PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8817062-6	1996	However, only the amosite+TNF combination caused significant depletion of cellular high-energy nucleotide when expressed as percentage of [14C]adenine labeling in cellular high-energy nucleotides.	Carbon-14	139-142	tumor necrosis factor	Homo sapiens	26-29	
9486175-4	1998	Treatment of human Hep G2 cells with 1 ng/ml TNF-alpha increased [14C]putrescine cross-linking to cellular proteins.	Carbon-14	66-69	tumor necrosis factor	Homo sapiens	45-54	
9030540-2	1997	TNF-alpha stimulation of adult feline cardiac myocytes provoked a rapid (<15 min) increase in the hydrolysis of [14C]sphingomyelin in cell-free extracts, as well as an increase in ceramide mass, consistent with cytokine-induced activation of the neutral sphingomyelinase pathway.	Carbon-14	116-119	tumor necrosis factor	Homo sapiens	0-9	
7720683-2	1995	In cells labelled with [methyl-14C]choline, TNF alpha induced a similar reduction in [14C]sphingomyelin content that was accompanied by a sustained elevation in [14C]phosphorylcholine levels.	Carbon-14	31-34	tumor necrosis factor	Homo sapiens	44-53	
7492275-7	1995	RESULTS: The incorporation of 14C-labeled glucose (D-[U-14C]glucose) into phosphatidylcholine and phosphatidylglycerol was selectively inhibited either by 8-Br-cGMP or in the presence of TNF-alpha, PGE2, or nitroprusside, all of which caused an increase in the intracellular levels of cGMP.	Carbon-14	30-33	tumor necrosis factor	Homo sapiens	187-196	
7720683-2	1995	In cells labelled with [methyl-14C]choline, TNF alpha induced a similar reduction in [14C]sphingomyelin content that was accompanied by a sustained elevation in [14C]phosphorylcholine levels.	Carbon-14	86-89	tumor necrosis factor	Homo sapiens	44-53	
1658188-5	1991	The increase in DAG was detectable as early as 15 s after TNF treatment and peaked at 60 s. DAG increments were most pronounced (approximately 360% of basal levels) when cells were preincubated with [14C]lysophosphatidylcholine, which was predominantly incorporated into the phosphatidylcholine (PC) pool of the plasma-membranes.	Carbon-14	200-203	tumor necrosis factor	Homo sapiens	58-61	
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Carbon-14	151-154	tumor necrosis factor	Homo sapiens	46-49	
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Carbon-14	170-173	tumor necrosis factor	Homo sapiens	46-49	
8286511-6	1993	RESULTS: All three cytokines, particularly TNF-alpha, inhibited the incorporation of D-glucose uniformly labelled with 14C (D-(U-14C) glucose) into phosphatidylcholine.	Carbon-14	119-122	tumor necrosis factor	Homo sapiens	43-52	
8286511-8	1993	When palmitate uniformly labelled with 14C was used as the radiolabelled precursor, TNF-alpha stimulated the synthesis of both triacylglycerol and phosphatidylcholine, neither of which was affected by IL-1 or IL-6.	Carbon-14	39-42	tumor necrosis factor	Homo sapiens	84-93	
8286512-5	1993	MAIN OUTCOME MEASURES: Effect of TNF-alpha on the incorporation of D-glucose and palmitate, both of which had been uniformly labelled with 14C (D-(U-14C) glucose and (U-14C) palmitate), into various phospholipid fractions by pneumocytes isolated from both healthy lungs and those from patients with lung cancer.	Carbon-14	139-142	tumor necrosis factor	Homo sapiens	33-42	
8142598-1	1993	The cytokine cachectin/TNF induces a rapid increase in lactate production and in glucose metabolism in L6 myocytes in culture; glucose uptake was maximal after 17 h, while elevated glucose utilization and lactate production persisted for up to 32 h. These increases are suggestive of increased glycolytic activity, and were associated with a 10% decrease in cellular oxygen consumption and a comparable decrease in the production of 14C-labelled CO2 from 14C-labelled glucose.	Carbon-14	433-436	tumor necrosis factor	Homo sapiens	13-22	
8142598-1	1993	The cytokine cachectin/TNF induces a rapid increase in lactate production and in glucose metabolism in L6 myocytes in culture; glucose uptake was maximal after 17 h, while elevated glucose utilization and lactate production persisted for up to 32 h. These increases are suggestive of increased glycolytic activity, and were associated with a 10% decrease in cellular oxygen consumption and a comparable decrease in the production of 14C-labelled CO2 from 14C-labelled glucose.	Carbon-14	433-436	tumor necrosis factor	Homo sapiens	23-26	
8142598-1	1993	The cytokine cachectin/TNF induces a rapid increase in lactate production and in glucose metabolism in L6 myocytes in culture; glucose uptake was maximal after 17 h, while elevated glucose utilization and lactate production persisted for up to 32 h. These increases are suggestive of increased glycolytic activity, and were associated with a 10% decrease in cellular oxygen consumption and a comparable decrease in the production of 14C-labelled CO2 from 14C-labelled glucose.	Carbon-14	455-458	tumor necrosis factor	Homo sapiens	13-22	
8142598-1	1993	The cytokine cachectin/TNF induces a rapid increase in lactate production and in glucose metabolism in L6 myocytes in culture; glucose uptake was maximal after 17 h, while elevated glucose utilization and lactate production persisted for up to 32 h. These increases are suggestive of increased glycolytic activity, and were associated with a 10% decrease in cellular oxygen consumption and a comparable decrease in the production of 14C-labelled CO2 from 14C-labelled glucose.	Carbon-14	455-458	tumor necrosis factor	Homo sapiens	23-26	
3586712-2	1987	TNF was found to augment the capacity of peritoneal macrophages to convert 14C-labeled arginine into L-ornithine and to release L-ornithine into the culture medium.	Carbon-14	75-78	tumor necrosis factor	Homo sapiens	0-3	
1689552-2	1990	We studied the effect of human recombinant TNF alpha (rTNF alpha) on transfer of 14C-labeled bovine serum albumin (BSA) across cultured bovine pulmonary arterial endothelial cell monolayers.	Carbon-14	81-84	tumor necrosis factor	Homo sapiens	43-52	
33301441-5	2020	RA was also effective in alleviating TNF-alpha-induced 16HBE barrier leak, attenuating 60% of the TNF-alpha-induced leak to 14C-mannitol and 80% of the leak to 14C-inulin.	Carbon-14	124-127	tumor necrosis factor	Homo sapiens	37-46	
33301441-5	2020	RA was also effective in alleviating TNF-alpha-induced 16HBE barrier leak, attenuating 60% of the TNF-alpha-induced leak to 14C-mannitol and 80% of the leak to 14C-inulin.	Carbon-14	124-127	tumor necrosis factor	Homo sapiens	98-107	
28030347-6	2017	In contrast, paired females treated with rhTNFa incorporated significantly smaller amounts of [14C]-methionine in a TNFa dose-dependent but time-independent manner [2 hr (P = 0.001) or 4 hr (P = 0.027) One-Way ANOVA].	Carbon-14	95-98	tumor necrosis factor	Homo sapiens	43-47	
28030347-9	2017	These observations suggest that TNFa inhibits [14C]-methionine uptake and reduces fecundity in females paired with males.	Carbon-14	47-50	tumor necrosis factor	Homo sapiens	32-36