PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24596384-1	2014	Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299).	1-azabicyclo[2.2.2]octan-2-one	45-59	tumor protein p53	Homo sapiens	156-159	
28366825-0	2017	Novel quinuclidinone derivatives induced apoptosis in human breast cancer via targeting p53.	1-azabicyclo[2.2.2]octan-2-one	6-20	tumor protein p53	Homo sapiens	88-91	
23182046-6	2012	Quinuclidinone derivative 6 increased expression levels of p53 and Bax at  both protein and mRNA levels and reduced expression level of Mdm2, Bcl2, Akt and Bcl-XL It also increased mitochondrial apoptotic pathways by activating release of cytochrome c which is consistent with activation of caspase-9 as confirmed by caspase-9 inhibitor LEHD-CHO.	1-azabicyclo[2.2.2]octan-2-one	0-14	tumor protein p53	Homo sapiens	59-62	
21498708-1	2011	Novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299) have been previously reported.	1-azabicyclo[2.2.2]octan-2-one	6-20	tumor protein p53	Homo sapiens	117-120