PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30180990-1 2018 Lysophosphatidic acid acyltransferases (LPAAT) play an essential role in generating phosphatidic acid (PA), a key intermediate for phospholipids and triacylglycerol synthesis. Phosphatidic Acids 4-21 membrane bound O-acyltransferase domain containing 2 Homo sapiens 40-45 30180990-1 2018 Lysophosphatidic acid acyltransferases (LPAAT) play an essential role in generating phosphatidic acid (PA), a key intermediate for phospholipids and triacylglycerol synthesis. Phosphatidic Acids 41-43 membrane bound O-acyltransferase domain containing 2 Homo sapiens 0-38 24205284-1 2013 Lysophosphatidic acid acyltransferase (LPAAT-beta) is a phosphatidic acid (PA) generating enzyme that plays an essential role in triglyceride synthesis. Phosphatidic Acids 40-42 membrane bound O-acyltransferase domain containing 2 Homo sapiens 0-37 29373329-3 2018 RECENT FINDINGS: Recent molecular studies suggest that individual LPAAT homologues produce functionally distinct pools of phosphatidic acid, whereas gene ablation studies demonstrate unique roles despite a similar biochemical function. Phosphatidic Acids 122-139 membrane bound O-acyltransferase domain containing 2 Homo sapiens 66-71 24990952-3 2014 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids 40-42 membrane bound O-acyltransferase domain containing 2 Homo sapiens 100-137 24990952-3 2014 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids 40-42 membrane bound O-acyltransferase domain containing 2 Homo sapiens 139-144 24990952-7 2014 Although PLD has been widely implicated in the generation of PA needed for mTOR activation, it is becoming clear that PA generated via the LPAAT and DGK pathways is also involved in the regulation of mTOR. Phosphatidic Acids 118-120 membrane bound O-acyltransferase domain containing 2 Homo sapiens 139-144 17653611-6 2007 Based on this approach, we synthesized two membrane proteins (enzymes), GPAT and LPAAT, which are involved in the phosphatidic acid biosynthesis in bacteria. Phosphatidic Acids 114-131 membrane bound O-acyltransferase domain containing 2 Homo sapiens 81-86 17002884-1 2006 Lysophosphatidic acid acyltransferase (LPAAT) is an intrinsic membrane protein that catalyzes the synthesis of phosphatidic acid (PA) from lysophosphatidic acid (LPA). Phosphatidic Acids 4-21 membrane bound O-acyltransferase domain containing 2 Homo sapiens 39-44 17002884-1 2006 Lysophosphatidic acid acyltransferase (LPAAT) is an intrinsic membrane protein that catalyzes the synthesis of phosphatidic acid (PA) from lysophosphatidic acid (LPA). Phosphatidic Acids 40-42 membrane bound O-acyltransferase domain containing 2 Homo sapiens 0-37 16369050-1 2006 Membranes of mammalian cells contain lysophosphatidic acid acyltransferase (LPAAT) activities that catalyze the acylation of sn-1-acyl lysophosphatidic acid (lysoPA) to form phosphatidic acid. Phosphatidic Acids 41-58 membrane bound O-acyltransferase domain containing 2 Homo sapiens 76-81 14679006-1 2003 In this study, we examined the effects of isoform-specific functional inhibitors of lysophosphatidic acid acyltransferase (LPAAT), which converts lysophosphatidic acid to phosphatidic acid, on multiple myeloma (MM) cell growth and survival. Phosphatidic Acids 88-105 membrane bound O-acyltransferase domain containing 2 Homo sapiens 123-128 14498826-3 2003 The authors have investigated whether it would be possible to interrupt these known oncogenic pathways through the inhibition of lysophosphatidic acid acyltransferase (LPAAT), an enzyme that catalyses the biosynthesis of PA. Phosphatidic Acids 169-171 membrane bound O-acyltransferase domain containing 2 Homo sapiens 129-166 11108727-3 2000 In the presence of [(14)C]oleoyl-CoA, LPAAT selectively catalyzes the transformation of LPA and alkyl-LPA into [(14)C]phosphatidic acid. Phosphatidic Acids 118-135 membrane bound O-acyltransferase domain containing 2 Homo sapiens 38-43 9242711-4 1997 LPA is converted to phosphatidic acid, itself a lipid mediator, by an LPA acyltransferase (LPAAT). Phosphatidic Acids 20-37 membrane bound O-acyltransferase domain containing 2 Homo sapiens 70-89 9242711-4 1997 LPA is converted to phosphatidic acid, itself a lipid mediator, by an LPA acyltransferase (LPAAT). Phosphatidic Acids 20-37 membrane bound O-acyltransferase domain containing 2 Homo sapiens 91-96 19027713-13 2009 The activities of internally synthesized GPAT and LPAAT were confirmed by detecting the produced lysophosphatidic acid and phosphatidic acid, respectively. Phosphatidic Acids 101-118 membrane bound O-acyltransferase domain containing 2 Homo sapiens 50-55 12938015-2 2003 LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids 20-37 membrane bound O-acyltransferase domain containing 2 Homo sapiens 55-92 12938015-2 2003 LPA is converted to phosphatidic acid by the action of lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids 20-37 membrane bound O-acyltransferase domain containing 2 Homo sapiens 94-99 11487472-2 2001 LPA acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase (1-AGPAT) (EC 2.3.1.51), catalyzes the conversion of LPA to PA. Phosphatidic Acids 1-3 membrane bound O-acyltransferase domain containing 2 Homo sapiens 21-26 11352914-9 2001 These results indicate that the CoA-dependent transacylation of LPA consists of 1) acyl-CoA synthesis from PA through the reverse action of LPAAT and 2) the transfer of the fatty acyl moiety of the newly formed acyl-CoA to LPA through the forward reaction of LPAAT. Phosphatidic Acids 65-67 membrane bound O-acyltransferase domain containing 2 Homo sapiens 140-151 11352914-9 2001 These results indicate that the CoA-dependent transacylation of LPA consists of 1) acyl-CoA synthesis from PA through the reverse action of LPAAT and 2) the transfer of the fatty acyl moiety of the newly formed acyl-CoA to LPA through the forward reaction of LPAAT. Phosphatidic Acids 65-67 membrane bound O-acyltransferase domain containing 2 Homo sapiens 140-145 9461603-5 1998 LPAAT is the enzyme that in lipid metabolism converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). Phosphatidic Acids 58-75 membrane bound O-acyltransferase domain containing 2 Homo sapiens 0-5 9212163-2 1997 LPA acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acetyltransferase (EC 2.3.1.51), catalyzes the conversion of LPA to PA. Phosphatidic Acids 1-3 membrane bound O-acyltransferase domain containing 2 Homo sapiens 21-26 1905569-7 1991 We conclude that the PA pool was enlarged via the lipid A sensitive lyso-PA acyl transferase (lyso-PA-AT) and was decreased by a phosphatidate phosphohydrolase to form DAG. Phosphatidic Acids 21-23 membrane bound O-acyltransferase domain containing 2 Homo sapiens 68-92 1905569-7 1991 We conclude that the PA pool was enlarged via the lipid A sensitive lyso-PA acyl transferase (lyso-PA-AT) and was decreased by a phosphatidate phosphohydrolase to form DAG. Phosphatidic Acids 21-23 membrane bound O-acyltransferase domain containing 2 Homo sapiens 94-104