PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34013265-8	2021	A local analysis of seven key binding pockets reveals that six out them, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, and protein-glycan interaction sites, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.	Linoleic Acid	135-148	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	314-319	
33469977-1	2021	We investigate binding of linoleate and other potential ligands to the recently discovered fatty acid binding site in the SARS-CoV-2 spike protein, using docking and molecular dynamics simulations.	Linoleic Acid	26-35	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	133-138	
33469977-2	2021	Simulations suggest that linoleate and dexamethasone stabilize the locked spike conformation, thus reducing the opportunity for ACE2 interaction.	Linoleic Acid	25-34	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	74-79	
33573088-4	2021	Moreover, it was found that linoleic acid, an omega-6 PUFA, could stabilize the spike protein in a closed conformation, blocking its interaction with ACE2.	Linoleic Acid	28-41	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	80-85	
33573088-6	2021	We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects.	Linoleic Acid	115-128	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	189-194	
34934478-4	2021	The presence of linoleic acid at this site modulates binding of the spike to the human ACE2 receptor, stabilizing a locked conformation of the protein.	Linoleic Acid	16-29	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	68-73	
34934478-9	2021	These communication networks significantly involve positions that are prone to mutation, indicating that observed genetic variation in the spike may alter its response to linoleate binding and associated allosteric communication.	Linoleic Acid	171-180	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	139-144	
32958580-3	2020	Our 2.85 A cryo-EM structure of SARS-CoV-2 spike (S) glycoprotein reveals that the receptor binding domains (RBDs) tightly bind the essential free fatty acid (FFA) linoleic acid (LA) in three composite binding pockets.	Linoleic Acid	164-177	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	43-48