PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10913932-7	2000	Papaverine is a non-specific inhibitor of these enzymes; sildenafil is an orally active, potent and selective inhibitor of GMP-specific PDE5, the predominant isoenzyme metabolizing cGMP in the cells of the corpus cavernosum.	guanosine 5'-monophosphorothioate	123-126	phosphodiesterase 5A	Homo sapiens	136-140	
17305581-5	2007	The PDE4-AMP and PDE5-GMP structures reveal the conserved interactions of the phosphate groups of the products AMP and GMP, and thus suggest a universal mechanism of nucleophilic attack for all PDE families.	guanosine 5'-monophosphorothioate	119-122	phosphodiesterase 5A	Homo sapiens	17-21	
17305581-5	2007	The PDE4-AMP and PDE5-GMP structures reveal the conserved interactions of the phosphate groups of the products AMP and GMP, and thus suggest a universal mechanism of nucleophilic attack for all PDE families.	guanosine 5'-monophosphorothioate	22-25	phosphodiesterase 5A	Homo sapiens	17-21	
30747070-1	2019	BACKGROUND: PDE5A is a phosphodiesterase which specifically hydrolyzes the cGMP to GMP.	guanosine 5'-monophosphorothioate	76-79	phosphodiesterase 5A	Homo sapiens	12-17	
31539416-7	2019	In particular, compounds 3 and 7 exhibit Ki values of 0.036 +- 0.005 muM and 0.036 +- 0.007 muM towards PDE5 respectively, which are approaching those of commercial PDE5 inhibitors, and can effectively reduce GMP levels in cultured human BJ-hTERT cells.	guanosine 5'-monophosphorothioate	209-212	phosphodiesterase 5A	Homo sapiens	104-108	
25043200-5	2014	Phosphodiesterase 5 (PDE5) degrades cGMP to GMP.	guanosine 5'-monophosphorothioate	37-40	phosphodiesterase 5A	Homo sapiens	0-19	
25043200-5	2014	Phosphodiesterase 5 (PDE5) degrades cGMP to GMP.	guanosine 5'-monophosphorothioate	37-40	phosphodiesterase 5A	Homo sapiens	21-25