PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20170107-1 2010 Anthocyanins (cyanidin-3-glucoside (Cy-3-gluc) and delphinidin-3-glucoside (Dp-3-gluc)) and their respective vinylpyranoanthocyanin-catechins (portisins) were studied in order to evaluate the cytotoxicity effect on the estrogen responsive human breast cancer cell line (ER+) MCF-7 and their effect on estrogen receptor (ER-alpha and ER-beta) expression. Anthocyanins 0-12 estrogen receptor 2 Homo sapiens 333-340 29286333-0 2017 Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta. Anthocyanins 41-53 estrogen receptor 2 Homo sapiens 84-106 29286333-3 2017 In this study, we investigated the participation of ERbeta in the phytoestrogen activity of these anthocyanins. Anthocyanins 98-110 estrogen receptor 2 Homo sapiens 52-58 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 13-24 estrogen receptor 2 Homo sapiens 33-39 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 13-24 estrogen receptor 2 Homo sapiens 91-97 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 13-24 estrogen receptor 2 Homo sapiens 91-97 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 159-171 estrogen receptor 2 Homo sapiens 33-39 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 159-171 estrogen receptor 2 Homo sapiens 91-97 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 159-171 estrogen receptor 2 Homo sapiens 91-97 29286333-9 2017 These results show that blackcurrant anthocyanins exert phytoestrogen activity via ERbeta. Anthocyanins 37-49 estrogen receptor 2 Homo sapiens 83-89