PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15681813-0	2004	Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.	2-methylcyclopentadienyl manganese tricarbonyl	120-164	protein kinase C delta	Homo sapiens	12-20	
15681813-7	2004	Importantly, MMT induced proteolytic cleavage of protein kinase Cdelta (PKCdelta), resulting in persistently increased kinase activity.	2-methylcyclopentadienyl manganese tricarbonyl	13-16	protein kinase C delta	Homo sapiens	49-70	
15681813-7	2004	Importantly, MMT induced proteolytic cleavage of protein kinase Cdelta (PKCdelta), resulting in persistently increased kinase activity.	2-methylcyclopentadienyl manganese tricarbonyl	13-16	protein kinase C delta	Homo sapiens	72-80	
15681813-9	2004	Pretreatment with 100 microM Z-DEVD-FMK and 5 microM rottlerin (a PKCdelta inhibitor) also significantly attenuated MMT-induced DNA fragmentation.	2-methylcyclopentadienyl manganese tricarbonyl	116-119	protein kinase C delta	Homo sapiens	66-74	
15681813-10	2004	Furthermore, overexpression of either the kinase inactive dominant negative PKCdelta(K376R) mutant or the caspase cleavage resistant PKCdelta(D327A) mutant rescued N27 cells from MMT-induced DNA fragmentation.	2-methylcyclopentadienyl manganese tricarbonyl	179-182	protein kinase C delta	Homo sapiens	76-84	
15681813-10	2004	Furthermore, overexpression of either the kinase inactive dominant negative PKCdelta(K376R) mutant or the caspase cleavage resistant PKCdelta(D327A) mutant rescued N27 cells from MMT-induced DNA fragmentation.	2-methylcyclopentadienyl manganese tricarbonyl	179-182	protein kinase C delta	Homo sapiens	133-141	
15681813-11	2004	Collectively, these results demonstrate that the mitochondrial-dependent apoptotic cascade mediates apoptosis via proteolytic activation of PKCdelta in MMT-induced dopaminergic degeneration and suggest that PKCdelta may serve as an attractive therapeutic target in Parkinson-related neurological diseases.	2-methylcyclopentadienyl manganese tricarbonyl	152-155	protein kinase C delta	Homo sapiens	140-148	
15681813-11	2004	Collectively, these results demonstrate that the mitochondrial-dependent apoptotic cascade mediates apoptosis via proteolytic activation of PKCdelta in MMT-induced dopaminergic degeneration and suggest that PKCdelta may serve as an attractive therapeutic target in Parkinson-related neurological diseases.	2-methylcyclopentadienyl manganese tricarbonyl	152-155	protein kinase C delta	Homo sapiens	207-215	
15681813-0	2004	Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.	2-methylcyclopentadienyl manganese tricarbonyl	166-169	protein kinase C delta	Homo sapiens	12-20	
11880503-8	2002	Additionally, overexpression of catalytically inactive PKCdelta(K376R) (dominant-negative mutant) prevented MMT-induced apoptosis in immortalized mesencephalic dopaminergic cells.	2-methylcyclopentadienyl manganese tricarbonyl	108-111	protein kinase C delta	Homo sapiens	55-63	
11880503-0	2002	Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.	2-methylcyclopentadienyl manganese tricarbonyl	151-195	protein kinase C delta	Homo sapiens	44-65	
11880503-3	2002	Interestingly, we also found that MMT exposure induces a time- and dose-dependent proteolytic cleavage of native protein kinase Cdelta (PKCdelta, 72-74 kDa) to yield 41 kDa catalytically active and 38 kDa regulatory fragments.	2-methylcyclopentadienyl manganese tricarbonyl	34-37	protein kinase C delta	Homo sapiens	113-134	
11880503-3	2002	Interestingly, we also found that MMT exposure induces a time- and dose-dependent proteolytic cleavage of native protein kinase Cdelta (PKCdelta, 72-74 kDa) to yield 41 kDa catalytically active and 38 kDa regulatory fragments.	2-methylcyclopentadienyl manganese tricarbonyl	34-37	protein kinase C delta	Homo sapiens	136-144	
11880503-4	2002	Pretreatment with caspase inhibitors (Z-DEVD-FMK or Z-VAD-FMK) blocked MMT-induced proteolytic cleavage of PKCdelta, indicating that cleavage is mediated by caspase-3.	2-methylcyclopentadienyl manganese tricarbonyl	71-74	protein kinase C delta	Homo sapiens	107-115