcinogenesis. Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 63-66 17405772-5 2007 Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD). Phosphatidic Acids 97-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 190-205 17405772-5 2007 Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD). Phosphatidic Acids 97-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 207-210 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 143-160 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 162-164 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidic Acids 162-164 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 17465727-2 2007 Genetic and pharmacological methods have implicated PLD and its product PA in a wide variety of cellular processes including vesicle trafficking, receptor signaling, cell proliferation and survival. Phosphatidic Acids 72-74 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-55 17065600-7 2007 Treatment of ES cells with phosphatidic acid (PA) for 3 days induced PRL mRNA expression and morphological changes, which implies that PA is an end-product of PLD activation-induced decidualization. Phosphatidic Acids 27-44 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 159-162 17065600-7 2007 Treatment of ES cells with phosphatidic acid (PA) for 3 days induced PRL mRNA expression and morphological changes, which implies that PA is an end-product of PLD activation-induced decidualization. Phosphatidic Acids 46-48 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 159-162 17065600-7 2007 Treatment of ES cells with phosphatidic acid (PA) for 3 days induced PRL mRNA expression and morphological changes, which implies that PA is an end-product of PLD activation-induced decidualization. Phosphatidic Acids 135-137 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 159-162 17151288-6 2007 In this study, we show that platelet activation by PAR1-activating peptide (PAR1-AP) requires a phospholipase D (PLD)-mediated phosphatidic acid (PA) signaling pathway. Phosphatidic Acids 127-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 113-116 17151288-6 2007 In this study, we show that platelet activation by PAR1-activating peptide (PAR1-AP) requires a phospholipase D (PLD)-mediated phosphatidic acid (PA) signaling pathway. Phosphatidic Acids 51-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 96-111 17151288-6 2007 In this study, we show that platelet activation by PAR1-activating peptide (PAR1-AP) requires a phospholipase D (PLD)-mediated phosphatidic acid (PA) signaling pathway. Phosphatidic Acids 51-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 113-116 17151288-8 2007 Perturbation of this signaling pathway via inhibition of lipid phosphate phosphatase-1 (LPP-1) by propranolol or inhibition of the phosphatidylcholine-derived phosphatidic acid (PA) formation by PLD with a primary alcohol significantly attenuated platelet activation by PAR1-AP. Phosphatidic Acids 178-180 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 195-198 18453106-5 2007 PLD activity is measured as the appearance of its radiolabeled products, phosphatidic acid and phosphatidylethanol. Phosphatidic Acids 73-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidic Acids 14-16 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidic Acids 14-16 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-60 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidic Acids 18-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidic Acids 18-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-60 17233594-3 2007 Phosphatidyl 4-phosphate 5-kinase is stimulated by PA in vitro and this enzyme is the downstream effector of a significant subset of PLD signalling pathways. Phosphatidic Acids 51-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 133-136 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidic Acids 124-141 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidic Acids 124-141 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidic Acids 143-145 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidic Acids 143-145 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 17210675-4 2007 PA is the metabolic product of phospholipase D (PLD), whose activity is elevated in a large number of human cancers, and, like PI3K, has been implicated in the survival of human cancer cells. Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-46 17210675-4 2007 PA is the metabolic product of phospholipase D (PLD), whose activity is elevated in a large number of human cancers, and, like PI3K, has been implicated in the survival of human cancer cells. Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 16854376-4 2006 The production of CpG-induced PLD-dependent phosphatidic acid induced the maturation of phagolysosomes and intracellular mycobacterial growth inhibition. Phosphatidic Acids 44-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 16837165-1 2006 Mammalian target-of-rapamycin (mTOR), which is a master controller of cell growth, senses a mitogenic signal in part through the lipid second messenger phosphatidic acid (PA), generated by phospholipase D (PLD). Phosphatidic Acids 152-169 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 189-204 16837165-1 2006 Mammalian target-of-rapamycin (mTOR), which is a master controller of cell growth, senses a mitogenic signal in part through the lipid second messenger phosphatidic acid (PA), generated by phospholipase D (PLD). Phosphatidic Acids 152-169 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 206-209 16837165-1 2006 Mammalian target-of-rapamycin (mTOR), which is a master controller of cell growth, senses a mitogenic signal in part through the lipid second messenger phosphatidic acid (PA), generated by phospholipase D (PLD). Phosphatidic Acids 171-173 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 189-204 16837165-1 2006 Mammalian target-of-rapamycin (mTOR), which is a master controller of cell growth, senses a mitogenic signal in part through the lipid second messenger phosphatidic acid (PA), generated by phospholipase D (PLD). Phosphatidic Acids 171-173 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 206-209 16973278-5 2006 Furthermore, the concentration of mitochondrial phospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE) was increased and the content of phosphatidic acid (PA), a product of PLD activity, was up-regulated in the mitochondrial membrane fractions of AD brain compared with that of control brain. Phosphatidic Acids 162-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 199-202 16877031-4 2006 PLD and its product, phosphatidic acid, exert their effects by functioning in signal transduction cascades and by influencing the biophysical state of lipid membranes. Phosphatidic Acids 21-38 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 16797533-1 2006 Phospholipase D (PLD), a highly regulated enzyme that generates the second messenger phosphatidic acid, functions in signal transduction, membrane trafficking and cytoskeletal reorganization. Phosphatidic Acids 85-102 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16843818-5 2006 PLD catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA). Phosphatidic Acids 63-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 16916782-4 2006 This short review highlights these various phospholipid inputs into the regulation of PLD activity and also reviews potential roles for PLD-generated phosphatidic acid, particularly a mechanism by which the phospholipid may participate in the process of vesicular trafficking. Phosphatidic Acids 150-167 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-139 16916782-1 2006 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16916782-1 2006 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16843818-5 2006 PLD catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA). Phosphatidic Acids 82-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 16608858-2 2006 Phospholipase D (PLD) generates phosphatidic acid, a lipid second messenger. Phosphatidic Acids 32-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16608858-2 2006 Phospholipase D (PLD) generates phosphatidic acid, a lipid second messenger. Phosphatidic Acids 32-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16921342-1 2006 Phospholipase D (PLD) catalyzes the hydrolysis of the phosphodiester bond of glycerophospholipid phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16424010-3 2006 When formation of phosphatidic acid was inhibited by overexpression of catalytically inactive PLD during etoposide treatment, expression of Egr-1 and PTEN and the apoptotic effect of etoposide were not inhibited. Phosphatidic Acids 18-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-97 16253958-1 2006 Phosphatidylcholine-specific phospholipase D (PLD) is a major cellular source of phosphatidic acid and choline, which regulate various physiopathological processes. Phosphatidic Acids 81-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 16253958-1 2006 Phosphatidylcholine-specific phospholipase D (PLD) is a major cellular source of phosphatidic acid and choline, which regulate various physiopathological processes. Phosphatidic Acids 81-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 16878700-2 2006 The functional significance of PLD derives from its generation of phosphatidic acid, which has both direct signaling properties via activation of numerous kinases, phosphatases, phopspholipases, and other enzymes, as well as via its conversion to diglycerides, the endogenous activators of protein kinase C. The two mammalian PLD isoforms, PLD1 and PLD2, are peripheral membrane proteins that exhibit important physical and functional interactions with the actin cytoskeleton. Phosphatidic Acids 66-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 16878700-2 2006 The functional significance of PLD derives from its generation of phosphatidic acid, which has both direct signaling properties via activation of numerous kinases, phosphatases, phopspholipases, and other enzymes, as well as via its conversion to diglycerides, the endogenous activators of protein kinase C. The two mammalian PLD isoforms, PLD1 and PLD2, are peripheral membrane proteins that exhibit important physical and functional interactions with the actin cytoskeleton. Phosphatidic Acids 66-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 326-329 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidic Acids 106-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidic Acids 106-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidic Acids 125-127 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidic Acids 125-127 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16921342-1 2006 Phospholipase D (PLD) catalyzes the hydrolysis of the phosphodiester bond of glycerophospholipid phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidic Acids 148-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16179605-1 2005 Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules. Phosphatidic Acids 80-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16143829-1 2005 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the glycerolipid phosphatidylcholine, resulting in the production of phosphatidic acid and free choline. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16143829-1 2005 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the glycerolipid phosphatidylcholine, resulting in the production of phosphatidic acid and free choline. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16143829-2 2005 Phosphatidic acid is widely considered to be the intracellular lipid mediator of many of the biological functions attributed to PLD. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 128-131 16143829-7 2005 This review focuses on the lipid precursors and products of mammalian PLD metabolism, especially phosphatidic acid and the roles this lipid performs in the mediation of the functions of PLD. Phosphatidic Acids 97-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 16179605-1 2005 Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules. Phosphatidic Acids 80-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 15837704-9 2005 One of the targets is suggested to be PA, a product of PIP2 hydrolysis via phospholipase C (PLC) or phospholipase D (PLD) activity. Phosphatidic Acids 38-40 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-115 15769249-1 2005 PLD (phospholipase D) activity catalyses the generation of the lipid messenger phosphatidic acid, which has been implicated in a number of cellular processes, particularly the regulation of membrane traffic. Phosphatidic Acids 79-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 15769249-1 2005 PLD (phospholipase D) activity catalyses the generation of the lipid messenger phosphatidic acid, which has been implicated in a number of cellular processes, particularly the regulation of membrane traffic. Phosphatidic Acids 79-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 5-20 15769249-4 2005 Addition of exogenous phosphatidic acid reverses the effects of butan-1-ol, confirming that these effects are caused by inhibition of PLD. Phosphatidic Acids 22-39 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 134-137 15769249-6 2005 Inhibition of PLD caused a major decrease in the synthesis of PtdIns(4,5)P2, which could again be reversed by exogenously applied phosphatidic acid. Phosphatidic Acids 130-147 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 15772157-3 2005 We show here that phospholipase D (PLD) production of the lipid phosphatidic acid (PA) is a key event in the fusion process. Phosphatidic Acids 64-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-33 15772157-3 2005 We show here that phospholipase D (PLD) production of the lipid phosphatidic acid (PA) is a key event in the fusion process. Phosphatidic Acids 64-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 15772157-3 2005 We show here that phospholipase D (PLD) production of the lipid phosphatidic acid (PA) is a key event in the fusion process. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-33 15772157-3 2005 We show here that phospholipase D (PLD) production of the lipid phosphatidic acid (PA) is a key event in the fusion process. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 16222086-1 2005 Phospholipase D (PLD) hydrolyzes structural phospholipids of biological membrane to produce phosphatidic acid (PA) and a free-head group. Phosphatidic Acids 92-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16222086-1 2005 Phospholipase D (PLD) hydrolyzes structural phospholipids of biological membrane to produce phosphatidic acid (PA) and a free-head group. Phosphatidic Acids 92-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16222086-1 2005 Phospholipase D (PLD) hydrolyzes structural phospholipids of biological membrane to produce phosphatidic acid (PA) and a free-head group. Phosphatidic Acids 111-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16222086-1 2005 Phospholipase D (PLD) hydrolyzes structural phospholipids of biological membrane to produce phosphatidic acid (PA) and a free-head group. Phosphatidic Acids 111-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16099207-2 2005 Recent results have provided insights into the molecular mechanism by which PLD and its lipid product phosphatidic acid (PA) participate in cell signaling. Phosphatidic Acids 102-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-79 16099207-2 2005 Recent results have provided insights into the molecular mechanism by which PLD and its lipid product phosphatidic acid (PA) participate in cell signaling. Phosphatidic Acids 121-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-79 15837704-9 2005 One of the targets is suggested to be PA, a product of PIP2 hydrolysis via phospholipase C (PLC) or phospholipase D (PLD) activity. Phosphatidic Acids 38-40 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 117-120 15803754-3 2004 The activity of PLD was measured by the production of 3H-phosphatidylethanol from phosphatidic acid (PA), and the expression of PLD or IL-2 Ralpha was determined by reverse transcription-polymerase chain reaction (RT-PCR) analysis. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 15451027-0 2005 Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils. Phosphatidic Acids 4-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-76 15451027-4 2005 One of the functions of the lipid product, phosphatidic acid (PA), of PLD action in neutrophils is to promote degranulation. Phosphatidic Acids 43-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 15451027-4 2005 One of the functions of the lipid product, phosphatidic acid (PA), of PLD action in neutrophils is to promote degranulation. Phosphatidic Acids 62-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 15451027-6 2005 The results show that exogenous LPA increased PA formation, PLD activity and degranulation by human neutrophils in a time and concentration dependent manner. Phosphatidic Acids 33-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-63 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidic Acids 90-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-26 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidic Acids 90-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 28-31 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidic Acids 109-111 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-26 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidic Acids 109-111 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 28-31 15843515-10 2005 These results suggested that the production of phosphatidic acid by PLD facilitates activation of PKC and, in turn, degranulation, although additional PLD-dependent processes appear to be critical for Ag-mediated degranulation. Phosphatidic Acids 47-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 68-71 15803754-3 2004 The activity of PLD was measured by the production of 3H-phosphatidylethanol from phosphatidic acid (PA), and the expression of PLD or IL-2 Ralpha was determined by reverse transcription-polymerase chain reaction (RT-PCR) analysis. Phosphatidic Acids 101-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 15803754-6 2004 Our results indicated that (1) LPS-stimulated pHi elevation was PKC dependent; (2) After 30 min stimulation, LPS increased PLD activity via a measured production of 3H-phosphatidylethanol from phosphatidic acid and the initiation of PLD1a mRNA expression started; (2) LPS stimulated IL-2 R expression but not IL-2 and IL-4 secretion. Phosphatidic Acids 193-210 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-126 15210717-5 2004 Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. Phosphatidic Acids 228-230 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 15210717-5 2004 Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. Phosphatidic Acids 209-226 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 15210717-5 2004 Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. Phosphatidic Acids 256-258 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 15087463-6 2004 Most importantly, blockade of PLD-catalyzed phosphatidic acid formation using butan-1-ol inhibited insulin secretion in both MIN6 cells and isolated pancreatic islets. Phosphatidic Acids 44-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 15255942-7 2004 Taken together, these results indicate that PLD activation plays an important role in carbachol-induced astroglial cell proliferation by generating the second messenger PA, which activates PKC zeta. Phosphatidic Acids 169-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 44-47 15255942-8 2004 Moreover, the effect of ethanol on carbachol-induced proliferation appears to be mediated, at least in part, by its ability to interact with PLD leading to a decreased synthesis of PA. Phosphatidic Acids 181-183 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 141-144 15206940-8 2004 Moreover, propranolol, which causes an increase in PLD-derived phosphatidic acid accumulation, caused a selective increase in agonist-stimulated myeloperoxidase release. Phosphatidic Acids 63-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 14769825-3 2004 We studied the role of PLD in the phosphorylation of p70(S6K) and 4E-BP1 induced by lysophosphatidic acid (LPA) and platelet-derived growth factor (PDGF) using fibroblasts deficient in PLD activity and also 1-butanol, which inhibits phosphatidic acid production by PLD. Phosphatidic Acids 88-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 23-26 14975729-5 2004 The involvement of PLD is supported by specific inhibition of F-actin formation during sperm capacitation by PLD inhibitors and the stimulation of fast F-actin formation by exogenous PLD or phosphatidic acid (PA). Phosphatidic Acids 190-207 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 19-22 14975729-5 2004 The involvement of PLD is supported by specific inhibition of F-actin formation during sperm capacitation by PLD inhibitors and the stimulation of fast F-actin formation by exogenous PLD or phosphatidic acid (PA). Phosphatidic Acids 209-211 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 19-22 14871550-1 2004 Phospholipase D (PLD) plays a central role in receptor-mediated breakdown of choline phospholipids and formation of phosphatidic acid (PA), an important regulator of cardiac function. Phosphatidic Acids 116-133 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 14871550-1 2004 Phospholipase D (PLD) plays a central role in receptor-mediated breakdown of choline phospholipids and formation of phosphatidic acid (PA), an important regulator of cardiac function. Phosphatidic Acids 116-133 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 14871550-1 2004 Phospholipase D (PLD) plays a central role in receptor-mediated breakdown of choline phospholipids and formation of phosphatidic acid (PA), an important regulator of cardiac function. Phosphatidic Acids 135-137 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 14871550-1 2004 Phospholipase D (PLD) plays a central role in receptor-mediated breakdown of choline phospholipids and formation of phosphatidic acid (PA), an important regulator of cardiac function. Phosphatidic Acids 135-137 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 14871550-6 2004 PIP2-stimulated PLD activity was accompanied by a consecutive increase in diacylglycerol, indicating dephosphorylation of PA by PA phosphohydrolase. Phosphatidic Acids 122-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 12787242-0 2003 Substrate preference of stress-activated phospholipase D in Chlamydomonas and its contribution to PA formation. Phosphatidic Acids 98-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidic Acids 101-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidic Acids 101-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 12963729-6 2003 In both mPA-PLA1alpha and beta-expressing cells, most of the PA generated by the phospholipase D (PLD) treatment was converted to LPA, whereas in control cells it was converted to diacylglycerol. Phosphatidic Acids 9-11 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 81-96 12963729-6 2003 In both mPA-PLA1alpha and beta-expressing cells, most of the PA generated by the phospholipase D (PLD) treatment was converted to LPA, whereas in control cells it was converted to diacylglycerol. Phosphatidic Acids 9-11 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 98-101 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidic Acids 67-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidic Acids 86-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 12935885-2 2003 It has been suggested that phosphatidic acid, produced upon activation of phospholipase D (PLD), is a common mediator of growth factor activation of mTOR signaling. Phosphatidic Acids 27-44 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-89 12935885-2 2003 It has been suggested that phosphatidic acid, produced upon activation of phospholipase D (PLD), is a common mediator of growth factor activation of mTOR signaling. Phosphatidic Acids 27-44 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 91-94 12813467-3 2003 mTOR signaling was reported to require phosphatidic acid (PA), the metabolic product of phospholipase D (PLD). Phosphatidic Acids 39-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-103 12813467-3 2003 mTOR signaling was reported to require phosphatidic acid (PA), the metabolic product of phospholipase D (PLD). Phosphatidic Acids 39-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 105-108 12813467-3 2003 mTOR signaling was reported to require phosphatidic acid (PA), the metabolic product of phospholipase D (PLD). Phosphatidic Acids 58-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-103 12813467-3 2003 mTOR signaling was reported to require phosphatidic acid (PA), the metabolic product of phospholipase D (PLD). Phosphatidic Acids 58-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 105-108 12837850-8 2003 SK-OV-3 cells express and secrete a phospholipase A2 activity that can generate LPA from the lipid product of PLD, phosphatidic acid. Phosphatidic Acids 115-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 110-113 12787242-4 2003 This allowed us to establish: (i) PLD"s in vivo substrate preference; and (ii) PLD"s contribution to PA formation during stress signalling. Phosphatidic Acids 101-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 79-82 12787242-8 2003 The fatty acid composition of PA was much more complex, reflecting the different contributions from the PLC/DGK and PLD pathways. Phosphatidic Acids 30-32 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 116-119 12787242-9 2003 During KCl-induced stress, the PA rise was largely accounted for by PLD activity. Phosphatidic Acids 31-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 68-71 12787242-10 2003 In contrast, PLD"s contribution to hyperosmotic stress-induced PA was less, being approximately 63% of the total increase. Phosphatidic Acids 63-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 13-16 12525155-3 2003 BK and S1P each elicited a sustained increase in phosphatidic acid content through a rapid and transient activation of PLD. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidic Acids 58-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidic Acids 77-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidic Acids 77-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidic Acids 58-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidic Acids 65-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12724857-6 2003 The initial PA burst was due to phospholipase D (PLD)-mediated PC hydrolysis. Phosphatidic Acids 12-14 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-47 12724857-6 2003 The initial PA burst was due to phospholipase D (PLD)-mediated PC hydrolysis. Phosphatidic Acids 12-14 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidic Acids 65-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidic Acids 140-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12162465-0 2002 Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung. Phosphatidic Acids 16-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidic Acids 140-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidic Acids 159-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidic Acids 159-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12162465-5 2002 PA derived from the PLD pathway has second-messenger functions. Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-23 11927657-2 2002 In accordance with this, the PLD product phosphatidic acid (PA) was able to induce mobilization of secretory vesicles. Phosphatidic Acids 41-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 11944907-1 2002 One of the proposed functions of phosphatidic acid (PA) formation from phospholipase D (PLD) activation in neutrophils is to promote degranulation induced by receptor agonists. Phosphatidic Acids 33-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-86 11944907-1 2002 One of the proposed functions of phosphatidic acid (PA) formation from phospholipase D (PLD) activation in neutrophils is to promote degranulation induced by receptor agonists. Phosphatidic Acids 33-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-91 11944907-1 2002 One of the proposed functions of phosphatidic acid (PA) formation from phospholipase D (PLD) activation in neutrophils is to promote degranulation induced by receptor agonists. Phosphatidic Acids 52-54 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-86 11944907-1 2002 One of the proposed functions of phosphatidic acid (PA) formation from phospholipase D (PLD) activation in neutrophils is to promote degranulation induced by receptor agonists. Phosphatidic Acids 52-54 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-91 12191592-2 2002 PLD metabolizes phosphatidylcholine to generate phosphatidic acid (PA). Phosphatidic Acids 48-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 12191592-2 2002 PLD metabolizes phosphatidylcholine to generate phosphatidic acid (PA). Phosphatidic Acids 67-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 11906165-4 2002 During established [Ca(2+)](i) oscillations induced by 1 microM histamine, 0.3% n-butanol, which "functionally" redirects phosphatidic acid formed by PLD to PBt, decreased [Ca(2+)](i) oscillation frequency by approximately 50% and produced a similar reduction in NF-kappaB activity. Phosphatidic Acids 122-139 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 150-153 11927657-2 2002 In accordance with this, the PLD product phosphatidic acid (PA) was able to induce mobilization of secretory vesicles. Phosphatidic Acids 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 11839707-8 2002 Furthermore, TNF-alpha pretreated cells were found to have decreased phosphatidic acid levels, the intermediate product of the PLD pathway, which indicates upregulation of the enzyme phosphatidic acid phosphatase. Phosphatidic Acids 69-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 127-130 11830497-2 2002 Here it is postulated that increased PLD activity generating phosphatidic acid and diacylglycerol (DAG) is essential for superoxide release and degranulation and that ceramide, previously shown to be generated during PMN activation, inhibits PLD activation, thereby leading to inhibition of PMN function. Phosphatidic Acids 61-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 11854442-6 2002 In addition, evidence that PLD was involved in the stimulation of COX-2 expression was provided by the observations that COX-2 expression was stimulated by the dioctanoyl phosphatidic acid (PA) and that the prevention of PA dephosphorylation by 1-propranolol potentiated COX-2 expression by IL-1 beta. Phosphatidic Acids 190-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 11854442-6 2002 In addition, evidence that PLD was involved in the stimulation of COX-2 expression was provided by the observations that COX-2 expression was stimulated by the dioctanoyl phosphatidic acid (PA) and that the prevention of PA dephosphorylation by 1-propranolol potentiated COX-2 expression by IL-1 beta. Phosphatidic Acids 221-223 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 11747992-1 2002 In human airway epithelial cells, sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA) stimulated the production of phosphatidic acid (PA), which was inhibited by the primary alcohol butan-1-ol, but not by the inactive butan-2-ol, clearly indicating phospholipase D (PLD) involvement. Phosphatidic Acids 72-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 259-274 11747992-1 2002 In human airway epithelial cells, sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA) stimulated the production of phosphatidic acid (PA), which was inhibited by the primary alcohol butan-1-ol, but not by the inactive butan-2-ol, clearly indicating phospholipase D (PLD) involvement. Phosphatidic Acids 72-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 276-279 11747992-1 2002 In human airway epithelial cells, sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA) stimulated the production of phosphatidic acid (PA), which was inhibited by the primary alcohol butan-1-ol, but not by the inactive butan-2-ol, clearly indicating phospholipase D (PLD) involvement. Phosphatidic Acids 92-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 259-274 11747992-1 2002 In human airway epithelial cells, sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA) stimulated the production of phosphatidic acid (PA), which was inhibited by the primary alcohol butan-1-ol, but not by the inactive butan-2-ol, clearly indicating phospholipase D (PLD) involvement. Phosphatidic Acids 92-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 276-279 11749856-0 2001 Propranolol increases phosphatidic acid level via activation of phospholipase D. Phosphatidic Acids 22-39 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 64-79 11500317-1 2001 GLUT-4-containing membranes immunoprecipitated from insulin-stimulated rat skeletal muscle produce the phospholipase D (PLD) product phosphatidic acid. Phosphatidic Acids 133-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-118 11500317-1 2001 GLUT-4-containing membranes immunoprecipitated from insulin-stimulated rat skeletal muscle produce the phospholipase D (PLD) product phosphatidic acid. Phosphatidic Acids 133-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 120-123 11530878-6 2001 This review summarises the data implicating signaling via PLD in these cell functions, obtained from: (i) molecular analyses of PLD/effector interactions, (ii) correlation between PA production and cell responses, (iii) experimental manipulation of PA levels, (iv) inhibition of PLD regulators, and (v) direct inhibition of PA production. Phosphatidic Acids 180-182 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 11530878-6 2001 This review summarises the data implicating signaling via PLD in these cell functions, obtained from: (i) molecular analyses of PLD/effector interactions, (ii) correlation between PA production and cell responses, (iii) experimental manipulation of PA levels, (iv) inhibition of PLD regulators, and (v) direct inhibition of PA production. Phosphatidic Acids 249-251 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 11530878-6 2001 This review summarises the data implicating signaling via PLD in these cell functions, obtained from: (i) molecular analyses of PLD/effector interactions, (ii) correlation between PA production and cell responses, (iii) experimental manipulation of PA levels, (iv) inhibition of PLD regulators, and (v) direct inhibition of PA production. Phosphatidic Acids 249-251 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidic Acids 151-168 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 219-234 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidic Acids 151-168 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 236-239 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidic Acids 170-172 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 219-234 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidic Acids 170-172 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 236-239 11530878-3 2001 Research in this field has intensified, due in part to the recent cloning and partial characterization of the two PLD isoforms in mammalian cells, and this work has contributed significantly to our understanding of events downstream of PA generation. Phosphatidic Acids 236-238 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 11749856-9 2001 CONCLUSION: Propranolol induces rapid activation of PLD activity, which results in the increase in intracellular level of PA. Phosphatidic Acids 122-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-55 11294898-1 2001 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid. Phosphatidic Acids 65-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11294898-1 2001 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid. Phosphatidic Acids 65-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11401484-1 2001 Phosphatidic acid (PA), the product of phospholipase D (PLD) metabolism, is not only an important second messenger in neutrophil signal transduction but PA generation increases membrane fusogenicity. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-54 11401484-1 2001 Phosphatidic acid (PA), the product of phospholipase D (PLD) metabolism, is not only an important second messenger in neutrophil signal transduction but PA generation increases membrane fusogenicity. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 11401484-1 2001 Phosphatidic acid (PA), the product of phospholipase D (PLD) metabolism, is not only an important second messenger in neutrophil signal transduction but PA generation increases membrane fusogenicity. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-54 11401484-1 2001 Phosphatidic acid (PA), the product of phospholipase D (PLD) metabolism, is not only an important second messenger in neutrophil signal transduction but PA generation increases membrane fusogenicity. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 11401484-1 2001 Phosphatidic acid (PA), the product of phospholipase D (PLD) metabolism, is not only an important second messenger in neutrophil signal transduction but PA generation increases membrane fusogenicity. Phosphatidic Acids 153-155 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-54 11401484-1 2001 Phosphatidic acid (PA), the product of phospholipase D (PLD) metabolism, is not only an important second messenger in neutrophil signal transduction but PA generation increases membrane fusogenicity. Phosphatidic Acids 153-155 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21331729-1 2001 Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2). Phosphatidic Acids 99-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21331729-1 2001 Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2). Phosphatidic Acids 99-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidic Acids 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidic Acids 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11154852-5 2000 Concomitantly, ethanol caused the formation of phosphatidylethanol (PEth) by phospholipase D (PLD) and reduced PLD-mediated formation of phosphatidic acid (PA). Phosphatidic Acids 137-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 11154852-5 2000 Concomitantly, ethanol caused the formation of phosphatidylethanol (PEth) by phospholipase D (PLD) and reduced PLD-mediated formation of phosphatidic acid (PA). Phosphatidic Acids 156-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 10591409-6 1999 Meanwhile, lysophosphatidylcholine (IC50, 25 microM) and phosphatidic acid (IC50, >100 microM), ionic amphiphiles, inhibited the GPI-PLD activity, which was determined in the presence of monooleoylglycerol as a detergent. Phosphatidic Acids 57-74 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 132-139 10974061-4 2000 However, this separation principle is not applicable in evaluating N-acylphosphatidylethanolamine (NAPE)-hydrolyzing PLD activity, which produces two lipophilic products, N-acylethanolamine (NAE) and phosphatidic acid. Phosphatidic Acids 200-217 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 117-120 10642495-1 2000 Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. Phosphatidic Acids 193-210 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-107 10642495-1 2000 Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. Phosphatidic Acids 193-210 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 10660303-1 2000 The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway. Phosphatidic Acids 205-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 127-142 10660303-1 2000 The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway. Phosphatidic Acids 205-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 144-147 10589680-2 1999 Unexpectedly, we find that the GTPgammaS-dependent activator of PI(4)P5Kalpha is the small G protein ADP-ribosylation factor (ARF) and that the activation strictly requires phosphatidic acid, the product of phospholipase D (PLD). Phosphatidic Acids 173-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 207-222 10589680-2 1999 Unexpectedly, we find that the GTPgammaS-dependent activator of PI(4)P5Kalpha is the small G protein ADP-ribosylation factor (ARF) and that the activation strictly requires phosphatidic acid, the product of phospholipase D (PLD). Phosphatidic Acids 173-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 224-227 10545222-1 1999 Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a plasma enzyme with extensive sequence similarity to integrin alpha subunits, is inhibited by micromolar concentrations of lipid A, phosphatidic acid (PA) and lysophosphatidic acid (M. G. Low and K.-S. Huang, J. Biol. Phosphatidic Acids 217-219 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-62 10545222-0 1999 Inhibition of the plasma glycosylphosphatidylinositol-specific phospholipase D by synthetic analogs of lipid A and phosphatidic acid. Phosphatidic Acids 115-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-78 10545222-1 1999 Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a plasma enzyme with extensive sequence similarity to integrin alpha subunits, is inhibited by micromolar concentrations of lipid A, phosphatidic acid (PA) and lysophosphatidic acid (M. G. Low and K.-S. Huang, J. Biol. Phosphatidic Acids 198-215 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-53 10545222-1 1999 Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a plasma enzyme with extensive sequence similarity to integrin alpha subunits, is inhibited by micromolar concentrations of lipid A, phosphatidic acid (PA) and lysophosphatidic acid (M. G. Low and K.-S. Huang, J. Biol. Phosphatidic Acids 198-215 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-62 10545222-1 1999 Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a plasma enzyme with extensive sequence similarity to integrin alpha subunits, is inhibited by micromolar concentrations of lipid A, phosphatidic acid (PA) and lysophosphatidic acid (M. G. Low and K.-S. Huang, J. Biol. Phosphatidic Acids 217-219 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-53 10940387-3 2000 Here we show that the depletion of cellular Ca2+ stores by thapsigargin or bradykinin is functionally linked to a phosphoinositide-specific phospholipase D (PLD) activity in cultured vascular smooth muscle cells (VSMC), and that phosphatidic acid formed via PLD enhances sustained calcium entry in this cell type. Phosphatidic Acids 229-246 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 140-155 10940387-3 2000 Here we show that the depletion of cellular Ca2+ stores by thapsigargin or bradykinin is functionally linked to a phosphoinositide-specific phospholipase D (PLD) activity in cultured vascular smooth muscle cells (VSMC), and that phosphatidic acid formed via PLD enhances sustained calcium entry in this cell type. Phosphatidic Acids 229-246 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 157-160 10873862-2 2000 PLD hydrolyzes the terminal phosphodiester bond of phospholipids to phosphatidic acid and a hydrophilic constituent. Phosphatidic Acids 68-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 10792830-1 2000 In mammalian cells, phospholipase D (PLD) and its product phosphatidic acid (PA) are involved in a number of signalling cascades, including cell proliferation, membrane trafficking and defence responses. Phosphatidic Acids 58-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 10792830-1 2000 In mammalian cells, phospholipase D (PLD) and its product phosphatidic acid (PA) are involved in a number of signalling cascades, including cell proliferation, membrane trafficking and defence responses. Phosphatidic Acids 58-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 10792830-1 2000 In mammalian cells, phospholipase D (PLD) and its product phosphatidic acid (PA) are involved in a number of signalling cascades, including cell proliferation, membrane trafficking and defence responses. Phosphatidic Acids 77-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 10792830-1 2000 In mammalian cells, phospholipase D (PLD) and its product phosphatidic acid (PA) are involved in a number of signalling cascades, including cell proliferation, membrane trafficking and defence responses. Phosphatidic Acids 77-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 10792830-6 2000 Part of the PA produced is due to PLD activity as measured by the in vivo transphosphatidylation of 1-butanol, and part is due to diacylglycerol kinase activity as monitored via 32P-PA formation in a differential labelling protocol. Phosphatidic Acids 12-14 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-37 10683250-10 2000 Phosphatidic acid formation was insensitive to protein kinase C inhibitors and almost completely inhibited by pertussis toxin treatment, suggesting that SPP activates phospholipase D via a G(i/o) protein-coupled receptor. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 167-182 10597278-7 1999 This increase did not result from activation of phospholipase D (PLD), although the enzyme was activatable by treatment with phorbol ester Thus, a phosphohydrolase-mediated DAG synthesis from PLD-produced PA can be excluded. Phosphatidic Acids 205-207 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 192-195 10545222-9 1999 Inhibition of GPI-PLD by long-chain PA could not be blocked by high concentrations of glycerol 1-phosphate or dibutyryl PA. Phosphatidic Acids 36-38 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-21 10548551-7 1999 Furthermore, 5-HT and 2Me-5-HT stimulated phospholipase D (PLD) activity, as measured by the production of phosphatidylethanol and phosphatidylbutanol at the expense of phosphatidic acid (PA). Phosphatidic Acids 169-186 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 59-62 10548551-7 1999 Furthermore, 5-HT and 2Me-5-HT stimulated phospholipase D (PLD) activity, as measured by the production of phosphatidylethanol and phosphatidylbutanol at the expense of phosphatidic acid (PA). Phosphatidic Acids 188-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-57 10548551-7 1999 Furthermore, 5-HT and 2Me-5-HT stimulated phospholipase D (PLD) activity, as measured by the production of phosphatidylethanol and phosphatidylbutanol at the expense of phosphatidic acid (PA). Phosphatidic Acids 188-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 59-62 10548551-9 1999 The PLD/PA pathway stimulated by these two serotonergic agents resulted in the production of 1,2-diacylglycerol (DAG) mass in Jurkat T-cells. Phosphatidic Acids 8-10 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 10564277-2 1999 PC-specific phospholipase D (PLD) and phosphatidic acid phosphohydrolase (PAP) are two pivotal enzymes in this signaling system, and they act in series to generate the biologically active lipids phosphatidic acid (PA) and diglyceride. Phosphatidic Acids 74-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 12-27 10564277-2 1999 PC-specific phospholipase D (PLD) and phosphatidic acid phosphohydrolase (PAP) are two pivotal enzymes in this signaling system, and they act in series to generate the biologically active lipids phosphatidic acid (PA) and diglyceride. Phosphatidic Acids 74-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 10564277-4 1999 We provide the first evidence for a functional role of a type 2 PAP, PAP2b, in the metabolism of PLD-generated PA. Phosphatidic Acids 64-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-100 10482394-8 1999 Taken together, the combined levels of PEt and PA (an end product of phopholipase D, PLD) were about 42-fold higher than the level of AA at 5-10 min. Phosphatidic Acids 47-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 85-88 10794595-2 1999 Plasma membranes were treated with phospholipase D (PLD) to increase concentrations of PA within the membranes. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-50 10529371-4 1999 Using a range of concentrations (3-20 microM) which inhibit ERK activity, PD 98059 inhibited PLD activity induced by fMLP in cytochalasin B-primed PMN, as assessed by production-tritiated phosphatidylethanol (PEt), phosphatidic acid (PA), and hydrolysis of PC. Phosphatidic Acids 215-232 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 10529371-4 1999 Using a range of concentrations (3-20 microM) which inhibit ERK activity, PD 98059 inhibited PLD activity induced by fMLP in cytochalasin B-primed PMN, as assessed by production-tritiated phosphatidylethanol (PEt), phosphatidic acid (PA), and hydrolysis of PC. Phosphatidic Acids 234-236 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 10518598-4 1999 Treatment of guard cell protoplasts with phosphatidic acid (PtdOH), one of the products of PLD activity, led to an inhibition of the activity of the inward K+ channel. Phosphatidic Acids 41-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 91-94 10794595-2 1999 Plasma membranes were treated with phospholipase D (PLD) to increase concentrations of PA within the membranes. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-55 10087440-1 1999 Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidic Acids 105-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 10425391-2 1999 Virtually every cell uses phosphatidylcholine as substrate to produce phosphatidic acid in a controlled reaction catalyzed by specific PLD isoforms. Phosphatidic Acids 70-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 10381372-6 1999 Ethanol acts as an alternate substrate in place of water for PLD producing phosphatidylethanol (PEt) instead of phosphatidic acid. Phosphatidic Acids 112-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 10381372-8 1999 Further evidence for the involvement of PLD in the regulation of cPLA2 came from the observation that the stimulated production of diacylglycerol (for which phosphatidic acid is a major source) was greatly diminished in undifferentiated cells as compared to differentiated cells. Phosphatidic Acids 157-174 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 10087440-1 1999 Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidic Acids 105-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9973503-6 1999 Levels of phosphatidic acid, the physiologic product of PLD-mediated catalysis, were significantly increased in the absence of ethanol (6.4-fold, p < 0.001). Phosphatidic Acids 10-27 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 9873009-3 1999 Evidence that PLD was involved in the stimulation of MMP-9 secretion was provided by the observations that the secretion of MMP-9 was stimulated by the introduction of short-chain phosphatidic acid (PA) into the growth medium and that inhibition of PA production by 1-propanol inhibited secretion. Phosphatidic Acids 180-197 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidic Acids 107-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidic Acids 107-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidic Acids 107-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 198-201 9873061-0 1999 Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. Phosphatidic Acids 33-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidic Acids 67-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidic Acids 67-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidic Acids 86-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidic Acids 86-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 9873061-3 1999 We report here evidence that links the activation of PLD by insulin and the subsequent generation of PA to the activation of the Raf-1-mitogen-activated protein kinase (MAPK) cascade. Phosphatidic Acids 101-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-56 9873009-3 1999 Evidence that PLD was involved in the stimulation of MMP-9 secretion was provided by the observations that the secretion of MMP-9 was stimulated by the introduction of short-chain phosphatidic acid (PA) into the growth medium and that inhibition of PA production by 1-propanol inhibited secretion. Phosphatidic Acids 199-201 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 9873009-3 1999 Evidence that PLD was involved in the stimulation of MMP-9 secretion was provided by the observations that the secretion of MMP-9 was stimulated by the introduction of short-chain phosphatidic acid (PA) into the growth medium and that inhibition of PA production by 1-propanol inhibited secretion. Phosphatidic Acids 249-251 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 10323682-10 1999 Preliminary studies have shown that 1,25(OH)2D3 also activated phosphatidylcholine phospholipase D (PLD) in Caco-2 cells, generating phosphatidic acid and contributing to the sustained rise in DAG. Phosphatidic Acids 133-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 83-98 10323682-10 1999 Preliminary studies have shown that 1,25(OH)2D3 also activated phosphatidylcholine phospholipase D (PLD) in Caco-2 cells, generating phosphatidic acid and contributing to the sustained rise in DAG. Phosphatidic Acids 133-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-103 9813240-1 1998 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9516474-6 1998 PMA also activates phospholipase D (PLD) in these cells and ethanol, a compound that inhibits PLD-mediated phosphatidic acid (PA) formation, blocked AA release. Phosphatidic Acids 107-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-39 10397465-8 1998 In this report we show that there is an increase in phospholipase D (PLD) activity during butyrate-induced differentiation of HT-29 cells as indicated by the formation of phosphatidic acid (PA). Phosphatidic Acids 171-188 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-67 10397465-8 1998 In this report we show that there is an increase in phospholipase D (PLD) activity during butyrate-induced differentiation of HT-29 cells as indicated by the formation of phosphatidic acid (PA). Phosphatidic Acids 171-188 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 10397465-8 1998 In this report we show that there is an increase in phospholipase D (PLD) activity during butyrate-induced differentiation of HT-29 cells as indicated by the formation of phosphatidic acid (PA). Phosphatidic Acids 190-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-67 10397465-8 1998 In this report we show that there is an increase in phospholipase D (PLD) activity during butyrate-induced differentiation of HT-29 cells as indicated by the formation of phosphatidic acid (PA). Phosphatidic Acids 190-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 10397465-10 1998 This PA was formed due to PLD activity that was confirmed by the generation of phosphatidylethanol by in vitro incubation of HT-29 cell homogenates in the presence of ethanol. Phosphatidic Acids 5-7 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 26-29 9754716-2 1998 PLD activation was also analysed by measuring tritiated phosphatidic acid (PA) and diglycerides (GDs) in PMNs labelled with tritiated alkyl-lyso PC. Phosphatidic Acids 75-77 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 9720761-2 1998 With the recent cloning of PLD isoenzymes, their association with low-molecular-weight G proteins, protein kinase C and tyrosine kinases, the availability of antibodies and an understanding of the role of PLD product, phosphatidic acid (PA), in cell physiology, the field is gaining momentum. Phosphatidic Acids 218-235 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 9720761-2 1998 With the recent cloning of PLD isoenzymes, their association with low-molecular-weight G proteins, protein kinase C and tyrosine kinases, the availability of antibodies and an understanding of the role of PLD product, phosphatidic acid (PA), in cell physiology, the field is gaining momentum. Phosphatidic Acids 237-239 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 9720761-3 1998 In this review, we will explore the molecular properties of mammalian PLD and its gene(s), the complexity of this enzyme regulation and the myriad physiological roles for PLD and PA and related metabolic products, with particular emphasis on a role in the activation of NADPH oxidase, or respiratory burst, leading to the generation of oxygen radicals. Phosphatidic Acids 179-181 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 9761774-1 1998 Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Phosphatidic Acids 102-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9761774-1 1998 Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Phosphatidic Acids 102-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9698536-3 1998 Phospholipase D (PLD) production of phosphatidic acid (PA) is thought to be pivotal in reactive oxygen species generation but its role in degranulation (i. e., protease release) remains unclear. Phosphatidic Acids 36-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9698536-3 1998 Phospholipase D (PLD) production of phosphatidic acid (PA) is thought to be pivotal in reactive oxygen species generation but its role in degranulation (i. e., protease release) remains unclear. Phosphatidic Acids 36-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9698536-3 1998 Phospholipase D (PLD) production of phosphatidic acid (PA) is thought to be pivotal in reactive oxygen species generation but its role in degranulation (i. e., protease release) remains unclear. Phosphatidic Acids 55-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9698536-3 1998 Phospholipase D (PLD) production of phosphatidic acid (PA) is thought to be pivotal in reactive oxygen species generation but its role in degranulation (i. e., protease release) remains unclear. Phosphatidic Acids 55-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9698536-4 1998 Our hypothesis was that primed neutrophils require PLD production of PA for maximal activated release of elastase. Phosphatidic Acids 69-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 9575167-0 1998 Activation of phospholipase D by phosphatidic acid. Phosphatidic Acids 33-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-29 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidic Acids 159-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 26-41 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidic Acids 159-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidic Acids 178-180 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 26-41 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidic Acids 178-180 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 9575167-5 1998 Changes in vesicle curvature and fusion were not the reason for PA activation; rather, a metal ion-induced lateral segregation of PA in the vesicle bilayer correlated with PLD activation. Phosphatidic Acids 130-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 172-175 9575167-7 1998 The PA activation was caused by Ca2+.PA interacting with PLD at an allosteric site other than active site. Phosphatidic Acids 4-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 9575167-7 1998 The PA activation was caused by Ca2+.PA interacting with PLD at an allosteric site other than active site. Phosphatidic Acids 37-39 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 9560313-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, generating phosphatidic acid and choline. Phosphatidic Acids 82-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9516474-6 1998 PMA also activates phospholipase D (PLD) in these cells and ethanol, a compound that inhibits PLD-mediated phosphatidic acid (PA) formation, blocked AA release. Phosphatidic Acids 107-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-97 9516474-6 1998 PMA also activates phospholipase D (PLD) in these cells and ethanol, a compound that inhibits PLD-mediated phosphatidic acid (PA) formation, blocked AA release. Phosphatidic Acids 126-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-39 9516474-6 1998 PMA also activates phospholipase D (PLD) in these cells and ethanol, a compound that inhibits PLD-mediated phosphatidic acid (PA) formation, blocked AA release. Phosphatidic Acids 126-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-97 9580032-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells. Phosphatidic Acids 93-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9481487-2 1998 To gain insights into the mechanisms of this priming, we analysed staurosporine effects on formation of second messengers issued from phospholipase D (PLD), i.e., phosphatidic acid (PA) and its dephosphorylated form, diglycerides (DG). Phosphatidic Acids 182-184 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 134-149 9465287-6 1998 On the other hand, late DAG, derived from phosphatidic acid (PA) via PLD, may activate Ca(2+)-independent novel PKC isoforms (nPKC). Phosphatidic Acids 42-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 9465287-6 1998 On the other hand, late DAG, derived from phosphatidic acid (PA) via PLD, may activate Ca(2+)-independent novel PKC isoforms (nPKC). Phosphatidic Acids 61-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 9507109-6 1998 The enhancement of hydrolysis in the presence of PA could also be achieved by prior treatment of pure PC vesicles with PLD, an effect that was dependent on the concentration of PLD and the duration of exposure to this enzyme. Phosphatidic Acids 49-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 9507109-6 1998 The enhancement of hydrolysis in the presence of PA could also be achieved by prior treatment of pure PC vesicles with PLD, an effect that was dependent on the concentration of PLD and the duration of exposure to this enzyme. Phosphatidic Acids 49-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 9580032-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells. Phosphatidic Acids 93-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9366247-5 1997 Moreover, in contrast to sphingosine which activates phospholipase D (PLD) leading to an increase in phosphatidic acid levels, sphingomyelinase, but not ceramide analogs, reduced TPA-stimulated PLD activity. Phosphatidic Acids 101-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 9366248-1 1997 Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids. Phosphatidic Acids 142-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-46 9366248-1 1997 Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids. Phosphatidic Acids 142-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 9366248-1 1997 Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids. Phosphatidic Acids 161-163 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-46 9366248-1 1997 Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids. Phosphatidic Acids 161-163 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-121 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-126 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-121 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-126 9366247-5 1997 Moreover, in contrast to sphingosine which activates phospholipase D (PLD) leading to an increase in phosphatidic acid levels, sphingomyelinase, but not ceramide analogs, reduced TPA-stimulated PLD activity. Phosphatidic Acids 101-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 9245781-6 1997 The release of nascent secretory vesicles from the TGN was sensitive to 1% 1-butanol, a concentration that inhibited PLD-catalyzed formation of phosphatidic acid. Phosphatidic Acids 144-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 117-120 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). Phosphatidic Acids 231-248 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). Phosphatidic Acids 231-248 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). Phosphatidic Acids 250-252 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). Phosphatidic Acids 250-252 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 9310372-7 1997 Furthermore, we demonstrate that phosphatidic acid (PtdH), generated through the action of PLD in response to SCF, is metabolized to diacylglycerol by dephosphorylation. Phosphatidic Acids 33-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 91-94 8816991-11 1996 Therefore, we propose that the PC-PLC pathway may be temporarily inactivated for a short period of time by exposure to pulsed stimuli, and the PC-PLD pathway is up-regulated based on: (1) cellular release of [3H]choline; (2) rapid intracellular formation of [3H]PA followed by [3H]DAG; (3)active transphosphatidylation; and (4) blockade of DAG formation by propranolol. Phosphatidic Acids 262-264 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 146-149 9199889-11 1997 These findings suggest that superoxide anion stimulates intestinal mitochondrial PLD resulting in PE degradation and PA formation. Phosphatidic Acids 117-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 81-84 8911682-4 1996 One such function is neutrophil superoxide generation, which is induced when phosphatidic acid, generated by activated phospholipase D (PLD), facilitates the interaction of a cytoplasmic low-molecular-weight G-protein with dormant, membrane-bound reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Phosphatidic Acids 77-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-134 8911682-4 1996 One such function is neutrophil superoxide generation, which is induced when phosphatidic acid, generated by activated phospholipase D (PLD), facilitates the interaction of a cytoplasmic low-molecular-weight G-protein with dormant, membrane-bound reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Phosphatidic Acids 77-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-139 8768715-3 1996 PMA caused a delayed release of arachidonic acid from PMNL, which occurred within minutes of the generation of the PLD products, phosphatidic acid and diglyceride, from [3H]lysophosphatidylcholine prelabeled PMNL. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 115-118 9271075-1 1997 Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidic Acids 90-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9271075-1 1997 Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidic Acids 90-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9065750-1 1997 Relationships between phospholipases are poorly understood, but phosphatidic acid (PA) and diglycerides (DGs), produced by phospholipase D (PLD) and phosphatidate phosphohydrolase actions, might function as second messengers coupling cell stimulation to cellular responses. Phosphatidic Acids 64-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-138 9065750-1 1997 Relationships between phospholipases are poorly understood, but phosphatidic acid (PA) and diglycerides (DGs), produced by phospholipase D (PLD) and phosphatidate phosphohydrolase actions, might function as second messengers coupling cell stimulation to cellular responses. Phosphatidic Acids 64-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 140-143 9065750-1 1997 Relationships between phospholipases are poorly understood, but phosphatidic acid (PA) and diglycerides (DGs), produced by phospholipase D (PLD) and phosphatidate phosphohydrolase actions, might function as second messengers coupling cell stimulation to cellular responses. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-138 9065750-1 1997 Relationships between phospholipases are poorly understood, but phosphatidic acid (PA) and diglycerides (DGs), produced by phospholipase D (PLD) and phosphatidate phosphohydrolase actions, might function as second messengers coupling cell stimulation to cellular responses. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 140-143 9065750-2 1997 This study investigates the role of PLD-mediated PA and DG formation in inducing phospholipase A2 (PLA2) activity in intact human neutrophils (PMNs) and in PMNs permeabilized with Staphylococcus aureus alpha-toxin. Phosphatidic Acids 49-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-39 8906565-12 1996 The main lipid mediator produced by PLD, phosphatidic acid, could regulate membrane traffic events by direct regulation of target proteins involved in vesicle targeting, docking and fusion. Phosphatidic Acids 41-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-39 8681422-2 1996 Phospholipase D catalyzed hydrolysis of phospholipids generates phosphatidic acid (PA) which is subsequently metabolized to lyso-PA (LPA) or diacylglycerol (DAG). Phosphatidic Acids 64-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 8681422-2 1996 Phospholipase D catalyzed hydrolysis of phospholipids generates phosphatidic acid (PA) which is subsequently metabolized to lyso-PA (LPA) or diacylglycerol (DAG). Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 8681427-3 1996 Phospholipase D catalyzes the hydrolysis of phospholipids to generate phosphatidic acid with secondarily generation of diradylglycerol; both of these products have been implicated as second messengers. Phosphatidic Acids 70-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 8681431-6 1996 Similar to activated PKC, some of the primary and secondary products of PLD-mediated phospholipid hydrolysis, including phosphatidic acid, 1,2-diacylglycerol, choline phosphate and ethanolamine, also exhibit mitogenic/co-mitogenic effects in cultured cells. Phosphatidic Acids 120-137 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 72-75 8928743-13 1996 However, PMA blocked inhibition of protein kinase C (PKC) and secretion by quercetin, suggesting that PA formed by PLD supports PKC activation and GTP gamma S-induced secretion. Phosphatidic Acids 102-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 115-118 8699936-4 1996 Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-36 8699936-4 1996 Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 8574168-7 1995 Since phosphatidic acid, produced as a result of PLD activation, may be implicated in the regulation of several oncogenes, perturbations of the PLD system could theoretically be important for the development of PV. Phosphatidic Acids 6-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 7477381-1 1995 An early response to the tyrosine kinase activity of v-Src is an increase in phospholipase D (PLD) activity, which leads to the generation of biologically active lipid second messengers, including phosphatidic acid, lysophosphatidic acid and diacylglycerol. Phosphatidic Acids 197-214 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 77-92 7477381-1 1995 An early response to the tyrosine kinase activity of v-Src is an increase in phospholipase D (PLD) activity, which leads to the generation of biologically active lipid second messengers, including phosphatidic acid, lysophosphatidic acid and diacylglycerol. Phosphatidic Acids 197-214 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-97 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidic Acids 170-187 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidic Acids 170-187 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 7672124-2 1995 On the basis that phosphatidic acid is a mitogen, PLD is often considered to have a major role in the regulation of cell growth by PKC activators. Phosphatidic Acids 18-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 7761430-2 1995 ARF also stimulates phospholipase D (PLD) activity, which can alter the lipid content of membranes by conversion of phospholipids into phosphatidic acid. Phosphatidic Acids 135-152 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 7538121-1 1995 Many receptors, in response to their specific ligands, trigger activation of phospholipase D (PLD), resulting in the production of phosphatidic acid which, in turn, is acted upon by a specific phosphatase, phosphatidate phosphohydrolase, to produce diacylglycerol. Phosphatidic Acids 131-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-97 7538121-9 1995 Measurements of phosphatidic acid and diacylglycerol levels at increasing amounts of ethanol demonstrated that PLD and phosphatidate phosphohydrolase are responsible for generating the majority of the diacylglycerol accumulating in MDCK-D1 cell nuclei. Phosphatidic Acids 16-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 7761430-2 1995 ARF also stimulates phospholipase D (PLD) activity, which can alter the lipid content of membranes by conversion of phospholipids into phosphatidic acid. Phosphatidic Acids 135-152 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 7802684-1 1994 The activation of phospholipase D (PLD) induced by formyl peptides (fMLP), as evaluated by production of tritiated phosphatidylethanol (PEt) and phosphatidic acid (PA) in polymorphonuclear leukocytes (PMN), was markedly enhanced (50-125%) by low okadaic acid concentrations (0.25-0.5 microM) but inhibited by higher concentrations (2-3 microM), although the drug caused protein hyperphosphorylation. Phosphatidic Acids 145-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-33 7583175-12 1995 PLD is stimulated by LPS to release phosphatidic acid (PA). Phosphatidic Acids 36-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 7583175-12 1995 PLD is stimulated by LPS to release phosphatidic acid (PA). Phosphatidic Acids 55-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 7882615-3 1995 The present study was designed to examine the role of phospholipase D (PLD) and its product, phosphatidic acid, in the intracellular signal transduction mechanisms that mediate induction of MMP-2 by laminin. Phosphatidic Acids 93-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 7882615-9 1995 These data indicate that laminin-induced activation of PLD and consequent generation of phosphatidic acid are involved in a signal propagation pathway leading to induction of MMP-2 and enhanced invasiveness of metastatic tumor cells. Phosphatidic Acids 88-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-58 7802684-1 1994 The activation of phospholipase D (PLD) induced by formyl peptides (fMLP), as evaluated by production of tritiated phosphatidylethanol (PEt) and phosphatidic acid (PA) in polymorphonuclear leukocytes (PMN), was markedly enhanced (50-125%) by low okadaic acid concentrations (0.25-0.5 microM) but inhibited by higher concentrations (2-3 microM), although the drug caused protein hyperphosphorylation. Phosphatidic Acids 145-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 7802684-1 1994 The activation of phospholipase D (PLD) induced by formyl peptides (fMLP), as evaluated by production of tritiated phosphatidylethanol (PEt) and phosphatidic acid (PA) in polymorphonuclear leukocytes (PMN), was markedly enhanced (50-125%) by low okadaic acid concentrations (0.25-0.5 microM) but inhibited by higher concentrations (2-3 microM), although the drug caused protein hyperphosphorylation. Phosphatidic Acids 164-166 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-33 7802684-1 1994 The activation of phospholipase D (PLD) induced by formyl peptides (fMLP), as evaluated by production of tritiated phosphatidylethanol (PEt) and phosphatidic acid (PA) in polymorphonuclear leukocytes (PMN), was markedly enhanced (50-125%) by low okadaic acid concentrations (0.25-0.5 microM) but inhibited by higher concentrations (2-3 microM), although the drug caused protein hyperphosphorylation. Phosphatidic Acids 164-166 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 8051627-6 1994 Phosphatidic acid produced from the membrane phospholipids through the PLD activation was shown to act as an intracellular mediator to stimulate the PLA2 activation. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-74 8077660-3 1994 We have detected activatable PLD in Jurkat cells, and we have found that addition of phosphatidic acid (PA), the physiologic product of PLD action on phospholipids, is rapidly incorporated into Jurkat cells and leads to activation of transcription factor AP-1. Phosphatidic Acids 85-102 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-139 8077660-3 1994 We have detected activatable PLD in Jurkat cells, and we have found that addition of phosphatidic acid (PA), the physiologic product of PLD action on phospholipids, is rapidly incorporated into Jurkat cells and leads to activation of transcription factor AP-1. Phosphatidic Acids 104-106 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 8077660-3 1994 We have detected activatable PLD in Jurkat cells, and we have found that addition of phosphatidic acid (PA), the physiologic product of PLD action on phospholipids, is rapidly incorporated into Jurkat cells and leads to activation of transcription factor AP-1. Phosphatidic Acids 104-106 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-139 8077660-11 1994 These data indicate that PLD stimulation can activate the transcription factor AP-1 in T lymphocytes, and suggest that the induction of AP-1 enhancer factor activity by PA is mediated via PKC stimulation, either through a direct activating effect of PA or through PA-derived diacylglycerol formation. Phosphatidic Acids 169-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-28 7931078-12 1994 In cells labeled with L-lyso-3-PC 1-[1-14C]palmitoyl, PLD but not IL-4, increased the production of phosphatidic acid (PA) and phosphatidyl-ethanol when pretreated with ethanol. Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 7931078-12 1994 In cells labeled with L-lyso-3-PC 1-[1-14C]palmitoyl, PLD but not IL-4, increased the production of phosphatidic acid (PA) and phosphatidyl-ethanol when pretreated with ethanol. Phosphatidic Acids 119-121 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 8207217-4 1994 In the presence of propranolol (phosphatidic acid (PA) phosphohydrolase inhibitor), or ethanol, the activation of PLD results in the modulation of PA and/or diglyceride (DG) generation, producing an irregularity in O2- production. Phosphatidic Acids 32-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 8207217-4 1994 In the presence of propranolol (phosphatidic acid (PA) phosphohydrolase inhibitor), or ethanol, the activation of PLD results in the modulation of PA and/or diglyceride (DG) generation, producing an irregularity in O2- production. Phosphatidic Acids 51-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 8207217-4 1994 In the presence of propranolol (phosphatidic acid (PA) phosphohydrolase inhibitor), or ethanol, the activation of PLD results in the modulation of PA and/or diglyceride (DG) generation, producing an irregularity in O2- production. Phosphatidic Acids 147-149 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidic Acids 111-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidic Acids 111-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidic Acids 130-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidic Acids 130-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 8176221-7 1994 Moreover, the addition of ethanol diverted PLD into the formation of phosphatidylethanol (PEt) thus inhibiting the amounts of PA and DAG formed. Phosphatidic Acids 126-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 8504157-2 1993 The PLD activity was detected as signal-induced synthesis of phosphatidic acid (PA) and in the presence of ethanol, phosphatidylethanol (PEt). Phosphatidic Acids 61-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 8268464-2 1993 The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells. Phosphatidic Acids 34-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 8268464-2 1993 The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells. Phosphatidic Acids 53-55 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 8268464-10 1993 The PLD product PA was identified as a precursor of "late phase" diacylglycerol which, at least in some cases, was temporally correlated and causally related to the sustained activation of PKC. Phosphatidic Acids 16-18 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 8392931-0 1993 Rapid attenuation of receptor-induced diacylglycerol and phosphatidic acid by phospholipase D-mediated transphosphatidylation: formation of bisphosphatidic acid. Phosphatidic Acids 57-74 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 78-93 8392931-3 1993 We here report a novel mechanism of DG attenuation by phospholipase D (PLD), which also precludes the production of another (putative) second messenger, phosphatidic acid (PA). Phosphatidic Acids 153-170 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 8392931-3 1993 We here report a novel mechanism of DG attenuation by phospholipase D (PLD), which also precludes the production of another (putative) second messenger, phosphatidic acid (PA). Phosphatidic Acids 153-170 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-74 8392931-3 1993 We here report a novel mechanism of DG attenuation by phospholipase D (PLD), which also precludes the production of another (putative) second messenger, phosphatidic acid (PA). Phosphatidic Acids 172-174 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 8392931-3 1993 We here report a novel mechanism of DG attenuation by phospholipase D (PLD), which also precludes the production of another (putative) second messenger, phosphatidic acid (PA). Phosphatidic Acids 172-174 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-74 8392931-4 1993 In the presence of an alcohol, PLD converts phosphatidylcholine (PC) into a phosphatidylalcohol (by transphosphatidylation) rather than into PA. Phosphatidic Acids 141-143 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8178956-0 1994 Interleukin-1 stimulates phosphatidic acid-mediated phospholipase D activity in human mesangial cells. Phosphatidic Acids 25-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-67 8178956-2 1994 Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA). Phosphatidic Acids 155-172 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-126 8178956-2 1994 Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA). Phosphatidic Acids 155-172 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 128-131 8178956-2 1994 Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA). Phosphatidic Acids 174-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-126 8178956-2 1994 Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA). Phosphatidic Acids 174-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 128-131 8178956-3 1994 PLD acts on a subfraction of PE enriched in 1-o-alkyl and 1-o-alkenyl, sn-2-unsaturated species, generating a unique PA subspecies 30-120 s after stimulation. Phosphatidic Acids 117-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 8261513-1 1993 The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline. Phosphatidic Acids 92-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 8261513-1 1993 The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline. Phosphatidic Acids 92-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 8504157-2 1993 The PLD activity was detected as signal-induced synthesis of phosphatidic acid (PA) and in the presence of ethanol, phosphatidylethanol (PEt). Phosphatidic Acids 80-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 8504157-8 1993 The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine. Phosphatidic Acids 4-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 8504157-8 1993 The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine. Phosphatidic Acids 4-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 319-322 1334678-5 1992 Phosphatidic acid (PA), the initial product of the PLD pathway, also appears to act as a second messenger by directly activating the NADPH oxidase responsible for generating O2-. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 8383432-9 1993 generation is associated with marked inhibition of phospholipase D (PLD) activity, with limited hydrolysis of phosphatidylcholine and formation of phosphatidic acid. Phosphatidic Acids 147-164 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-66 8383432-9 1993 generation is associated with marked inhibition of phospholipase D (PLD) activity, with limited hydrolysis of phosphatidylcholine and formation of phosphatidic acid. Phosphatidic Acids 147-164 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 68-71 8473292-0 1993 Phosphatidic acid, lysophosphatidic acid, and lipid A are inhibitors of glycosylphosphatidylinositol-specific phospholipase D. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 72-125 8473292-2 1993 Previous work has suggested that the glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) purified from bovine serum is inhibited by phosphatidic acid (PA). Phosphatidic Acids 144-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-90 8473292-2 1993 Previous work has suggested that the glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) purified from bovine serum is inhibited by phosphatidic acid (PA). Phosphatidic Acids 144-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-99 8473292-2 1993 Previous work has suggested that the glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) purified from bovine serum is inhibited by phosphatidic acid (PA). Phosphatidic Acids 163-165 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-90 8473292-2 1993 Previous work has suggested that the glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) purified from bovine serum is inhibited by phosphatidic acid (PA). Phosphatidic Acids 163-165 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-99 8473292-8 1993 The data suggest that inhibition is due to a direct interaction between PA (or lipid A) and the GPI-PLD rather than an indirect effect on the substrate particle. Phosphatidic Acids 72-74 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 96-103 8416807-4 1993 Staurosporine concentrations that induced an elevation in PA completely depressed protein kinase C (PKC) activity in both soluble and particulate cell fractions, suggesting that PLD activation may occur independently from PKC activation. Phosphatidic Acids 58-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 178-181 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidic Acids 290-307 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-31 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidic Acids 290-307 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 33-36 1334678-5 1992 Phosphatidic acid (PA), the initial product of the PLD pathway, also appears to act as a second messenger by directly activating the NADPH oxidase responsible for generating O2-. Phosphatidic Acids 19-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 1320409-8 1992 This phenomenon is attributed to phospholipase D (PLD) stimulation by staurosporine, which augments the DG synthesis, in part through PA degradation via phosphatidic acid (PA) phosphohydrolase. Phosphatidic Acids 134-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 33-48 1320409-8 1992 This phenomenon is attributed to phospholipase D (PLD) stimulation by staurosporine, which augments the DG synthesis, in part through PA degradation via phosphatidic acid (PA) phosphohydrolase. Phosphatidic Acids 134-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 1864964-2 1991 Receptor-mediated agonists, such as FMLP, induce an early, phospholipase D (PLD)-mediated accumulation of phosphatidic acid (PA) which may play a role in the activation of NADPH oxidase in human PMN. Phosphatidic Acids 106-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 59-74 1314112-13 1992 These studies demonstrate that alpha-thrombin is a potent stimulus for human PLD-mediated PA formation and that cyclic adenosine nucleotides modulate agonist-induced cellular PLD activity. Phosphatidic Acids 90-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 77-80 1543719-4 1992 3.1.44., PLD) converted L-alpha-dipalmitoylphosphatidylcholine (DPPC) in the monolayer to L-alpha-dipalmitoylphosphatidic acid (DPPA), leading to a drastic decrease in Cdl. Phosphatidic Acids 90-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 9-12 1727727-8 1992 These findings demonstrate for the first time that a physiological nutrient activates a phospholipase directed against endogenous phosphatidylcholine in intact islet cells; furthermore, they indicate a role for PLD in a delayed formation of phosphatidic acid in the islet cell. Phosphatidic Acids 241-258 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 211-214 1659906-2 1991 To define the role of the PC-specific PLD products phosphatidic acid (PA) and diacylglycerol (DAG) in O2- production in response to agonists which activate the PLD pathway, we blocked the metabolism of PA to DAG with propranolol, an inhibitor of PA phosphohydrolase. Phosphatidic Acids 70-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 1864964-12 1991 Taken together, these results indicate that PA plays a second messenger role in the activation of NADPH oxidase in human PMN and that regulation of phospholipase D is a key step in the activation pathway. Phosphatidic Acids 44-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 148-163 1314112-2 1992 The activation of membrane-bound phospholipase D (PLD) resulting in the generation of phosphatidic acid (PA) is increasingly recognized as an integral event in the initiation of a variety of cellular responses. Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 33-48 1314112-2 1992 The activation of membrane-bound phospholipase D (PLD) resulting in the generation of phosphatidic acid (PA) is increasingly recognized as an integral event in the initiation of a variety of cellular responses. Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 1314112-2 1992 The activation of membrane-bound phospholipase D (PLD) resulting in the generation of phosphatidic acid (PA) is increasingly recognized as an integral event in the initiation of a variety of cellular responses. Phosphatidic Acids 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 33-48 1314112-2 1992 The activation of membrane-bound phospholipase D (PLD) resulting in the generation of phosphatidic acid (PA) is increasingly recognized as an integral event in the initiation of a variety of cellular responses. Phosphatidic Acids 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 1314112-5 1992 alpha-Thrombin rapidly (1 minute) increased PA and PEt formation in a dose-dependent manner (10(-6) to 10(-10)) with maximal PLD stimulation achieved with 10 nmol/L alpha-thrombin producing a threefold to fourfold increase in PA and a sixfold to eightfold increase in PEt over controls at 15 minutes. Phosphatidic Acids 226-228 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 125-128 1623116-7 1992 The data clearly indicate that LPS stimulates phosphatidylcholine breakdown, implying that the liberation of phosphatidic acid or diacylglycerol via PLC/PLD reaction may be relevant to the initiation of LPS-induced monocytic activation. Phosphatidic Acids 109-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 1659906-7 1991 These data are consistent with the hypothesis that PA produced through the hydrolysis of PC by PLD is an important mediator of O2- production in response to receptor-dependent agonists. Phosphatidic Acids 51-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 95-98 1659906-8 1991 However, the inhibitory effects of propranolol on receptor-independent stimuli suggest that PA generated through the PLD pathway plays a different role in the signal transduction mechanisms of these agonists or that propranolol may have additional effects beyond inhibition of PA phosphohydrolase. Phosphatidic Acids 92-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 117-120 1864964-2 1991 Receptor-mediated agonists, such as FMLP, induce an early, phospholipase D (PLD)-mediated accumulation of phosphatidic acid (PA) which may play a role in the activation of NADPH oxidase in human PMN. Phosphatidic Acids 106-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-79 1864964-2 1991 Receptor-mediated agonists, such as FMLP, induce an early, phospholipase D (PLD)-mediated accumulation of phosphatidic acid (PA) which may play a role in the activation of NADPH oxidase in human PMN. Phosphatidic Acids 125-127 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 59-74 1864964-2 1991 Receptor-mediated agonists, such as FMLP, induce an early, phospholipase D (PLD)-mediated accumulation of phosphatidic acid (PA) which may play a role in the activation of NADPH oxidase in human PMN. Phosphatidic Acids 125-127 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-79 1864964-4 1991 Pretreatment of cells with various concentrations of propranolol enhanced (less than or equal to 200 microM) or inhibited (greater than 300 microM) PLD-induced production of PA (mass and radiolabel) in a manner that correlated with enhancement or inhibition of O2 consumption in PMN stimulated with 1 microM FMLP in the absence of cytochalasin B. Phosphatidic Acids 174-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 148-151 2037586-7 1991 In the presence of ethanol or n-butanol, transphosphatidylation by PLD resulted in the formation of [3H]phosphatidylethanol or - butanol, respectively, at the cost of PA and DG formation. Phosphatidic Acids 167-169 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 2201747-0 1990 Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol. Phosphatidic Acids 207-224 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-32 2176212-6 1990 Treatment of 1321N1 cells with carbachol results in increases in radiolabeled choline, phosphatidic acid (PA) and phosphatidylethanol (PEt), metabolites that are products of phospholipase D (PLD) action on PC. Phosphatidic Acids 87-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 174-189 2176212-9 1990 It appears that most of the DG is formed through the action of PLD, since propranolol (which inhibits the conversion of PA to DG) and down-regulation of protein kinase C (which prevents activation of PLD by carbachol) both markedly inhibit DG production. Phosphatidic Acids 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 63-66 2176212-11 1990 We suggest that the rapid and transient activation of PLD results in delayed accumulation of DG due to the relatively slow conversion of PA to DG by PA phosphatase. Phosphatidic Acids 137-139 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 2307846-2 1990 The contribution of phospholipase D (PLD) to the production of phosphatidic acid (PA) and diglyceride (DG) by C5a-stimulated human neutrophils has been studied. Phosphatidic Acids 63-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 2307846-2 1990 The contribution of phospholipase D (PLD) to the production of phosphatidic acid (PA) and diglyceride (DG) by C5a-stimulated human neutrophils has been studied. Phosphatidic Acids 63-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 2307846-2 1990 The contribution of phospholipase D (PLD) to the production of phosphatidic acid (PA) and diglyceride (DG) by C5a-stimulated human neutrophils has been studied. Phosphatidic Acids 82-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 2307846-2 1990 The contribution of phospholipase D (PLD) to the production of phosphatidic acid (PA) and diglyceride (DG) by C5a-stimulated human neutrophils has been studied. Phosphatidic Acids 82-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 34810254-4 2021 Here, we merge advances in bioorthogonal fluorescent labeling and CRISPR screening technologies to discover regulators of phospholipase D (PLD) signaling, which generates the potent lipid second messenger phosphatidic acid. Phosphatidic Acids 205-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 122-137 34167393-2 2022 Phosphatidic acid, the product of PLD activity, is a vital signaling molecule. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-37 2130511-18 1990 Activation of phospholipase D (PLD) was demonstrated by the finding that phosphatidic acid increased in response to PMA or carbachol prior to the increase in PA. Phosphatidic Acids 73-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-29 2130511-18 1990 Activation of phospholipase D (PLD) was demonstrated by the finding that phosphatidic acid increased in response to PMA or carbachol prior to the increase in PA. Phosphatidic Acids 73-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8070364-3 1994 A GnRH receptor agonist (GnRH-A) activated PLD in the cells, causing a sustained elevation of phosphatidylethanol and a transient increase in cellular PA levels. Phosphatidic Acids 151-153 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 34876384-8 2022 Furthermore, a dopamine beta-hydroxylase (DbetaH) internalization assay revealed that PA produced by PLD is required for an optimal recovery of vesicular membrane content by compensatory endocytosis. Phosphatidic Acids 86-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 34810254-4 2021 Here, we merge advances in bioorthogonal fluorescent labeling and CRISPR screening technologies to discover regulators of phospholipase D (PLD) signaling, which generates the potent lipid second messenger phosphatidic acid. Phosphatidic Acids 205-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 139-142 35276134-6 2022 First, we describe techniques to visualize PA production by phospholipase D (PLD) enzymes, which are major producers of PA, called Imaging Phospholipase D Activity with Clickable Alcohols via Transphosphatidylation (IMPACT). Phosphatidic Acids 43-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-75 34659294-1 2021 Phospholipase D (PLD) and its hydrolysis product phosphatidic acid play an important role in the regulation of several cellular processes, including root growth, pollen tube elongation, and microtubule reorganization. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 34659294-1 2021 Phospholipase D (PLD) and its hydrolysis product phosphatidic acid play an important role in the regulation of several cellular processes, including root growth, pollen tube elongation, and microtubule reorganization. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidic Acids 121-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidic Acids 121-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidic Acids 140-142 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidic Acids 140-142 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 35276134-6 2022 First, we describe techniques to visualize PA production by phospholipase D (PLD) enzymes, which are major producers of PA, called Imaging Phospholipase D Activity with Clickable Alcohols via Transphosphatidylation (IMPACT). Phosphatidic Acids 43-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 77-80 35276134-6 2022 First, we describe techniques to visualize PA production by phospholipase D (PLD) enzymes, which are major producers of PA, called Imaging Phospholipase D Activity with Clickable Alcohols via Transphosphatidylation (IMPACT). Phosphatidic Acids 43-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 139-154 35276134-6 2022 First, we describe techniques to visualize PA production by phospholipase D (PLD) enzymes, which are major producers of PA, called Imaging Phospholipase D Activity with Clickable Alcohols via Transphosphatidylation (IMPACT). Phosphatidic Acids 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-75 35276134-6 2022 First, we describe techniques to visualize PA production by phospholipase D (PLD) enzymes, which are major producers of PA, called Imaging Phospholipase D Activity with Clickable Alcohols via Transphosphatidylation (IMPACT). Phosphatidic Acids 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 77-80 35276134-6 2022 First, we describe techniques to visualize PA production by phospholipase D (PLD) enzymes, which are major producers of PA, called Imaging Phospholipase D Activity with Clickable Alcohols via Transphosphatidylation (IMPACT). Phosphatidic Acids 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 139-154 35450377-1 2022 Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. Phosphatidic Acids 131-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 35289711-6 2022 These results elucidate the molecular mechanism of how PA inhibits autophagy through binding GAPC or PGK3 proteins and expand the understanding of the functional mode of PA, demonstrating the importance of phospholipids in plant autophagy and providing a new perspective for autophagy regulation by phospholipids.Abbreviation: ATG: autophagy-related; BiFC: bimolecular fluorescence complementation; co-IP: co-immunoprecipitation; Con A: concanamycin A; ER: endoplasmic reticulum; EZ: elongation zone; FRET-FLIM: fluorescence resonance energy transfer with fluorescence lifetime imaging microscopy; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GST: glutathione S-transferase; MDC: monodansylcadaverine; MZ: meristem zone; PA: phosphatidic acid; PAS: phagophore assembly site; PC: phosphatidylcholine; PE: phosphatidylethanolamine; PGK3: phosphoglycerate kinase; PtdIns3K: phosphatidylinositol 3-kinase; PLD: phospholipase D; TEM: transmission electron microscopy; TOR: target of rapamycin; VPS34: vacuolar protein sorting 34; WT: wild type; Y2H: yeast two-hybrid. Phosphatidic Acids 55-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 906-909 35450377-1 2022 Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. Phosphatidic Acids 131-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 35042010-2 2022 Phospholipase D (PLD), a major lipid hydrolase, hydrolyzes membrane phospholipids to produce phosphatidic acid (PA) and responds to many abiotic stresses. Phosphatidic Acids 93-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 35042010-2 2022 Phospholipase D (PLD), a major lipid hydrolase, hydrolyzes membrane phospholipids to produce phosphatidic acid (PA) and responds to many abiotic stresses. Phosphatidic Acids 93-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 35042010-2 2022 Phospholipase D (PLD), a major lipid hydrolase, hydrolyzes membrane phospholipids to produce phosphatidic acid (PA) and responds to many abiotic stresses. Phosphatidic Acids 112-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 35042010-2 2022 Phospholipase D (PLD), a major lipid hydrolase, hydrolyzes membrane phospholipids to produce phosphatidic acid (PA) and responds to many abiotic stresses. Phosphatidic Acids 112-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 2498324-2 1989 It has recently been demonstrated that the chemotactic peptide N-formyl-Met-Leu-Phe activates phospholipase D (PLD) in dimethyl sulfoxide-differentiated HL-60 granulocytes to produce phosphatidic acid (PA) and, in the presence of ethanol, phosphatidylethanol (PEt) (Pai, J.-K., Siegel, M. I., Egan, R. W., and Billah, M. M. (1988) J. Biol. Phosphatidic Acids 183-200 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-109 2498324-2 1989 It has recently been demonstrated that the chemotactic peptide N-formyl-Met-Leu-Phe activates phospholipase D (PLD) in dimethyl sulfoxide-differentiated HL-60 granulocytes to produce phosphatidic acid (PA) and, in the presence of ethanol, phosphatidylethanol (PEt) (Pai, J.-K., Siegel, M. I., Egan, R. W., and Billah, M. M. (1988) J. Biol. Phosphatidic Acids 183-200 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 2498324-2 1989 It has recently been demonstrated that the chemotactic peptide N-formyl-Met-Leu-Phe activates phospholipase D (PLD) in dimethyl sulfoxide-differentiated HL-60 granulocytes to produce phosphatidic acid (PA) and, in the presence of ethanol, phosphatidylethanol (PEt) (Pai, J.-K., Siegel, M. I., Egan, R. W., and Billah, M. M. (1988) J. Biol. Phosphatidic Acids 202-204 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-109 2498324-2 1989 It has recently been demonstrated that the chemotactic peptide N-formyl-Met-Leu-Phe activates phospholipase D (PLD) in dimethyl sulfoxide-differentiated HL-60 granulocytes to produce phosphatidic acid (PA) and, in the presence of ethanol, phosphatidylethanol (PEt) (Pai, J.-K., Siegel, M. I., Egan, R. W., and Billah, M. M. (1988) J. Biol. Phosphatidic Acids 202-204 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 33832505-2 2021 However, PLC-gamma1 could also be activated in a PTK-independent manner by phospholipase D (PLD)-derived phosphatidic acid (PA). Phosphatidic Acids 105-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 75-90 33832505-2 2021 However, PLC-gamma1 could also be activated in a PTK-independent manner by phospholipase D (PLD)-derived phosphatidic acid (PA). Phosphatidic Acids 105-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-95 33832505-2 2021 However, PLC-gamma1 could also be activated in a PTK-independent manner by phospholipase D (PLD)-derived phosphatidic acid (PA). Phosphatidic Acids 124-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 75-90 33832505-2 2021 However, PLC-gamma1 could also be activated in a PTK-independent manner by phospholipase D (PLD)-derived phosphatidic acid (PA). Phosphatidic Acids 124-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-95 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidic Acids 94-111 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 32586106-4 2021 Recent Advances: The tremendous progress in methods/technologies and animal modeling has allowed the clarification of phospholipase D (PLD) critical roles in multiple cellular processes, whether directly or indirectly via phosphatidic acid, the lipid product mediating signaling functions. Phosphatidic Acids 222-239 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 118-133 32586106-4 2021 Recent Advances: The tremendous progress in methods/technologies and animal modeling has allowed the clarification of phospholipase D (PLD) critical roles in multiple cellular processes, whether directly or indirectly via phosphatidic acid, the lipid product mediating signaling functions. Phosphatidic Acids 222-239 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 33495125-1 2021 Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary messenger involved with a broad spectrum of cellular functions including but not limited to metabolism, migration, and exocytosis. Phosphatidic Acids 42-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 33495125-1 2021 Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary messenger involved with a broad spectrum of cellular functions including but not limited to metabolism, migration, and exocytosis. Phosphatidic Acids 42-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 33181180-1 2021 Phospholipase D (PLD) and its metabolic active product phosphatidic acid (PA) engage in a wide range of physiopathologic processes in the cell. Phosphatidic Acids 55-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 33181180-1 2021 Phospholipase D (PLD) and its metabolic active product phosphatidic acid (PA) engage in a wide range of physiopathologic processes in the cell. Phosphatidic Acids 55-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 33181180-1 2021 Phospholipase D (PLD) and its metabolic active product phosphatidic acid (PA) engage in a wide range of physiopathologic processes in the cell. Phosphatidic Acids 74-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 33181180-1 2021 Phospholipase D (PLD) and its metabolic active product phosphatidic acid (PA) engage in a wide range of physiopathologic processes in the cell. Phosphatidic Acids 74-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 32447426-3 2021 Modulation of DAG and PA levels using DAG kinase (DGK) and phospholipase D (PLD) inhibitors gave a strong increase in retrograde ricin transport, but had little impact on ricin recycling or degradation. Phosphatidic Acids 22-24 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 59-74 32447426-3 2021 Modulation of DAG and PA levels using DAG kinase (DGK) and phospholipase D (PLD) inhibitors gave a strong increase in retrograde ricin transport, but had little impact on ricin recycling or degradation. Phosphatidic Acids 22-24 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-79 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidic Acids 94-111 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidic Acids 113-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidic Acids 113-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 32800947-12 2020 When the PLD product PA is combined with halopemide, exosome secretion is fully restored. Phosphatidic Acids 21-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 9-12 32661773-4 2020 Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking. Phosphatidic Acids 78-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 32661773-4 2020 Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking. Phosphatidic Acids 78-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 32327488-3 2020 Here, we hypothesized that phospholipase D (PLD)-generated phosphatidic acid (PA) signaling regulates VE-cadherin recycling and promotes endothelial barrier recovery by dephosphorylating VE-cadherin. Phosphatidic Acids 59-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-42 32073216-2 2020 PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Phosphatidic Acids 42-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 32073216-2 2020 PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Phosphatidic Acids 61-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 32327488-3 2020 Here, we hypothesized that phospholipase D (PLD)-generated phosphatidic acid (PA) signaling regulates VE-cadherin recycling and promotes endothelial barrier recovery by dephosphorylating VE-cadherin. Phosphatidic Acids 59-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 44-47 32327488-3 2020 Here, we hypothesized that phospholipase D (PLD)-generated phosphatidic acid (PA) signaling regulates VE-cadherin recycling and promotes endothelial barrier recovery by dephosphorylating VE-cadherin. Phosphatidic Acids 78-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-42 32327488-3 2020 Here, we hypothesized that phospholipase D (PLD)-generated phosphatidic acid (PA) signaling regulates VE-cadherin recycling and promotes endothelial barrier recovery by dephosphorylating VE-cadherin. Phosphatidic Acids 78-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 44-47 31830503-2 2020 PLD enzymes catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids producing phosphatidic acid and the free headgroup. Phosphatidic Acids 97-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 32490215-7 2020 Experiments using a phospholipase D (PLD) inhibitor strongly suggested that PA in the peripheral regions of the growth cone was primarily produced by PLD. Phosphatidic Acids 76-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 32490215-7 2020 Experiments using a phospholipase D (PLD) inhibitor strongly suggested that PA in the peripheral regions of the growth cone was primarily produced by PLD. Phosphatidic Acids 76-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 32490215-7 2020 Experiments using a phospholipase D (PLD) inhibitor strongly suggested that PA in the peripheral regions of the growth cone was primarily produced by PLD. Phosphatidic Acids 76-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 150-153 32227388-7 2020 Our findings show for the first time the ability of CgA to interact with PLD-generated PA, which allows membrane remodeling and curvature, key processes necessary to initiate secretory granule budding. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 73-76 31619765-1 2020 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid (PA), which acts as a second messenger in many living organisms. Phosphatidic Acids 94-111 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 31767684-4 2020 Amino acids and growth factors also induce the phospholipase D (PLD)-phosphatidic acid (PA) pathway, required for mTORC1 signaling through mechanisms that are not fully understood. Phosphatidic Acids 69-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-62 31767684-4 2020 Amino acids and growth factors also induce the phospholipase D (PLD)-phosphatidic acid (PA) pathway, required for mTORC1 signaling through mechanisms that are not fully understood. Phosphatidic Acids 69-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 64-67 31619765-1 2020 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid (PA), which acts as a second messenger in many living organisms. Phosphatidic Acids 94-111 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 31619765-1 2020 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid (PA), which acts as a second messenger in many living organisms. Phosphatidic Acids 113-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 31619765-1 2020 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid (PA), which acts as a second messenger in many living organisms. Phosphatidic Acids 113-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 31541319-0 2020 Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer. Phosphatidic Acids 32-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 82-85 31541319-3 2020 One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline. Phosphatidic Acids 95-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 31541319-3 2020 One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline. Phosphatidic Acids 95-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 32713538-5 2020 Our approach capitalizes on the ability of PLDs to catalyze transphosphatidylation reactions with exogenous alcohols to generate phosphatidyl alcohols, lipids whose location and abundance report on the extent of PLD-mediated PA synthesis. Phosphatidic Acids 225-227 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 32713538-9 2020 Together, IMPACT represents a major advance in our ability to dissect PLD-mediated PA signaling in native biological settings. Phosphatidic Acids 12-14 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 31311871-5 2019 Here, we describe a rapid, chemoenzymatic approach for imaging physiological PA production by phospholipase D (PLD) enzymes. Phosphatidic Acids 77-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-109 31563324-9 2019 Here we found that the attenuation of PA production with 1-butanol or a PLD inhibitor prevented the 1,25(OH)2D3-induced upregulation of CD14. Phosphatidic Acids 38-40 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 72-75 31090437-2 2019 In this study, we identified phospholipase D (PLD)-generated phosphatidic acid (PA) signaling in the development of pulmonary fibrosis (PF). Phosphatidic Acids 61-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 31090437-2 2019 In this study, we identified phospholipase D (PLD)-generated phosphatidic acid (PA) signaling in the development of pulmonary fibrosis (PF). Phosphatidic Acids 80-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 31311871-5 2019 Here, we describe a rapid, chemoenzymatic approach for imaging physiological PA production by phospholipase D (PLD) enzymes. Phosphatidic Acids 77-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 30877512-2 2019 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidic Acids 81-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30877512-2 2019 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidic Acids 81-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30695732-2 2019 Hydrolysis of phospholipids by PLD allows the release of phosphatidic acid which is a crucial intermediate of multiple pathways and signaling reactions, including tumorigenesis in mammals and defense responses in plants. Phosphatidic Acids 57-74 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 30320913-1 2019 Mammalian phospholipase D (PLD) mostly hydrolyzes phosphatidylcholine producing phosphatidic acid. Phosphatidic Acids 80-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidic Acids 113-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 30743104-4 2019 Here we show that PKA mediates PLD activation, and inhibition of PKA resulting in an increase of sAR and a decrease of F-actin levels, two functions which can be recovered by adding phosphatidic acid (PA), the product of PLD activity. Phosphatidic Acids 182-199 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 30743104-4 2019 Here we show that PKA mediates PLD activation, and inhibition of PKA resulting in an increase of sAR and a decrease of F-actin levels, two functions which can be recovered by adding phosphatidic acid (PA), the product of PLD activity. Phosphatidic Acids 182-199 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 221-224 30743104-4 2019 Here we show that PKA mediates PLD activation, and inhibition of PKA resulting in an increase of sAR and a decrease of F-actin levels, two functions which can be recovered by adding phosphatidic acid (PA), the product of PLD activity. Phosphatidic Acids 201-203 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 221-224 30837487-0 2019 PLD-dependent phosphatidic acid microdomains are signaling platforms for podosome formation. Phosphatidic Acids 14-31 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 30837487-3 2019 Recent evidence suggested the involvement of phospholipase D (PLD) and its product phosphatidic acid (PA) in podosome formation, but the spatiotemporal control of this process is poorly characterized. Phosphatidic Acids 83-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-60 30837487-3 2019 Recent evidence suggested the involvement of phospholipase D (PLD) and its product phosphatidic acid (PA) in podosome formation, but the spatiotemporal control of this process is poorly characterized. Phosphatidic Acids 83-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 62-65 30837487-3 2019 Recent evidence suggested the involvement of phospholipase D (PLD) and its product phosphatidic acid (PA) in podosome formation, but the spatiotemporal control of this process is poorly characterized. Phosphatidic Acids 102-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-60 30837487-3 2019 Recent evidence suggested the involvement of phospholipase D (PLD) and its product phosphatidic acid (PA) in podosome formation, but the spatiotemporal control of this process is poorly characterized. Phosphatidic Acids 102-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 62-65 30837487-4 2019 Here we determined the role of PLD1 and PLD2 isoforms in regulating podosome formation and dynamics in human primary DCs by combining PLD pharmacological inhibition with a fluorescent PA sensor and fluorescence microscopy. Phosphatidic Acids 184-186 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 30764505-8 2019 MPD interacts with phosphatidic acid (PA), a metabolite of the phospholipase D (PLD) pathway, in a specific manner as shown by lipid strips and Trp fluorescence quenching experiments. Phosphatidic Acids 19-36 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 63-78 30764505-8 2019 MPD interacts with phosphatidic acid (PA), a metabolite of the phospholipase D (PLD) pathway, in a specific manner as shown by lipid strips and Trp fluorescence quenching experiments. Phosphatidic Acids 19-36 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-83 30764505-8 2019 MPD interacts with phosphatidic acid (PA), a metabolite of the phospholipase D (PLD) pathway, in a specific manner as shown by lipid strips and Trp fluorescence quenching experiments. Phosphatidic Acids 38-40 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 63-78 30764505-8 2019 MPD interacts with phosphatidic acid (PA), a metabolite of the phospholipase D (PLD) pathway, in a specific manner as shown by lipid strips and Trp fluorescence quenching experiments. Phosphatidic Acids 38-40 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-83 30764505-10 2019 The presence of a PA binding domain in TRPV channels argues for putative PLD regulation. Phosphatidic Acids 18-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 73-76 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidic Acids 65-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidic Acids 65-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidic Acids 84-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidic Acids 84-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidic Acids 94-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidic Acids 94-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidic Acids 113-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidic Acids 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidic Acids 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 30091053-4 2018 We review the participation of PLD and phosphatidic acid (PA), its enzymatic product, as new "players" in breast cancer biology, with the aspects of regulation of the tumor microenvironment, macrophage polarization, regulation of PLD transcripts by specific miRs and deadenylases, and PLD-regulated exosome biogenesis. Phosphatidic Acids 58-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 230-233 30293781-6 2018 Inhibition of phospholipase D (PLD)-dependent PA production suppresses YAP oncogenic activities. Phosphatidic Acids 46-48 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-29 30293781-6 2018 Inhibition of phospholipase D (PLD)-dependent PA production suppresses YAP oncogenic activities. Phosphatidic Acids 46-48 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 30091053-4 2018 We review the participation of PLD and phosphatidic acid (PA), its enzymatic product, as new "players" in breast cancer biology, with the aspects of regulation of the tumor microenvironment, macrophage polarization, regulation of PLD transcripts by specific miRs and deadenylases, and PLD-regulated exosome biogenesis. Phosphatidic Acids 58-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 230-233 30109649-1 2018 Phospholipase D (PLD) hydrolyzes phospholipids to form phosphatidic acid (PA) and the corresponding headgroup. Phosphatidic Acids 55-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 29660846-1 2018 A hallmark of clear cell renal cell carcinoma (ccRCC) is the presence of intracellular lipid droplets (LD) and it is assumed that phosphatidic acid (PA) produced by phospholipase D (PLD) plays some role in the LD formation. Phosphatidic Acids 130-147 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 165-180 29660846-1 2018 A hallmark of clear cell renal cell carcinoma (ccRCC) is the presence of intracellular lipid droplets (LD) and it is assumed that phosphatidic acid (PA) produced by phospholipase D (PLD) plays some role in the LD formation. Phosphatidic Acids 130-147 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 182-185 29660846-1 2018 A hallmark of clear cell renal cell carcinoma (ccRCC) is the presence of intracellular lipid droplets (LD) and it is assumed that phosphatidic acid (PA) produced by phospholipase D (PLD) plays some role in the LD formation. Phosphatidic Acids 149-151 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 165-180 29660846-1 2018 A hallmark of clear cell renal cell carcinoma (ccRCC) is the presence of intracellular lipid droplets (LD) and it is assumed that phosphatidic acid (PA) produced by phospholipase D (PLD) plays some role in the LD formation. Phosphatidic Acids 149-151 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 182-185 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidic Acids 81-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidic Acids 81-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidic Acids 100-102 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidic Acids 100-102 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30159399-4 2018 While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA). Phosphatidic Acids 87-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 30159399-4 2018 While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA). Phosphatidic Acids 106-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 30159399-11 2018 Conversely, PLD-treated PC liposomes remain stable up to extremely high conversions to PA. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 12-15 28964725-1 2018 Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well as a cell signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). Phosphatidic Acids 179-196 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 28964725-1 2018 Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well as a cell signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). Phosphatidic Acids 179-196 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 28964725-1 2018 Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well as a cell signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). Phosphatidic Acids 198-200 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 28964725-1 2018 Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well as a cell signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). Phosphatidic Acids 198-200 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 28986032-0 2018 Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD? Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 28986032-5 2018 Our lab is particularly interested in the potential regulatory mechanisms and neuronal roles of two phosphatidic acid-producing enzymes: diacylglycerol kinase theta (DGKtheta) and phospholipase D (PLD). Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 180-195 28986032-5 2018 Our lab is particularly interested in the potential regulatory mechanisms and neuronal roles of two phosphatidic acid-producing enzymes: diacylglycerol kinase theta (DGKtheta) and phospholipase D (PLD). Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 197-200 30109649-1 2018 Phospholipase D (PLD) hydrolyzes phospholipids to form phosphatidic acid (PA) and the corresponding headgroup. Phosphatidic Acids 55-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30109649-1 2018 Phospholipase D (PLD) hydrolyzes phospholipids to form phosphatidic acid (PA) and the corresponding headgroup. Phosphatidic Acids 74-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30109649-1 2018 Phospholipase D (PLD) hydrolyzes phospholipids to form phosphatidic acid (PA) and the corresponding headgroup. Phosphatidic Acids 74-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30109649-5 2018 This assay exhibits a strong fluorescence signal upon Ca2+ complexation with the PLD-generated PA and is not limited to PC as the substrate but allows the use of natural phospholipids with various headgroups. Phosphatidic Acids 95-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 81-84 29104923-2 2017 Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. Phosphatidic Acids 104-121 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 29104923-2 2017 Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. Phosphatidic Acids 104-121 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 29104923-4 2017 Here, we report a chemical method for imaging phosphatidic acid synthesis by PLD enzymes in live cells. Phosphatidic Acids 46-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 77-80 28318354-7 2017 When HS1BP3 is depleted, the total cellular PA content is upregulated stemming from increased activity of the PA-producing enzyme PLD (phospholipase D) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 44-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 28318354-7 2017 When HS1BP3 is depleted, the total cellular PA content is upregulated stemming from increased activity of the PA-producing enzyme PLD (phospholipase D) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 44-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-150 28318354-7 2017 When HS1BP3 is depleted, the total cellular PA content is upregulated stemming from increased activity of the PA-producing enzyme PLD (phospholipase D) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 110-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidic Acids 80-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 212-215 28209987-2 2017 The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface receptors, including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and integrins. Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 28209987-2 2017 The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface receptors, including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and integrins. Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 28011629-9 2017 Between 30 and 300 nM phosphatidic acid (PA), the product of PLD enzymatic reaction, added exogenously to culture cells had a stabilizing role of both PARN and PLD2 mRNA decay. Phosphatidic Acids 22-39 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 28011629-9 2017 Between 30 and 300 nM phosphatidic acid (PA), the product of PLD enzymatic reaction, added exogenously to culture cells had a stabilizing role of both PARN and PLD2 mRNA decay. Phosphatidic Acids 41-43 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 28063497-0 2017 PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. We describe methods for studying phospholipase D (PLD) interactions with signaling proteins and modulation of these interactions by the PLD reaction product, phosphatidic acid (PA). Phosphatidic Acids 238-255 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 28063497-0 2017 PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. We describe methods for studying phospholipase D (PLD) interactions with signaling proteins and modulation of these interactions by the PLD reaction product, phosphatidic acid (PA). Phosphatidic Acids 238-255 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 28063497-0 2017 PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. We describe methods for studying phospholipase D (PLD) interactions with signaling proteins and modulation of these interactions by the PLD reaction product, phosphatidic acid (PA). Phosphatidic Acids 238-255 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 28063497-0 2017 PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. We describe methods for studying phospholipase D (PLD) interactions with signaling proteins and modulation of these interactions by the PLD reaction product, phosphatidic acid (PA). Phosphatidic Acids 76-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 113-128 28063497-0 2017 PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. We describe methods for studying phospholipase D (PLD) interactions with signaling proteins and modulation of these interactions by the PLD reaction product, phosphatidic acid (PA). Phosphatidic Acids 76-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 28063497-0 2017 PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. We describe methods for studying phospholipase D (PLD) interactions with signaling proteins and modulation of these interactions by the PLD reaction product, phosphatidic acid (PA). Phosphatidic Acids 76-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 28063497-3 2017 The involvement of PLD as an effector of protein-protein interactions and downstream signaling via PA-mediated processes has led to the investigation of PA-binding domains in target protein partners. Phosphatidic Acids 99-101 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 19-22 28063499-3 2017 It is of interest that PI(4,5)P2 is also a critical cofactor for the activation of the PA-generating enzyme, phospholipase D (PLD). Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-124 28063499-3 2017 It is of interest that PI(4,5)P2 is also a critical cofactor for the activation of the PA-generating enzyme, phospholipase D (PLD). Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-129 28004827-5 2016 Furthermore, we find the total PA content of cells to be significantly upregulated in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 150-152 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 170-185 27633714-3 2016 Here, a chemoenzymatic strategy for imaging sites of cellular PA synthesis by phospholipase D (PLD) enzymes is reported. Phosphatidic Acids 62-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 78-93 27633714-3 2016 Here, a chemoenzymatic strategy for imaging sites of cellular PA synthesis by phospholipase D (PLD) enzymes is reported. Phosphatidic Acids 62-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 95-98 27633714-6 2016 Our studies revealed several intracellular sites of PLD-mediated PA synthesis. Phosphatidic Acids 65-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-55 28004827-5 2016 Furthermore, we find the total PA content of cells to be significantly upregulated in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 31-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 170-185 28004827-5 2016 Furthermore, we find the total PA content of cells to be significantly upregulated in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1 to ATG16L1-positive membranes. Phosphatidic Acids 31-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 187-190 27256981-4 2016 Upon binding to its ligand, EGF receptor (EGFR)-initiated activation of phospholipase D (PLD) causes a spike in intracellular PA production that forms vesicles transporting EGFR from early endosomes (EEA1 marker) and prolonged internalization in late endosomes and Golgi (RCAS marker). Phosphatidic Acids 126-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 72-87 27256981-4 2016 Upon binding to its ligand, EGF receptor (EGFR)-initiated activation of phospholipase D (PLD) causes a spike in intracellular PA production that forms vesicles transporting EGFR from early endosomes (EEA1 marker) and prolonged internalization in late endosomes and Golgi (RCAS marker). Phosphatidic Acids 126-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-92 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidic Acids 99-101 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 212-215 26020241-0 2015 Phosphatidic acid produced by phospholipase D promotes RNA replication of a plant RNA virus. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 26787840-5 2016 First, during initial starvation, an elevated PA (the product of PLD enzymatic activity) activates mTOR and S6K, known to inhibit apoptosis, and enhances cell migration especially in post-epithelial-to-mesenchymal transition (post-EMT) cancer cells. Phosphatidic Acids 46-48 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-68 26787840-6 2016 Second, continued PA production in later starvation induces expression of PLD-targeting microRNA 203 (miR-203), miR-887, miR-3619-5p, and miR-182, which reduce PLD translation. Phosphatidic Acids 18-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 26787840-6 2016 Second, continued PA production in later starvation induces expression of PLD-targeting microRNA 203 (miR-203), miR-887, miR-3619-5p, and miR-182, which reduce PLD translation. Phosphatidic Acids 18-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 160-163 26787840-7 2016 We provide direct evidence for a feedback loop, whereby PLD induction upon starvation leads to PA, which induces expression of miRNAs, which in turn inhibits PLD2 translation. Phosphatidic Acids 95-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 25926691-1 2015 Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms. Phosphatidic Acids 152-169 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 25926691-1 2015 Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms. Phosphatidic Acids 152-169 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-56 27058440-3 2016 PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Phosphatidic Acids 68-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 27058440-3 2016 PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Phosphatidic Acids 87-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 27058440-4 2016 Agonist-induced PLD activation results in PA synthesis, which is thought to be involved in a variety of rapid cellular responses such as cytokine secretion. Phosphatidic Acids 42-44 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 26124282-1 2015 Overexpression of epidermal growth factor receptor (EGFR) is one of the frequent mechanisms implicated in cancer progression, and so is the overexpression of the enzyme phospholipase D (PLD) and its reaction product, phosphatidic acid (PA). Phosphatidic Acids 217-234 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-184 26124282-1 2015 Overexpression of epidermal growth factor receptor (EGFR) is one of the frequent mechanisms implicated in cancer progression, and so is the overexpression of the enzyme phospholipase D (PLD) and its reaction product, phosphatidic acid (PA). Phosphatidic Acids 217-234 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 186-189 26124282-1 2015 Overexpression of epidermal growth factor receptor (EGFR) is one of the frequent mechanisms implicated in cancer progression, and so is the overexpression of the enzyme phospholipase D (PLD) and its reaction product, phosphatidic acid (PA). Phosphatidic Acids 236-238 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-184 26124282-1 2015 Overexpression of epidermal growth factor receptor (EGFR) is one of the frequent mechanisms implicated in cancer progression, and so is the overexpression of the enzyme phospholipase D (PLD) and its reaction product, phosphatidic acid (PA). Phosphatidic Acids 236-238 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 186-189 25646564-3 2015 The lipid signaling molecule phosphatidic acid (PtdOH), which is produced by the hydrolytic enzyme phospholipase D (PLD), has been identified as a critical regulatory molecule for oncogenic signaling in many cancers. Phosphatidic Acids 29-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 99-114 25646564-3 2015 The lipid signaling molecule phosphatidic acid (PtdOH), which is produced by the hydrolytic enzyme phospholipase D (PLD), has been identified as a critical regulatory molecule for oncogenic signaling in many cancers. Phosphatidic Acids 29-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 116-119 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidic Acids 129-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidic Acids 148-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25936805-4 2015 This mitogen-stimulated DEPTOR dissociation is blocked by inhibition or depletion of the mTORC1 regulator, phospholipase D (PLD), and recapitulated with the addition of the PLD product phosphatidic acid (PA). Phosphatidic Acids 185-202 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 124-127 25936805-4 2015 This mitogen-stimulated DEPTOR dissociation is blocked by inhibition or depletion of the mTORC1 regulator, phospholipase D (PLD), and recapitulated with the addition of the PLD product phosphatidic acid (PA). Phosphatidic Acids 185-202 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 173-176 25936805-4 2015 This mitogen-stimulated DEPTOR dissociation is blocked by inhibition or depletion of the mTORC1 regulator, phospholipase D (PLD), and recapitulated with the addition of the PLD product phosphatidic acid (PA). Phosphatidic Acids 204-206 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 124-127 25936805-4 2015 This mitogen-stimulated DEPTOR dissociation is blocked by inhibition or depletion of the mTORC1 regulator, phospholipase D (PLD), and recapitulated with the addition of the PLD product phosphatidic acid (PA). Phosphatidic Acids 204-206 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 173-176 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidic Acids 148-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 25855286-7 2015 On the other hand, in mammals, phospholipases D (PLD), that produce PA, are involved in a variety of signaling cascades that control a broad spectrum of cellular functions, and play a role in the development of cancers. Phosphatidic Acids 68-70 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-47 25681440-6 2015 Small molecule inhibitors of phospholipase D (PLD), an enzyme that produces phosphatidic acid in cells, also attenuated the ERBB2 phenotype. Phosphatidic Acids 76-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 25681440-6 2015 Small molecule inhibitors of phospholipase D (PLD), an enzyme that produces phosphatidic acid in cells, also attenuated the ERBB2 phenotype. Phosphatidic Acids 76-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 25681440-7 2015 Exogenously added phosphatidic acid rescued the PLD-inhibition phenotype, but only when PTPD2 was present. Phosphatidic Acids 18-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidic Acids 37-54 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-151 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidic Acids 37-54 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidic Acids 56-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-151 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidic Acids 56-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 25855286-7 2015 On the other hand, in mammals, phospholipases D (PLD), that produce PA, are involved in a variety of signaling cascades that control a broad spectrum of cellular functions, and play a role in the development of cancers. Phosphatidic Acids 68-70 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 25523098-0 2014 Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25308783-1 2015 The phospholipase D (PLD) superfamily catalyzes the hydrolysis of cell membrane phospholipids generating the key intracellular lipid second messenger phosphatidic acid. Phosphatidic Acids 150-167 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 25308783-1 2015 The phospholipase D (PLD) superfamily catalyzes the hydrolysis of cell membrane phospholipids generating the key intracellular lipid second messenger phosphatidic acid. Phosphatidic Acids 150-167 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 25501815-7 2015 The reason why PLD activates AURA is because of the production of phosphatidic acid by the lipase, which binds directly to AURA, with the region E171-E211 projected to be a phosphatidic-acid-binding pocket. Phosphatidic Acids 66-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-18 25501815-7 2015 The reason why PLD activates AURA is because of the production of phosphatidic acid by the lipase, which binds directly to AURA, with the region E171-E211 projected to be a phosphatidic-acid-binding pocket. Phosphatidic Acids 173-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-18 25450673-6 2014 Treatment of RAW264.7 macrophages with exogenous phospholipase D (PLD), an enzyme that produces PA from membrane phospholipids, also inhibited C1P-stimulated cell migration. Phosphatidic Acids 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-64 25450673-6 2014 Treatment of RAW264.7 macrophages with exogenous phospholipase D (PLD), an enzyme that produces PA from membrane phospholipids, also inhibited C1P-stimulated cell migration. Phosphatidic Acids 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 66-69 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidic Acids 112-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidic Acids 112-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidic Acids 131-133 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidic Acids 131-133 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 25523098-6 2014 PLD induction of HIF-1alpha was significantly attenuated by 1-butanol which blocks PA production by PLD, and PA per se was able to elevate HIF-1alpha protein level. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 25523098-6 2014 PLD induction of HIF-1alpha was significantly attenuated by 1-butanol which blocks PA production by PLD, and PA per se was able to elevate HIF-1alpha protein level. Phosphatidic Acids 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-103 25275439-2 2014 Like other primary alcohols, 1-butanol is a substrate for PLD and thereby disrupts formation of the intracellular signaling lipid phosphatidic acid. Phosphatidic Acids 130-147 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 25187519-2 2014 We show here that phospholipase D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune cells (macrophages and neutrophils) to collagen and have defined the underlying molecular mechanism in a spatio-temporal manner that coincides with PLD activity timing. Phosphatidic Acids 76-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-33 25187519-2 2014 We show here that phospholipase D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune cells (macrophages and neutrophils) to collagen and have defined the underlying molecular mechanism in a spatio-temporal manner that coincides with PLD activity timing. Phosphatidic Acids 76-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 25187519-2 2014 We show here that phospholipase D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune cells (macrophages and neutrophils) to collagen and have defined the underlying molecular mechanism in a spatio-temporal manner that coincides with PLD activity timing. Phosphatidic Acids 76-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 281-284 25187519-2 2014 We show here that phospholipase D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune cells (macrophages and neutrophils) to collagen and have defined the underlying molecular mechanism in a spatio-temporal manner that coincides with PLD activity timing. Phosphatidic Acids 95-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-33 25187519-2 2014 We show here that phospholipase D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune cells (macrophages and neutrophils) to collagen and have defined the underlying molecular mechanism in a spatio-temporal manner that coincides with PLD activity timing. Phosphatidic Acids 95-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 25187519-2 2014 We show here that phospholipase D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune cells (macrophages and neutrophils) to collagen and have defined the underlying molecular mechanism in a spatio-temporal manner that coincides with PLD activity timing. Phosphatidic Acids 95-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 281-284 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidic Acids 51-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-112 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidic Acids 51-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidic Acids 70-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-112 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidic Acids 70-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 24990948-1 2014 Phospholipase D (PLD) regulates downstream effectors by generating phosphatidic acid. Phosphatidic Acids 67-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 24990948-1 2014 Phospholipase D (PLD) regulates downstream effectors by generating phosphatidic acid. Phosphatidic Acids 67-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 24990952-3 2014 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids 40-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 44-59 24990952-3 2014 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids 40-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 24990952-7 2014 Although PLD has been widely implicated in the generation of PA needed for mTOR activation, it is becoming clear that PA generated via the LPAAT and DGK pathways is also involved in the regulation of mTOR. Phosphatidic Acids 61-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 9-12 24618697-6 2014 Treatment of cells with the primary alcohol 1-butanol inhibits the hydrolysis of phosphatidylcoline by PLD thereby suppressing phosphatidic acid (PA) production. Phosphatidic Acids 127-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-106 24995811-4 2014 The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking. Phosphatidic Acids 91-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 24995811-4 2014 The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking. Phosphatidic Acids 110-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 24858808-5 2014 Inhibition of PLD and consequently production of phosphatidic acid inhibitis targeting of PDZGEF to the plasma membrane. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 24618697-6 2014 Treatment of cells with the primary alcohol 1-butanol inhibits the hydrolysis of phosphatidylcoline by PLD thereby suppressing phosphatidic acid (PA) production. Phosphatidic Acids 146-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-106 24302719-1 2014 The activation of mTOR signaling is essential for mechanically induced changes in skeletal muscle mass, and previous studies have suggested that mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D (PLD)-dependent increase in the concentration of phosphatidic acid (PA). Phosphatidic Acids 295-312 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 247-250 24257753-4 2014 In this report, we show that the lipid-metabolizing enzyme phospholipaseD(PLD) is a novel regulator of Akt inGBM.Studies using a combination of small molecule PLD inhibitors and siRNA knockdowns establish phosphatidic acid, the product of the PLD reaction, as an essential component for the membrane recruitment and activation of Akt. Phosphatidic Acids 205-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 24456402-0 2014 Monitoring phosphatidic acid formation in intact phosphatidylcholine bilayers upon phospholipase D catalysis. Phosphatidic Acids 11-28 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 83-98 24302719-1 2014 The activation of mTOR signaling is essential for mechanically induced changes in skeletal muscle mass, and previous studies have suggested that mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D (PLD)-dependent increase in the concentration of phosphatidic acid (PA). Phosphatidic Acids 295-312 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 230-245 24302719-1 2014 The activation of mTOR signaling is essential for mechanically induced changes in skeletal muscle mass, and previous studies have suggested that mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D (PLD)-dependent increase in the concentration of phosphatidic acid (PA). Phosphatidic Acids 314-316 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 230-245 24302719-1 2014 The activation of mTOR signaling is essential for mechanically induced changes in skeletal muscle mass, and previous studies have suggested that mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D (PLD)-dependent increase in the concentration of phosphatidic acid (PA). Phosphatidic Acids 314-316 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 247-250 25036123-0 2014 Detection of choline and phosphatidic acid (PA) catalyzed by phospholipase D (PLD) using MALDI-QIT-TOF/MS with 9-aminoacridine matrix. Phosphatidic Acids 25-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-76 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidic Acids 171-188 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidic Acids 171-188 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidic Acids 190-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidic Acids 190-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 25036123-0 2014 Detection of choline and phosphatidic acid (PA) catalyzed by phospholipase D (PLD) using MALDI-QIT-TOF/MS with 9-aminoacridine matrix. Phosphatidic Acids 25-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 78-81 25036123-0 2014 Detection of choline and phosphatidic acid (PA) catalyzed by phospholipase D (PLD) using MALDI-QIT-TOF/MS with 9-aminoacridine matrix. Phosphatidic Acids 44-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-76 25036123-0 2014 Detection of choline and phosphatidic acid (PA) catalyzed by phospholipase D (PLD) using MALDI-QIT-TOF/MS with 9-aminoacridine matrix. Phosphatidic Acids 44-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 78-81 24504948-5 2014 PLD activity is measured as the appearance of its radiolabeled products, phosphatidic acid and phosphatidylethanol. Phosphatidic Acids 73-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 24164897-3 2014 Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity), we found that PA was generated sequentially by PLD and DGK in epidermal growth factor (EGF)-stimulated HCC1806 breast cancer cells. Phosphatidic Acids 38-40 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 147-150 24164897-4 2014 Inhibition of PLD2, one of the two PLD members, was sufficient to eliminate most of the PA production, whereas inhibition of DGK decreased PA production only at the later stages of EGF stimulation, suggesting that PLD2 precedes DGK activation. Phosphatidic Acids 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 24164897-2 2014 One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK). Phosphatidic Acids 40-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 24164897-2 2014 One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK). Phosphatidic Acids 40-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 24164897-2 2014 One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK). Phosphatidic Acids 59-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 24164897-2 2014 One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK). Phosphatidic Acids 59-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 24164897-3 2014 Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity), we found that PA was generated sequentially by PLD and DGK in epidermal growth factor (EGF)-stimulated HCC1806 breast cancer cells. Phosphatidic Acids 24-26 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 147-150 24164897-3 2014 Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity), we found that PA was generated sequentially by PLD and DGK in epidermal growth factor (EGF)-stimulated HCC1806 breast cancer cells. Phosphatidic Acids 44-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 147-150 23723068-2 2013 Generation of signaling PA has long been primarily attributed to the activation of phospholipase D (PLD). Phosphatidic Acids 24-26 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 83-98 23664415-2 2013 Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). Phosphatidic Acids 136-153 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-67 23664415-2 2013 Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). Phosphatidic Acids 136-153 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 23664415-2 2013 Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). Phosphatidic Acids 155-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-67 23664415-2 2013 Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). Phosphatidic Acids 155-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 24009738-2 2013 Emerging evidence suggests that phospholipase D (PLD) and its product phosphatidic acid (PA) regulate mTOR activity. Phosphatidic Acids 89-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-47 24009738-2 2013 Emerging evidence suggests that phospholipase D (PLD) and its product phosphatidic acid (PA) regulate mTOR activity. Phosphatidic Acids 89-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 24009738-5 2013 Targeting PLD by small molecule inhibitors reduced cell proliferation and blocked mTOR signaling, whereas exogenous PA stimulated mTOR signaling and abolished the inhibitory effect of PLD on PKD cell proliferation. Phosphatidic Acids 116-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 184-187 24103753-5 2013 CAPE also decreased activation of matrix metalloproteinases-2 induced by phosphatidic acid, a product of PLD activity. Phosphatidic Acids 73-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 105-108 23752189-10 2013 In order to define the underlying mechanism, we determined that the machinery of PLD-induced cell invasion is mediated by phosphatidic acid, Wiscott-Aldrich Syndrome protein, growth receptor-bound protein 2 and Rac2 signaling events that ultimately affect actin polymerization and cell invasion. Phosphatidic Acids 122-139 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 81-84 23895284-2 2013 In contrast, phospholipase D (PLD) and its metabolite phosphatidic acid (PA) positively regulate mTORC1 signaling, whereas their role in mTORC2 function is less well defined. Phosphatidic Acids 54-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 13-28 23895284-2 2013 In contrast, phospholipase D (PLD) and its metabolite phosphatidic acid (PA) positively regulate mTORC1 signaling, whereas their role in mTORC2 function is less well defined. Phosphatidic Acids 54-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 23895284-2 2013 In contrast, phospholipase D (PLD) and its metabolite phosphatidic acid (PA) positively regulate mTORC1 signaling, whereas their role in mTORC2 function is less well defined. Phosphatidic Acids 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 13-28 23895284-2 2013 In contrast, phospholipase D (PLD) and its metabolite phosphatidic acid (PA) positively regulate mTORC1 signaling, whereas their role in mTORC2 function is less well defined. Phosphatidic Acids 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 23895284-18 2013 EtOH and PA regulate mTORC1 via a PI3K/AMPK/TSC2/PLD signaling cascade. Phosphatidic Acids 9-11 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 23686948-1 2013 Phospholipase D (PLD) exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid (PA). Phosphatidic Acids 126-143 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23686948-1 2013 Phospholipase D (PLD) exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid (PA). Phosphatidic Acids 126-143 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23686948-1 2013 Phospholipase D (PLD) exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid (PA). Phosphatidic Acids 145-147 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23686948-1 2013 Phospholipase D (PLD) exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid (PA). Phosphatidic Acids 145-147 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23686948-8 2013 These results demonstrate the important role of PLD-derived PA in normal PP2A-mediated PIN dephosphorylation and reveal a novel mechanism, in which PA recruits PP2AA1 to the membrane system and regulates PP2A function on membrane-targeted proteins. Phosphatidic Acids 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 23686948-8 2013 These results demonstrate the important role of PLD-derived PA in normal PP2A-mediated PIN dephosphorylation and reveal a novel mechanism, in which PA recruits PP2AA1 to the membrane system and regulates PP2A function on membrane-targeted proteins. Phosphatidic Acids 148-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 24009738-2 2013 Emerging evidence suggests that phospholipase D (PLD) and its product phosphatidic acid (PA) regulate mTOR activity. Phosphatidic Acids 70-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-47 24009738-2 2013 Emerging evidence suggests that phospholipase D (PLD) and its product phosphatidic acid (PA) regulate mTOR activity. Phosphatidic Acids 70-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 23723068-2 2013 Generation of signaling PA has long been primarily attributed to the activation of phospholipase D (PLD). Phosphatidic Acids 24-26 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-103 23723068-3 2013 PLD catalyzes the hydrolysis of phosphatidylcholine into PA. Phosphatidic Acids 57-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 23723068-7 2013 By following PA flux in the cell we show that PLD is involved in an initial increase in PA upon receptor stimulation; however, when PLD is blocked, the cell compensates by increasing PA production from other sources. Phosphatidic Acids 13-15 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 23723068-7 2013 By following PA flux in the cell we show that PLD is involved in an initial increase in PA upon receptor stimulation; however, when PLD is blocked, the cell compensates by increasing PA production from other sources. Phosphatidic Acids 13-15 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 132-135 23723068-7 2013 By following PA flux in the cell we show that PLD is involved in an initial increase in PA upon receptor stimulation; however, when PLD is blocked, the cell compensates by increasing PA production from other sources. Phosphatidic Acids 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 23723068-7 2013 By following PA flux in the cell we show that PLD is involved in an initial increase in PA upon receptor stimulation; however, when PLD is blocked, the cell compensates by increasing PA production from other sources. Phosphatidic Acids 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 132-135 23723068-7 2013 By following PA flux in the cell we show that PLD is involved in an initial increase in PA upon receptor stimulation; however, when PLD is blocked, the cell compensates by increasing PA production from other sources. Phosphatidic Acids 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 23723068-7 2013 By following PA flux in the cell we show that PLD is involved in an initial increase in PA upon receptor stimulation; however, when PLD is blocked, the cell compensates by increasing PA production from other sources. Phosphatidic Acids 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 132-135 23404507-2 2013 Phosphatidic acid, as synthesized by phospholipase D (PLD), enhances cancer cell survival. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 23644991-4 2013 On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid. Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-54 23644991-4 2013 On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid. Phosphatidic Acids 86-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 23404507-2 2013 Phosphatidic acid, as synthesized by phospholipase D (PLD), enhances cancer cell survival. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 23662182-8 2013 For the first time, this study demonstrated that the PLD-generated intracellular bioactive lipid signal mediator, PA, played a critical role in the ROS-induced barrier dysfunction in lung vascular ECs. Phosphatidic Acids 114-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-56 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidic Acids 127-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidic Acids 127-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidic Acids 146-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidic Acids 146-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23662182-2 2013 Earlier, we have demonstrated that ROS stimulate lung endothelial cell (EC) phospholipase D (PLD) that generates phosphatidic acid (PA), a second messenger involved in signal transduction. Phosphatidic Acids 113-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 23662182-2 2013 Earlier, we have demonstrated that ROS stimulate lung endothelial cell (EC) phospholipase D (PLD) that generates phosphatidic acid (PA), a second messenger involved in signal transduction. Phosphatidic Acids 113-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 23662182-2 2013 Earlier, we have demonstrated that ROS stimulate lung endothelial cell (EC) phospholipase D (PLD) that generates phosphatidic acid (PA), a second messenger involved in signal transduction. Phosphatidic Acids 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 23662182-2 2013 Earlier, we have demonstrated that ROS stimulate lung endothelial cell (EC) phospholipase D (PLD) that generates phosphatidic acid (PA), a second messenger involved in signal transduction. Phosphatidic Acids 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 23662182-5 2013 1-Butanol, the quencher of PLD, generated PA leading to the formation of physiologically inactive phosphatidyl butanol but not its biologically inactive analog, 2-butanol, blocked the H2O2-mediated barrier dysfunction. Phosphatidic Acids 42-44 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 22187071-10 2012 5-ASA treatment inhibited PLD activity and proliferation; these effects could be rescued with exogenous PA. Phosphatidic Acids 104-106 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 26-29 22187071-9 2012 Both proliferation and mTOR activity depended on PLD, an enzyme that generates phosphatidic acid (PA). Phosphatidic Acids 79-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 22187071-9 2012 Both proliferation and mTOR activity depended on PLD, an enzyme that generates phosphatidic acid (PA). Phosphatidic Acids 98-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 49-52 22187071-11 2012 CONCLUSION: 5-ASA interferes with proliferation of colorectal cancer cells via inhibition of PLD-dependent generation of PA and loss of mTOR signalling. Phosphatidic Acids 121-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 22622287-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid. Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22932846-7 2012 Treatments with phosphatidic acid, the product of PLD activity, induced stomatal closure in plddelta mutants. Phosphatidic Acids 16-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 22622287-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid. Phosphatidic Acids 100-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22579635-5 2012 The production of PA is abrogated by primary alcohols that have been widely used for the analysis of PLD-mediated processes. Phosphatidic Acids 18-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 22824913-1 2012 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. Phosphatidic Acids 110-127 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22824913-1 2012 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. Phosphatidic Acids 110-127 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidic Acids 122-139 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidic Acids 122-139 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidic Acids 141-143 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidic Acids 141-143 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22472346-7 2012 Phosphatidic acid, produced by shear stress-induced PLD activation, stimulated mTOR signaling, and caused podocyte hypertrophy and apoptosis. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 52-55 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidic Acids 87-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22504301-8 2012 When signal transducer and activator of transcription 3 (STAT3) activity was blocked by a STAT3 specific siRNA, PA-induced Bcl-2 expression was remarkably decreased, suggesting that STAT3 is an essential transcription factor linking PLD to Bcl-2 upregulation. Phosphatidic Acids 112-114 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 233-236 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidic Acids 87-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidic Acids 106-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidic Acids 106-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22212660-5 2012 In addition, we describe the functional roles played by PLD and PA in these interactions, and provide PLD network that summarizes these interactions. Phosphatidic Acids 64-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-105 21740967-1 2011 Phospholipase D (PLD) catalyzes the conversion of the membrane phospholipid phosphatidylcholine to choline and phosphatidic acid (PA). Phosphatidic Acids 111-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22178154-7 2012 Inhibition of Phosphatidic Acid (PA) formation by PLD using butan-1-ol, inhibited actin polymerization and motility, as well as in vitro fertilization (IVF) and the ability of the sperm to undergo the AR. Phosphatidic Acids 14-31 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 22178154-7 2012 Inhibition of Phosphatidic Acid (PA) formation by PLD using butan-1-ol, inhibited actin polymerization and motility, as well as in vitro fertilization (IVF) and the ability of the sperm to undergo the AR. Phosphatidic Acids 33-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 22178154-8 2012 The inhibition of sperm HAM by low concentration of butan-1-ol is completely restored by adding PA, further indicating the involvement of PLD in these processes. Phosphatidic Acids 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 138-141 21447092-1 2012 Phospholipase D (PLD), a superfamily of signalling enzymes that most commonly generate the lipid second messenger phosphatidic acid, is found in diverse organisms from bacteria to humans and functions in multiple cellular pathways. Phosphatidic Acids 114-131 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21447092-1 2012 Phospholipase D (PLD), a superfamily of signalling enzymes that most commonly generate the lipid second messenger phosphatidic acid, is found in diverse organisms from bacteria to humans and functions in multiple cellular pathways. Phosphatidic Acids 114-131 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22281006-1 2012 Phospholipase D (PLD), a superfamily of signaling enzymes that most commonly generate the lipid second messenger Phosphatidic Acid (PA), is found in diverse organisms from bacteria to man and functions in multiple cellular pathways. Phosphatidic Acids 113-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22281006-1 2012 Phospholipase D (PLD), a superfamily of signaling enzymes that most commonly generate the lipid second messenger Phosphatidic Acid (PA), is found in diverse organisms from bacteria to man and functions in multiple cellular pathways. Phosphatidic Acids 113-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22281006-1 2012 Phospholipase D (PLD), a superfamily of signaling enzymes that most commonly generate the lipid second messenger Phosphatidic Acid (PA), is found in diverse organisms from bacteria to man and functions in multiple cellular pathways. Phosphatidic Acids 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22281006-1 2012 Phospholipase D (PLD), a superfamily of signaling enzymes that most commonly generate the lipid second messenger Phosphatidic Acid (PA), is found in diverse organisms from bacteria to man and functions in multiple cellular pathways. Phosphatidic Acids 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22426721-2 2012 Phosphatidic acid, a chief product of PLD enzymatic activity, is a pleiotropic second messenger with key roles in membrane trafficking, cell invasion, cell growth, and anti-apoptosis. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 22339628-1 2012 Phospholipase D (PLD) catalyzes hydrolysis of phospholipids with production of phosphatidic acid, which often acts as secondary messenger of transduction of intracellular signals. Phosphatidic Acids 79-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22339628-1 2012 Phospholipase D (PLD) catalyzes hydrolysis of phospholipids with production of phosphatidic acid, which often acts as secondary messenger of transduction of intracellular signals. Phosphatidic Acids 79-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 21740967-1 2011 Phospholipase D (PLD) catalyzes the conversion of the membrane phospholipid phosphatidylcholine to choline and phosphatidic acid (PA). Phosphatidic Acids 111-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 21740967-1 2011 Phospholipase D (PLD) catalyzes the conversion of the membrane phospholipid phosphatidylcholine to choline and phosphatidic acid (PA). Phosphatidic Acids 130-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21740967-1 2011 Phospholipase D (PLD) catalyzes the conversion of the membrane phospholipid phosphatidylcholine to choline and phosphatidic acid (PA). Phosphatidic Acids 130-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 21740967-2 2011 PLD"s mission in the cell is two-fold: phospholipid turnover with maintenance of the structural integrity of cellular/intracellular membranes and cell signaling through PA and its metabolites. Phosphatidic Acids 169-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 21740967-6 2011 Over the past few years, we have reported, in regards to the catalytic action of PLD, that PA is a chemoattractant agent that binds to and signals inside the cell through the ribosomal S6 kinases (S6K). Phosphatidic Acids 91-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 81-84 22024166-2 2011 Phospholipase D (PLD) and its product, phosphatidic acid, have been established as mediators of mitogenic activation of mTORC1. Phosphatidic Acids 39-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21984187-2 2011 At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidic Acids 112-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 21984187-2 2011 At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidic Acids 131-133 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 21900174-2 2011 Earlier, we found that hypersalinity induced a rapid increase in the putative lipid second messenger, phosphatidic acid (PA), which was suggested to be generated via activation of a phospholipase D (PLD) pathway and the combined action of a phospholipase C/diacylglycerol kinase (PLC/DGK) pathway. Phosphatidic Acids 102-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 182-197 21900174-2 2011 Earlier, we found that hypersalinity induced a rapid increase in the putative lipid second messenger, phosphatidic acid (PA), which was suggested to be generated via activation of a phospholipase D (PLD) pathway and the combined action of a phospholipase C/diacylglycerol kinase (PLC/DGK) pathway. Phosphatidic Acids 102-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 199-202 21900174-2 2011 Earlier, we found that hypersalinity induced a rapid increase in the putative lipid second messenger, phosphatidic acid (PA), which was suggested to be generated via activation of a phospholipase D (PLD) pathway and the combined action of a phospholipase C/diacylglycerol kinase (PLC/DGK) pathway. Phosphatidic Acids 121-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 182-197 21900174-2 2011 Earlier, we found that hypersalinity induced a rapid increase in the putative lipid second messenger, phosphatidic acid (PA), which was suggested to be generated via activation of a phospholipase D (PLD) pathway and the combined action of a phospholipase C/diacylglycerol kinase (PLC/DGK) pathway. Phosphatidic Acids 121-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 199-202 22024166-2 2011 Phospholipase D (PLD) and its product, phosphatidic acid, have been established as mediators of mitogenic activation of mTORC1. Phosphatidic Acids 39-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 21867678-8 2011 Furthermore, quercetin inhibited activation and invasion of metalloproteinase-2 (MMP-2), a key modulator of glioma cell invasion, induced by phosphatidic acid (PA), a product of PLD activity. Phosphatidic Acids 141-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 178-181 21867678-8 2011 Furthermore, quercetin inhibited activation and invasion of metalloproteinase-2 (MMP-2), a key modulator of glioma cell invasion, induced by phosphatidic acid (PA), a product of PLD activity. Phosphatidic Acids 160-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 178-181 20158570-5 2011 Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst. Phosphatidic Acids 228-230 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 180-183 21338572-2 2011 PA is mainly produced by phospholipase D (PLD) and diacylglycerol kinase (DGK). Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 21338572-2 2011 PA is mainly produced by phospholipase D (PLD) and diacylglycerol kinase (DGK). Phosphatidic Acids 0-2 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 21622984-4 2011 Phospholipase D (PLD) generates a metabolite, phosphatidic acid, that facilitates association between mTOR and the mTORC1 co-factor Raptor. Phosphatidic Acids 46-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21622984-4 2011 Phospholipase D (PLD) generates a metabolite, phosphatidic acid, that facilitates association between mTOR and the mTORC1 co-factor Raptor. Phosphatidic Acids 46-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 21622984-7 2011 Thus, a key stimulatory event for mTORC1 activation in response to nutrients is the generation of phosphatidic acid by PLD. Phosphatidic Acids 98-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 20158570-5 2011 Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst. Phosphatidic Acids 43-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 19-22 20158570-5 2011 Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst. Phosphatidic Acids 43-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 180-183 20158570-5 2011 Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst. Phosphatidic Acids 62-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 19-22 20158570-5 2011 Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst. Phosphatidic Acids 62-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 180-183 21224347-2 2011 PLD regulates downstream effectors by generating phosphatidic acid (PA), and the expression and activity of PLD are elevated in many different types of human cancer. Phosphatidic Acids 49-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 20473892-5 2011 Phosphatidic acid, the product of PLD activity, leads to an increase in the Ras-ERK/PI3K-NFkappaB signaling cascade and enhances binding of NFkappaB to the PLD1 promoter, consequently inducing selective PLD1 expression in SK-BR3 breast cancer cells. Phosphatidic Acids 0-17 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-37 21224347-2 2011 PLD regulates downstream effectors by generating phosphatidic acid (PA), and the expression and activity of PLD are elevated in many different types of human cancer. Phosphatidic Acids 68-70 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 21224347-5 2011 In this review, we discuss the emerging importance of PLD and PA in the Wnt/beta-catenin signaling network, which is associated with tumorigenesis, and suggest that the PLD/PA signaling pathway is a potential therapeutic target for the treatment of cancer. Phosphatidic Acids 173-175 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 21224347-5 2011 In this review, we discuss the emerging importance of PLD and PA in the Wnt/beta-catenin signaling network, which is associated with tumorigenesis, and suggest that the PLD/PA signaling pathway is a potential therapeutic target for the treatment of cancer. Phosphatidic Acids 173-175 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-172