PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22445327-5 2012 Aging affected the expression of enzymes involved in 5-methylcytosine and 5-hydroxymethylcytosine synthesis (mitochondrial DNA methyltransferase 1 [mtDNMT1] and ten-eleven-translocation [TET]1-TET3, respectively). 5-hydroxymethylcytosine 74-97 tet methylcytosine dioxygenase 3 Homo sapiens 193-197 34719681-1 2022 TET3 at 2p13.1 encodes tet methylcytosine dioxygenase 3, a demethylation enzyme that converts 5-methylcytosine to 5-hydroxymethylcytosine. 5-hydroxymethylcytosine 114-137 tet methylcytosine dioxygenase 3 Homo sapiens 0-4 21407207-6 2011 A knockdown of the 5hmC generating dioxygenase Tet3 simultaneously affects the patterns of 5hmC and 5mC in the paternal pronucleus. 5-hydroxymethylcytosine 19-23 tet methylcytosine dioxygenase 3 Homo sapiens 47-51 21407207-6 2011 A knockdown of the 5hmC generating dioxygenase Tet3 simultaneously affects the patterns of 5hmC and 5mC in the paternal pronucleus. 5-hydroxymethylcytosine 91-95 tet methylcytosine dioxygenase 3 Homo sapiens 47-51 34948036-1 2021 TET3 is a member of the TET (ten-eleven translocation) proteins family that catalyzes the conversion of the 5-methylcytosine into 5-hydroxymethylcytosine. 5-hydroxymethylcytosine 130-153 tet methylcytosine dioxygenase 3 Homo sapiens 0-4 34719681-1 2022 TET3 at 2p13.1 encodes tet methylcytosine dioxygenase 3, a demethylation enzyme that converts 5-methylcytosine to 5-hydroxymethylcytosine. 5-hydroxymethylcytosine 114-137 tet methylcytosine dioxygenase 3 Homo sapiens 23-55 35136034-1 2022 DNA methylation is a reversible process catalyzed by the ten-eleven translocation (TET) family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 164-187 tet methylcytosine dioxygenase 3 Homo sapiens 119-123 35136034-1 2022 DNA methylation is a reversible process catalyzed by the ten-eleven translocation (TET) family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 189-193 tet methylcytosine dioxygenase 3 Homo sapiens 119-123 32822029-3 2021 Using the same method employed above, which detects modified bases in the denatured single stranded DNA, we showed that this active DNA "demethylation" in the paternal pronucleus involves oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine (5caC) by the TET3 enzyme. 5-hydroxymethylcytosine 233-237 tet methylcytosine dioxygenase 3 Homo sapiens 300-304 33388378-3 2021 Ten-eleven translocation (TET1, TET2 and TET3), which is the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), plays a central role in the DNA demethylation process. 5-hydroxymethylcytosine 101-124 tet methylcytosine dioxygenase 3 Homo sapiens 41-45 33388378-3 2021 Ten-eleven translocation (TET1, TET2 and TET3), which is the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), plays a central role in the DNA demethylation process. 5-hydroxymethylcytosine 126-130 tet methylcytosine dioxygenase 3 Homo sapiens 41-45 34009615-2 2021 Active DNA demethylation is mediated by TET enzymes: TET1, TET2, and TET3, which convert 5-methylcytosine to 5-hydroxymethylcytosine. 5-hydroxymethylcytosine 109-132 tet methylcytosine dioxygenase 3 Homo sapiens 69-73 32024762-1 2020 Ten-eleven translocation (TET) family enzymes (TET1, TET2, and TET3) oxidize 5-methylcytosine (5mC) and generate 5-hydroxymethylcytosine (5hmC) marks on the genome. 5-hydroxymethylcytosine 113-136 tet methylcytosine dioxygenase 3 Homo sapiens 63-67 32024762-1 2020 Ten-eleven translocation (TET) family enzymes (TET1, TET2, and TET3) oxidize 5-methylcytosine (5mC) and generate 5-hydroxymethylcytosine (5hmC) marks on the genome. 5-hydroxymethylcytosine 138-142 tet methylcytosine dioxygenase 3 Homo sapiens 63-67 31656201-3 2019 Ten-eleven translocation protein 3 (TET3) belongs to the family of ten-eleven translocations (TETs) which induce DNA demethylation and gene regulation in epigenetic level by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 211-234 tet methylcytosine dioxygenase 3 Homo sapiens 0-34 31656201-3 2019 Ten-eleven translocation protein 3 (TET3) belongs to the family of ten-eleven translocations (TETs) which induce DNA demethylation and gene regulation in epigenetic level by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 211-234 tet methylcytosine dioxygenase 3 Homo sapiens 36-40 31656201-3 2019 Ten-eleven translocation protein 3 (TET3) belongs to the family of ten-eleven translocations (TETs) which induce DNA demethylation and gene regulation in epigenetic level by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 236-240 tet methylcytosine dioxygenase 3 Homo sapiens 0-34 31656201-3 2019 Ten-eleven translocation protein 3 (TET3) belongs to the family of ten-eleven translocations (TETs) which induce DNA demethylation and gene regulation in epigenetic level by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 236-240 tet methylcytosine dioxygenase 3 Homo sapiens 36-40 28745936-5 2017 Recently, Jiang and colleagues have demonstrated that DNA damage response-activated ATR kinase phosphorylates TET3 in mammalian cells and promotes DNA demethylation and 5-hydroxymethylcytosine accumulation. 5-hydroxymethylcytosine 169-192 tet methylcytosine dioxygenase 3 Homo sapiens 110-114 31286885-1 2019 BACKGROUND: The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency. 5-hydroxymethylcytosine 125-148 tet methylcytosine dioxygenase 3 Homo sapiens 52-56 31088968-1 2019 Genome-wide DNA "demethylation" in the zygote involves global TET3-mediated oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in the paternal pronucleus. 5-hydroxymethylcytosine 115-138 tet methylcytosine dioxygenase 3 Homo sapiens 62-66 31088968-1 2019 Genome-wide DNA "demethylation" in the zygote involves global TET3-mediated oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in the paternal pronucleus. 5-hydroxymethylcytosine 140-144 tet methylcytosine dioxygenase 3 Homo sapiens 62-66 30099980-5 2019 In HeLa cells, the expressed Dppa3 was predominantly localised in the nucleus and could partially suppress Tet3-induced 5hmC accumulation, but this suppressive function was not correlated with H3K9me2. 5-hydroxymethylcytosine 120-124 tet methylcytosine dioxygenase 3 Homo sapiens 107-111 29791079-6 2018 Overexpression of Tet3 in somatic cells can initiate DNA demethylation, reduce 5-methylcytosine level, increase 5-hydroxymethylcytosine level and promote the expression of key pluripotency genes. 5-hydroxymethylcytosine 112-135 tet methylcytosine dioxygenase 3 Homo sapiens 18-22 27918235-2 2017 In a screen for chromatin regulators of the regenerative responses in this conditioning lesion paradigm, we identified Tet methylcytosine dioxygenase 3 (Tet3) as upregulated in DRG neurons, along with increased 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 211-234 tet methylcytosine dioxygenase 3 Homo sapiens 153-157 27918235-2 2017 In a screen for chromatin regulators of the regenerative responses in this conditioning lesion paradigm, we identified Tet methylcytosine dioxygenase 3 (Tet3) as upregulated in DRG neurons, along with increased 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 236-240 tet methylcytosine dioxygenase 3 Homo sapiens 153-157 27918235-5 2017 Our analyses also predicted HIF-1, STAT, and IRF as potential transcription factors that may collaborate with Tet3 for 5hmC modifications. 5-hydroxymethylcytosine 119-123 tet methylcytosine dioxygenase 3 Homo sapiens 110-114 26769901-4 2016 Here, we found that methyl-CpG-binding domain protein 3 (MBD3) and its homolog MBD3-like 2 (MBD3L2) can specifically modulate the enzymatic activity of Tet2 protein, but not Tet1 and Tet3 proteins, in converting 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 240-263 tet methylcytosine dioxygenase 3 Homo sapiens 183-187 26769901-4 2016 Here, we found that methyl-CpG-binding domain protein 3 (MBD3) and its homolog MBD3-like 2 (MBD3L2) can specifically modulate the enzymatic activity of Tet2 protein, but not Tet1 and Tet3 proteins, in converting 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine 265-269 tet methylcytosine dioxygenase 3 Homo sapiens 183-187 26917261-1 2016 Our previous whole genome expression analysis of endometriomas suggested dysregulation of the ten-eleven translocation genes (TET1, TET2, and TET3), involved in converting 5- methylcytosine to 5-hydroxymethylcytosine (5-hmC). 5-hydroxymethylcytosine 193-216 tet methylcytosine dioxygenase 3 Homo sapiens 142-146 26917261-1 2016 Our previous whole genome expression analysis of endometriomas suggested dysregulation of the ten-eleven translocation genes (TET1, TET2, and TET3), involved in converting 5- methylcytosine to 5-hydroxymethylcytosine (5-hmC). 5-hydroxymethylcytosine 218-223 tet methylcytosine dioxygenase 3 Homo sapiens 142-146 26671928-4 2015 TET proteins (TET1, TET2, TET3) are iron(II) and alpha-ketoglutarate dependent dioxygenases, and their enzymatic activity involves hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine and 5-carboxylcytosine. 5-hydroxymethylcytosine 168-191 tet methylcytosine dioxygenase 3 Homo sapiens 26-30 25304979-1 2015 In mammalian cells, 5-methylcytosine (5-meC) can be transformed into 5-hydroxymethylcytosine (5-hmC) by the methylcytosine dioxygenase TET proteins (TET1, TET2 and TET3). 5-hydroxymethylcytosine 69-92 tet methylcytosine dioxygenase 3 Homo sapiens 164-168 26093090-2 2015 The Ten-eleven translocation (TET) enzymes (TET1, TET2, and TET3) are implicated in DNA demethylation, through dioxygenase activity that converts 5-mC to 5-hydroxymethylcytosine (5-hmC). 5-hydroxymethylcytosine 154-177 tet methylcytosine dioxygenase 3 Homo sapiens 60-64 26093090-2 2015 The Ten-eleven translocation (TET) enzymes (TET1, TET2, and TET3) are implicated in DNA demethylation, through dioxygenase activity that converts 5-mC to 5-hydroxymethylcytosine (5-hmC). 5-hydroxymethylcytosine 179-184 tet methylcytosine dioxygenase 3 Homo sapiens 60-64 26199412-3 2015 Embryos lacking Tet1 and Tet3 (Tet1/3 DKO) displayed a strong loss of 5-hydroxymethylcytosine (5hmC) and a concurrent increase in 5-methylcytosine (5mC) at the eight-cell stage. 5-hydroxymethylcytosine 70-93 tet methylcytosine dioxygenase 3 Homo sapiens 25-29 26199412-3 2015 Embryos lacking Tet1 and Tet3 (Tet1/3 DKO) displayed a strong loss of 5-hydroxymethylcytosine (5hmC) and a concurrent increase in 5-methylcytosine (5mC) at the eight-cell stage. 5-hydroxymethylcytosine 70-93 tet methylcytosine dioxygenase 3 Homo sapiens 31-41 26199412-3 2015 Embryos lacking Tet1 and Tet3 (Tet1/3 DKO) displayed a strong loss of 5-hydroxymethylcytosine (5hmC) and a concurrent increase in 5-methylcytosine (5mC) at the eight-cell stage. 5-hydroxymethylcytosine 95-99 tet methylcytosine dioxygenase 3 Homo sapiens 25-29 26199412-3 2015 Embryos lacking Tet1 and Tet3 (Tet1/3 DKO) displayed a strong loss of 5-hydroxymethylcytosine (5hmC) and a concurrent increase in 5-methylcytosine (5mC) at the eight-cell stage. 5-hydroxymethylcytosine 95-99 tet methylcytosine dioxygenase 3 Homo sapiens 31-41 26294212-4 2015 We discovered that hypoxia deregulates TET1 and TET3, the enzymes that catalyze conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), thereby leading to breast tumor-initiating cell (BTIC) properties. 5-hydroxymethylcytosine 120-143 tet methylcytosine dioxygenase 3 Homo sapiens 48-52 26294212-4 2015 We discovered that hypoxia deregulates TET1 and TET3, the enzymes that catalyze conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), thereby leading to breast tumor-initiating cell (BTIC) properties. 5-hydroxymethylcytosine 145-149 tet methylcytosine dioxygenase 3 Homo sapiens 48-52 24838624-1 2015 5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytocine (5mC) by Tet family of dioxygenases (Tet1, Tet2, and Tet3), is enriched in the embryonic stem cells (ESCs) and in the brain. 5-hydroxymethylcytosine 0-23 tet methylcytosine dioxygenase 3 Homo sapiens 117-121 24838624-1 2015 5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytocine (5mC) by Tet family of dioxygenases (Tet1, Tet2, and Tet3), is enriched in the embryonic stem cells (ESCs) and in the brain. 5-hydroxymethylcytosine 25-29 tet methylcytosine dioxygenase 3 Homo sapiens 117-121 25304979-1 2015 In mammalian cells, 5-methylcytosine (5-meC) can be transformed into 5-hydroxymethylcytosine (5-hmC) by the methylcytosine dioxygenase TET proteins (TET1, TET2 and TET3). 5-hydroxymethylcytosine 94-99 tet methylcytosine dioxygenase 3 Homo sapiens 164-168 25089631-5 2014 CT-GABRA3 also carries a microRNA (miR-767) with predicted target sites in TET1 and TET3, two members of the ten-eleven-translocation family of tumor suppressor genes, which are involved in the conversion of 5-methylcytosines to 5-hydroxymethylcytosines (5hmC) in DNA. 5-hydroxymethylcytosine 229-253 tet methylcytosine dioxygenase 3 Homo sapiens 84-88 25089631-5 2014 CT-GABRA3 also carries a microRNA (miR-767) with predicted target sites in TET1 and TET3, two members of the ten-eleven-translocation family of tumor suppressor genes, which are involved in the conversion of 5-methylcytosines to 5-hydroxymethylcytosines (5hmC) in DNA. 5-hydroxymethylcytosine 255-259 tet methylcytosine dioxygenase 3 Homo sapiens 84-88 24958354-4 2014 TET2 or TET3 depletion also causes increased 5hmC, suggesting these proteins play a major role in 5hmC removal. 5-hydroxymethylcytosine 45-49 tet methylcytosine dioxygenase 3 Homo sapiens 8-12 24958354-4 2014 TET2 or TET3 depletion also causes increased 5hmC, suggesting these proteins play a major role in 5hmC removal. 5-hydroxymethylcytosine 98-102 tet methylcytosine dioxygenase 3 Homo sapiens 8-12 23403289-8 2013 Functional perturbation of the H3K27 methyltransferase Ezh2 or of Tet2 and Tet3 leads to defects in neuronal differentiation, suggesting that formation of 5hmC and loss of H3K27me3 cooperate to promote brain development. 5-hydroxymethylcytosine 155-159 tet methylcytosine dioxygenase 3 Homo sapiens 75-79 23634848-3 2013 5hmC is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. 5-hydroxymethylcytosine 0-4 tet methylcytosine dioxygenase 3 Homo sapiens 123-127 23222540-1 2013 Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. 5-hydroxymethylcytosine 99-122 tet methylcytosine dioxygenase 3 Homo sapiens 65-69