PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32873592-16	2020	Therefore, we determined whether pharmacological depletion of GSTZ1 through repeat administration of DCA produced similar changes in the liver, which could affect responses to other drugs and toxicants.	Dichloroacetic Acid	101-104	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	62-67	
15277241-1	2004	Glutathione transferase zeta (GSTZ1-1) is the major enzyme that catalyzes the metabolism of alpha-halo acids such as dichloroacetic acid, a carcinogenic contaminant of chlorinated water.	Dichloroacetic Acid	117-136	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	30-37	
22127296-2	2012	However, DCA can create a deficiency of glutathione transferase Zeta (GSTZ1-1).	Dichloroacetic Acid	9-12	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	70-77	
21303221-8	2011	DCA was shown to be a k(cat) inactivator of human, rat, and mouse GSTZ1-1; human GSTZ1-1 was more resistant to inactivation than mouse or rat GSTZ1-1.	Dichloroacetic Acid	0-3	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	66-73	
19426674-8	2009	However, although we found that DCA at 200mg/(kg day) causes a severe loss of hepatic GSTZ1-1 activity in BALB/c mice, it did not induce WBC cytotoxicity when combined with high dietary phenylalanine.	Dichloroacetic Acid	32-35	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	86-93	
16581029-3	2006	The objective of the present study was to evaluate whether administration of dichloroacetate, an inhibitor of maleyl acetoacetate isomerase (MAAI) to FAH-knockout mice could prevent acute pathological injury caused by NTBC withdrawal.	Dichloroacetic Acid	77-92	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	110-139	
16581029-3	2006	The objective of the present study was to evaluate whether administration of dichloroacetate, an inhibitor of maleyl acetoacetate isomerase (MAAI) to FAH-knockout mice could prevent acute pathological injury caused by NTBC withdrawal.	Dichloroacetic Acid	77-92	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	141-145	
16581029-7	2006	DCA was shown to inhibit hepatic MAAI activity to 86% (0.5g/L) and 94% (5g/L) of untreated wild-type mice.	Dichloroacetic Acid	0-3	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	33-37	
11960676-20	2002	Reduced MAAI activity alone is unlikely to be the carcinogenic mode of action for DCA and may in fact, only be important during the early stages of DCA exposure.	Dichloroacetic Acid	82-85	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	8-12	
14599561-2	2003	DCA is biotransformed to glyoxylate by maleylacetoacetate isomerase (MAAI).	Dichloroacetic Acid	0-3	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	39-67	
14599561-2	2003	DCA is biotransformed to glyoxylate by maleylacetoacetate isomerase (MAAI).	Dichloroacetic Acid	0-3	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	69-73	
11960676-20	2002	Reduced MAAI activity alone is unlikely to be the carcinogenic mode of action for DCA and may in fact, only be important during the early stages of DCA exposure.	Dichloroacetic Acid	148-151	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	8-12