PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9801932-0	1998	Effect of HMG-CoA reductase inhibitors on plasma polyunsaturated fatty acid concentrations in patients with hyperlipidemia.	Fatty Acids, Unsaturated	49-75	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	10-27	
9801932-1	1998	We investigated the effect of 12 months" HMG-CoA reductase inhibitor treatment on plasma polyunsaturated fatty acid concentrations in 19 patients with hyperlipidemia.	Fatty Acids, Unsaturated	89-115	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	41-58	
9254057-1	1997	In the monocytic THP-1 cells, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor simvastatin (5 microM) enhances the conversion of exogenous linoleic (18:2 n-6) and eicosapentaenoic (20:5 n-3) acids to their long-chain polyunsaturated fatty acid (LC-PUFA) derivatives, and this effect is associated with changes in the desaturation steps.	Fatty Acids, Unsaturated	240-266	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	34-91	
29615666-5	2018	Notably, significant upregulation of genes involved in unsaturated fatty acid metabolism [stearoyl-CoA desaturase (SCD)] and cholesterol biosynthesis [3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)], were associated with atorvastatin insensitivity.	Fatty Acids, Unsaturated	55-77	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	151-191	
29615666-5	2018	Notably, significant upregulation of genes involved in unsaturated fatty acid metabolism [stearoyl-CoA desaturase (SCD)] and cholesterol biosynthesis [3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)], were associated with atorvastatin insensitivity.	Fatty Acids, Unsaturated	55-77	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	193-198	
24057001-8	2013	First, we found that mutant livers accumulate multiple polyunsaturated fatty acids (PUFAs) and PUFA-CoAs, and we showed that human HMGCR is inhibited by PUFA-CoAs in vitro.	Fatty Acids, Unsaturated	55-82	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	131-136	
11844650-5	2002	For instance, the binding of estrogen to its receptor on the cell membrane may be determined by its lipid content, statins and PUFAs inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, statins influence the metabolism of PUFAs, and PUFA deficiency enhances 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.	Fatty Acids, Unsaturated	127-132	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	141-188