PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9078265-3 1997 SNP stimulated the rate of 2-deoxyglucose transport and insulin-mediated (100 mu-units/ml) rates of both net and [14C]lactate release and the rate of glucose oxidation. Carbon-14 114-117 insulin Homo sapiens 56-63 11272131-5 2001 In myotubes, overexpression of AGAT-alpha did not affect total [14C]glucose uptake in the presence or absence of insulin, whereas insulin-stimulated [14C]glucose conversion to cellular lipids increased significantly (33%, P = 0.004) with a concomitant decrease (-30%, P = 0.005) in glycogen formation. Carbon-14 150-153 insulin Homo sapiens 130-137 9078265-6 1997 SNP stimulated the insulin-stimulated rates of net and [14C]lactate release and glucose oxidation in a concentration-dependent manner. Carbon-14 56-59 insulin Homo sapiens 19-26 8528146-3 1995 Stimulation of [14C]deoxyglucose uptake by PDGF and EGF was 29% and 70%, respectively, while that by insulin was 5-fold. Carbon-14 16-19 insulin Homo sapiens 101-108 1400874-2 1992 Since the response of the liver to insulin-induced hypoglycemia normally involves activation of gluconeogenesis, we measured [14C]alanine conversion to [14C]glucose (a qualitative index of gluconeogenesis) and glucose production (using [3-3H]glucose) in seven intensively treated type I diabetic subjects (hemoglobin-A1, 7.1 +/- 0.4%) during low dose infusion of insulin (0.3 mU/kg.min for 210 min). Carbon-14 126-129 insulin Homo sapiens 35-42 8243874-7 1993 The addition of HDL3 (50 micrograms) resulted in a significant decrease in 14C-labelled cholesterol ester, reflecting a decrease in intracellular unesterified cholesterol, which was partially reversed by the addition of insulin. Carbon-14 75-78 insulin Homo sapiens 220-227 8387542-8 1993 The decrease in insulin receptors was accompanied as expected, by a reduction in [14C]acetate incorporation, an index of lipid synthesis, whereas PAI-1 secretion and PAI-1 mRNA expression were enhanced. Carbon-14 82-85 insulin Homo sapiens 16-23 1400874-2 1992 Since the response of the liver to insulin-induced hypoglycemia normally involves activation of gluconeogenesis, we measured [14C]alanine conversion to [14C]glucose (a qualitative index of gluconeogenesis) and glucose production (using [3-3H]glucose) in seven intensively treated type I diabetic subjects (hemoglobin-A1, 7.1 +/- 0.4%) during low dose infusion of insulin (0.3 mU/kg.min for 210 min). Carbon-14 153-156 insulin Homo sapiens 35-42 1618850-6 1992 (ii) By contrast, under similar conditions, CHO-Y2 cells exhibited a marked decrease in their response to insulin for [U-14C]glucose incorporation into glycogen (decreased sensitivity and maximal responsiveness) and for [U-14C]leucine incorporation into protein (decreased sensitivity) as compared with CHO-R cells. Carbon-14 121-124 insulin Homo sapiens 106-113 2546962-4 1989 In comparison to normal fibroblasts, [125I]insulin binding, insulin-stimulated [14C]glucose, and [3H]thymidine uptake, and insulin-stimulated autophosphorylation were each reduced by approximately 50-60% of the absolute values in controls. Carbon-14 80-83 insulin Homo sapiens 60-67 2546962-4 1989 In comparison to normal fibroblasts, [125I]insulin binding, insulin-stimulated [14C]glucose, and [3H]thymidine uptake, and insulin-stimulated autophosphorylation were each reduced by approximately 50-60% of the absolute values in controls. Carbon-14 80-83 insulin Homo sapiens 60-67 2661589-7 1989 This was associated with impaired suppression by insulin of plasma FFA turnover, FFA oxidation (measured by [14C]palmitate) and nonoxidative FFA disposal (an estimate of reesterification of FFA). Carbon-14 109-112 insulin Homo sapiens 49-56 2542108-10 1989 Insulin stimulated [14C]glucose incorporation into cellular lipid in a dose-dependent manner, with 50% effective concentration (EC50) of 0.3 nM. Carbon-14 20-23 insulin Homo sapiens 0-7 2548853-4 1989 These PTK blockers inhibit the insulin induced [14C]glucose assimilation into lipids (lipogenesis), but fail to inhibit the anti-lipolytic effect of the hormone. Carbon-14 48-51 insulin Homo sapiens 31-38 3047525-5 1988 The in vitro stimulatory effect of insulin on [14C]glucose oxidation by parametrial adipose tissue was unchanged at three hours but suppressed six hours following administration of RCM-hGH. Carbon-14 47-50 insulin Homo sapiens 35-42 2656686-8 1989 When 3T3/HIR cells were preincubated with MA10, subsequent insulin- or IGF-I-stimulated deoxy[14C]glucose uptake was markedly inhibited. Carbon-14 94-97 insulin Homo sapiens 59-66 3146971-10 1988 In addition to increases in [3H]glycerol labelling of PC/PE, insulin rapidly (within 30 s) increased PC/PE labelling by [3H]arachidonic acid, [3H]myristic acid, and [14C]choline. Carbon-14 166-169 insulin Homo sapiens 61-68 3047525-6 1988 When the plasma insulin level of ob/ob mice was increased threefold by the administration of neutral protamine Hagedorn (NPH) insulin, the in vitro stimulatory effect of insulin on [14C]glucose oxidation by adipose tissue isolated from these animals was not altered, suggesting that insulin-induced receptor or postreceptor changes do not account for the increased insulin resistance produced by RCM-hGH. Carbon-14 182-185 insulin Homo sapiens 16-23 3047525-6 1988 When the plasma insulin level of ob/ob mice was increased threefold by the administration of neutral protamine Hagedorn (NPH) insulin, the in vitro stimulatory effect of insulin on [14C]glucose oxidation by adipose tissue isolated from these animals was not altered, suggesting that insulin-induced receptor or postreceptor changes do not account for the increased insulin resistance produced by RCM-hGH. Carbon-14 182-185 insulin Homo sapiens 126-133 3047525-6 1988 When the plasma insulin level of ob/ob mice was increased threefold by the administration of neutral protamine Hagedorn (NPH) insulin, the in vitro stimulatory effect of insulin on [14C]glucose oxidation by adipose tissue isolated from these animals was not altered, suggesting that insulin-induced receptor or postreceptor changes do not account for the increased insulin resistance produced by RCM-hGH. Carbon-14 182-185 insulin Homo sapiens 126-133 3047525-6 1988 When the plasma insulin level of ob/ob mice was increased threefold by the administration of neutral protamine Hagedorn (NPH) insulin, the in vitro stimulatory effect of insulin on [14C]glucose oxidation by adipose tissue isolated from these animals was not altered, suggesting that insulin-induced receptor or postreceptor changes do not account for the increased insulin resistance produced by RCM-hGH. Carbon-14 182-185 insulin Homo sapiens 126-133 3047525-6 1988 When the plasma insulin level of ob/ob mice was increased threefold by the administration of neutral protamine Hagedorn (NPH) insulin, the in vitro stimulatory effect of insulin on [14C]glucose oxidation by adipose tissue isolated from these animals was not altered, suggesting that insulin-induced receptor or postreceptor changes do not account for the increased insulin resistance produced by RCM-hGH. Carbon-14 182-185 insulin Homo sapiens 126-133 2439067-2 1987 Two antibodies which reacted with receptor alpha-subunit and completely inhibited 125I-insulin binding mimicked the actions of insulin to stimulate lipogenesis from [14C]glucose and to inhibit catecholamine-induced lipolysis. Carbon-14 166-169 insulin Homo sapiens 87-94 2439067-2 1987 Two antibodies which reacted with receptor alpha-subunit and completely inhibited 125I-insulin binding mimicked the actions of insulin to stimulate lipogenesis from [14C]glucose and to inhibit catecholamine-induced lipolysis. Carbon-14 166-169 insulin Homo sapiens 127-134 3895980-8 1985 [14C]phenylalanine incorporation was stimulated by 108% in cardiocytes cultured in the presence of high concentrations of insulin (1.7 X 10(-7) mol/l) for 63 h, when compared with control cells cultured in the absence of insulin. Carbon-14 1-4 insulin Homo sapiens 122-129 3517555-2 1986 [14C]acetate incorporation into total lipids, cholesterol, and phospholipids was significantly increased in familial hypercholesterolemic cells at insulin concentrations of 0.4 and 4 ng/mL, which had no effect in normal cells. Carbon-14 1-4 insulin Homo sapiens 147-154 3895980-8 1985 [14C]phenylalanine incorporation was stimulated by 108% in cardiocytes cultured in the presence of high concentrations of insulin (1.7 X 10(-7) mol/l) for 63 h, when compared with control cells cultured in the absence of insulin. Carbon-14 1-4 insulin Homo sapiens 221-228 6349621-3 1983 Cycloheximide (2.8 micrograms/ml) increased insulin binding by 30% within 6 h, an effect that persisted for up to 25 h. This drug had a specific inhibitory effect on the degradation of proteins prelabelled for 10 h with [14C]glucosamine, without affecting the degradation of total proteins. Carbon-14 220-225 insulin Homo sapiens 44-51 3894762-4 1985 In contrast (14C)-D-glucose transport exhibited decreased sensitivity to insulin. Carbon-14 13-16 insulin Homo sapiens 73-80 3991568-3 1985 In contrast (14C)-D-glucose transport exhibited decreased sensitivity to insulin. Carbon-14 13-16 insulin Homo sapiens 73-80 6363863-1 1984 Glucose in concentrations of 20 mg% (or greater) significantly inhibited 14C-labelled ascorbic acid (1.25 mg%) uptake in endothelial cells in the presence of insulin (1600 microU/ml). Carbon-14 73-76 insulin Homo sapiens 158-165 6364983-3 1983 [14C]Glucose incorporation into glycogen was maximally stimulated approximately 80% by insulin, whereas maximum stimulation by insulin-ricin B hybrid was greater than 100%. Carbon-14 1-4 insulin Homo sapiens 87-94 6309340-5 1983 The method was tested on insulin, pancreatic ribonuclease, and lysozyme which gave high 3H/14C ratios only in the expected amino-terminal amino acids. Carbon-14 91-94 insulin Homo sapiens 25-32 7046731-8 1982 Chloroquine, and also bacitracin, at concentrations that inhibited insulin degradation, decreased the insulin-stimulated incorporation of [14C]glucose into glycogen over 2 h. This effect of chloroquine was specific, since it did not modify the basal glycogenesis, or the glycogenic effect of a glucose load in the absence of insulin. Carbon-14 139-142 insulin Homo sapiens 67-74 6750314-1 1982 We have studied (125I)-insulin binding and insulin dose response relationships of (14C)-methylglucose transport conversion of (14C)-glucose to CO2 and total lipids, and lipolysis at 37 degrees C and pH 7.4 in adipocytes from obese patients before (n = 15) and after fasting for 10 days (n = 6). Carbon-14 83-86 insulin Homo sapiens 23-30 6750314-1 1982 We have studied (125I)-insulin binding and insulin dose response relationships of (14C)-methylglucose transport conversion of (14C)-glucose to CO2 and total lipids, and lipolysis at 37 degrees C and pH 7.4 in adipocytes from obese patients before (n = 15) and after fasting for 10 days (n = 6). Carbon-14 83-86 insulin Homo sapiens 43-50 7046731-8 1982 Chloroquine, and also bacitracin, at concentrations that inhibited insulin degradation, decreased the insulin-stimulated incorporation of [14C]glucose into glycogen over 2 h. This effect of chloroquine was specific, since it did not modify the basal glycogenesis, or the glycogenic effect of a glucose load in the absence of insulin. Carbon-14 139-142 insulin Homo sapiens 102-109 176151-8 1976 Insulin addition (10 nM) stimulated [14C]glucose incorporation into glycogen at all stages of the culture when grown in the presence of cortisol; no glycogenic response to insulin was observed 6 hours after transplantation where cortisol was not previously introduced. Carbon-14 37-40 insulin Homo sapiens 0-7 190261-8 1977 14C-labeled protein was observed in the V0, and in the proinsulin and insulin regions. Carbon-14 0-3 insulin Homo sapiens 55-65 190261-8 1977 14C-labeled protein was observed in the V0, and in the proinsulin and insulin regions. Carbon-14 0-3 insulin Homo sapiens 58-65 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 6-9 insulin Homo sapiens 55-62 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 6-9 insulin Homo sapiens 134-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 6-9 insulin Homo sapiens 137-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 6-9 insulin Homo sapiens 137-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 115-118 insulin Homo sapiens 134-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 115-118 insulin Homo sapiens 137-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 115-118 insulin Homo sapiens 137-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 115-118 insulin Homo sapiens 134-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 115-118 insulin Homo sapiens 137-144 190261-9 1977 These 14C-labeled proteins were precipitated with anti-insulin serum, and it was determined that whereas 60-90% of 14C-protein in the proinsulin-insulin region was precipitated, virtually none of the 14C-protein in the V0 was immunoprecipitated with anti-insulin serum. Carbon-14 115-118 insulin Homo sapiens 137-144 396302-2 1979 Influence of insulin on total cell glucose incorporation was evaluated using [14C] glucose. Carbon-14 78-81 insulin Homo sapiens 13-20 1030569-6 1976 Incorporation of 14C-activity into fat cell triglyceride showed a slight age-related increase under basal conditions as well as on insulin stimulation. Carbon-14 17-20 insulin Homo sapiens 131-138 14910646-0 1951 Stimulation by insulin of in vitro fat synthesis by mammary tissue studied with carbon-14 and tritium. Carbon-14 80-89 insulin Homo sapiens 15-22 15959962-3 1975 Analyses of six studies performed in young healthy men in the postabsorptive state utilizing the concurrent administration of [14C]glucose and 1 mU/kg per min (40 mU/m2 per min) porcine insulin led to the development of kinetic models for insulin and for glucose. Carbon-14 127-130 insulin Homo sapiens 239-246 5808104-0 1969 Effect of insulin on the incorporation of 14C of radioactive glucose into glycogen and carbon dioxide in cerebral cortical slices. Carbon-14 42-45 insulin Homo sapiens 10-17 14459745-0 1962 Sites of incorporation of phenylalanine labelled with carbon-14 into insulin and its chain B in vitro. Carbon-14 54-63 insulin Homo sapiens 69-76 14472437-0 1962 Effects of insulin on turnover of carbon-14 in HeLa cells. Carbon-14 34-43 insulin Homo sapiens 11-18 12780388-7 2003 Insulin stimulated [14C]Gly-Sar uptake with an ED50 value of 3.5 +/- 2.0 ng mL-1 (n = 3-6) and a maximal stimulation of approximately 18% (n = 3-6). Carbon-14 20-23 insulin Homo sapiens 0-7 14656049-4 2003 Insulin"s stimulation of pyruvate dehydrogenase as measured by lactate oxidation ([1-14C]-lactate --> 14CO2) in intact BC3H-1 myocytes reached a maximum at 15-30 min and returned to basal activity during the 60-90 min measurement interval. Carbon-14 85-88 insulin Homo sapiens 0-7 16420480-6 2006 It had no effect on insulin-stimulated 2-deoxglucose uptake by isolated adipocytes but inhibited insulin-stimulated oxidation of [14C]glucose with a half-maximal concentration of approximately 4 nM. Carbon-14 130-133 insulin Homo sapiens 97-104