PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12200414-5	2002	Exposure of primary neurons to glutamate or 3-nitropropionic acid increases intracellular calcium concentration, leading to loss of intact full-length wild-type huntingtin.	3-nitropropionic acid	44-65	huntingtin	Homo sapiens	161-171	
17455294-9	2007	Finally, treatment with 3-nitropropionic acid, a succinate dehydrogenase inhibitor, had opposite effects on the ubiquitin-proteasome system with activation in wild-type and decreased activity in mutant huntingtin expressing cells.	3-nitropropionic acid	24-45	huntingtin	Homo sapiens	202-212	
8858182-4	1996	The confirmation of the complex II inhibitor 3-nitropropionic acid as a toxin model for Huntington"s disease, together with the demonstration of reduced mitochondrial function in Huntington"s disease caudate, supports the proposition that mutant huntingtin may exert its effect through an abnormality of energy metabolism.	3-nitropropionic acid	45-66	huntingtin	Homo sapiens	246-256	
22589249-6	2012	In cultured WT and mutant Htt striatal cells, small hairpin RNA-mediated TORC1 knockdown resulted in decreased PGC-1alpha expression and increased susceptibility to 3-NP-induced toxicity.	3-nitropropionic acid	165-169	huntingtin	Homo sapiens	26-29	
30529228-9	2019	3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.	3-nitropropionic acid	0-21	huntingtin	Homo sapiens	168-178	
30529228-9	2019	3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.	3-nitropropionic acid	0-21	huntingtin	Homo sapiens	228-238	
30529228-9	2019	3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.	3-nitropropionic acid	23-27	huntingtin	Homo sapiens	168-178	
30529228-9	2019	3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.	3-nitropropionic acid	23-27	huntingtin	Homo sapiens	228-238	
22415443-6	2012	3-nitropropionic acid, on the aggregation of mutant huntingtin (mthtt) protein, whose misfolding and aggregation results in cellular abnormalities characteristic of HD.	3-nitropropionic acid	0-21	huntingtin	Homo sapiens	52-62