PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34920170-2	2022	We faced this challenge with a 3,4,5,6-tetrahydropyridine-2-amine scaffold harboring an amidine, a key structural component of potential inhibitors of BACE1, the rate-limiting enzyme in the production of Abeta species that make up amyloid plaques in Alzheimer"s disease.	3,4,5,6-tetrahydropyridine-2-amine	31-65	beta-secretase 1	Homo sapiens	151-156