PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17498346-1	2007	OBJECTIVE: To explore the function of Caspase-3 and p38 MAPK in MMT-induced apoptosis in PC-3M cells.	2-methylcyclopentadienyl manganese tricarbonyl	64-67	caspase 3	Homo sapiens	38-47	
17498346-6	2007	RESULTS: The activity of Caspase-3 increased significantly in MMT-induced apoptosis in PC-3M cells /9P < 0.01), and Z-DEVD-FMK could protect cells from apoptosis (P < 0.01).	2-methylcyclopentadienyl manganese tricarbonyl	62-65	caspase 3	Homo sapiens	25-34	
11880503-0	2002	Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.	2-methylcyclopentadienyl manganese tricarbonyl	151-195	caspase 3	Homo sapiens	0-9	
11880503-2	2002	In pheochromocytoma cells, MMT exposure resulted in rapid increase in generation of reactive oxygen species (ROS) within 5--15 min, followed by release of mitochondrial cytochrome C into cytoplasm and subsequent activation of cysteine proteases, caspase-9 (twofold to threefold) and caspase-3 (15- to 25-fold), but not caspase-8, in a time- and dose-dependent manner.	2-methylcyclopentadienyl manganese tricarbonyl	27-30	caspase 3	Homo sapiens	283-292	
11880503-4	2002	Pretreatment with caspase inhibitors (Z-DEVD-FMK or Z-VAD-FMK) blocked MMT-induced proteolytic cleavage of PKCdelta, indicating that cleavage is mediated by caspase-3.	2-methylcyclopentadienyl manganese tricarbonyl	71-74	caspase 3	Homo sapiens	157-166