PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3166242-5 1988 To more specifically elucidate the anti-factor Xa mediated antithrombotic mechanism of action of this pentasaccharide, it was studied in several thrombin generation assays. pentasaccharide 102-117 prothrombin Oryctolagus cuniculus 145-153 3166242-6 1988 Pentasaccharide added to human and rabbit plasmas in vitro from 0 to 5.0 micrograms/ml produced a concentration dependent effect up to a 35 to 50% inhibition of generated thrombin. pentasaccharide 0-15 prothrombin Oryctolagus cuniculus 171-179 3166242-9 1988 These results indicate that a relationship exists between the pentasaccharide induced inhibition of experimental venous stasis thrombosis and the inhibition of thrombin generation. pentasaccharide 62-77 prothrombin Oryctolagus cuniculus 160-168 3603420-1 1987 A synthetic pentasaccharide, representing the critical sequence required in heparin for binding to antithrombin III (AT III), produces strong anti-factor Xa activity in vitro in the presence of AT III and is devoid of any activity directed towards thrombin. pentasaccharide 12-27 prothrombin Oryctolagus cuniculus 103-111 20941458-0 2011 Efficacy of prothrombin complex concentrate to reverse the anticoagulant effect of the pentasaccharide fondaparinux in a rabbit model. pentasaccharide 87-102 prothrombin Oryctolagus cuniculus 12-23